Click here to switch to the map view.

The map label for this gene is pccB1 [H]

Identifier: 38233265

GI number: 38233265

Start: 633347

End: 634978

Strand: Reverse

Name: pccB1 [H]

Synonym: DIP0658

Alternate gene names: 38233265

Gene position: 634978-633347 (Counterclockwise)

Preceding gene: 38233267

Following gene: 38233264

Centisome position: 25.52

GC content: 55.82

Gene sequence:

>1632_bases
ATGACTGCCGCAACAATTAACGACACAGGGGCCCAGACCCCCGACCTGACAACGACCGCAGGCAAGCTTGCGGATCTTCG
CGCACGTATTGCAGAAACCCAGGCTCCTATGGGTCCTGCATCCATCGAAAAAGTTCATGCAAAGGGTAAGAAGACCGCTC
GTGAACGTATCGAGTACCTCTTGGATGAGGGTTCTTTCGTTGAGATTGACGCTCTCGCCCGTCACCGCTCTAAGAACTTC
GGCCTTGATGCCAAGCGCCCCGTTACCGATGGCGTGGTCACCGGCTACGGCACTATCGACGGTCGCAAGGTCTGTGTTTT
CTCCCAAGACGGAGCAGTGTTTGGCGGTGCTCTTGGTGAGGTCTACGGCGAGAAAATCGTTAAGATCATGGATCTTGCCA
TTAAAACTGGCGTTCCACTGATCGGTATTAATGAAGGCGCCGGTGCTCGTATTCAAGAGGGCGTTGTATCCCTTGGCCTT
TATTCCAAGATCTTCTACCGCAACACCCTCGCTTCCGGCGTTATCCCACAGATCTCGCTCATCATGGGTGCTTGTGCAGG
TGGCCACGTGTACTCCCCTGCCCTCACCGACTTCATCATCATGGTGGACAAAACCTCCAAGATGTTCATCACCGGACCAG
ACGTGATCAAGACGGTCACCGGCGAAGAAGTCACCCAAGAAGAGCTCGGTGGTGCACACACCCACATGGCAACCTCCGGT
ACCTCGCACTACACTGCTTCGGATGATGCTGATGCACTCGACTGGGTTCGCGACCTCGTAGGCTTCTTGCCTTCCAACAA
CCGCGCAGAAGCTCCTCGCGAGCCTGCCGAGATCATGGTGGGCTCCATCAAGGAGAACATCACCGACTCCGATCTCGAGC
TCGACACCATTATTCCCGACTCCCCTAACCAGCCATACGACATGAAGGACGTGATTACTCGCGTTCTTGATGATGGCGAT
TTCTTCGAGATCCAGGAAAACTACGCAGGCAATATCATTGTCGGCTTCGGCCGCGTCGAAGGCCGCAGCGTTGGTGTTGT
TGCCAACCAGCCAACCGAGTTCGCTGGCTGCCTCGACATCAAGGCCGCTGAGAAGGCTGCTCGCTTTATCCGCACCTGCG
ATGCGTTCAATGTTCCGATCATCGAATTCGTTGACGTACCTGGCTTCTTGCCAGGCACGAGCCAAGAATACGACGGAATC
ATTCGCCGTGGCGCCAAGCTCCTCTACGCCTACTCTGAAGCAACCGTCGGCAAGATCACTGTGATTACCCGCAAGTCCTA
CGGTGGCGCTTACTGCGTGATGGGTTCGAAGGACATGGGCGCCGACCTCGTCTTGGCATGGCCAACCGCACAGATCGCTG
TCATGGGCGCCGCTGGTGCCGTGGGATTCATCTACCGCAAGGAAATCAAGGCCGCTGCTGCCGAAGGCAAGGACATGCTC
GCTGTAGCTAAGGAATACGAGCGCGAGTACGAAGAAACTTTGGTCAACCCTTACATGGCAGCCGAGCGTGGTTACGTCGA
CGCCGTTATTCCACCAAGCGAAACCCGTGGTCAGATCATTGAAGCGCTACGCCTCTTGGACCGCAAGGTTGTTAACGTTC
CTGCGAAGAAGCACGGCAACATCCCGCTGTAA

Upstream 100 bases:

>100_bases
GAAAATCATCTACCCCCACATGCAAAGTTTTTTGCCGTGGATTCGACAAAGTTGTCAAACAGTTCACAAGTTTTTGCCCC
AGCCCCTACACTATTGTGTC

Downstream 100 bases:

>100_bases
TCGGTCGCAGTTACGTTTTCTACCTCACCTCTCGCAGGTGAGGTGAGGTAGAATGGCTCGCATCCATCTTCCACATAGTC
TGAAATAGGTTTGACATGTC

Product: propionyl CoA carboxylase beta chain 1

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MTAATINDTGAQTPDLTTTAGKLADLRARIAETQAPMGPASIEKVHAKGKKTARERIEYLLDEGSFVEIDALARHRSKNF
GLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKIMDLAIKTGVPLIGINEGAGARIQEGVVSLGL
YSKIFYRNTLASGVIPQISLIMGACAGGHVYSPALTDFIIMVDKTSKMFITGPDVIKTVTGEEVTQEELGGAHTHMATSG
TSHYTASDDADALDWVRDLVGFLPSNNRAEAPREPAEIMVGSIKENITDSDLELDTIIPDSPNQPYDMKDVITRVLDDGD
FFEIQENYAGNIIVGFGRVEGRSVGVVANQPTEFAGCLDIKAAEKAARFIRTCDAFNVPIIEFVDVPGFLPGTSQEYDGI
IRRGAKLLYAYSEATVGKITVITRKSYGGAYCVMGSKDMGADLVLAWPTAQIAVMGAAGAVGFIYRKEIKAAAAEGKDML
AVAKEYEREYEETLVNPYMAAERGYVDAVIPPSETRGQIIEALRLLDRKVVNVPAKKHGNIPL

Sequences:

>Translated_543_residues
MTAATINDTGAQTPDLTTTAGKLADLRARIAETQAPMGPASIEKVHAKGKKTARERIEYLLDEGSFVEIDALARHRSKNF
GLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKIMDLAIKTGVPLIGINEGAGARIQEGVVSLGL
YSKIFYRNTLASGVIPQISLIMGACAGGHVYSPALTDFIIMVDKTSKMFITGPDVIKTVTGEEVTQEELGGAHTHMATSG
TSHYTASDDADALDWVRDLVGFLPSNNRAEAPREPAEIMVGSIKENITDSDLELDTIIPDSPNQPYDMKDVITRVLDDGD
FFEIQENYAGNIIVGFGRVEGRSVGVVANQPTEFAGCLDIKAAEKAARFIRTCDAFNVPIIEFVDVPGFLPGTSQEYDGI
IRRGAKLLYAYSEATVGKITVITRKSYGGAYCVMGSKDMGADLVLAWPTAQIAVMGAAGAVGFIYRKEIKAAAAEGKDML
AVAKEYEREYEETLVNPYMAAERGYVDAVIPPSETRGQIIEALRLLDRKVVNVPAKKHGNIPL
>Mature_542_residues
TAATINDTGAQTPDLTTTAGKLADLRARIAETQAPMGPASIEKVHAKGKKTARERIEYLLDEGSFVEIDALARHRSKNFG
LDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKIMDLAIKTGVPLIGINEGAGARIQEGVVSLGLY
SKIFYRNTLASGVIPQISLIMGACAGGHVYSPALTDFIIMVDKTSKMFITGPDVIKTVTGEEVTQEELGGAHTHMATSGT
SHYTASDDADALDWVRDLVGFLPSNNRAEAPREPAEIMVGSIKENITDSDLELDTIIPDSPNQPYDMKDVITRVLDDGDF
FEIQENYAGNIIVGFGRVEGRSVGVVANQPTEFAGCLDIKAAEKAARFIRTCDAFNVPIIEFVDVPGFLPGTSQEYDGII
RRGAKLLYAYSEATVGKITVITRKSYGGAYCVMGSKDMGADLVLAWPTAQIAVMGAAGAVGFIYRKEIKAAAAEGKDMLA
VAKEYEREYEETLVNPYMAAERGYVDAVIPPSETRGQIIEALRLLDRKVVNVPAKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=55.3816046966732, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=53.2956685499058, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI11545863, Length=480, Percent_Identity=31.6666666666667, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=29.2553191489362, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=53.9525691699605, Blast_Score=544, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=53.9525691699605, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17552936, Length=528, Percent_Identity=31.25, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24586065, Length=520, Percent_Identity=32.5, Blast_Score=230, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 58272; Mature: 58141

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAATINDTGAQTPDLTTTAGKLADLRARIAETQAPMGPASIEKVHAKGKKTARERIEYL
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LDEGSFVEIDALARHRSKNFGLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGE
HCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECHHHHH
VYGEKIVKIMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSKIFYRNTLASGVIPQISL
HHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IMGACAGGHVYSPALTDFIIMVDKTSKMFITGPDVIKTVTGEEVTQEELGGAHTHMATSG
HHHHCCCCCEECCCCEEEEEEEECCCEEEEECCHHHHCCCCCHHHHHHHCCCCEEEECCC
TSHYTASDDADALDWVRDLVGFLPSNNRAEAPREPAEIMVGSIKENITDSDLELDTIIPD
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCC
SPNQPYDMKDVITRVLDDGDFFEIQENYAGNIIVGFGRVEGRSVGVVANQPTEFAGCLDI
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCHHCEECH
KAAEKAARFIRTCDAFNVPIIEFVDVPGFLPGTSQEYDGIIRRGAKLLYAYSEATVGKIT
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEE
VITRKSYGGAYCVMGSKDMGADLVLAWPTAQIAVMGAAGAVGFIYRKEIKAAAAEGKDML
EEEEECCCCEEEEECCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHH
AVAKEYEREYEETLVNPYMAAERGYVDAVIPPSETRGQIIEALRLLDRKVVNVPAKKHGN
HHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IPL
CCC
>Mature Secondary Structure 
TAATINDTGAQTPDLTTTAGKLADLRARIAETQAPMGPASIEKVHAKGKKTARERIEYL
CCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LDEGSFVEIDALARHRSKNFGLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGE
HCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECHHHHH
VYGEKIVKIMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSKIFYRNTLASGVIPQISL
HHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IMGACAGGHVYSPALTDFIIMVDKTSKMFITGPDVIKTVTGEEVTQEELGGAHTHMATSG
HHHHCCCCCEECCCCEEEEEEEECCCEEEEECCHHHHCCCCCHHHHHHHCCCCEEEECCC
TSHYTASDDADALDWVRDLVGFLPSNNRAEAPREPAEIMVGSIKENITDSDLELDTIIPD
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCC
SPNQPYDMKDVITRVLDDGDFFEIQENYAGNIIVGFGRVEGRSVGVVANQPTEFAGCLDI
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCHHCEECH
KAAEKAARFIRTCDAFNVPIIEFVDVPGFLPGTSQEYDGIIRRGAKLLYAYSEATVGKIT
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEE
VITRKSYGGAYCVMGSKDMGADLVLAWPTAQIAVMGAAGAVGFIYRKEIKAAAAEGKDML
EEEEECCCCEEEEECCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHH
AVAKEYEREYEETLVNPYMAAERGYVDAVIPPSETRGQIIEALRLLDRKVVNVPAKKHGN
HHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IPL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]