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The map label for this gene is thiL [H]

Identifier: 38233723

GI number: 38233723

Start: 1118468

End: 1119457

Strand: Direct

Name: thiL [H]

Synonym: DIP1133

Alternate gene names: 38233723

Gene position: 1118468-1119457 (Clockwise)

Preceding gene: 38233721

Following gene: 38233724

Centisome position: 44.94

GC content: 58.38

Gene sequence:

>990_bases
GTGACTGAAGAACACATCCGAAACAACCCCACCCTCAAAGAAGTCGGCGAACAAGCCGCCATCAATGTCATCACAGCACA
CGCACCAAGCTCCCGCAATGGCGATGACGCAGCAGTTCTTAGTCACGCAGGGGCTAACTCCAGGGCAGTCGTCACCACCG
ACATGCTCGTAGAAAACCGACACTTCCGCCTCGACTGGTCCACCCCAGCAGAAATCGGCCGCAAAGCCATCACCCAAAAC
TTCGCCGACATCGAAGCGATGGGAGCGCGCCCCGTCGCAGCCCTTCTAGCCATATCCGCACCCGCATACACACGATTGCA
GTTCGTCTCCGACCTAGCACGCGGAATCGCAGAACGCGTGAGCGACTACTCAGCAGAACTTGTCGGCGGCGACATCACCG
ACGGCGACGCCATCGTCTTATCCGTCACAGCCGTAGGCCAACTCGGTGGATCACTACCCGAACTTGCCCTCGACCGTGCC
CGCTCTGGTCACACTGTCATCGTCAGTGGAGTGATAGGCGAATCAGCCGCAGGACTAGCCTTGCTCAACAGATTCGGTAG
AGACGGTGTCCCCGAACGATTCATGCCACTAGTATCAGCACACTGCGCAACCTACGTCCCTGAAGGACGAGGCTTTGTCG
CACGTGCCGCAGGCGTATCCTCTCTTACCGACAACTCCGATGGCCTCATCGTGGATCTGCGCACCATGGCCCGCAAATCC
GGCGTAGTCATAGACTTGGACCCCAGCGCCATCCAACCCAGCGCACTGATGCGTGAAGCAGCCGAAATTCTCGAAGAAGA
CCCATGGCACTGGGTCCTAGGCGGTGGGGAAGACCACACACTTATGGGAACAACAGCGCACGCAGTACCTACCGGATTCC
GAAAAATCGGCACGGTAATCAAACGCAGCAACCAACCAACTCACGCTGCCGGCGAAGTCCTCGTCGGCGGCGAAGCACCA
GCATACGACGACGGATGGGTGAGCTTTTAA

Upstream 100 bases:

>100_bases
TGAGTGCATAAGCACATAGTAGATCAGATAGAGAACCTGCCAAGAAGTGGCCTACTATCGAAACCACACCGGACCCCACC
ACCGAGGAGTACCCACCACC

Downstream 100 bases:

>100_bases
ACATGAACAACACACCACTGCCAGTTCATCCCTCATGGATAGAACCACTAGCGCCCGTGACTGACAACATTCACGCCATG
GGAGACTTCCTCCGCAATGA

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTEEHIRNNPTLKEVGEQAAINVITAHAPSSRNGDDAAVLSHAGANSRAVVTTDMLVENRHFRLDWSTPAEIGRKAITQN
FADIEAMGARPVAALLAISAPAYTRLQFVSDLARGIAERVSDYSAELVGGDITDGDAIVLSVTAVGQLGGSLPELALDRA
RSGHTVIVSGVIGESAAGLALLNRFGRDGVPERFMPLVSAHCATYVPEGRGFVARAAGVSSLTDNSDGLIVDLRTMARKS
GVVIDLDPSAIQPSALMREAAEILEEDPWHWVLGGGEDHTLMGTTAHAVPTGFRKIGTVIKRSNQPTHAAGEVLVGGEAP
AYDDGWVSF

Sequences:

>Translated_329_residues
MTEEHIRNNPTLKEVGEQAAINVITAHAPSSRNGDDAAVLSHAGANSRAVVTTDMLVENRHFRLDWSTPAEIGRKAITQN
FADIEAMGARPVAALLAISAPAYTRLQFVSDLARGIAERVSDYSAELVGGDITDGDAIVLSVTAVGQLGGSLPELALDRA
RSGHTVIVSGVIGESAAGLALLNRFGRDGVPERFMPLVSAHCATYVPEGRGFVARAAGVSSLTDNSDGLIVDLRTMARKS
GVVIDLDPSAIQPSALMREAAEILEEDPWHWVLGGGEDHTLMGTTAHAVPTGFRKIGTVIKRSNQPTHAAGEVLVGGEAP
AYDDGWVSF
>Mature_328_residues
TEEHIRNNPTLKEVGEQAAINVITAHAPSSRNGDDAAVLSHAGANSRAVVTTDMLVENRHFRLDWSTPAEIGRKAITQNF
ADIEAMGARPVAALLAISAPAYTRLQFVSDLARGIAERVSDYSAELVGGDITDGDAIVLSVTAVGQLGGSLPELALDRAR
SGHTVIVSGVIGESAAGLALLNRFGRDGVPERFMPLVSAHCATYVPEGRGFVARAAGVSSLTDNSDGLIVDLRTMARKSG
VVIDLDPSAIQPSALMREAAEILEEDPWHWVLGGGEDHTLMGTTAHAVPTGFRKIGTVIKRSNQPTHAAGEVLVGGEAPA
YDDGWVSF

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=258, Percent_Identity=31.7829457364341, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 34601; Mature: 34470

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEHIRNNPTLKEVGEQAAINVITAHAPSSRNGDDAAVLSHAGANSRAVVTTDMLVENR
CCCHHHCCCCCHHHHCHHHEEEEEEECCCCCCCCCCHHHEECCCCCCCEEEEEHHEECCC
HFRLDWSTPAEIGRKAITQNFADIEAMGARPVAALLAISAPAYTRLQFVSDLARGIAERV
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SDYSAELVGGDITDGDAIVLSVTAVGQLGGSLPELALDRARSGHTVIVSGVIGESAAGLA
HHHHHHHCCCCCCCCCEEEEEEEEHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHH
LLNRFGRDGVPERFMPLVSAHCATYVPEGRGFVARAAGVSSLTDNSDGLIVDLRTMARKS
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEHHHHHHHC
GVVIDLDPSAIQPSALMREAAEILEEDPWHWVLGGGEDHTLMGTTAHAVPTGFRKIGTVI
CEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCHHHCCHHHHHHHHHH
KRSNQPTHAAGEVLVGGEAPAYDDGWVSF
HCCCCCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TEEHIRNNPTLKEVGEQAAINVITAHAPSSRNGDDAAVLSHAGANSRAVVTTDMLVENR
CCHHHCCCCCHHHHCHHHEEEEEEECCCCCCCCCCHHHEECCCCCCCEEEEEHHEECCC
HFRLDWSTPAEIGRKAITQNFADIEAMGARPVAALLAISAPAYTRLQFVSDLARGIAERV
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SDYSAELVGGDITDGDAIVLSVTAVGQLGGSLPELALDRARSGHTVIVSGVIGESAAGLA
HHHHHHHCCCCCCCCCEEEEEEEEHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHH
LLNRFGRDGVPERFMPLVSAHCATYVPEGRGFVARAAGVSSLTDNSDGLIVDLRTMARKS
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEHHHHHHHC
GVVIDLDPSAIQPSALMREAAEILEEDPWHWVLGGGEDHTLMGTTAHAVPTGFRKIGTVI
CEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCHHHCCHHHHHHHHHH
KRSNQPTHAAGEVLVGGEAPAYDDGWVSF
HCCCCCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]