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The map label for this gene is aroP2 [H]

Identifier: 38233575

GI number: 38233575

Start: 951237

End: 952601

Strand: Reverse

Name: aroP2 [H]

Synonym: DIP0980

Alternate gene names: 38233575

Gene position: 952601-951237 (Counterclockwise)

Preceding gene: 38233576

Following gene: 38233574

Centisome position: 38.28

GC content: 57.95

Gene sequence:

>1365_bases
ATGACACAAGCAACCACTGAGACCGAGCTTGGCACAGGCCTAAAAACTCGGCACCTAACAATGATGGGACTCGGCTCCGC
CATCGGAGCCGGCCTCTTCCTCGGAACCGGCGTTGGAATTGCAGCAGCAGGACCCGCCGTTCTCATCGCCTACGTCCTCG
CAGGCATCTTCGTCGTATTCGTGATGCAAATGCTCGGAGAGCTCGCGGCAGCCCGCCCAGCCTCCGGATCCTTCTCCGTC
TACGCCGAGCAGGCATTCGGCCACTGGGCCGGCTTCAGCCTCGGCTGGCTTTACTGGTTCATGCTCACGATGGTCCTCGG
TGCCGAAATGACCGGCGCCGCAGCCATCATGGGTCAATGGTTCGGCATCGCGCCATGGATCCCAGCTCTCATCTGCGTTA
TCTTCTTCGCAGTCGTCAACCTCGCACGTGTCAGCGGCTTTGGCGAATTCGAATTCTGGTTTGCTTTTATCAAGGTTGCC
GTCATTATTCTCTTCCTCGTCATCGGCGTACTGCTCATCTTCGGGCTACTACCCAACTATGACTTCGTAGGAACCCAGCA
CTTCCTCGGCGACGGATTTATGCCTAATGGTATCTCAGGCGTAGCCACCGGCCTCCTAGCCGTCGCCTTCGCTTTCGGTG
GTATCGAGATCGTCACCATCGCCGCAGCGGAATCCGAAGATCCCAAGACTGCCATCGCCACAGCCGTGCGCTCCGTGATC
TGGCGTATCTCCTTGTTCTACCTGGGCTCTGTCCTTGTGATCTGCTTCCTCATCCCATTCTCCAGCATCGGAGGCGCCAA
GAGCGCAGCAGACTCCCCCTTCACCATCATCCTTGGCATGGCCAACATTCCTGGTGTGGTCGGATTCATGGAAGCCGTGA
TCGTCCTCGCACTCCTTTCAGCATTCAACGCCCAGATCTACGCCACCTCACGCATCGTCCACTCCTTCGCAGAACGTGGC
GACGCCCCCAAGATCTTCGCAGCCACCAACCCCTCCGGCGTCCCCATGCCAGCCGTACTCCTCAGCATGTTCTTCGCATT
CGTTTCCGTAGGACTGCAGTACTGGAACCCCGCAGGCCTCCTCAACTTCCTCCTCAACGCTGTAGGCGGATGCCTGATCG
TCATCTGGGTCATCATCGCCTTCGCATACCTTAAACTGCACCCAGAACTCGTCCGCAACGGAGAAATCACCACCGTGCGT
ATGTGGGGCTTCCCATGGCTCGGCTGGGTCACCATCGCAGGATTCCTCGGACTGACCGTCCTCATGCTGACTGACGACGC
CTCCCGCAGCCAGATCACCTCCGTTACGGTCGTATTCCTCCTACTCATAGTCGTGTCATTCTTCACCAAGAAAAAGAGTA
AGTAG

Upstream 100 bases:

>100_bases
CCGACCGGAGCCCGTCGTTCGCCCCACATAGACACCCCCGCATAAAATTAACTTGCCGTAGATTATATGCAACGGACCTT
GGGAGTTTATTCTCAGATCT

Downstream 100 bases:

>100_bases
ACTTCCACCCATGACTTCAGCACTAGCAACAGGACTTGCCACCATCACCGCCGACGGCACCGTGCTCGACGCCTGGTTCC
CAGCGCCAGAGCTCACCGCC

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTQATTETELGTGLKTRHLTMMGLGSAIGAGLFLGTGVGIAAAGPAVLIAYVLAGIFVVFVMQMLGELAAARPASGSFSV
YAEQAFGHWAGFSLGWLYWFMLTMVLGAEMTGAAAIMGQWFGIAPWIPALICVIFFAVVNLARVSGFGEFEFWFAFIKVA
VIILFLVIGVLLIFGLLPNYDFVGTQHFLGDGFMPNGISGVATGLLAVAFAFGGIEIVTIAAAESEDPKTAIATAVRSVI
WRISLFYLGSVLVICFLIPFSSIGGAKSAADSPFTIILGMANIPGVVGFMEAVIVLALLSAFNAQIYATSRIVHSFAERG
DAPKIFAATNPSGVPMPAVLLSMFFAFVSVGLQYWNPAGLLNFLLNAVGGCLIVIWVIIAFAYLKLHPELVRNGEITTVR
MWGFPWLGWVTIAGFLGLTVLMLTDDASRSQITSVTVVFLLLIVVSFFTKKKSK

Sequences:

>Translated_454_residues
MTQATTETELGTGLKTRHLTMMGLGSAIGAGLFLGTGVGIAAAGPAVLIAYVLAGIFVVFVMQMLGELAAARPASGSFSV
YAEQAFGHWAGFSLGWLYWFMLTMVLGAEMTGAAAIMGQWFGIAPWIPALICVIFFAVVNLARVSGFGEFEFWFAFIKVA
VIILFLVIGVLLIFGLLPNYDFVGTQHFLGDGFMPNGISGVATGLLAVAFAFGGIEIVTIAAAESEDPKTAIATAVRSVI
WRISLFYLGSVLVICFLIPFSSIGGAKSAADSPFTIILGMANIPGVVGFMEAVIVLALLSAFNAQIYATSRIVHSFAERG
DAPKIFAATNPSGVPMPAVLLSMFFAFVSVGLQYWNPAGLLNFLLNAVGGCLIVIWVIIAFAYLKLHPELVRNGEITTVR
MWGFPWLGWVTIAGFLGLTVLMLTDDASRSQITSVTVVFLLLIVVSFFTKKKSK
>Mature_453_residues
TQATTETELGTGLKTRHLTMMGLGSAIGAGLFLGTGVGIAAAGPAVLIAYVLAGIFVVFVMQMLGELAAARPASGSFSVY
AEQAFGHWAGFSLGWLYWFMLTMVLGAEMTGAAAIMGQWFGIAPWIPALICVIFFAVVNLARVSGFGEFEFWFAFIKVAV
IILFLVIGVLLIFGLLPNYDFVGTQHFLGDGFMPNGISGVATGLLAVAFAFGGIEIVTIAAAESEDPKTAIATAVRSVIW
RISLFYLGSVLVICFLIPFSSIGGAKSAADSPFTIILGMANIPGVVGFMEAVIVLALLSAFNAQIYATSRIVHSFAERGD
APKIFAATNPSGVPMPAVLLSMFFAFVSVGLQYWNPAGLLNFLLNAVGGCLIVIWVIIAFAYLKLHPELVRNGEITTVRM
WGFPWLGWVTIAGFLGLTVLMLTDDASRSQITSVTVVFLLLIVVSFFTKKKSK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=372, Percent_Identity=24.7311827956989, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789017, Length=436, Percent_Identity=41.2844036697248, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=36.1797752808989, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1786302, Length=449, Percent_Identity=32.5167037861915, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=35.9801488833747, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081708, Length=424, Percent_Identity=33.7264150943396, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87081915, Length=454, Percent_Identity=33.7004405286344, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786602, Length=394, Percent_Identity=37.5634517766497, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1790653, Length=457, Percent_Identity=31.5098468271335, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=33.0376940133038, Blast_Score=215, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17532491, Length=368, Percent_Identity=25.5434782608696, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324553, Length=409, Percent_Identity=30.0733496332518, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=405, Percent_Identity=31.358024691358, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=439, Percent_Identity=29.6127562642369, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=359, Percent_Identity=33.983286908078, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=408, Percent_Identity=28.4313725490196, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324061, Length=405, Percent_Identity=29.3827160493827, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6320772, Length=406, Percent_Identity=30.7881773399015, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=26.5, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=27.6807980049875, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=402, Percent_Identity=27.1144278606965, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=399, Percent_Identity=30.0751879699248, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=360, Percent_Identity=28.8888888888889, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324059, Length=410, Percent_Identity=28.0487804878049, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=28.1725888324873, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320251, Length=350, Percent_Identity=26, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=441, Percent_Identity=25.1700680272109, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=333, Percent_Identity=31.5315315315315, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=515, Percent_Identity=23.8834951456311, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667468, Length=360, Percent_Identity=22.7777777777778, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221512776, Length=289, Percent_Identity=25.9515570934256, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24666159, Length=289, Percent_Identity=25.9515570934256, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48312; Mature: 48181

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQATTETELGTGLKTRHLTMMGLGSAIGAGLFLGTGVGIAAAGPAVLIAYVLAGIFVVF
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHH
VMQMLGELAAARPASGSFSVYAEQAFGHWAGFSLGWLYWFMLTMVLGAEMTGAAAIMGQW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FGIAPWIPALICVIFFAVVNLARVSGFGEFEFWFAFIKVAVIILFLVIGVLLIFGLLPNY
HCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFVGTQHFLGDGFMPNGISGVATGLLAVAFAFGGIEIVTIAAAESEDPKTAIATAVRSVI
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHH
WRISLFYLGSVLVICFLIPFSSIGGAKSAADSPFTIILGMANIPGVVGFMEAVIVLALLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
AFNAQIYATSRIVHSFAERGDAPKIFAATNPSGVPMPAVLLSMFFAFVSVGLQYWNPAGL
HHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
LNFLLNAVGGCLIVIWVIIAFAYLKLHPELVRNGEITTVRMWGFPWLGWVTIAGFLGLTV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LMLTDDASRSQITSVTVVFLLLIVVSFFTKKKSK
HHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592354; 12948626 [H]