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The map label for this gene is hisC [C]

Identifier: 38234252

GI number: 38234252

Start: 1718437

End: 1719471

Strand: Reverse

Name: hisC [C]

Synonym: DIP1681

Alternate gene names: 38234252

Gene position: 1719471-1718437 (Counterclockwise)

Preceding gene: 38234256

Following gene: 38234251

Centisome position: 69.09

GC content: 52.95

Gene sequence:

>1035_bases
GTGTCACTTTCTAGGATTCACGGCGACGACGATGCCTTTGGGGCCCGCCTCGACTTTGCCGTCAACGTTGCCGAAGCCCA
ACCACCTACATGGCTTATTCAACGCCTACAATCCGCCGTCACTGATCTAGCCGCCTATCCGCATTCCAGCGATCTAGCAG
CAGTGACCGCTATGATCGCTCGCTACCACGGAGTAAGTGAAGACCACGTACTAGTTCTATCGGGAGTATCAGAAGGCTTC
GCCATGTTGCCGCAGCTAAAGCCTGAAAACGCGGTGATTATCCATCCAGGTTTTAGCGAACCAGACATCGTTTTAACCGA
CGCCCAGATCCCTGTTCATCGCTGCATCTTGGCGCCGCCATTCGAGCTTTCTTTTGAAAATATCCCCGCCAACGCAGACC
TCGTGGTAATTGGTAACCCCACTAATCCCACAGGAGTCGTACATAGCAAAGAACTACTTGCTCAATTATGCGCGCCGGGG
CGTACCGTGGTGATCGACGAAGCATTCTTGGACATCGTCGGAGAACAGTACTCGATGATCGATCAACTTGATGCGGTGGA
AGGTGAACTGATTATCTTCCGCAGTCTGACAAAGACGTGGTCAATTGCGGGACTTCGAGTAGGCTACGCCATTGCCCGTC
CGGAAACACTTGCGCGCTTAAGTGCGTATCGACGCCACTGGCCCATGGGTACCCTGCAGCTTCGAGCCATTGAGGCAGTT
TTTGACACCGGTATCATGCAGTTGCCTGAGCGACGAGCAGAGATGATAGCGCAGCGTACCGAGATGATTGAGATGTTGAC
CAACAGTGGCTTTAGGTGTGTGAGCAGCTCTCAAGCCCCGTATATCCTGGTGCGACCACCTAGCACGCAACCGGAAGAAC
TACGAATGGCGTTAAAAGCTCAAGGAATCGCTGTTCGCCGATGCGATACTTTCCCAGGACTTGAGTTTTCCTATTGGCGC
CTTGCGGTGCGTCCTCGTGACCAAGTACAACGGCTACTAACCGCCATCGACAACATTATTGGAGCAAAGAAGTAA

Upstream 100 bases:

>100_bases
TAAAAGCCTCACGGATGCCGGGATAGGAATCAACCACAGTCCCGTCAACATCGATTAATAGAGTTCCCACACCCAGTAGT
CTCCCACTAAAATCAACGCA

Downstream 100 bases:

>100_bases
CGATGATCACCGTTTCAGATGTAAGAAAAGTAATGGATCGTGCGTATCCACCACACCTCGCGGAATCTTGGGATGCAGTA
GGCCTTATCTGTGGTGATCC

Product: hypothetical protein

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSLSRIHGDDDAFGARLDFAVNVAEAQPPTWLIQRLQSAVTDLAAYPHSSDLAAVTAMIARYHGVSEDHVLVLSGVSEGF
AMLPQLKPENAVIIHPGFSEPDIVLTDAQIPVHRCILAPPFELSFENIPANADLVVIGNPTNPTGVVHSKELLAQLCAPG
RTVVIDEAFLDIVGEQYSMIDQLDAVEGELIIFRSLTKTWSIAGLRVGYAIARPETLARLSAYRRHWPMGTLQLRAIEAV
FDTGIMQLPERRAEMIAQRTEMIEMLTNSGFRCVSSSQAPYILVRPPSTQPEELRMALKAQGIAVRRCDTFPGLEFSYWR
LAVRPRDQVQRLLTAIDNIIGAKK

Sequences:

>Translated_344_residues
MSLSRIHGDDDAFGARLDFAVNVAEAQPPTWLIQRLQSAVTDLAAYPHSSDLAAVTAMIARYHGVSEDHVLVLSGVSEGF
AMLPQLKPENAVIIHPGFSEPDIVLTDAQIPVHRCILAPPFELSFENIPANADLVVIGNPTNPTGVVHSKELLAQLCAPG
RTVVIDEAFLDIVGEQYSMIDQLDAVEGELIIFRSLTKTWSIAGLRVGYAIARPETLARLSAYRRHWPMGTLQLRAIEAV
FDTGIMQLPERRAEMIAQRTEMIEMLTNSGFRCVSSSQAPYILVRPPSTQPEELRMALKAQGIAVRRCDTFPGLEFSYWR
LAVRPRDQVQRLLTAIDNIIGAKK
>Mature_343_residues
SLSRIHGDDDAFGARLDFAVNVAEAQPPTWLIQRLQSAVTDLAAYPHSSDLAAVTAMIARYHGVSEDHVLVLSGVSEGFA
MLPQLKPENAVIIHPGFSEPDIVLTDAQIPVHRCILAPPFELSFENIPANADLVVIGNPTNPTGVVHSKELLAQLCAPGR
TVVIDEAFLDIVGEQYSMIDQLDAVEGELIIFRSLTKTWSIAGLRVGYAIARPETLARLSAYRRHWPMGTLQLRAIEAVF
DTGIMQLPERRAEMIAQRTEMIEMLTNSGFRCVSSSQAPYILVRPPSTQPEELRMALKAQGIAVRRCDTFPGLEFSYWRL
AVRPRDQVQRLLTAIDNIIGAKK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=308, Percent_Identity=27.9220779220779, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 37959; Mature: 37828

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSRIHGDDDAFGARLDFAVNVAEAQPPTWLIQRLQSAVTDLAAYPHSSDLAAVTAMIA
CCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RYHGVSEDHVLVLSGVSEGFAMLPQLKPENAVIIHPGFSEPDIVLTDAQIPVHRCILAPP
HHCCCCCCCEEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHEEECCC
FELSFENIPANADLVVIGNPTNPTGVVHSKELLAQLCAPGRTVVIDEAFLDIVGEQYSMI
CCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHH
DQLDAVEGELIIFRSLTKTWSIAGLRVGYAIARPETLARLSAYRRHWPMGTLQLRAIEAV
HHHHHCCCCEEEEEEHHHHHHHHHEEECEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHH
FDTGIMQLPERRAEMIAQRTEMIEMLTNSGFRCVSSSQAPYILVRPPSTQPEELRMALKA
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHH
QGIAVRRCDTFPGLEFSYWRLAVRPRDQVQRLLTAIDNIIGAKK
CCEEEEECCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLSRIHGDDDAFGARLDFAVNVAEAQPPTWLIQRLQSAVTDLAAYPHSSDLAAVTAMIA
CCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RYHGVSEDHVLVLSGVSEGFAMLPQLKPENAVIIHPGFSEPDIVLTDAQIPVHRCILAPP
HHCCCCCCCEEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHEEECCC
FELSFENIPANADLVVIGNPTNPTGVVHSKELLAQLCAPGRTVVIDEAFLDIVGEQYSMI
CCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHH
DQLDAVEGELIIFRSLTKTWSIAGLRVGYAIARPETLARLSAYRRHWPMGTLQLRAIEAV
HHHHHCCCCEEEEEEHHHHHHHHHEEECEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHH
FDTGIMQLPERRAEMIAQRTEMIEMLTNSGFRCVSSSQAPYILVRPPSTQPEELRMALKA
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHH
QGIAVRRCDTFPGLEFSYWRLAVRPRDQVQRLLTAIDNIIGAKK
CCEEEEECCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]