| Definition | Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome. |
|---|---|
| Accession | NC_002935 |
| Length | 2,488,635 |
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The map label for this gene is yqhE [C]
Identifier: 38233387
GI number: 38233387
Start: 769059
End: 769931
Strand: Direct
Name: yqhE [C]
Synonym: DIP0788
Alternate gene names: 38233387
Gene position: 769059-769931 (Clockwise)
Preceding gene: 38233385
Following gene: 38233388
Centisome position: 30.9
GC content: 54.41
Gene sequence:
>873_bases ATGGTGACCATGAAACAACACGAGAACATCATTCCCACCATCACGCTCAATGATGGTACGGAAATGCCCGCGATTGGTTT TGGTACATATAAGTTGCGTGAACAAGATGCCTATAGGGCAGTGCGTAGCGCCATCGAGGTGGGGTATCGCCATATTGATA CTGCTTCTTTGTATAAGAACGAAGAGGAGGTAGGCCGTGCGGTGGCTGACGCGATCACTGCAGGCGAGGTAGCTCGTGAC GAGCTTTTTATCACCACCAAGGTGTGGAATGACATGCACGGGGACCAGCTCACGCAGCGCTCGTTCCAAGAATCCCTCCA CCGGCTTGGCCTAGATTACATCGATTGCTGCATGGTGCATTGGCCGTGGCCGCAAAAGGGGCTCTACGTAGAATCCTTTG CAGCATTGGCAAAGATTCAGGGGTTGGGGCAGCTGCAGTCGGTTGCGGTAGCTAATTTCTATCCTGAAGTTCTGCGCGAG ATCGTCGCGGAGACTGGTATTGCGCCTGTGTTGAATCAGGTGGAATTGCATCCTGGTTTTTCTCAAGCCGAGCAGCGCGC CGTGGACCGTGAATTGGGAGTGGTTACGGAGGCATGGTCGCCTTTGGGGCGGGGTGATTCGCTGAACGCGGAGGCTATTA CGTTGATCGCGCAGTGTTATGAGAAAACGCCGGCGCAGGTGACGTTGCGGTGGATTCATCAGTTGGGTTGCTCTGTGGTG CCTAAATCGGCGAACCCTCAGCGGCAGCGTGAGAACCTCGACATTTTCGATTTTGAGCTCAACACGGAGGACATGAACAG CATTACATCGCTCGACGAGCAAGGTGGTCGGCTGTTTGTTGATCCGCACGACTTCCCAGGCGAGGTGGAGTAG
Upstream 100 bases:
>100_bases CGGGTCATGGCACCACCCTATAAAGAACACGAGTGGTTGGTGCAGAAATTGTGCAAAAATTTGCCAATAGGGGGTGCATA GGGTGGATTATCGGTGTTGA
Downstream 100 bases:
>100_bases TGGCGCAGGTAGAGGTGCGTATCGACGGCCACCTGATGTGTGTCACCGTAAATAGACACGAGGCTCGCAACGCACTTTCT GCACAGATGTGCGATGATAT
Product: putative oxidoreductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 290; Mature: 290
Protein sequence:
>290_residues MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKNEEEVGRAVADAITAGEVARD ELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVHWPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLRE IVAETGIAPVLNQVELHPGFSQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE
Sequences:
>Translated_290_residues MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKNEEEVGRAVADAITAGEVARD ELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVHWPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLRE IVAETGIAPVLNQVELHPGFSQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE >Mature_290_residues MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKNEEEVGRAVADAITAGEVARD ELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVHWPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLRE IVAETGIAPVLNQVELHPGFSQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI310109922, Length=294, Percent_Identity=35.0340136054422, Blast_Score=180, Evalue=1e-45, Organism=Homo sapiens, GI310109920, Length=312, Percent_Identity=33.6538461538462, Blast_Score=173, Evalue=1e-43, Organism=Homo sapiens, GI45446745, Length=312, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=6e-43, Organism=Homo sapiens, GI4503285, Length=312, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=6e-43, Organism=Homo sapiens, GI5453543, Length=312, Percent_Identity=33.6538461538462, Blast_Score=170, Evalue=1e-42, Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=32.1799307958478, Blast_Score=168, Evalue=4e-42, Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=32.1799307958478, Blast_Score=168, Evalue=4e-42, Organism=Homo sapiens, GI24497583, Length=294, Percent_Identity=33.6734693877551, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=32.5259515570934, Blast_Score=163, Evalue=1e-40, Organism=Homo sapiens, GI24497585, Length=302, Percent_Identity=33.7748344370861, Blast_Score=163, Evalue=2e-40, Organism=Homo sapiens, GI5174695, Length=296, Percent_Identity=33.7837837837838, Blast_Score=157, Evalue=1e-38, Organism=Homo sapiens, GI4502049, Length=289, Percent_Identity=34.2560553633218, Blast_Score=156, Evalue=2e-38, Organism=Homo sapiens, GI93277124, Length=318, Percent_Identity=29.874213836478, Blast_Score=154, Evalue=7e-38, Organism=Homo sapiens, GI291291012, Length=285, Percent_Identity=31.9298245614035, Blast_Score=149, Evalue=2e-36, Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=32.8519855595668, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI300116271, Length=278, Percent_Identity=31.294964028777, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI310109926, Length=112, Percent_Identity=43.75, Blast_Score=108, Evalue=5e-24, Organism=Homo sapiens, GI207028673, Length=112, Percent_Identity=42.8571428571429, Blast_Score=107, Evalue=2e-23, Organism=Homo sapiens, GI310109924, Length=168, Percent_Identity=30.952380952381, Blast_Score=81, Evalue=9e-16, Organism=Escherichia coli, GI87082198, Length=279, Percent_Identity=42.6523297491039, Blast_Score=226, Evalue=2e-60, Organism=Escherichia coli, GI1786400, Length=254, Percent_Identity=35.4330708661417, Blast_Score=157, Evalue=6e-40, Organism=Escherichia coli, GI1788081, Length=272, Percent_Identity=27.2058823529412, Blast_Score=84, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17537077, Length=293, Percent_Identity=34.8122866894198, Blast_Score=186, Evalue=1e-47, Organism=Caenorhabditis elegans, GI17537075, Length=302, Percent_Identity=35.0993377483444, Blast_Score=184, Evalue=3e-47, Organism=Caenorhabditis elegans, GI71998625, Length=275, Percent_Identity=37.0909090909091, Blast_Score=177, Evalue=7e-45, Organism=Caenorhabditis elegans, GI17564128, Length=304, Percent_Identity=32.5657894736842, Blast_Score=172, Evalue=1e-43, Organism=Caenorhabditis elegans, GI17566692, Length=285, Percent_Identity=31.2280701754386, Blast_Score=165, Evalue=2e-41, Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=31.986531986532, Blast_Score=162, Evalue=2e-40, Organism=Caenorhabditis elegans, GI17538386, Length=270, Percent_Identity=31.4814814814815, Blast_Score=154, Evalue=6e-38, Organism=Caenorhabditis elegans, GI17550248, Length=296, Percent_Identity=31.7567567567568, Blast_Score=150, Evalue=9e-37, Organism=Caenorhabditis elegans, GI17561298, Length=269, Percent_Identity=30.1115241635688, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=30.7984790874525, Blast_Score=135, Evalue=4e-32, Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=31.3868613138686, Blast_Score=133, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17562292, Length=280, Percent_Identity=29.6428571428571, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17550246, Length=77, Percent_Identity=48.0519480519481, Blast_Score=78, Evalue=4e-15, Organism=Saccharomyces cerevisiae, GI6324694, Length=307, Percent_Identity=35.8306188925081, Blast_Score=185, Evalue=8e-48, Organism=Saccharomyces cerevisiae, GI6320576, Length=305, Percent_Identity=33.7704918032787, Blast_Score=176, Evalue=4e-45, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=30.9160305343511, Blast_Score=144, Evalue=2e-35, Organism=Saccharomyces cerevisiae, GI6319625, Length=302, Percent_Identity=30.1324503311258, Blast_Score=144, Evalue=2e-35, Organism=Saccharomyces cerevisiae, GI6321896, Length=303, Percent_Identity=27.3927392739274, Blast_Score=134, Evalue=2e-32, Organism=Saccharomyces cerevisiae, GI6320079, Length=285, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=2e-26, Organism=Drosophila melanogaster, GI24663317, Length=283, Percent_Identity=37.4558303886926, Blast_Score=203, Evalue=9e-53, Organism=Drosophila melanogaster, GI24657054, Length=275, Percent_Identity=37.8181818181818, Blast_Score=203, Evalue=1e-52, Organism=Drosophila melanogaster, GI20129731, Length=279, Percent_Identity=39.426523297491, Blast_Score=203, Evalue=1e-52, Organism=Drosophila melanogaster, GI21356425, Length=312, Percent_Identity=34.6153846153846, Blast_Score=190, Evalue=9e-49, Organism=Drosophila melanogaster, GI24644950, Length=297, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=4e-43, Organism=Drosophila melanogaster, GI45553081, Length=289, Percent_Identity=32.1799307958478, Blast_Score=171, Evalue=5e-43, Organism=Drosophila melanogaster, GI24662789, Length=295, Percent_Identity=32.5423728813559, Blast_Score=169, Evalue=1e-42, Organism=Drosophila melanogaster, GI221378297, Length=317, Percent_Identity=31.2302839116719, Blast_Score=164, Evalue=9e-41, Organism=Drosophila melanogaster, GI24662781, Length=296, Percent_Identity=34.7972972972973, Blast_Score=148, Evalue=4e-36, Organism=Drosophila melanogaster, GI24662785, Length=295, Percent_Identity=34.9152542372881, Blast_Score=147, Evalue=1e-35, Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=30.1587301587302, Blast_Score=135, Evalue=3e-32,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 32487; Mature: 32487
Theoretical pI: Translated: 4.49; Mature: 4.49
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKN CCCCCCCCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC EEEVGRAVADAITAGEVARDELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVH HHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHEE WPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLREIVAETGIAPVLNQVELHPGF CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCH SQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE CCCCCCHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCC >Mature Secondary Structure MVTMKQHENIIPTITLNDGTEMPAIGFGTYKLREQDAYRAVRSAIEVGYRHIDTASLYKN CCCCCCCCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC EEEVGRAVADAITAGEVARDELFITTKVWNDMHGDQLTQRSFQESLHRLGLDYIDCCMVH HHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHEE WPWPQKGLYVESFAALAKIQGLGQLQSVAVANFYPEVLREIVAETGIAPVLNQVELHPGF CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCH SQAEQRAVDRELGVVTEAWSPLGRGDSLNAEAITLIAQCYEKTPAQVTLRWIHQLGCSVV HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC PKSANPQRQRENLDIFDFELNTEDMNSITSLDEQGGRLFVDPHDFPGEVE CCCCCCHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA