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The map label for this gene is glmU

Identifier: 38233500

GI number: 38233500

Start: 874524

End: 875978

Strand: Reverse

Name: glmU

Synonym: DIP0904

Alternate gene names: 38233500

Gene position: 875978-874524 (Counterclockwise)

Preceding gene: 38233501

Following gene: 38233499

Centisome position: 35.2

GC content: 57.25

Gene sequence:

>1455_bases
GTGAGCAATCCTCATTCCAGCGCAGTGATCGTGTTAGCGGCCGGAGCTGGCACCCGAATGAAATCCGCAAAACAAAAAAC
TTTGCACTCGATCGGTGGCCGTTCGCTGCTGGCGCATTCCCTGCACGCAGCAGCAGGATTAAGCCCACAGCGCATCGTGG
CAGTTATCGGACATCGTCGTGAGCAAGTCCGCCCCGAGGTCGAGGCCGTTGCCGCCACCGTGGACTGCGAAATCTCCGTA
GCGATCCAAGAGCAACAAAACGGCACTGGCCATGCGGTTCAATGCGCGATGCACGAACTCGAAGGCTTCGAAGGCACTGT
CGTGGTCACTAACGGCGATGTTCCATTGTTGCGATCAGAAACGCTTCGCTCGCTTGTCGACGCCCACACCGCCGTCCCCA
CGGCCGTCACCGTGCTCACCATGTCGCTGAGCGATCCCACCGGCTATGGCCGCATCGTACGCAACGATGAAGGAGAAGTC
ACCGCAATTGTTGAGCAAAAAGACGGTGATGAAGAAACCCTCAAAATCACCGAAGTCAACTCTGGTGTTTTTGCTTTCGA
TGCCGCCATTTTGCGATCCAGCCTCGGCAAATTGGATTCCAACAACGCCCAAGGCGAGCTCTACCTCACCGATGTTTTAA
GCATCGCACGCACCGAAGGCCACCCCGTTCGCGCATACCGCGCACACGATCACCGTGAACTCGCCGGAGTCAACGATCGC
GTTCAGCTCGCCCAAGCAGGAAAAATCCTGAATCAGCGTCTCGTCGAAGATGCCATGCGCAACGGTGCCACCATCGTCGA
TCCCGACACCACGTGGATCGACTCCGAAGTCACCATCGGACGCGACGTTATCATCCATCCGAGTACCCAACTTTTGGGGA
AGACCAGCATCGCGGATAACTGTGTGATTGGCCCCGACACCACCTTGACCAACATGGTCATTGACGAAGACGCACATGTG
ATTCGCACCCACGGATTCGATTCACGCATCGGCGCCCACGCCAACATTGGCCCCTTCACCTACATCCGTCCTGGGACCGT
TGTGGGCGAAAACGGCAAACTCGGTGGCTTCGTCGAAGCCAAGAATGCCCAGATTGGACGCGGTTCCAAAGTGCCACACC
TGACCTACATTGGCGATGCCACGGTAGGTGAAGAGTCCAACATTGGTGCCTCCAGCGTCTTCGTAAACTACGACGGTGTG
AACAAGCATCACACCACGATTGGCTCCCATGTACGCACCGGCTCCGACACCATGTTTATCGCTCCAGTCACCGTGGGCGA
CGGCGCATACTCTGGAGCAGGTACAGTAATTAAAGAGGATGTTCCCGCGGGAGCACTCGTCGTCTCCGGCGGCAAACAAC
GCAACATTGAAGGCTGGGTGGAAAAAAACCGCCCCGGCACTCCAGCTGCCGATGCCGCCCGTCAGGCACATGCCCACGAA
ACCAAGGAAGGTTAA

Upstream 100 bases:

>100_bases
GAGTCATCGCTATAAGCTAGTACGGCACACTAATTATCAGACGCGGTGGCGATGGAATAGACCGCCACCAGACTTTGCCT
CTCCAAGGAGTATGTCACCT

Downstream 100 bases:

>100_bases
GCGAAAACATGACTTCGCACAACTGGACCGCGAACCAGAAGAATTTGATGGTATTAACTGGTCGCGCCCACCCAGAGCTT
GCCGACGCCGTCGCAAAGGA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSNPHSSAVIVLAAGAGTRMKSAKQKTLHSIGGRSLLAHSLHAAAGLSPQRIVAVIGHRREQVRPEVEAVAATVDCEISV
AIQEQQNGTGHAVQCAMHELEGFEGTVVVTNGDVPLLRSETLRSLVDAHTAVPTAVTVLTMSLSDPTGYGRIVRNDEGEV
TAIVEQKDGDEETLKITEVNSGVFAFDAAILRSSLGKLDSNNAQGELYLTDVLSIARTEGHPVRAYRAHDHRELAGVNDR
VQLAQAGKILNQRLVEDAMRNGATIVDPDTTWIDSEVTIGRDVIIHPSTQLLGKTSIADNCVIGPDTTLTNMVIDEDAHV
IRTHGFDSRIGAHANIGPFTYIRPGTVVGENGKLGGFVEAKNAQIGRGSKVPHLTYIGDATVGEESNIGASSVFVNYDGV
NKHHTTIGSHVRTGSDTMFIAPVTVGDGAYSGAGTVIKEDVPAGALVVSGGKQRNIEGWVEKNRPGTPAADAARQAHAHE
TKEG

Sequences:

>Translated_484_residues
MSNPHSSAVIVLAAGAGTRMKSAKQKTLHSIGGRSLLAHSLHAAAGLSPQRIVAVIGHRREQVRPEVEAVAATVDCEISV
AIQEQQNGTGHAVQCAMHELEGFEGTVVVTNGDVPLLRSETLRSLVDAHTAVPTAVTVLTMSLSDPTGYGRIVRNDEGEV
TAIVEQKDGDEETLKITEVNSGVFAFDAAILRSSLGKLDSNNAQGELYLTDVLSIARTEGHPVRAYRAHDHRELAGVNDR
VQLAQAGKILNQRLVEDAMRNGATIVDPDTTWIDSEVTIGRDVIIHPSTQLLGKTSIADNCVIGPDTTLTNMVIDEDAHV
IRTHGFDSRIGAHANIGPFTYIRPGTVVGENGKLGGFVEAKNAQIGRGSKVPHLTYIGDATVGEESNIGASSVFVNYDGV
NKHHTTIGSHVRTGSDTMFIAPVTVGDGAYSGAGTVIKEDVPAGALVVSGGKQRNIEGWVEKNRPGTPAADAARQAHAHE
TKEG
>Mature_483_residues
SNPHSSAVIVLAAGAGTRMKSAKQKTLHSIGGRSLLAHSLHAAAGLSPQRIVAVIGHRREQVRPEVEAVAATVDCEISVA
IQEQQNGTGHAVQCAMHELEGFEGTVVVTNGDVPLLRSETLRSLVDAHTAVPTAVTVLTMSLSDPTGYGRIVRNDEGEVT
AIVEQKDGDEETLKITEVNSGVFAFDAAILRSSLGKLDSNNAQGELYLTDVLSIARTEGHPVRAYRAHDHRELAGVNDRV
QLAQAGKILNQRLVEDAMRNGATIVDPDTTWIDSEVTIGRDVIIHPSTQLLGKTSIADNCVIGPDTTLTNMVIDEDAHVI
RTHGFDSRIGAHANIGPFTYIRPGTVVGENGKLGGFVEAKNAQIGRGSKVPHLTYIGDATVGEESNIGASSVFVNYDGVN
KHHTTIGSHVRTGSDTMFIAPVTVGDGAYSGAGTVIKEDVPAGALVVSGGKQRNIEGWVEKNRPGTPAADAARQAHAHET
KEG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=38.3771929824561, Blast_Score=296, Evalue=1e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_CORDI (Q6NI74)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939267.1
- ProteinModelPortal:   Q6NI74
- SMR:   Q6NI74
- GeneID:   2648588
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0904
- NMPDR:   fig|257309.1.peg.858
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q6NI74
- ProtClustDB:   PRK14352
- BioCyc:   CDIP257309:DIP0904-MONOMER
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 51115; Mature: 50984

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 373-373 BINDING 83-83 BINDING 150-150 BINDING 165-165 BINDING 180-180 BINDING 397-397 BINDING 415-415 BINDING 433-433

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPHSSAVIVLAAGAGTRMKSAKQKTLHSIGGRSLLAHSLHAAAGLSPQRIVAVIGHRR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCH
EQVRPEVEAVAATVDCEISVAIQEQQNGTGHAVQCAMHELEGFEGTVVVTNGDVPLLRSE
HHCCCCHHHEEEEECEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEHHH
TLRSLVDAHTAVPTAVTVLTMSLSDPTGYGRIVRNDEGEVTAIVEQKDGDEETLKITEVN
HHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEC
SGVFAFDAAILRSSLGKLDSNNAQGELYLTDVLSIARTEGHPVRAYRAHDHRELAGVNDR
CCEEHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCCHHHCCCCHH
VQLAQAGKILNQRLVEDAMRNGATIVDPDTTWIDSEVTIGRDVIIHPSTQLLGKTSIADN
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCEEECCEEEECCCHHHHCCCCCCCC
CVIGPDTTLTNMVIDEDAHVIRTHGFDSRIGAHANIGPFTYIRPGTVVGENGKLGGFVEA
CEECCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEECCCCCCCCEEEE
KNAQIGRGSKVPHLTYIGDATVGEESNIGASSVFVNYDGVNKHHTTIGSHVRTGSDTMFI
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCEEEE
APVTVGDGAYSGAGTVIKEDVPAGALVVSGGKQRNIEGWVEKNRPGTPAADAARQAHAHE
EEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCC
TKEG
CCCC
>Mature Secondary Structure 
SNPHSSAVIVLAAGAGTRMKSAKQKTLHSIGGRSLLAHSLHAAAGLSPQRIVAVIGHRR
CCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCH
EQVRPEVEAVAATVDCEISVAIQEQQNGTGHAVQCAMHELEGFEGTVVVTNGDVPLLRSE
HHCCCCHHHEEEEECEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEHHH
TLRSLVDAHTAVPTAVTVLTMSLSDPTGYGRIVRNDEGEVTAIVEQKDGDEETLKITEVN
HHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEC
SGVFAFDAAILRSSLGKLDSNNAQGELYLTDVLSIARTEGHPVRAYRAHDHRELAGVNDR
CCEEHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCCHHHCCCCHH
VQLAQAGKILNQRLVEDAMRNGATIVDPDTTWIDSEVTIGRDVIIHPSTQLLGKTSIADN
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCEEECCEEEECCCHHHHCCCCCCCC
CVIGPDTTLTNMVIDEDAHVIRTHGFDSRIGAHANIGPFTYIRPGTVVGENGKLGGFVEA
CEECCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEECCCCCCCCEEEE
KNAQIGRGSKVPHLTYIGDATVGEESNIGASSVFVNYDGVNKHHTTIGSHVRTGSDTMFI
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCEEEE
APVTVGDGAYSGAGTVIKEDVPAGALVVSGGKQRNIEGWVEKNRPGTPAADAARQAHAHE
EEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCC
TKEG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910