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The map label for this gene is uvrB

Identifier: 38233744

GI number: 38233744

Start: 1142204

End: 1144249

Strand: Direct

Name: uvrB

Synonym: DIP1154

Alternate gene names: 38233744

Gene position: 1142204-1144249 (Clockwise)

Preceding gene: 38233743

Following gene: 38233745

Centisome position: 45.9

GC content: 47.7

Gene sequence:

>2046_bases
GTGGGCGATATTGAGCGTACAGATGCGCGATTTGAGGTCATCTCCGAATACGAGCCGGCTGGTGACCAGCCGGCGGCTAT
TGAGGAATTAGACGCACGATTGTCACGTGGAGAACGAGACGTTGTTTTATTAGGTGCCACTGGCACTGGTAAGTCTGCAA
CGGCTGCGTGGCTGATTGAGCAACAACAGCGGCCTACTCTTGTGATGGCGCCTAACAAGACGCTAGCGGCGCAATTGGCA
AATGAGCTACGTCAATTGCTTCCTAATAACGCGGTTGAGTACTTCGTTTCTTATTACGACTATTACCAGCCTGAAGCGTA
TATCGCGCAAACAGATACCTATATTGAAAAAGACTCATCAATTAACGATGACGTCGAAAGGCTTAGGCACCGCGCCACCA
GTTCGTTGTTATCTCGGCGCGACGTTGTGGTGGTGTCTTCAGTTTCCTGCATTTATGGTTTGGGAACTCCGCAGTCATAT
TTGGATCGCTCTGTTGTTTTGCGCGTAGACGAAGAAGTCGAACGTGATCGTTTTCTGAGACTACTTGTGGATATTCAATA
CGATCGCAATGATGTTGGGTTTACTCGAGGTACGTTCCGCGTAAAAGGTGACACAGTCGATATTATTCCCGCATATGAAG
AGGTCGCGGTCCGCGTTGAGTTCTTTGGTGATGATATTGATGCGTTGTATTACATCCATCCTTTAACTGGAGACGTTATT
CGGCAGGTAGATGAAGTTCGCATATTTCCTGCGACTCACTACGTCGCTGGACCAGAACGCATGGCAAAAGCTGTCGAGGA
TATTAAAGCTGAGTTGCGTGATCGTCTCGAAGATTTGGAAAACAGAGGCAAGCTTCTAGAGGCACAGCGGTTACGTATGC
GCACTGAATATGACCTAGAAATGATCGAGCAGGTCGGATTTTGTTCCGGGATTGAGAACTATTCTCGGCATCTAGACGGT
CGACCAGCTGGGTCTGCACCGGCAACGTTGTTGGATTATTTCCCTGAGGATTTTCTTACGATTATCGACGAGTCCCACGT
GACGGTTCCGCAAATTGGCGGAATGTTTGAAGGAGACATGTCGCGTAAGCGCAATTTGGTTGAATTTGGATTCCGGTTGC
CTTCAGCTCTTGATAATCGTCCACTAAAGTGGGAAGAATTTGAGCAACGCGTTGGTCAAACGGTGTATATGTCGGCCACG
CCTGGGGATTATGAACTTGCGGCTTCGGGCGGTGAGTACGTTGAACAAGTCATTCGACCTACAGGTCTGGTAGATCCTGA
AATTGATGTGCGGCCAACTAGGGGCCAAATTGACGATCTCATTCATGAGATCAAACAGAGGACTACTAAAGACGAGCGTG
TATTAGTAACCACTCTGACAAAGAAGATGGCCGAAGACCTTACAGATTATCTTCTAGAAAATGGTATTAGGGTGCGATAC
CTGCATTCCGATATCGATACTTTGCAGCGTGTTGAGTTGCTGAGGCAGCTCAGATTAGGGGAGTATGATGTTCTCGTTGG
CATCAACTTGTTGCGTGAGGGCTTGGACTTGCCTGAGGTTTCTCTCGTAGCGATTTTGGACGCCGATAAAGAGGGGTTCC
TCCGATCAACTAAATCGTTGATTCAGACTATTGGCCGTGCAGCCCGAAATGTTTCAGGCACTGTAATTATGTACGCAGAT
AAGATCACAGATTCTATGCAGTACGCGATTGATGAGACCGAGCGGCGTCGAGAAAAACAGATCGCATACAACAAAGAACA
CGGCATTGACCCACAGCCGCTACGTAAAAAGATTGCGGATATCTTGGAACAGGTTCAAGAAAGTAAAGCAGAAAGTACGG
CACCTTCGTCCGATGCCGTAGTCGTTTCTAAAACAAATACGTCGTCGATGCCGGTGGCAGAATTGCGATCGCTTATCGAC
GACCTTACGACCCAGATGGGAACGGCAGCACGTGAATTAAAGTTTGAATTAGCTGGACGTTTACGTGATGAAATCGCCGA
ATTGAAGAAAGAACTTCGTGGTATGGAAGAAATAGGGCTTGCATAA

Upstream 100 bases:

>100_bases
AACTTGGCGTCTCGGGCGAGAAGTTGATTCAGACACTACACTTTTGGATATGGCTTTTGCGGCGGAACATCCAGAGTTAT
CGGTTTCAGAATTTCGTCCG

Downstream 100 bases:

>100_bases
ATGGGTGTTTTCTAGGCCACTGTTGTGAGTATCGGTAATGAATTTTCCTATTGTGACGTGCCTTAATTCTGCTATCTGCT
TGTTATAACGTCACCATTCA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MGDIERTDARFEVISEYEPAGDQPAAIEELDARLSRGERDVVLLGATGTGKSATAAWLIEQQQRPTLVMAPNKTLAAQLA
NELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHRATSSLLSRRDVVVVSSVSCIYGLGTPQSY
LDRSVVLRVDEEVERDRFLRLLVDIQYDRNDVGFTRGTFRVKGDTVDIIPAYEEVAVRVEFFGDDIDALYYIHPLTGDVI
RQVDEVRIFPATHYVAGPERMAKAVEDIKAELRDRLEDLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHLDG
RPAGSAPATLLDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSALDNRPLKWEEFEQRVGQTVYMSAT
PGDYELAASGGEYVEQVIRPTGLVDPEIDVRPTRGQIDDLIHEIKQRTTKDERVLVTTLTKKMAEDLTDYLLENGIRVRY
LHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTKSLIQTIGRAARNVSGTVIMYAD
KITDSMQYAIDETERRREKQIAYNKEHGIDPQPLRKKIADILEQVQESKAESTAPSSDAVVVSKTNTSSMPVAELRSLID
DLTTQMGTAARELKFELAGRLRDEIAELKKELRGMEEIGLA

Sequences:

>Translated_681_residues
MGDIERTDARFEVISEYEPAGDQPAAIEELDARLSRGERDVVLLGATGTGKSATAAWLIEQQQRPTLVMAPNKTLAAQLA
NELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHRATSSLLSRRDVVVVSSVSCIYGLGTPQSY
LDRSVVLRVDEEVERDRFLRLLVDIQYDRNDVGFTRGTFRVKGDTVDIIPAYEEVAVRVEFFGDDIDALYYIHPLTGDVI
RQVDEVRIFPATHYVAGPERMAKAVEDIKAELRDRLEDLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHLDG
RPAGSAPATLLDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSALDNRPLKWEEFEQRVGQTVYMSAT
PGDYELAASGGEYVEQVIRPTGLVDPEIDVRPTRGQIDDLIHEIKQRTTKDERVLVTTLTKKMAEDLTDYLLENGIRVRY
LHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTKSLIQTIGRAARNVSGTVIMYAD
KITDSMQYAIDETERRREKQIAYNKEHGIDPQPLRKKIADILEQVQESKAESTAPSSDAVVVSKTNTSSMPVAELRSLID
DLTTQMGTAARELKFELAGRLRDEIAELKKELRGMEEIGLA
>Mature_680_residues
GDIERTDARFEVISEYEPAGDQPAAIEELDARLSRGERDVVLLGATGTGKSATAAWLIEQQQRPTLVMAPNKTLAAQLAN
ELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHRATSSLLSRRDVVVVSSVSCIYGLGTPQSYL
DRSVVLRVDEEVERDRFLRLLVDIQYDRNDVGFTRGTFRVKGDTVDIIPAYEEVAVRVEFFGDDIDALYYIHPLTGDVIR
QVDEVRIFPATHYVAGPERMAKAVEDIKAELRDRLEDLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHLDGR
PAGSAPATLLDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSALDNRPLKWEEFEQRVGQTVYMSATP
GDYELAASGGEYVEQVIRPTGLVDPEIDVRPTRGQIDDLIHEIKQRTTKDERVLVTTLTKKMAEDLTDYLLENGIRVRYL
HSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTKSLIQTIGRAARNVSGTVIMYADK
ITDSMQYAIDETERRREKQIAYNKEHGIDPQPLRKKIADILEQVQESKAESTAPSSDAVVVSKTNTSSMPVAELRSLIDD
LTTQMGTAARELKFELAGRLRDEIAELKKELRGMEEIGLA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=57.3795180722892, Blast_Score=742, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CORDI (Q6NHI3)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939511.1
- ProteinModelPortal:   Q6NHI3
- GeneID:   2648480
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1154
- NMPDR:   fig|257309.1.peg.1102
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   Q6NHI3
- ProtClustDB:   PRK05298
- BioCyc:   CDIP257309:DIP1154-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77077; Mature: 76946

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDIERTDARFEVISEYEPAGDQPAAIEELDARLSRGERDVVLLGATGTGKSATAAWLIE
CCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
QQQRPTLVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSS
HCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCHHHCCCCC
INDDVERLRHRATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLRVDEEVERDRFLR
CCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHCCHHEEEECHHHHHHHHHH
LLVDIQYDRNDVGFTRGTFRVKGDTVDIIPAYEEVAVRVEFFGDDIDALYYIHPLTGDVI
HHHHEEECCCCCCCCCCEEEECCCEEEEEECHHHHEEEEEEECCCCCEEEEEECCCHHHH
RQVDEVRIFPATHYVAGPERMAKAVEDIKAELRDRLEDLENRGKLLEAQRLRMRTEYDLE
HHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIEQVGFCSGIENYSRHLDGRPAGSAPATLLDYFPEDFLTIIDESHVTVPQIGGMFEGDM
HHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCHHCCCCCCCCCH
SRKRNLVEFGFRLPSALDNRPLKWEEFEQRVGQTVYMSATPGDYELAASGGEYVEQVIRP
HHHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCCEEEEECCCCCCEEECCCHHHHHHHHCC
TGLVDPEIDVRPTRGQIDDLIHEIKQRTTKDERVLVTTLTKKMAEDLTDYLLENGIRVRY
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTKSL
ECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNVSGTVIMYADKITDSMQYAIDETERRREKQIAYNKEHGIDPQPLRKKIAD
HHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ILEQVQESKAESTAPSSDAVVVSKTNTSSMPVAELRSLIDDLTTQMGTAARELKFELAGR
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRDEIAELKKELRGMEEIGLA
HHHHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure 
GDIERTDARFEVISEYEPAGDQPAAIEELDARLSRGERDVVLLGATGTGKSATAAWLIE
CCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
QQQRPTLVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSS
HCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCHHHCCCCC
INDDVERLRHRATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLRVDEEVERDRFLR
CCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHCCHHEEEECHHHHHHHHHH
LLVDIQYDRNDVGFTRGTFRVKGDTVDIIPAYEEVAVRVEFFGDDIDALYYIHPLTGDVI
HHHHEEECCCCCCCCCCEEEECCCEEEEEECHHHHEEEEEEECCCCCEEEEEECCCHHHH
RQVDEVRIFPATHYVAGPERMAKAVEDIKAELRDRLEDLENRGKLLEAQRLRMRTEYDLE
HHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIEQVGFCSGIENYSRHLDGRPAGSAPATLLDYFPEDFLTIIDESHVTVPQIGGMFEGDM
HHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCHHCCCCCCCCCH
SRKRNLVEFGFRLPSALDNRPLKWEEFEQRVGQTVYMSATPGDYELAASGGEYVEQVIRP
HHHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCCEEEEECCCCCCEEECCCHHHHHHHHCC
TGLVDPEIDVRPTRGQIDDLIHEIKQRTTKDERVLVTTLTKKMAEDLTDYLLENGIRVRY
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTKSL
ECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNVSGTVIMYADKITDSMQYAIDETERRREKQIAYNKEHGIDPQPLRKKIAD
HHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ILEQVQESKAESTAPSSDAVVVSKTNTSSMPVAELRSLIDDLTTQMGTAARELKFELAGR
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRDEIAELKKELRGMEEIGLA
HHHHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910