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The map label for this gene is pth2 [H]

Identifier: 38233493

GI number: 38233493

Start: 867987

End: 868529

Strand: Reverse

Name: pth2 [H]

Synonym: DIP0897

Alternate gene names: 38233493

Gene position: 868529-867987 (Counterclockwise)

Preceding gene: 38233496

Following gene: 38233492

Centisome position: 34.9

GC content: 55.8

Gene sequence:

>543_bases
GTGGGGTTGGGTAATCCTGGGGTTCGGTATGCGTCGACACGCCATAACGTGGGATATATGGTGGTTGATGAATTGTTGGG
GCCTGCTGAATTGCGGCCTCTGCGTGGGTTCAAGGCGTCTGGCGCTGTCATTGAGGTTGGGGGTTGCCGTGTGTTGGTGG
TGCGGTCGTCGACGTTTATGAACACTTCCGGTGAGGCTGTGGGGCCAATTGTCCAAGAGTATGGGGTGTCGCCGGATCAT
GTTGTTGTGGTTCATGATGAATTGGATCTGCCGGCGCATAAAGTTCGGGTGAAGGTTGGCGGTAATGAGAATGGCCACAA
TGGGTTGAAGTCGGTGTCGCAATGGCTGGGGACTCGGGATTATGTGCGGATTCGGGTAGGAATTGGTCGCCCTCCCCGTG
GGGGAACGGTGCCGGACTATGTGCTTGGTGCGTTGGATTCTGGTGAGGTATTGGATGCGGCGGTTCGTTGTGGGGCGGAT
GCGATTCGTCTTGTGATTGAGCGTGGTGTGAGTGTGGCTCAGAATGAGATTCATCGTCGTTGA

Upstream 100 bases:

>100_bases
TCAGACTTAGACCATGGGATTTTTTAGTGATGTTGTCGCTCGTATTCGTGGTGTTGGCCAATCGGGTTTGTCGGGGGCTG
ATCCTGTGGATTGGGTTGTT

Downstream 100 bases:

>100_bases
TTAAGAGGCGGATGGGGTTAGAATCGCTTCCATGATGAGTGAACGCACCTTTGTTGTTACTGGCGCTTCGGATGGAATTG
GTGCTGCTGCGATACGGCGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH 2 [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MGLGNPGVRYASTRHNVGYMVVDELLGPAELRPLRGFKASGAVIEVGGCRVLVVRSSTFMNTSGEAVGPIVQEYGVSPDH
VVVVHDELDLPAHKVRVKVGGNENGHNGLKSVSQWLGTRDYVRIRVGIGRPPRGGTVPDYVLGALDSGEVLDAAVRCGAD
AIRLVIERGVSVAQNEIHRR

Sequences:

>Translated_180_residues
MGLGNPGVRYASTRHNVGYMVVDELLGPAELRPLRGFKASGAVIEVGGCRVLVVRSSTFMNTSGEAVGPIVQEYGVSPDH
VVVVHDELDLPAHKVRVKVGGNENGHNGLKSVSQWLGTRDYVRIRVGIGRPPRGGTVPDYVLGALDSGEVLDAAVRCGAD
AIRLVIERGVSVAQNEIHRR
>Mature_179_residues
GLGNPGVRYASTRHNVGYMVVDELLGPAELRPLRGFKASGAVIEVGGCRVLVVRSSTFMNTSGEAVGPIVQEYGVSPDHV
VVVHDELDLPAHKVRVKVGGNENGHNGLKSVSQWLGTRDYVRIRVGIGRPPRGGTVPDYVLGALDSGEVLDAAVRCGADA
IRLVIERGVSVAQNEIHRR

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=183, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1787455, Length=184, Percent_Identity=37.5, Blast_Score=100, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321983, Length=179, Percent_Identity=32.4022346368715, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 19196; Mature: 19065

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGNPGVRYASTRHNVGYMVVDELLGPAELRPLRGFKASGAVIEVGGCRVLVVRSSTFM
CCCCCCCCEEECCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEECCEEE
NTSGEAVGPIVQEYGVSPDHVVVVHDELDLPAHKVRVKVGGNENGHNGLKSVSQWLGTRD
CCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCC
YVRIRVGIGRPPRGGTVPDYVLGALDSGEVLDAAVRCGADAIRLVIERGVSVAQNEIHRR
EEEEEEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
GLGNPGVRYASTRHNVGYMVVDELLGPAELRPLRGFKASGAVIEVGGCRVLVVRSSTFM
CCCCCCCEEECCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEECCEEE
NTSGEAVGPIVQEYGVSPDHVVVVHDELDLPAHKVRVKVGGNENGHNGLKSVSQWLGTRD
CCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCC
YVRIRVGIGRPPRGGTVPDYVLGALDSGEVLDAAVRCGADAIRLVIERGVSVAQNEIHRR
EEEEEEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]