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The map label for this gene is ectP [H]

Identifier: 38234310

GI number: 38234310

Start: 1781790

End: 1783616

Strand: Reverse

Name: ectP [H]

Synonym: DIP1739

Alternate gene names: 38234310

Gene position: 1783616-1781790 (Counterclockwise)

Preceding gene: 38234315

Following gene: 38234305

Centisome position: 71.67

GC content: 53.42

Gene sequence:

>1827_bases
ATGTCCGACCCGATAGTCGCAGAACCTGTTTCTGCCAAAAGACCTTTTTTAGGTCTTAAAACAGACCCGTTCATTTTCCT
TAGTTCACTTGGATTCGTGATCCTTTTCGTCGTGGCCACGATCCTTCTTGGTGAAAAAGCCAGCAGCGCCTTCACCACCA
TTGCACAAGGCCTGCTCAAAAACACCGGTTGGCTATATGTCGGCGGTGTGAGCTTCATGTTCATCTTCCTCATCGCAATT
TTCATTTCCCGCTACGGGCGCTTGCGTCTAGGTGATGACGACGACGAACCAGAGCACGGCCTCATCGCATGGTTCTGCAT
GCTATTCGCAGGCGGCATCGGCGCCGTGCTGATGTTCTGGGGAGTCGCGGAGCCACTCAACCACTCCGTCAACGTTCCGC
AGCAAGATGCCGAGCCGATGAGCGAACAAGCCATCACTGAAGCATTTGCTTACACCTTCTACCACTTCGGTATCCACATG
TGGGCGATTGTCGCCCTGCCAGGTTTGGCACTGGGATACTTCATTTATAAACGTAAGCTGCCGCCACGTGTGAGCTCTGT
ATTTGCCCCGATCCTTGGATCACGAATCTACTCATTGCCAGGCAAGCTTATCGACGCCCTCTCGATCATCGCCACCACCT
TCGGTATCGCCGTTTCGGTCGGTTTGGGCGTATTGCAGATCAACTCCGGGTTGAAACGCTTGTGGGGCGTACCCGAGGTG
AGCTGGGTTCAGCTCGCCATCATTTTGGTCATTACCGTTATCGCTTGCATCTCCGTGGCCTCCGGTTTGGAAAAAGGCAT
CAAGCTGCTGTCCAACATCAACATCGGACTCGCAGTGCTACTGATGATCTTTGTGCTTGTCACTGGTCCAACGTTGACGC
TTTTGCGTTTTACCACCGAAGCTTTTGGCATTTACGCTGACTGGCTGCCAAGCCTCATGTTCTGGACTGACTCCTATGGG
GATAACCCAGGCTGGCAGGGCAAATGGACCGTGTTCTACTGGGCATGGACGATCTGCTGGTCGCCTTACGTGGGCATGTT
TGTGGCTCGCATCTCTCGCGGTCGTACAGTCCGCGAATACATTGGTGGCGTGTTGGCACTCCCTGCGATTTTCTCCGTTA
TCTGGTTCGCGATCTTTGGCCGTGCAGGTATCGAAATTGAGCTCAACAGCCCAGGCAAGCTCACAGGCCCTATCGTCCAC
GACGGCGATGTGCCATTCGCACTCTTTGGCTTCTTCCACGAGTATCCCCTGTCAGGACTAGTTTCCGCGCTCGCACTCCT
TGTGGTGGTTATCTTCTTTATCACCTCAATCGACTCTGCCGGAATGGTCAATGACATGTTCTCCACCGGCGAAGAAGAAG
TTTCACCCGTCGGTTACCGCGTGCTGTGGGTAGTAGCCATCGGCGCCGTCGCTGGTGCACTGCTTATCATTTCGCCGAAC
TCTGGCATCGCTACCTTGCAGGAAGTCGTCATCATTGTGGCGTTCCCGTTCTTCATTACTCAATTCGTCATGATGTACTC
CCTGATCAAGGGCATGACCGACGACTCGGCAGCAGAACGACGCATCCAAACCCGCCAGTGGCAAAAGACCGACACTGCCG
AAAAATTGGAAGCTCACGAAGCCATGCCAGCACCAGGCTACGATCTCGAAGGCAATGAACTTCCTGTAGTCGCCCTAGCT
CACGACGAAGACGGCAACATCGTCATTCCTGGCAACGTAGTTATCGAAGGCGACCTAGGTGTGGTTGGCGACATGGTGGA
AGAGGAAGAAGAACCAGGTTTTAAGATCGTGGAACAAACACGACCTAAGACACAAGAAGACTGGTAA

Upstream 100 bases:

>100_bases
CTTAGGCTGATCCCTAAATCGGGGGGATAGCCGATACGTATATGTCTGAAAACCAAGCAGAAATGGGTATCCTACGCAAC
GTTTTATTAGGGTTTTTATC

Downstream 100 bases:

>100_bases
TTTCCACAGCCCGCATGGTGTCCTCCCACGAAGTGGATAACAAAGACACCATGAGCTCATCAGCCCCACAATGGCGCTGA
AACTTGGTGAGGTAGTCACG

Product: ectoine, glycine betaine and proline transport system membrane protein

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSDPIVAEPVSAKRPFLGLKTDPFIFLSSLGFVILFVVATILLGEKASSAFTTIAQGLLKNTGWLYVGGVSFMFIFLIAI
FISRYGRLRLGDDDDEPEHGLIAWFCMLFAGGIGAVLMFWGVAEPLNHSVNVPQQDAEPMSEQAITEAFAYTFYHFGIHM
WAIVALPGLALGYFIYKRKLPPRVSSVFAPILGSRIYSLPGKLIDALSIIATTFGIAVSVGLGVLQINSGLKRLWGVPEV
SWVQLAIILVITVIACISVASGLEKGIKLLSNINIGLAVLLMIFVLVTGPTLTLLRFTTEAFGIYADWLPSLMFWTDSYG
DNPGWQGKWTVFYWAWTICWSPYVGMFVARISRGRTVREYIGGVLALPAIFSVIWFAIFGRAGIEIELNSPGKLTGPIVH
DGDVPFALFGFFHEYPLSGLVSALALLVVVIFFITSIDSAGMVNDMFSTGEEEVSPVGYRVLWVVAIGAVAGALLIISPN
SGIATLQEVVIIVAFPFFITQFVMMYSLIKGMTDDSAAERRIQTRQWQKTDTAEKLEAHEAMPAPGYDLEGNELPVVALA
HDEDGNIVIPGNVVIEGDLGVVGDMVEEEEEPGFKIVEQTRPKTQEDW

Sequences:

>Translated_608_residues
MSDPIVAEPVSAKRPFLGLKTDPFIFLSSLGFVILFVVATILLGEKASSAFTTIAQGLLKNTGWLYVGGVSFMFIFLIAI
FISRYGRLRLGDDDDEPEHGLIAWFCMLFAGGIGAVLMFWGVAEPLNHSVNVPQQDAEPMSEQAITEAFAYTFYHFGIHM
WAIVALPGLALGYFIYKRKLPPRVSSVFAPILGSRIYSLPGKLIDALSIIATTFGIAVSVGLGVLQINSGLKRLWGVPEV
SWVQLAIILVITVIACISVASGLEKGIKLLSNINIGLAVLLMIFVLVTGPTLTLLRFTTEAFGIYADWLPSLMFWTDSYG
DNPGWQGKWTVFYWAWTICWSPYVGMFVARISRGRTVREYIGGVLALPAIFSVIWFAIFGRAGIEIELNSPGKLTGPIVH
DGDVPFALFGFFHEYPLSGLVSALALLVVVIFFITSIDSAGMVNDMFSTGEEEVSPVGYRVLWVVAIGAVAGALLIISPN
SGIATLQEVVIIVAFPFFITQFVMMYSLIKGMTDDSAAERRIQTRQWQKTDTAEKLEAHEAMPAPGYDLEGNELPVVALA
HDEDGNIVIPGNVVIEGDLGVVGDMVEEEEEPGFKIVEQTRPKTQEDW
>Mature_607_residues
SDPIVAEPVSAKRPFLGLKTDPFIFLSSLGFVILFVVATILLGEKASSAFTTIAQGLLKNTGWLYVGGVSFMFIFLIAIF
ISRYGRLRLGDDDDEPEHGLIAWFCMLFAGGIGAVLMFWGVAEPLNHSVNVPQQDAEPMSEQAITEAFAYTFYHFGIHMW
AIVALPGLALGYFIYKRKLPPRVSSVFAPILGSRIYSLPGKLIDALSIIATTFGIAVSVGLGVLQINSGLKRLWGVPEVS
WVQLAIILVITVIACISVASGLEKGIKLLSNINIGLAVLLMIFVLVTGPTLTLLRFTTEAFGIYADWLPSLMFWTDSYGD
NPGWQGKWTVFYWAWTICWSPYVGMFVARISRGRTVREYIGGVLALPAIFSVIWFAIFGRAGIEIELNSPGKLTGPIVHD
GDVPFALFGFFHEYPLSGLVSALALLVVVIFFITSIDSAGMVNDMFSTGEEEVSPVGYRVLWVVAIGAVAGALLIISPNS
GIATLQEVVIIVAFPFFITQFVMMYSLIKGMTDDSAAERRIQTRQWQKTDTAEKLEAHEAMPAPGYDLEGNELPVVALAH
DEDGNIVIPGNVVIEGDLGVVGDMVEEEEEPGFKIVEQTRPKTQEDW

Specific function: High-affinity uptake of glycine betaine [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=520, Percent_Identity=33.4615384615385, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788102, Length=476, Percent_Identity=29.4117647058824, Blast_Score=182, Evalue=8e-47,
Organism=Escherichia coli, GI1786224, Length=441, Percent_Identity=27.891156462585, Blast_Score=161, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 66460; Mature: 66329

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPIVAEPVSAKRPFLGLKTDPFIFLSSLGFVILFVVATILLGEKASSAFTTIAQGLLK
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
NTGWLYVGGVSFMFIFLIAIFISRYGRLRLGDDDDEPEHGLIAWFCMLFAGGIGAVLMFW
CCCEEEECHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVAEPLNHSVNVPQQDAEPMSEQAITEAFAYTFYHFGIHMWAIVALPGLALGYFIYKRKL
HCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPRVSSVFAPILGSRIYSLPGKLIDALSIIATTFGIAVSVGLGVLQINSGLKRLWGVPEV
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
SWVQLAIILVITVIACISVASGLEKGIKLLSNINIGLAVLLMIFVLVTGPTLTLLRFTTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
AFGIYADWLPSLMFWTDSYGDNPGWQGKWTVFYWAWTICWSPYVGMFVARISRGRTVREY
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
IGGVLALPAIFSVIWFAIFGRAGIEIELNSPGKLTGPIVHDGDVPFALFGFFHEYPLSGL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEECCCCCHHHHHHHHHCCHHHH
VSALALLVVVIFFITSIDSAGMVNDMFSTGEEEVSPVGYRVLWVVAIGAVAGALLIISPN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHCEEEEECCC
SGIATLQEVVIIVAFPFFITQFVMMYSLIKGMTDDSAAERRIQTRQWQKTDTAEKLEAHE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
AMPAPGYDLEGNELPVVALAHDEDGNIVIPGNVVIEGDLGVVGDMVEEEEEPGFKIVEQT
CCCCCCCCCCCCCCCEEEEEECCCCCEEECCCEEEECCCCHHHHHHHHCCCCCCCHHHHC
RPKTQEDW
CCCCCCCC
>Mature Secondary Structure 
SDPIVAEPVSAKRPFLGLKTDPFIFLSSLGFVILFVVATILLGEKASSAFTTIAQGLLK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
NTGWLYVGGVSFMFIFLIAIFISRYGRLRLGDDDDEPEHGLIAWFCMLFAGGIGAVLMFW
CCCEEEECHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVAEPLNHSVNVPQQDAEPMSEQAITEAFAYTFYHFGIHMWAIVALPGLALGYFIYKRKL
HCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPRVSSVFAPILGSRIYSLPGKLIDALSIIATTFGIAVSVGLGVLQINSGLKRLWGVPEV
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
SWVQLAIILVITVIACISVASGLEKGIKLLSNINIGLAVLLMIFVLVTGPTLTLLRFTTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
AFGIYADWLPSLMFWTDSYGDNPGWQGKWTVFYWAWTICWSPYVGMFVARISRGRTVREY
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
IGGVLALPAIFSVIWFAIFGRAGIEIELNSPGKLTGPIVHDGDVPFALFGFFHEYPLSGL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEECCCCCHHHHHHHHHCCHHHH
VSALALLVVVIFFITSIDSAGMVNDMFSTGEEEVSPVGYRVLWVVAIGAVAGALLIISPN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHCEEEEECCC
SGIATLQEVVIIVAFPFFITQFVMMYSLIKGMTDDSAAERRIQTRQWQKTDTAEKLEAHE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
AMPAPGYDLEGNELPVVALAHDEDGNIVIPGNVVIEGDLGVVGDMVEEEEEPGFKIVEQT
CCCCCCCCCCCCCCCEEEEEECCCCCEEECCCEEEECCCCHHHHHHHHCCCCCCCHHHHC
RPKTQEDW
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8752321; 9387221; 9384377 [H]