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The map label for this gene is groEL

Identifier: 38233185

GI number: 38233185

Start: 543685

End: 545304

Strand: Direct

Name: groEL

Synonym: DIP0576

Alternate gene names: 38233185

Gene position: 543685-545304 (Clockwise)

Preceding gene: 38233184

Following gene: 38233186

Centisome position: 21.85

GC content: 57.41

Gene sequence:

>1620_bases
ATGGCAAAGCTGATTGCATTTAATCAAGAAGCACGCGAAGGCATCCTCAAGGGTGTCGACGCACTGGCCAACGCAGTCAA
GGTGACCTTGGGGCCTCGCGGCCGCAACGTTGTGTTGCAAAAAGCCTTTGGTAGCCCAACCGTGACTAACGACGGTGTGA
CCATTGCGCGCGAGATCGATCTCAGCGATCCTTTTGAAAACCTTGGCGCACAGCTGGTGAAGTCCGTTGCAGTCAAGACC
AACGACATCGCTGGCGACGGCACCACCACCGCAACCCTGCTCGCTCAGGCTGTTGTGACCGAGGGTCTGCGCAACGTTGC
TGCAGGTGCTAACCCTATCGAGCTCAACCGCGGTATCGCAGCCGGTTCCGAGTTCGTAGTAGGAAAGCTGCGCGAGCGTG
CAACCGATGTTTCTTCGGCTGCAGACATCGCTAACGTTGCTACCGTTTCTTCGCGTGACCCAGAGGTCGGCGACATGGTG
GCAGCAGCGATGGAAAAAGTGGGCAAAGACGGTGTCGTCACCGTTGAGGAGTCGCAGTCCATCGAGTCATACCTCGACGT
CACCGAGGGTGTGTCCTTCGATAAAGGCTTCCTGTCCCCATACTTCATCACCGACACTGACACCCAGCACGCTGTGCTCG
AGCAGCCAGCTATCCTACTGGTCCGCAACAAGATTTCCTCTCTGCCAGACTTCCTTCCAGTGTTGGAAAAGGCTCTTGAG
GCAAGCAAGCCAATCTTGATCATTGCGGAAGATGTCGAAGGCGAGCCACTACAGACGCTCGTCGTCAACTCGATCCGTAA
GACCCTGCGTGCGGTTGCTGTGAAAGCTCCGTACTTTGGTGAGCGTCGTAAAGCGTTCATGGACGACCTCGCTGTGGTCA
CCGGTGCTACCGTCATCGACCCAGAGGTCGGCGTAAATCTCAACGAAGCAGGCGCTGAGGTATTTGGTACCGCTCGCCGC
GTGACCGTCACCAAGGACGAGACGATCATCGTCGATGGTGCCGGTACCGCCGAGGCGGTAGAAAACCGTCGTGCGCAGAT
CCGCCGCGAGATCGAAAACACCGATTCTGCATGGGATCGCGAAAAAGCTGAGGAGCGCCTAGCTAAGCTCTCCGGCGGTG
TCGCTGTGATCAAGGTGGGCGCTGCAACAGAAACCGAGGTTTCTGAGCGTAAGCTGCGCGTCGAAGACGCCATCAACGCT
GCTCGTGCCGCCGCACAAGAAGGCGTTATCGCTGGTGGCGGTTCCGCACTGGTGCAGATCTCCAAGGAGCTGCGCGAATT
CGCCCAGGAATTTGAGGGTGACGCAAAGATCGGCGTCATCGCATTGGCTAACGCTTTGGCAAAGCCTACGTACTGGATCG
CAGACAACGCAGGTCTCGACGGCGCTGTCGTCGTGTCAAAGGTATCCGAGCTTCCTAACGGTGAAGGCTTTAACGCTGCC
ACCTTGGAGTACGGCAACCTGATCGAGCAGGGCATTATTGATCCTGTGAAGGTCACTCACTCGGCAGTGGTGAACGCCAC
CTCCGTGGCACGCATGGTTCTTACCACCGAAGCATCGGTAGTAGAAAAGCCAGCTGCACCAGCTCCTGAGGCTGGTCACC
ACCACCATCACCACCACTAA

Upstream 100 bases:

>100_bases
CAAGTACGGCGGAACCGAGTTGAAGTACAACGGCGAAGAGTACTTGCTGCTCAACGCTCGCGACGTTCTCGCCATCATCG
AGAAGTAAGGCAGCCCCCGT

Downstream 100 bases:

>100_bases
AAACGGCGGAGTAGCAGGGGGTATGCACTTACATGCCGGTGCGTGAGAAACGCTTAAACAGCGTCTTCTCCCACCGGCAT
GTGGTGTTTTAAGGAAAACC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MAKLIAFNQEAREGILKGVDALANAVKVTLGPRGRNVVLQKAFGSPTVTNDGVTIAREIDLSDPFENLGAQLVKSVAVKT
NDIAGDGTTTATLLAQAVVTEGLRNVAAGANPIELNRGIAAGSEFVVGKLRERATDVSSAADIANVATVSSRDPEVGDMV
AAAMEKVGKDGVVTVEESQSIESYLDVTEGVSFDKGFLSPYFITDTDTQHAVLEQPAILLVRNKISSLPDFLPVLEKALE
ASKPILIIAEDVEGEPLQTLVVNSIRKTLRAVAVKAPYFGERRKAFMDDLAVVTGATVIDPEVGVNLNEAGAEVFGTARR
VTVTKDETIIVDGAGTAEAVENRRAQIRREIENTDSAWDREKAEERLAKLSGGVAVIKVGAATETEVSERKLRVEDAINA
ARAAAQEGVIAGGGSALVQISKELREFAQEFEGDAKIGVIALANALAKPTYWIADNAGLDGAVVVSKVSELPNGEGFNAA
TLEYGNLIEQGIIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAAPAPEAGHHHHHHH

Sequences:

>Translated_539_residues
MAKLIAFNQEAREGILKGVDALANAVKVTLGPRGRNVVLQKAFGSPTVTNDGVTIAREIDLSDPFENLGAQLVKSVAVKT
NDIAGDGTTTATLLAQAVVTEGLRNVAAGANPIELNRGIAAGSEFVVGKLRERATDVSSAADIANVATVSSRDPEVGDMV
AAAMEKVGKDGVVTVEESQSIESYLDVTEGVSFDKGFLSPYFITDTDTQHAVLEQPAILLVRNKISSLPDFLPVLEKALE
ASKPILIIAEDVEGEPLQTLVVNSIRKTLRAVAVKAPYFGERRKAFMDDLAVVTGATVIDPEVGVNLNEAGAEVFGTARR
VTVTKDETIIVDGAGTAEAVENRRAQIRREIENTDSAWDREKAEERLAKLSGGVAVIKVGAATETEVSERKLRVEDAINA
ARAAAQEGVIAGGGSALVQISKELREFAQEFEGDAKIGVIALANALAKPTYWIADNAGLDGAVVVSKVSELPNGEGFNAA
TLEYGNLIEQGIIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAAPAPEAGHHHHHHH
>Mature_538_residues
AKLIAFNQEAREGILKGVDALANAVKVTLGPRGRNVVLQKAFGSPTVTNDGVTIAREIDLSDPFENLGAQLVKSVAVKTN
DIAGDGTTTATLLAQAVVTEGLRNVAAGANPIELNRGIAAGSEFVVGKLRERATDVSSAADIANVATVSSRDPEVGDMVA
AAMEKVGKDGVVTVEESQSIESYLDVTEGVSFDKGFLSPYFITDTDTQHAVLEQPAILLVRNKISSLPDFLPVLEKALEA
SKPILIIAEDVEGEPLQTLVVNSIRKTLRAVAVKAPYFGERRKAFMDDLAVVTGATVIDPEVGVNLNEAGAEVFGTARRV
TVTKDETIIVDGAGTAEAVENRRAQIRREIENTDSAWDREKAEERLAKLSGGVAVIKVGAATETEVSERKLRVEDAINAA
RAAAQEGVIAGGGSALVQISKELREFAQEFEGDAKIGVIALANALAKPTYWIADNAGLDGAVVVSKVSELPNGEGFNAAT
LEYGNLIEQGIIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAAPAPEAGHHHHHHH

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=42.8571428571429, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=42.8571428571429, Blast_Score=432, Evalue=1e-121,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=52.8625954198473, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=42.4528301886792, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI193210679, Length=218, Percent_Identity=40.8256880733945, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=46.0952380952381, Blast_Score=468, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322524, Length=133, Percent_Identity=33.0827067669173, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=44.952380952381, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=44.952380952381, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=44.5714285714286, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=44.5714285714286, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=44.5714285714286, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=38.7404580152672, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=34.280303030303, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=34.280303030303, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_CORDI (Q6NJ37)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_938952.1
- ProteinModelPortal:   Q6NJ37
- SMR:   Q6NJ37
- GeneID:   2648772
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0576
- NMPDR:   fig|257309.1.peg.543
- HOGENOM:   HBG625289
- OMA:   WIASNAG
- ProtClustDB:   PRK12849
- BioCyc:   CDIP257309:DIP0576-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56772; Mature: 56640

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLIAFNQEAREGILKGVDALANAVKVTLGPRGRNVVLQKAFGSPTVTNDGVTIAREID
CCCEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEECC
LSDPFENLGAQLVKSVAVKTNDIAGDGTTTATLLAQAVVTEGLRNVAAGANPIELNRGIA
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCC
AGSEFVVGKLRERATDVSSAADIANVATVSSRDPEVGDMVAAAMEKVGKDGVVTVEESQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHH
IESYLDVTEGVSFDKGFLSPYFITDTDTQHAVLEQPAILLVRNKISSLPDFLPVLEKALE
HHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCHHEEEHHHHHCCHHHHHHHHHHHH
ASKPILIIAEDVEGEPLQTLVVNSIRKTLRAVAVKAPYFGERRKAFMDDLAVVTGATVID
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEC
PEVGVNLNEAGAEVFGTARRVTVTKDETIIVDGAGTAEAVENRRAQIRREIENTDSAWDR
CCCCCCCCHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHH
EKAEERLAKLSGGVAVIKVGAATETEVSERKLRVEDAINAARAAAQEGVIAGGGSALVQI
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHH
SKELREFAQEFEGDAKIGVIALANALAKPTYWIADNAGLDGAVVVSKVSELPNGEGFNAA
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
TLEYGNLIEQGIIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAAPAPEAGHHHHHHH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKLIAFNQEAREGILKGVDALANAVKVTLGPRGRNVVLQKAFGSPTVTNDGVTIAREID
CCEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEECC
LSDPFENLGAQLVKSVAVKTNDIAGDGTTTATLLAQAVVTEGLRNVAAGANPIELNRGIA
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCC
AGSEFVVGKLRERATDVSSAADIANVATVSSRDPEVGDMVAAAMEKVGKDGVVTVEESQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHH
IESYLDVTEGVSFDKGFLSPYFITDTDTQHAVLEQPAILLVRNKISSLPDFLPVLEKALE
HHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCHHEEEHHHHHCCHHHHHHHHHHHH
ASKPILIIAEDVEGEPLQTLVVNSIRKTLRAVAVKAPYFGERRKAFMDDLAVVTGATVID
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEC
PEVGVNLNEAGAEVFGTARRVTVTKDETIIVDGAGTAEAVENRRAQIRREIENTDSAWDR
CCCCCCCCHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHH
EKAEERLAKLSGGVAVIKVGAATETEVSERKLRVEDAINAARAAAQEGVIAGGGSALVQI
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHH
SKELREFAQEFEGDAKIGVIALANALAKPTYWIADNAGLDGAVVVSKVSELPNGEGFNAA
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
TLEYGNLIEQGIIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAAPAPEAGHHHHHHH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910