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The map label for this gene is pth

Identifier: 38233496

GI number: 38233496

Start: 870146

End: 870700

Strand: Reverse

Name: pth

Synonym: DIP0900

Alternate gene names: 38233496

Gene position: 870700-870146 (Counterclockwise)

Preceding gene: 38233497

Following gene: 38233493

Centisome position: 34.99

GC content: 49.55

Gene sequence:

>555_bases
GTGACTTCGCCATATCTAATCGTCGGCCTTGGAAATCTAGGACCGGAATACACAAAAACACGCCATAACATCGGTTACAT
GGCTATCGACGAACTCCTCACGAGAACCAGTCCCATGCCAGCCACGCTTACCGTGCATAAAAAGACCAACACGCTAGTGG
CAGAAACTCGGTTGGGAACGCAGAAAGTTATCGTCGCAAAGCCGCGAGCGTTTATGAATGTTACGGGTCCTTCCGTGAGG
AAACTCGCGGATTTCTTTACGGTAGATAGGAACCGCATTGTGGTCTTATATGACGACTTAGACTTGGAGTTCGGTGCCAT
CAAGTTTCGCCACGGGGGTGGGGATCATGGGCACAACGGTTTGAAGTCAATCACGCAGGCTTTGGGAACAAAGGATTATA
TCCGTGGCGGAATAGGAATCGGTCGTCCACCAGGGCGGATGGCTCCGAAAAGTTTTGTTCTGAAACCTTTTTCTAAAATT
GAGCAGTCTGAATTGCCAATTGTGTGCGCAGATGCGGCAGACGAGGTGGAAAAGATTACCACTTCCGAGCTTTAG

Upstream 100 bases:

>100_bases
GAAGACGCCGAAGAAGCTCCAGCTGCAGAAGGCGAAGAGTAAAAACTCTCGAAGCCGGCCTGTTTTGTACAGGCCGGCTT
TTTGCTGCCACAATACCTTT

Downstream 100 bases:

>100_bases
TTAGGGCACGTTTAAGGGCGGCGTCGTCAAGCTTGAGGGCGCCGGATTTTTTGAGTCGGTGCAGTACAACTGGGCAAGTT
TTGCAACGCGGATTGGACTT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MTSPYLIVGLGNLGPEYTKTRHNIGYMAIDELLTRTSPMPATLTVHKKTNTLVAETRLGTQKVIVAKPRAFMNVTGPSVR
KLADFFTVDRNRIVVLYDDLDLEFGAIKFRHGGGDHGHNGLKSITQALGTKDYIRGGIGIGRPPGRMAPKSFVLKPFSKI
EQSELPIVCADAADEVEKITTSEL

Sequences:

>Translated_184_residues
MTSPYLIVGLGNLGPEYTKTRHNIGYMAIDELLTRTSPMPATLTVHKKTNTLVAETRLGTQKVIVAKPRAFMNVTGPSVR
KLADFFTVDRNRIVVLYDDLDLEFGAIKFRHGGGDHGHNGLKSITQALGTKDYIRGGIGIGRPPGRMAPKSFVLKPFSKI
EQSELPIVCADAADEVEKITTSEL
>Mature_183_residues
TSPYLIVGLGNLGPEYTKTRHNIGYMAIDELLTRTSPMPATLTVHKKTNTLVAETRLGTQKVIVAKPRAFMNVTGPSVRK
LADFFTVDRNRIVVLYDDLDLEFGAIKFRHGGGDHGHNGLKSITQALGTKDYIRGGIGIGRPPGRMAPKSFVLKPFSKIE
QSELPIVCADAADEVEKITTSEL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=32.3529411764706, Blast_Score=94, Evalue=7e-20,
Organism=Escherichia coli, GI1787455, Length=176, Percent_Identity=38.6363636363636, Blast_Score=81, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321983, Length=149, Percent_Identity=30.2013422818792, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_CORDI (Q6NI78)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939263.1
- ProteinModelPortal:   Q6NI78
- SMR:   Q6NI78
- GeneID:   2648584
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0900
- NMPDR:   fig|257309.1.peg.854
- HOGENOM:   HBG610927
- OMA:   GDHGHNG
- ProtClustDB:   PRK05426
- BioCyc:   CDIP257309:DIP0900-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20123; Mature: 19991

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPYLIVGLGNLGPEYTKTRHNIGYMAIDELLTRTSPMPATLTVHKKTNTLVAETRLGT
CCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCC
QKVIVAKPRAFMNVTGPSVRKLADFFTVDRNRIVVLYDDLDLEFGAIKFRHGGGDHGHNG
EEEEEECCCEEEEECCHHHHHHHHHHEECCCEEEEEEECCCCEEEEEEEECCCCCCCCHH
LKSITQALGTKDYIRGGIGIGRPPGRMAPKSFVLKPFSKIEQSELPIVCADAADEVEKIT
HHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCEEECCCHHHHHHHH
TSEL
HCCC
>Mature Secondary Structure 
TSPYLIVGLGNLGPEYTKTRHNIGYMAIDELLTRTSPMPATLTVHKKTNTLVAETRLGT
CCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCC
QKVIVAKPRAFMNVTGPSVRKLADFFTVDRNRIVVLYDDLDLEFGAIKFRHGGGDHGHNG
EEEEEECCCEEEEECCHHHHHHHHHHEECCCEEEEEEECCCCEEEEEEEECCCCCCCCHH
LKSITQALGTKDYIRGGIGIGRPPGRMAPKSFVLKPFSKIEQSELPIVCADAADEVEKIT
HHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCEEECCCHHHHHHHH
TSEL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910