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The map label for this gene is tmk [H]

Identifier: 38233300

GI number: 38233300

Start: 667945

End: 668562

Strand: Direct

Name: tmk [H]

Synonym: DIP0693

Alternate gene names: 38233300

Gene position: 667945-668562 (Clockwise)

Preceding gene: 38233299

Following gene: 38233301

Centisome position: 26.84

GC content: 53.88

Gene sequence:

>618_bases
ATGATCATCGCGATTGAGGGTATTGATGGCGCTGGCAAGAACACCTTGGTCAGCGCCATCAAGGAGCGTTTCGACGCCGA
TGTGATCGGTTTCCCACGCTACGAACAGTCCATTCATGCCAAGCTGGCCCAGCGTGCCTTATACGGATCGATGGGGGATC
TGACAGATTCTGCCTACGCGATGGCTACGCTGTTTGCATTGGACCGCTACGACGCAAAGGCGGTGCTGGGGCGCTATGTG
GGGACGTCGAAAGTTGTGTTGTTGGATCGCTACGTGGCTTCTAACGCTGCTTATTCCGCCGCGCGGACTCGAAATGATGC
CATGGTGCAATGGGTTCAAGAACTCGAATTTGAGGAATTGGGCCTACCGGTACCAGATATTCATATTTTGCTGCATACCT
CTCCGGAATTAGCCGCGCAGCGGGCGCAACGTCGCGAGGCTACCGATGCATCTCGCAAACTAGACCGCTATGAGGAAGAC
GCTGGTCTACAGGAACGAACCTTCCAAGCGTATGAGTCGCTGGCACAGCAAAAATGGATGTCTCCATGGCTGCTAGTACA
CCCAGATGAGTCACCGGATACGGTGACTCAACGAATTATTCAAGCGCTCAGTGCATAA

Upstream 100 bases:

>100_bases
AGGCATTGGGTGGCACGATTACCGAACTGACAAAGGAGCAAGCCGAATACATCGGAGTTGATGTTGCTGGCCCTTACAAG
CCGGAGCATTACCGCTACTA

Downstream 100 bases:

>100_bases
CTGAGGCTACGATGAGGTGCTAAGACACCTATTGGGCTCGCATGTGAGCCGCTTACATGGAAAGGACCACGGACGGTATG
GCACCGAAAATTTTGGTTGT

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MIIAIEGIDGAGKNTLVSAIKERFDADVIGFPRYEQSIHAKLAQRALYGSMGDLTDSAYAMATLFALDRYDAKAVLGRYV
GTSKVVLLDRYVASNAAYSAARTRNDAMVQWVQELEFEELGLPVPDIHILLHTSPELAAQRAQRREATDASRKLDRYEED
AGLQERTFQAYESLAQQKWMSPWLLVHPDESPDTVTQRIIQALSA

Sequences:

>Translated_205_residues
MIIAIEGIDGAGKNTLVSAIKERFDADVIGFPRYEQSIHAKLAQRALYGSMGDLTDSAYAMATLFALDRYDAKAVLGRYV
GTSKVVLLDRYVASNAAYSAARTRNDAMVQWVQELEFEELGLPVPDIHILLHTSPELAAQRAQRREATDASRKLDRYEED
AGLQERTFQAYESLAQQKWMSPWLLVHPDESPDTVTQRIIQALSA
>Mature_205_residues
MIIAIEGIDGAGKNTLVSAIKERFDADVIGFPRYEQSIHAKLAQRALYGSMGDLTDSAYAMATLFALDRYDAKAVLGRYV
GTSKVVLLDRYVASNAAYSAARTRNDAMVQWVQELEFEELGLPVPDIHILLHTSPELAAQRAQRREATDASRKLDRYEED
AGLQERTFQAYESLAQQKWMSPWLLVHPDESPDTVTQRIIQALSA

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22905; Mature: 22905

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIAIEGIDGAGKNTLVSAIKERFDADVIGFPRYEQSIHAKLAQRALYGSMGDLTDSAYA
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
MATLFALDRYDAKAVLGRYVGTSKVVLLDRYVASNAAYSAARTRNDAMVQWVQELEFEEL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
GLPVPDIHILLHTSPELAAQRAQRREATDASRKLDRYEEDAGLQERTFQAYESLAQQKWM
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SPWLLVHPDESPDTVTQRIIQALSA
CCEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIAIEGIDGAGKNTLVSAIKERFDADVIGFPRYEQSIHAKLAQRALYGSMGDLTDSAYA
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
MATLFALDRYDAKAVLGRYVGTSKVVLLDRYVASNAAYSAARTRNDAMVQWVQELEFEEL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
GLPVPDIHILLHTSPELAAQRAQRREATDASRKLDRYEEDAGLQERTFQAYESLAQQKWM
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SPWLLVHPDESPDTVTQRIIQALSA
CCEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]