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The map label for this gene is pccB2 [H]

Identifier: 38233267

GI number: 38233267

Start: 636944

End: 638575

Strand: Reverse

Name: pccB2 [H]

Synonym: DIP0660

Alternate gene names: 38233267

Gene position: 638575-636944 (Counterclockwise)

Preceding gene: 38233273

Following gene: 38233265

Centisome position: 25.66

GC content: 60.6

Gene sequence:

>1632_bases
ATGACCATTTCCTCATCTTTTATCGACGTGGACGCTTTACACCACCCAAGCACCACCGCAGGCAAGATCGCCGACTTCAA
GGCACGGCGCGCTGAAGCCAACACTCCGATGGGCGAAACGGCACTCAACAAAGTGCGCGGACAAGGCCGAATGACAGCAC
GCGAACGCCTCGACTATCTCCTCGACGAAGGCTCCTTCATCGAAACCGACCAGCTCGCCCGGCACCGCACCCACGACTTC
GGCCTCTACGGCAAGCGCCCCGTCACCGACGGCATCGTCACCGGCTGGGGCACCATCGACGGCCGCGAAGTATGCATCTT
CTCCCAAGACGGCACCGTATTCGGCGGCGCCCTCGGCGAGGTCTACGGCGAAAAAATGATCAAAATCATGGAACTCGCCG
TCACCACCGGCCGCCCCCTCATCGGTCTCTACGAAGGCGCCGGTGCCCGTATCCAAGACGGTGCGGTCTCCCTCGACATG
ATCGCCCGCACCTTCTACCACAACATCAACGCCTCCGGAGTTGTCCCCCAAATCTCCGTCATCATGGGCGCCTGCGCGGG
AGGAAATGCCTATTCCCCAGCACTCACGGACTTCGTGCTCATGGTGGATCAGACCTCCAAAATGTTCGTCACCGGCCCCG
ACGTGATCAAAACCGTCACCGGCGAAATGATTACCCAAGAAGAACTCGGCGGCGCCTCCGCACACATGGCTGCCGCCGGC
AACAGCCACTACACCGCATCCAGCGACGAAGACGCACTCGAATTCGTTCAAGAACTCGTAGGCTTCCTGCCCTCCAACAA
TCGCAGCATGGCACCACGCGAGGACTATGACCGTGAGGACGGTAGCATCGACGACAACCTCACCCCTGATGATCTGCGCC
TCGACCACATCATCCCCGACTCCCCCGCCAGCCCCTACGACGTACGCGACATCATCGAATCCCTCACCGACGACGGCGAC
TACCTTGAGATTCAAGCCGACCGCGCCGAAAACGTCGTCATCGCATTCGGACGCATCGAGGGCGAATCCATCGGCTTTGT
TGCCAATCAACCCACACAACTCGCGGGATGCCTCGACATCGACGCCTCCGAAAAAGCAGCACGCTTCATCCGCACCTGCG
ATGCCTTCAACATCCCCGTCGTCATGCTTGTCGACGTCCCAGGCTTCCTCCCAGGCGCCGGACAAGAACATAACGGCATC
CTGCGCCGCGGCGCCAAACTCCTCTACGCCTACGGCGAAGCCACAGTGCCAAAGATTACCGTCACCATGCGCAAAGCCTA
CGGCGGAGCCTACTGCGTGATGGGGTCCAAGGGGCTCGGCGCCGACGTCAACCTCGCCTGGCCCACCGCCCAAATCGCCG
TCATGGGCGCCGCCGGAGCCGTAGGATTCCTACACCGCAAAGAACTAGCCAAGGCAGTAGAAAACGACGAAGATGTTTTC
GCCCTCACCCAAGCCTTCGAGCAAGAATACGAAAACCACATGCTCAATCCATACATGGCCGCCGAACGCGGGCTTATCGA
CGCAGTCATCCTCCCCAGCGAAACCCGCGGACACATTTCCCGCAACCTCCGCCTACTGCGCAACAAGCACGTGCAACGCC
CAGCCCGCAAACACGGCAACATCCCGCTCTAA

Upstream 100 bases:

>100_bases
CCGGCTGCCGGTGACCTTTGGGGAGAAATTTTTTAATTTTTCCACACGCCGAACGTTTTTGTATTGAAAACTAACCATCG
AGGCGCTATCCTCTCAAAAC

Downstream 100 bases:

>100_bases
AAGCGTGGTACTGGTGAGATCCTTTTAAGCTTCTCGCACTAGCGCGGGTACTCGGAGCGAGCGCTAGTACGAGATAAGAA
TGTGGCTGCCCTTCCTAGGT

Product: propionyl-CoA carboxylase beta chain 2

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MTISSSFIDVDALHHPSTTAGKIADFKARRAEANTPMGETALNKVRGQGRMTARERLDYLLDEGSFIETDQLARHRTHDF
GLYGKRPVTDGIVTGWGTIDGREVCIFSQDGTVFGGALGEVYGEKMIKIMELAVTTGRPLIGLYEGAGARIQDGAVSLDM
IARTFYHNINASGVVPQISVIMGACAGGNAYSPALTDFVLMVDQTSKMFVTGPDVIKTVTGEMITQEELGGASAHMAAAG
NSHYTASSDEDALEFVQELVGFLPSNNRSMAPREDYDREDGSIDDNLTPDDLRLDHIIPDSPASPYDVRDIIESLTDDGD
YLEIQADRAENVVIAFGRIEGESIGFVANQPTQLAGCLDIDASEKAARFIRTCDAFNIPVVMLVDVPGFLPGAGQEHNGI
LRRGAKLLYAYGEATVPKITVTMRKAYGGAYCVMGSKGLGADVNLAWPTAQIAVMGAAGAVGFLHRKELAKAVENDEDVF
ALTQAFEQEYENHMLNPYMAAERGLIDAVILPSETRGHISRNLRLLRNKHVQRPARKHGNIPL

Sequences:

>Translated_543_residues
MTISSSFIDVDALHHPSTTAGKIADFKARRAEANTPMGETALNKVRGQGRMTARERLDYLLDEGSFIETDQLARHRTHDF
GLYGKRPVTDGIVTGWGTIDGREVCIFSQDGTVFGGALGEVYGEKMIKIMELAVTTGRPLIGLYEGAGARIQDGAVSLDM
IARTFYHNINASGVVPQISVIMGACAGGNAYSPALTDFVLMVDQTSKMFVTGPDVIKTVTGEMITQEELGGASAHMAAAG
NSHYTASSDEDALEFVQELVGFLPSNNRSMAPREDYDREDGSIDDNLTPDDLRLDHIIPDSPASPYDVRDIIESLTDDGD
YLEIQADRAENVVIAFGRIEGESIGFVANQPTQLAGCLDIDASEKAARFIRTCDAFNIPVVMLVDVPGFLPGAGQEHNGI
LRRGAKLLYAYGEATVPKITVTMRKAYGGAYCVMGSKGLGADVNLAWPTAQIAVMGAAGAVGFLHRKELAKAVENDEDVF
ALTQAFEQEYENHMLNPYMAAERGLIDAVILPSETRGHISRNLRLLRNKHVQRPARKHGNIPL
>Mature_542_residues
TISSSFIDVDALHHPSTTAGKIADFKARRAEANTPMGETALNKVRGQGRMTARERLDYLLDEGSFIETDQLARHRTHDFG
LYGKRPVTDGIVTGWGTIDGREVCIFSQDGTVFGGALGEVYGEKMIKIMELAVTTGRPLIGLYEGAGARIQDGAVSLDMI
ARTFYHNINASGVVPQISVIMGACAGGNAYSPALTDFVLMVDQTSKMFVTGPDVIKTVTGEMITQEELGGASAHMAAAGN
SHYTASSDEDALEFVQELVGFLPSNNRSMAPREDYDREDGSIDDNLTPDDLRLDHIIPDSPASPYDVRDIIESLTDDGDY
LEIQADRAENVVIAFGRIEGESIGFVANQPTQLAGCLDIDASEKAARFIRTCDAFNIPVVMLVDVPGFLPGAGQEHNGIL
RRGAKLLYAYGEATVPKITVTMRKAYGGAYCVMGSKGLGADVNLAWPTAQIAVMGAAGAVGFLHRKELAKAVENDEDVFA
LTQAFEQEYENHMLNPYMAAERGLIDAVILPSETRGHISRNLRLLRNKHVQRPARKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=510, Percent_Identity=50.3921568627451, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI295821216, Length=530, Percent_Identity=48.4905660377358, Blast_Score=481, Evalue=1e-135,
Organism=Homo sapiens, GI11545863, Length=489, Percent_Identity=31.6973415132924, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=29.6296296296296, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=49.7041420118343, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=49.7041420118343, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17552936, Length=523, Percent_Identity=32.6959847036329, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71997163, Length=297, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24586065, Length=519, Percent_Identity=31.2138728323699, Blast_Score=221, Evalue=8e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 58756; Mature: 58625

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISSSFIDVDALHHPSTTAGKIADFKARRAEANTPMGETALNKVRGQGRMTARERLDYL
CCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
LDEGSFIETDQLARHRTHDFGLYGKRPVTDGIVTGWGTIDGREVCIFSQDGTVFGGALGE
HCCCCEECHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCEECHHHHH
VYGEKMIKIMELAVTTGRPLIGLYEGAGARIQDGAVSLDMIARTFYHNINASGVVPQISV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCHHHHHHHHHHHCCCCCCCCHHHHH
IMGACAGGNAYSPALTDFVLMVDQTSKMFVTGPDVIKTVTGEMITQEELGGASAHMAAAG
HHEECCCCCCCCHHHHHEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEECC
NSHYTASSDEDALEFVQELVGFLPSNNRSMAPREDYDREDGSIDDNLTPDDLRLDHIIPD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
SPASPYDVRDIIESLTDDGDYLEIQADRAENVVIAFGRIEGESIGFVANQPTQLAGCLDI
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCEEEEEECCCCCEEEEECC
DASEKAARFIRTCDAFNIPVVMLVDVPGFLPGAGQEHNGILRRGAKLLYAYGEATVPKIT
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCEEE
VTMRKAYGGAYCVMGSKGLGADVNLAWPTAQIAVMGAAGAVGFLHRKELAKAVENDEDVF
EEEECCCCCEEEEECCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHH
ALTQAFEQEYENHMLNPYMAAERGLIDAVILPSETRGHISRNLRLLRNKHVQRPARKHGN
HHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCC
IPL
CCC
>Mature Secondary Structure 
TISSSFIDVDALHHPSTTAGKIADFKARRAEANTPMGETALNKVRGQGRMTARERLDYL
CCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
LDEGSFIETDQLARHRTHDFGLYGKRPVTDGIVTGWGTIDGREVCIFSQDGTVFGGALGE
HCCCCEECHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCEECHHHHH
VYGEKMIKIMELAVTTGRPLIGLYEGAGARIQDGAVSLDMIARTFYHNINASGVVPQISV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCHHHHHHHHHHHCCCCCCCCHHHHH
IMGACAGGNAYSPALTDFVLMVDQTSKMFVTGPDVIKTVTGEMITQEELGGASAHMAAAG
HHEECCCCCCCCHHHHHEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEECC
NSHYTASSDEDALEFVQELVGFLPSNNRSMAPREDYDREDGSIDDNLTPDDLRLDHIIPD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
SPASPYDVRDIIESLTDDGDYLEIQADRAENVVIAFGRIEGESIGFVANQPTQLAGCLDI
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCEEEEEECCCCCEEEEECC
DASEKAARFIRTCDAFNIPVVMLVDVPGFLPGAGQEHNGILRRGAKLLYAYGEATVPKIT
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCEEE
VTMRKAYGGAYCVMGSKGLGADVNLAWPTAQIAVMGAAGAVGFLHRKELAKAVENDEDVF
EEEECCCCCEEEEECCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHH
ALTQAFEQEYENHMLNPYMAAERGLIDAVILPSETRGHISRNLRLLRNKHVQRPARKHGN
HHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCC
IPL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]