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The map label for this gene is echA6 [H]

Identifier: 38233388

GI number: 38233388

Start: 769931

End: 770707

Strand: Direct

Name: echA6 [H]

Synonym: DIP0789

Alternate gene names: 38233388

Gene position: 769931-770707 (Clockwise)

Preceding gene: 38233387

Following gene: 38233389

Centisome position: 30.94

GC content: 53.93

Gene sequence:

>777_bases
GTGGCGCAGGTAGAGGTGCGTATCGACGGCCACCTGATGTGTGTCACCGTAAATAGACACGAGGCTCGCAACGCACTTTC
TGCACAGATGTGCGATGATATTACATCTGCTCTTAATAATGCAGATGAGCAGGCGCGTGACACTGCAGCTATTCGCGCCG
TGCTCATCCGTTCTGTTGGTACGACCTTTTGTGCCGGAGCAGATTTGGGCAGTACCACCCAAAGTGATGATGCGGCTGAG
GTAACGCAGTCGGATTTCCATGACTCTCTTACGCGCATGTTGGAATCGGTTGTTTCCTGTGGAGTCCCAGTTATTGCTGA
TATTCAAGGACCAGCTGTTGGCGCTGGCATGCAGCTGGCATTGAGCTGCGATCTGCGTTTGGTTCATCATGCTGCATGGT
TTAAGGTGCCGGCGGCGTCTCTTGGGTTCGCGCTCGACGGATGGACTATTAATAGGGCACAGTGTTTGCTGGGCGGTGGT
TGGGCGCGATCAATTTTCTTGGGCGGCGCAACGCTATCGGCACCGCAGGCGGTGGCAACTGGTTTTGCGCTGGAGATCGC
TGATTCCGATTCTGCGATTGCCTATGCTCATCGTATTGCTGGAATGGCACCCTTGGCGCTGCGGCAACTTAAATCCGCGC
TCAACAGTGCTGATTTTGAATATGCGCTTGTTGGGGAATCTCGTGATCTTTTTGCCCAATGTTGGGCTAGTACGGATGCT
CGCGAAGGGCAGCTGGCTCGAAAACAAAAGCGAGATCCGGTGTTTACTGGTCGCTGA

Upstream 100 bases:

>100_bases
TTGAGCTCAACACGGAGGACATGAACAGCATTACATCGCTCGACGAGCAAGGTGGTCGGCTGTTTGTTGATCCGCACGAC
TTCCCAGGCGAGGTGGAGTA

Downstream 100 bases:

>100_bases
TTCTGCTAGGACTGTGGTGGCCTCTTTGCAAGGGTTTTCCTTGTGATGAGGTCATTTTTTATTGTGTAGGGGGCATTAAC
AAACTTTGCAAAAGTCTCTG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MAQVEVRIDGHLMCVTVNRHEARNALSAQMCDDITSALNNADEQARDTAAIRAVLIRSVGTTFCAGADLGSTTQSDDAAE
VTQSDFHDSLTRMLESVVSCGVPVIADIQGPAVGAGMQLALSCDLRLVHHAAWFKVPAASLGFALDGWTINRAQCLLGGG
WARSIFLGGATLSAPQAVATGFALEIADSDSAIAYAHRIAGMAPLALRQLKSALNSADFEYALVGESRDLFAQCWASTDA
REGQLARKQKRDPVFTGR

Sequences:

>Translated_258_residues
MAQVEVRIDGHLMCVTVNRHEARNALSAQMCDDITSALNNADEQARDTAAIRAVLIRSVGTTFCAGADLGSTTQSDDAAE
VTQSDFHDSLTRMLESVVSCGVPVIADIQGPAVGAGMQLALSCDLRLVHHAAWFKVPAASLGFALDGWTINRAQCLLGGG
WARSIFLGGATLSAPQAVATGFALEIADSDSAIAYAHRIAGMAPLALRQLKSALNSADFEYALVGESRDLFAQCWASTDA
REGQLARKQKRDPVFTGR
>Mature_257_residues
AQVEVRIDGHLMCVTVNRHEARNALSAQMCDDITSALNNADEQARDTAAIRAVLIRSVGTTFCAGADLGSTTQSDDAAEV
TQSDFHDSLTRMLESVVSCGVPVIADIQGPAVGAGMQLALSCDLRLVHHAAWFKVPAASLGFALDGWTINRAQCLLGGGW
ARSIFLGGATLSAPQAVATGFALEIADSDSAIAYAHRIAGMAPLALRQLKSALNSADFEYALVGESRDLFAQCWASTDAR
EGQLARKQKRDPVFTGR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI25453481, Length=244, Percent_Identity=24.1803278688525, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI51538573, Length=244, Percent_Identity=24.1803278688525, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4757966, Length=244, Percent_Identity=24.1803278688525, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI51538581, Length=244, Percent_Identity=24.1803278688525, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4757968, Length=179, Percent_Identity=26.8156424581006, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI49355787, Length=179, Percent_Identity=26.8156424581006, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=27.3809523809524, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI221136756, Length=250, Percent_Identity=21.6, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI221136753, Length=250, Percent_Identity=21.6, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI221307494, Length=251, Percent_Identity=21.9123505976096, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=219, Percent_Identity=27.8538812785388, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=27.1317829457364, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787659, Length=265, Percent_Identity=31.6981132075472, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI221142681, Length=262, Percent_Identity=27.4809160305344, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788597, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87082183, Length=259, Percent_Identity=24.7104247104247, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787660, Length=264, Percent_Identity=30.3030303030303, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=250, Percent_Identity=28.4, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=202, Percent_Identity=30.6930693069307, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=224, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=216, Percent_Identity=27.3148148148148, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=256, Percent_Identity=27.34375, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129971, Length=262, Percent_Identity=26.7175572519084, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24653477, Length=262, Percent_Identity=26.7175572519084, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24653139, Length=265, Percent_Identity=24.1509433962264, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24654903, Length=182, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19920382, Length=223, Percent_Identity=27.8026905829596, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27293; Mature: 27162

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVEVRIDGHLMCVTVNRHEARNALSAQMCDDITSALNNADEQARDTAAIRAVLIRSVG
CCEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
TTFCAGADLGSTTQSDDAAEVTQSDFHDSLTRMLESVVSCGVPVIADIQGPAVGAGMQLA
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEE
LSCDLRLVHHAAWFKVPAASLGFALDGWTINRAQCLLGGGWARSIFLGGATLSAPQAVAT
EECCHHHHHHHHHHCCCHHHHCEEECCEEECCHHEEECCCHHHHEEECCCCCCCCHHHHC
GFALEIADSDSAIAYAHRIAGMAPLALRQLKSALNSADFEYALVGESRDLFAQCWASTDA
CEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCC
REGQLARKQKRDPVFTGR
CCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AQVEVRIDGHLMCVTVNRHEARNALSAQMCDDITSALNNADEQARDTAAIRAVLIRSVG
CEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
TTFCAGADLGSTTQSDDAAEVTQSDFHDSLTRMLESVVSCGVPVIADIQGPAVGAGMQLA
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEE
LSCDLRLVHHAAWFKVPAASLGFALDGWTINRAQCLLGGGWARSIFLGGATLSAPQAVAT
EECCHHHHHHHHHHCCCHHHHCEEECCEEECCHHEEECCCHHHHEEECCCCCCCCHHHHC
GFALEIADSDSAIAYAHRIAGMAPLALRQLKSALNSADFEYALVGESRDLFAQCWASTDA
CEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCC
REGQLARKQKRDPVFTGR
CCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]