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The map label for this gene is aroP1 [H]

Identifier: 38233573

GI number: 38233573

Start: 948776

End: 950188

Strand: Reverse

Name: aroP1 [H]

Synonym: DIP0978

Alternate gene names: 38233573

Gene position: 950188-948776 (Counterclockwise)

Preceding gene: 38233574

Following gene: 38233572

Centisome position: 38.18

GC content: 59.73

Gene sequence:

>1413_bases
ATGACCGAACACACCGCCCCAACCCTCACAAAAGGGCTCAAAGTCCGCCATCTGACCATGATGGGACTCGGCTCCACCAT
CGGCGCCGGCCTCTTCCTCGGCACCGGCGTAGGAATCAAAGCAGCAGGACCCGCCGTACTCATCGCCTACATCATCGCCG
GATTCATCGCCGTCATGATCATGCGCATGCTCGGCGAAATGGGATCCGTCGTCCCCGCCTCCGGCTCCTTCTCCGAATAC
GCCGACGCAGGCATCGGCCACTGGGCCGGATTCATCCAAGGCTGGGTCTACTGGCTCGCCACCGTCGCAGTCCTCGGCGC
AGAAATCACCGGAGCCTCCGGATTCGTCGCCTCATGGCTCGGCGTCTCACCATGGATACCAGCGCTCGTCTTCGTCGCAT
TCTTCGGACTCGTCAACCTCATGCGCGTCCGCGCCTTCGGCGAATTCGAATTCTGGTTCGCCTTCATCAAAGTGGCAGTA
CTCGTCGTTTTCTTGATCATCGGCTCCCTCCTAGTACTCGGCCTCCTACCAAATCACGACTTCGTTGGGCTCAGCAATGT
TCGCGCCGAAGGATTCGCGCCCACCGGACTAGGAGGAATCGCAGCCGCCCTCCTAGCCGTCGCCTTCGGCTTCGGCGGCA
TCGAAGTCGTCGCCATCGCCTCGGCAGAATCCGAAGATCCACAAAAATCGCTCGTCAACGCCGTGCGCACCACCATCACG
CGTATCAGCATCTTCTACCTCGGCTCAGTAGCCATCATCGTATTGCTCTTGCCTTACTCGTCTCTTGGTAAGGCGAAAAG
CGCAGCAGAAAGCCCCTTCTCCCAAGTACTTGCCATGGCAAACATCCCAGGAGTAGTAGGCGTCATCGAAGTCGTCATTG
TGCTCGCACTGCTCTCCGCATTCAACGCCCAGATCTACGCCAGCTCACGCATGATGATGTCCCTCGCGGAACGTCGACAA
GCACCAAACATCTTCGCACGCGTCGACAACCGCGGAGTCCCACTGCCCGCCATCGTGCTCTCCGTCGTACTCAGCGTCAT
CATGGTGATCCTCAACTACGTCGACACCGGCTGGCTCCTCACCTTCCTACTCAACGCCGCAGGCGCCTCCCTCCTCACCG
TCTGGACCTTCATCGCCGTCTCCCAACTCAAACTCCGACGACGCCTCGAAGCACTCCAAGGCAACCTAGCCGTACGCATG
TGGGCCTTCCCAGGACTCACCATCGCCACCCTCGCCATCCTCTTCGGACTCGCCATCCTCATGCTTAGCGACGCCGGCGC
ACGCATCGAACTACTCTCCGCCATCGCCATGGTCGCCATCCTCTTCGCGATCAGCCTTATAGCAGTAAAACAGCCCTTTG
ACAAGGCCCTCCTGCCAAGAGAGGCGAGTTATCCACAGAACTCCCCCTCCTAG

Upstream 100 bases:

>100_bases
AGCAGTCGAACTCAACGACGCGCTCCACGCAAACTAACCGCACACCACCAAGGGAGCCCCTCCTAGAGAGCGGCTCCCTT
TTTTACCGCAGAAAAAACAC

Downstream 100 bases:

>100_bases
AGAACGCCTCTAGGAGTTATCCACAGAAATCGACGCCCAGGCCCGCCTCCACCACTAGGAGGCGGGCCATCGTCATTACC
GTGCGAAGTATGAATACGCA

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTEHTAPTLTKGLKVRHLTMMGLGSTIGAGLFLGTGVGIKAAGPAVLIAYIIAGFIAVMIMRMLGEMGSVVPASGSFSEY
ADAGIGHWAGFIQGWVYWLATVAVLGAEITGASGFVASWLGVSPWIPALVFVAFFGLVNLMRVRAFGEFEFWFAFIKVAV
LVVFLIIGSLLVLGLLPNHDFVGLSNVRAEGFAPTGLGGIAAALLAVAFGFGGIEVVAIASAESEDPQKSLVNAVRTTIT
RISIFYLGSVAIIVLLLPYSSLGKAKSAAESPFSQVLAMANIPGVVGVIEVVIVLALLSAFNAQIYASSRMMMSLAERRQ
APNIFARVDNRGVPLPAIVLSVVLSVIMVILNYVDTGWLLTFLLNAAGASLLTVWTFIAVSQLKLRRRLEALQGNLAVRM
WAFPGLTIATLAILFGLAILMLSDAGARIELLSAIAMVAILFAISLIAVKQPFDKALLPREASYPQNSPS

Sequences:

>Translated_470_residues
MTEHTAPTLTKGLKVRHLTMMGLGSTIGAGLFLGTGVGIKAAGPAVLIAYIIAGFIAVMIMRMLGEMGSVVPASGSFSEY
ADAGIGHWAGFIQGWVYWLATVAVLGAEITGASGFVASWLGVSPWIPALVFVAFFGLVNLMRVRAFGEFEFWFAFIKVAV
LVVFLIIGSLLVLGLLPNHDFVGLSNVRAEGFAPTGLGGIAAALLAVAFGFGGIEVVAIASAESEDPQKSLVNAVRTTIT
RISIFYLGSVAIIVLLLPYSSLGKAKSAAESPFSQVLAMANIPGVVGVIEVVIVLALLSAFNAQIYASSRMMMSLAERRQ
APNIFARVDNRGVPLPAIVLSVVLSVIMVILNYVDTGWLLTFLLNAAGASLLTVWTFIAVSQLKLRRRLEALQGNLAVRM
WAFPGLTIATLAILFGLAILMLSDAGARIELLSAIAMVAILFAISLIAVKQPFDKALLPREASYPQNSPS
>Mature_469_residues
TEHTAPTLTKGLKVRHLTMMGLGSTIGAGLFLGTGVGIKAAGPAVLIAYIIAGFIAVMIMRMLGEMGSVVPASGSFSEYA
DAGIGHWAGFIQGWVYWLATVAVLGAEITGASGFVASWLGVSPWIPALVFVAFFGLVNLMRVRAFGEFEFWFAFIKVAVL
VVFLIIGSLLVLGLLPNHDFVGLSNVRAEGFAPTGLGGIAAALLAVAFGFGGIEVVAIASAESEDPQKSLVNAVRTTITR
ISIFYLGSVAIIVLLLPYSSLGKAKSAAESPFSQVLAMANIPGVVGVIEVVIVLALLSAFNAQIYASSRMMMSLAERRQA
PNIFARVDNRGVPLPAIVLSVVLSVIMVILNYVDTGWLLTFLLNAAGASLLTVWTFIAVSQLKLRRRLEALQGNLAVRMW
AFPGLTIATLAILFGLAILMLSDAGARIELLSAIAMVAILFAISLIAVKQPFDKALLPREASYPQNSPS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=435, Percent_Identity=25.0574712643678, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI258645169, Length=434, Percent_Identity=23.0414746543779, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI258614003, Length=435, Percent_Identity=22.5287356321839, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI258614005, Length=435, Percent_Identity=22.5287356321839, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI33286428, Length=357, Percent_Identity=24.3697478991597, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI110347453, Length=290, Percent_Identity=25.8620689655172, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789017, Length=436, Percent_Identity=38.5321100917431, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI1786302, Length=387, Percent_Identity=36.9509043927649, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=33.9019189765458, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1786789, Length=393, Percent_Identity=38.676844783715, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI48994972, Length=454, Percent_Identity=35.0220264317181, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788480, Length=399, Percent_Identity=36.0902255639098, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=33.5, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1786602, Length=391, Percent_Identity=36.5728900255754, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1790653, Length=412, Percent_Identity=30.8252427184466, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17532491, Length=383, Percent_Identity=24.2819843342037, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=286, Percent_Identity=25.8741258741259, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=386, Percent_Identity=23.0569948186528, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=32.1078431372549, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=406, Percent_Identity=36.9458128078818, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=357, Percent_Identity=33.6134453781513, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324553, Length=405, Percent_Identity=31.1111111111111, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=428, Percent_Identity=31.7757009345794, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320772, Length=399, Percent_Identity=29.3233082706767, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6321053, Length=439, Percent_Identity=28.9293849658314, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319542, Length=402, Percent_Identity=30.5970149253731, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=398, Percent_Identity=29.1457286432161, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=29.7029702970297, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324061, Length=407, Percent_Identity=28.5012285012285, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=401, Percent_Identity=29.6758104738155, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321629, Length=410, Percent_Identity=28.2926829268293, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=401, Percent_Identity=31.6708229426434, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324059, Length=401, Percent_Identity=28.428927680798, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=31.0606060606061, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=420, Percent_Identity=25.4761904761905, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=478, Percent_Identity=25.3138075313808, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667468, Length=403, Percent_Identity=23.8213399503722, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24666159, Length=287, Percent_Identity=25.4355400696864, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221512776, Length=287, Percent_Identity=25.4355400696864, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24668806, Length=426, Percent_Identity=23.2394366197183, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356285, Length=426, Percent_Identity=23.2394366197183, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24668802, Length=426, Percent_Identity=23.2394366197183, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357367, Length=415, Percent_Identity=23.1325301204819, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49584; Mature: 49453

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TEHTAPTLTKGLKVRHLTMMGLGSTIGAGLFLGTGVGIKAAGPAVLIAYIIAGFIAVMI
CCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH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HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592354; 12948626 [H]