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The map label for this gene is ung [H]

Identifier: 38233724

GI number: 38233724

Start: 1119460

End: 1120128

Strand: Direct

Name: ung [H]

Synonym: DIP1134

Alternate gene names: 38233724

Gene position: 1119460-1120128 (Clockwise)

Preceding gene: 38233723

Following gene: 38233725

Centisome position: 44.98

GC content: 57.25

Gene sequence:

>669_bases
ATGAACAACACACCACTGCCAGTTCATCCCTCATGGATAGAACCACTAGCGCCCGTGACTGACAACATTCACGCCATGGG
AGACTTCCTCCGCAATGAAATCGCCCAAGGCCGTGGCTACTTGCCCGCAGGATCAGACATCCTCCGCGCATTCCAATACC
CATTCGACGACATCAAAGTGCTCATCGTTGGCCAAGATCCCTACCCAACACCAGGACACGCCATGGGCCTATCCTTTTCC
ACACAACCCGGCGTACGCCCACTGCCACGCAGCCTCGCCAACATTTTCAAAGAACTGTCCGCCGACCTCGGCATCCCAGC
CCCCACAGACGGCGACCTCACCGCATGGTCGCGACAAGGCGTGGCACTGTTCAACAGAGTCCTTAGCGTCCAACCCGGAA
ACGCTGGCTCTCACCGCAAAAAAGGATGGGAAACCATCACAGAAACCGCCATCCGAGCACTCGCACAACGCAACACACCA
CTCGTCGCAATCCTGTGGGGCAAAGACGCCCAAACAACCCAAGCATTCCTCGGCGACACCCCCGTCATCACCTCACCACA
TCCCTCACCACTATCAGCATCCCGTGGTTTCTTCGGATCCCGCCCCTTTAGCCGAGCCAACACCATCCTCGAACAACTAG
GCACCACCCCCATCAACTGGGAACTATAA

Upstream 100 bases:

>100_bases
CGGTAATCAAACGCAGCAACCAACCAACTCACGCTGCCGGCGAAGTCCTCGTCGGCGGCGAAGCACCAGCATACGACGAC
GGATGGGTGAGCTTTTAAAC

Downstream 100 bases:

>100_bases
AACCCCTGTGCCAAACCAACCCCCACCCGCTTTCAACCACTACACTATTTTTCCATGCCAAACATCACGTTCCTCGGTGC
ACACGACCTTCTCACATGGG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNNTPLPVHPSWIEPLAPVTDNIHAMGDFLRNEIAQGRGYLPAGSDILRAFQYPFDDIKVLIVGQDPYPTPGHAMGLSFS
TQPGVRPLPRSLANIFKELSADLGIPAPTDGDLTAWSRQGVALFNRVLSVQPGNAGSHRKKGWETITETAIRALAQRNTP
LVAILWGKDAQTTQAFLGDTPVITSPHPSPLSASRGFFGSRPFSRANTILEQLGTTPINWEL

Sequences:

>Translated_222_residues
MNNTPLPVHPSWIEPLAPVTDNIHAMGDFLRNEIAQGRGYLPAGSDILRAFQYPFDDIKVLIVGQDPYPTPGHAMGLSFS
TQPGVRPLPRSLANIFKELSADLGIPAPTDGDLTAWSRQGVALFNRVLSVQPGNAGSHRKKGWETITETAIRALAQRNTP
LVAILWGKDAQTTQAFLGDTPVITSPHPSPLSASRGFFGSRPFSRANTILEQLGTTPINWEL
>Mature_222_residues
MNNTPLPVHPSWIEPLAPVTDNIHAMGDFLRNEIAQGRGYLPAGSDILRAFQYPFDDIKVLIVGQDPYPTPGHAMGLSFS
TQPGVRPLPRSLANIFKELSADLGIPAPTDGDLTAWSRQGVALFNRVLSVQPGNAGSHRKKGWETITETAIRALAQRNTP
LVAILWGKDAQTTQAFLGDTPVITSPHPSPLSASRGFFGSRPFSRANTILEQLGTTPINWEL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=170, Percent_Identity=45.8823529411765, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI19718751, Length=168, Percent_Identity=46.4285714285714, Blast_Score=148, Evalue=4e-36,
Organism=Escherichia coli, GI1788934, Length=193, Percent_Identity=45.5958549222798, Blast_Score=160, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17556304, Length=204, Percent_Identity=45.0980392156863, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323620, Length=216, Percent_Identity=38.8888888888889, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24083; Mature: 24083

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTPLPVHPSWIEPLAPVTDNIHAMGDFLRNEIAQGRGYLPAGSDILRAFQYPFDDIKV
CCCCCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEE
LIVGQDPYPTPGHAMGLSFSTQPGVRPLPRSLANIFKELSADLGIPAPTDGDLTAWSRQG
EEECCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
VALFNRVLSVQPGNAGSHRKKGWETITETAIRALAQRNTPLVAILWGKDAQTTQAFLGDT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCC
PVITSPHPSPLSASRGFFGSRPFSRANTILEQLGTTPINWEL
CEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNNTPLPVHPSWIEPLAPVTDNIHAMGDFLRNEIAQGRGYLPAGSDILRAFQYPFDDIKV
CCCCCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEE
LIVGQDPYPTPGHAMGLSFSTQPGVRPLPRSLANIFKELSADLGIPAPTDGDLTAWSRQG
EEECCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
VALFNRVLSVQPGNAGSHRKKGWETITETAIRALAQRNTPLVAILWGKDAQTTQAFLGDT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCC
PVITSPHPSPLSASRGFFGSRPFSRANTILEQLGTTPINWEL
CEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]