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The map label for this gene is hemK [H]

Identifier: 38233636

GI number: 38233636

Start: 1024509

End: 1025327

Strand: Direct

Name: hemK [H]

Synonym: DIP1042

Alternate gene names: 38233636

Gene position: 1024509-1025327 (Clockwise)

Preceding gene: 38233635

Following gene: 38233637

Centisome position: 41.17

GC content: 51.28

Gene sequence:

>819_bases
GTGCTAGCTCAGGCATTACACAAGGCGGAGGCCATTCTCGCTGAGGCGGGGGTGGCCTCGCCGCGTAACGACGTCCACCT
TATGGCGGCGCATTTACTGAACTGCCAACCTATGGAGTTATTCCTTAAAGGCGATCATGATGTTCCAGAGAACTTCTGGG
AATGGGTTGAGCGAAGGAAAAACCGTGAGCCACTCCAACACATTCTCCAAGTGACGTGGTTTGGCCCATTGGAACTTCAT
GTGGGCCCAGGTGTTTTTATTCCGCGTCCAGAAACTGAGGTGCTAGCCGATTGGGCAGTTCGTCATACTGACTCCGAGGA
CATCGTGGTCGATTTATGCACTGGGTCAGGGGCGTTAGCAGCTTACATTGCGCACGAACATCCTGAGTGCTCGGTATGGG
CTGTGGAACTATCTGATGCAGCCATGGCATTTGCTCGTAGAAATCTTCCTGACCGAGTCCATCTGGTTCAAGGTGACGTT
ACAGATCCAGAGATCTTAGATCACCTCAGTGGGGCAGTAGATCTCCTCGTGAGTAATCCACCCTATGTGCCATTAAGTAA
TGATTTAGAGCCCGAGGTGTACCAAGACCCCAGTATGGCGGTGTTTTCTGGTGATTCGGGAATGGACACTATTAACGCCA
TGATTCCAGTGATTTACCGGCTGTTGGCTCCTGGTGGGCTCGTGGGCATCGAGCATGATGATTTAACGTCTGAGCTAACG
CAACAGGCGCTCATAGATCATGGTGGATTTAGTAACATTGAACCGCTGAAGGACCTCACTGGCCGCAATAGGTTTGTGGT
TGCGAGTAAGATTCTCTAA

Upstream 100 bases:

>100_bases
GCCAATAACCTGGACTCCGTACTCAACGGTGATCTTGATGATCTGTTCTCTGCGTTGCAGGCAGCAGAGCGTGCCGAGAG
GCTCGAGGCGGAATAGCCAC

Downstream 100 bases:

>100_bases
GAAGTGGCTTCAAATGCATATCTTTGTTTTGAAGCGATGCAGAACAATTAGCCTCCCCCGTAGCATCGAGGGACCGAAAA
CTATCGAGAAGAGAAAGACT

Product: HemK family methytransferase

Products: NA

Alternate protein names: M.MtuHHemKP [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MLAQALHKAEAILAEAGVASPRNDVHLMAAHLLNCQPMELFLKGDHDVPENFWEWVERRKNREPLQHILQVTWFGPLELH
VGPGVFIPRPETEVLADWAVRHTDSEDIVVDLCTGSGALAAYIAHEHPECSVWAVELSDAAMAFARRNLPDRVHLVQGDV
TDPEILDHLSGAVDLLVSNPPYVPLSNDLEPEVYQDPSMAVFSGDSGMDTINAMIPVIYRLLAPGGLVGIEHDDLTSELT
QQALIDHGGFSNIEPLKDLTGRNRFVVASKIL

Sequences:

>Translated_272_residues
MLAQALHKAEAILAEAGVASPRNDVHLMAAHLLNCQPMELFLKGDHDVPENFWEWVERRKNREPLQHILQVTWFGPLELH
VGPGVFIPRPETEVLADWAVRHTDSEDIVVDLCTGSGALAAYIAHEHPECSVWAVELSDAAMAFARRNLPDRVHLVQGDV
TDPEILDHLSGAVDLLVSNPPYVPLSNDLEPEVYQDPSMAVFSGDSGMDTINAMIPVIYRLLAPGGLVGIEHDDLTSELT
QQALIDHGGFSNIEPLKDLTGRNRFVVASKIL
>Mature_272_residues
MLAQALHKAEAILAEAGVASPRNDVHLMAAHLLNCQPMELFLKGDHDVPENFWEWVERRKNREPLQHILQVTWFGPLELH
VGPGVFIPRPETEVLADWAVRHTDSEDIVVDLCTGSGALAAYIAHEHPECSVWAVELSDAAMAFARRNLPDRVHLVQGDV
TDPEILDHLSGAVDLLVSNPPYVPLSNDLEPEVYQDPSMAVFSGDSGMDTINAMIPVIYRLLAPGGLVGIEHDDLTSELT
QQALIDHGGFSNIEPLKDLTGRNRFVVASKIL

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=284, Percent_Identity=29.5774647887324, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1787463, Length=274, Percent_Identity=29.1970802919708, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI87082085, Length=196, Percent_Identity=30.1020408163265, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324266, Length=143, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24582226, Length=283, Percent_Identity=29.3286219081272, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 29946; Mature: 29946

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAQALHKAEAILAEAGVASPRNDVHLMAAHLLNCQPMELFLKGDHDVPENFWEWVERRK
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHC
NREPLQHILQVTWFGPLELHVGPGVFIPRPETEVLADWAVRHTDSEDIVVDLCTGSGALA
CCCHHHHHHHHHCCCCEEEEECCCEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEE
AYIAHEHPECSVWAVELSDAAMAFARRNLPDRVHLVQGDVTDPEILDHLSGAVDLLVSNP
EEEECCCCCCEEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHEEEEECCC
PYVPLSNDLEPEVYQDPSMAVFSGDSGMDTINAMIPVIYRLLAPGGLVGIEHDDLTSELT
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
QQALIDHGGFSNIEPLKDLTGRNRFVVASKIL
HHHHHHCCCCCCCCHHHHHCCCCEEEEEECCC
>Mature Secondary Structure
MLAQALHKAEAILAEAGVASPRNDVHLMAAHLLNCQPMELFLKGDHDVPENFWEWVERRK
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHC
NREPLQHILQVTWFGPLELHVGPGVFIPRPETEVLADWAVRHTDSEDIVVDLCTGSGALA
CCCHHHHHHHHHCCCCEEEEECCCEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEE
AYIAHEHPECSVWAVELSDAAMAFARRNLPDRVHLVQGDVTDPEILDHLSGAVDLLVSNP
EEEECCCCCCEEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHEEEEECCC
PYVPLSNDLEPEVYQDPSMAVFSGDSGMDTINAMIPVIYRLLAPGGLVGIEHDDLTSELT
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
QQALIDHGGFSNIEPLKDLTGRNRFVVASKIL
HHHHHHCCCCCCCCHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]