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The map label for this gene is argF

Identifier: 38233761

GI number: 38233761

Start: 1163790

End: 1164749

Strand: Direct

Name: argF

Synonym: DIP1171

Alternate gene names: 38233761

Gene position: 1163790-1164749 (Clockwise)

Preceding gene: 38233760

Following gene: 38233762

Centisome position: 46.76

GC content: 46.98

Gene sequence:

>960_bases
ATGAGTACTCAAACCCGTGTACGCCACTTTTTAGCGGACGACGACCTTACGCCTGCGCAGCAACGTGAAGTTCTGGAACT
TGCTTCGGAATTGAAGCAACATCCATATTCGCGAAAGACATATGACGGCCCACAATCAGTGGCAGTTCTATTCGATAAAA
CGTCGACACGCACGCGTTTTTCCTTCGACGCTGGTATTTCGCAACTCGGTGGACATGCGATCGTAGTCGACTCCGGCAAA
TCACAAATGGGTAAGGGAGAGACATTCCAAGACACTGGTGCTGTTCTTTCTCGTTTTGTCTCCACTATTGTGTGGCGGAC
GGGTTCTCACCAAAATCTTTTGGACATGGCAGAAACCGCAACTGTTCCTATCGTCAATGCATTGTCAGATGACCTGCATC
CCTGCCAAATATTGGCTGACTTGCAAACTTGTATCGAGCATCTATGCCCGCAAGAAGGTGTGCCTGGTTTAAAAGGTCTG
AAAGCTGTGTATTTGGGCGATGGTGATAACAACATGGCGAATTCTTATATGATCGGTTTCGCTACCGCTGGCCTTGATAT
CACTATTATTGCGCCTAAAAAATTCCAACCCAAGCAAGAATTCGTCGATAGGGCGGAAAAGCGCGCCAGCGAGACTGGCG
CAATTGTTTCGGTCACAGCTGATATTTCCGCAGTATCTGATGCAGATGTTGTAATCACAGACACATGGGTATCTATGGGT
ATGGAAAATGACGGTATCGACCGACGCACTCCATTTTTGCCTTATCAGGTCAATGATGAGGTGATGGCTTTAGCGAAAAA
GTCAGCAATTTTCTTGCATTGCTTACCGGCATATAGAGGTAGTGAGGTAGCGGCTTCGGTCATTGATGGACCGCAATCAG
TAGTTTTTGATGAGGCTGAAAATCGACTTCATGCGCAAAAAGCCCTACTTGTCTGGCTTATGGAAAATCAACCGCGATAA

Upstream 100 bases:

>100_bases
GCAGAAATTCATGAATCAATTGAACGCCTTTCAATAGTGCTGACTAAGATAAAGAAGAAAGAATGCCATTAGGGCGTTGT
CTTCGGAAGAAAGAATAGAT

Downstream 100 bases:

>100_bases
TTTATCGACTGGCATTTCATTTGTTTTAGTATGGCTTTGTACTATTTAGTATCAGGCGTGAAGTCAGACTTTTCCCCTGC
GTTTTAAGTTCTATAAGGAT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSTQTRVRHFLADDDLTPAQQREVLELASELKQHPYSRKTYDGPQSVAVLFDKTSTRTRFSFDAGISQLGGHAIVVDSGK
SQMGKGETFQDTGAVLSRFVSTIVWRTGSHQNLLDMAETATVPIVNALSDDLHPCQILADLQTCIEHLCPQEGVPGLKGL
KAVYLGDGDNNMANSYMIGFATAGLDITIIAPKKFQPKQEFVDRAEKRASETGAIVSVTADISAVSDADVVITDTWVSMG
MENDGIDRRTPFLPYQVNDEVMALAKKSAIFLHCLPAYRGSEVAASVIDGPQSVVFDEAENRLHAQKALLVWLMENQPR

Sequences:

>Translated_319_residues
MSTQTRVRHFLADDDLTPAQQREVLELASELKQHPYSRKTYDGPQSVAVLFDKTSTRTRFSFDAGISQLGGHAIVVDSGK
SQMGKGETFQDTGAVLSRFVSTIVWRTGSHQNLLDMAETATVPIVNALSDDLHPCQILADLQTCIEHLCPQEGVPGLKGL
KAVYLGDGDNNMANSYMIGFATAGLDITIIAPKKFQPKQEFVDRAEKRASETGAIVSVTADISAVSDADVVITDTWVSMG
MENDGIDRRTPFLPYQVNDEVMALAKKSAIFLHCLPAYRGSEVAASVIDGPQSVVFDEAENRLHAQKALLVWLMENQPR
>Mature_318_residues
STQTRVRHFLADDDLTPAQQREVLELASELKQHPYSRKTYDGPQSVAVLFDKTSTRTRFSFDAGISQLGGHAIVVDSGKS
QMGKGETFQDTGAVLSRFVSTIVWRTGSHQNLLDMAETATVPIVNALSDDLHPCQILADLQTCIEHLCPQEGVPGLKGLK
AVYLGDGDNNMANSYMIGFATAGLDITIIAPKKFQPKQEFVDRAEKRASETGAIVSVTADISAVSDADVVITDTWVSMGM
ENDGIDRRTPFLPYQVNDEVMALAKKSAIFLHCLPAYRGSEVAASVIDGPQSVVFDEAENRLHAQKALLVWLMENQPR

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=316, Percent_Identity=35.4430379746835, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI18105007, Length=312, Percent_Identity=22.7564102564103, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786469, Length=329, Percent_Identity=36.1702127659575, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=35.8662613981763, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI48994908, Length=360, Percent_Identity=24.4444444444444, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=32.6219512195122, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322331, Length=313, Percent_Identity=24.6006389776358, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24642586, Length=317, Percent_Identity=26.813880126183, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_CORDI (Q6NHG6)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939528.1
- ProteinModelPortal:   Q6NHG6
- SMR:   Q6NHG6
- GeneID:   2649723
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1171
- NMPDR:   fig|257309.1.peg.1119
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- PhylomeDB:   Q6NHG6
- ProtClustDB:   PRK00779
- BioCyc:   CDIP257309:DIP1171-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34856; Mature: 34725

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 106-106 BINDING 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQTRVRHFLADDDLTPAQQREVLELASELKQHPYSRKTYDGPQSVAVLFDKTSTRTRF
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEE
SFDAGISQLGGHAIVVDSGKSQMGKGETFQDTGAVLSRFVSTIVWRTGSHQNLLDMAETA
EHHHCHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHC
TVPIVNALSDDLHPCQILADLQTCIEHLCPQEGVPGLKGLKAVYLGDGDNNMANSYMIGF
CCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEE
ATAGLDITIIAPKKFQPKQEFVDRAEKRASETGAIVSVTADISAVSDADVVITDTWVSMG
EECCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEHHHHCC
MENDGIDRRTPFLPYQVNDEVMALAKKSAIFLHCLPAYRGSEVAASVIDGPQSVVFDEAE
CCCCCCCCCCCCCCEECCHHHHHHHHHCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHH
NRLHAQKALLVWLMENQPR
HHHHHHHHHEEEEECCCCC
>Mature Secondary Structure 
STQTRVRHFLADDDLTPAQQREVLELASELKQHPYSRKTYDGPQSVAVLFDKTSTRTRF
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEE
SFDAGISQLGGHAIVVDSGKSQMGKGETFQDTGAVLSRFVSTIVWRTGSHQNLLDMAETA
EHHHCHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHC
TVPIVNALSDDLHPCQILADLQTCIEHLCPQEGVPGLKGLKAVYLGDGDNNMANSYMIGF
CCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEE
ATAGLDITIIAPKKFQPKQEFVDRAEKRASETGAIVSVTADISAVSDADVVITDTWVSMG
EECCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEHHHHCC
MENDGIDRRTPFLPYQVNDEVMALAKKSAIFLHCLPAYRGSEVAASVIDGPQSVVFDEAE
CCCCCCCCCCCCCCEECCHHHHHHHHHCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHH
NRLHAQKALLVWLMENQPR
HHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910