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The map label for this gene is adk

Identifier: 38233150

GI number: 38233150

Start: 511081

End: 511626

Strand: Direct

Name: adk

Synonym: DIP0541

Alternate gene names: 38233150

Gene position: 511081-511626 (Clockwise)

Preceding gene: 38233149

Following gene: 38233151

Centisome position: 20.54

GC content: 54.95

Gene sequence:

>546_bases
ATGCGACTCGTACTTCTTGGACCTCCCGGTGCTGGCAAAGGCACCCAAGCGGCTATCCTCTCCGAAAAGCTGCGCATTCC
TCACATCTCTACCGGTGACCTATTCCGTGCCAACATTGGCGAAGGCACCCCACTGGGTAAGGAAGCAAAATCTTATATTG
ATGCCGGCAAGCTTGTGCCTACCGACGTCACCGCGCGCATGGTGAAGGCTCGCCTCCAAAAAGACGACGCAGAGGTTGGA
TTCCTTCTTGACGGCTTCCCACGCACTGTTGAGCAGGCTGAGATCCTCAAGGAAATGCTGAAAGGATTCGGCGTTGAGCT
CAACGGTGTTATTAACTACGAAGTCGCTGAAGATGTAGTAGTTGAGCGCATGCTTGCTCGTGGCCGTGCGGACGACAACG
AAGACACCATCCGCACCCGTCTGCAGGTTTACCGCGACGAAACCGCACCACTTATCCGCCACTATGGTGACGACATCATC
ACCATCAAGGCAGAAGGTAGCATCGAGGACATCAATGCTCGCACCCTCGGAGCACTGGGCAAGTAA

Upstream 100 bases:

>100_bases
GCGGTACTGCAATTTTGATTATGGTTTCCGTGGCTTTGACAACCGTCAAGCAGATCGAAAGCCAGCTACTGCAAAGCAAC
TACGAAGGACTTCTTAAATA

Downstream 100 bases:

>100_bases
TCTAGCTCTTATATAGCTCCGCATATCGTTGAAATCCGAGGCGTTTTCCGTGACACCACACAGGGGAACGATCCTCGGAT
TTTTTATGAACACAACAGAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MRLVLLGPPGAGKGTQAAILSEKLRIPHISTGDLFRANIGEGTPLGKEAKSYIDAGKLVPTDVTARMVKARLQKDDAEVG
FLLDGFPRTVEQAEILKEMLKGFGVELNGVINYEVAEDVVVERMLARGRADDNEDTIRTRLQVYRDETAPLIRHYGDDII
TIKAEGSIEDINARTLGALGK

Sequences:

>Translated_181_residues
MRLVLLGPPGAGKGTQAAILSEKLRIPHISTGDLFRANIGEGTPLGKEAKSYIDAGKLVPTDVTARMVKARLQKDDAEVG
FLLDGFPRTVEQAEILKEMLKGFGVELNGVINYEVAEDVVVERMLARGRADDNEDTIRTRLQVYRDETAPLIRHYGDDII
TIKAEGSIEDINARTLGALGK
>Mature_181_residues
MRLVLLGPPGAGKGTQAAILSEKLRIPHISTGDLFRANIGEGTPLGKEAKSYIDAGKLVPTDVTARMVKARLQKDDAEVG
FLLDGFPRTVEQAEILKEMLKGFGVELNGVINYEVAEDVVVERMLARGRADDNEDTIRTRLQVYRDETAPLIRHYGDDII
TIKAEGSIEDINARTLGALGK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=35.5140186915888, Blast_Score=133, Evalue=7e-32,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=35.5140186915888, Blast_Score=133, Evalue=7e-32,
Organism=Homo sapiens, GI19923437, Length=186, Percent_Identity=33.8709677419355, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=33.695652173913, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI7706497, Length=180, Percent_Identity=31.1111111111111, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=32.0652173913043, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=31.5508021390374, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI310110345, Length=183, Percent_Identity=31.6939890710383, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI53832003, Length=183, Percent_Identity=31.6939890710383, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI8051579, Length=183, Percent_Identity=31.6939890710383, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI53832001, Length=183, Percent_Identity=31.6939890710383, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=31.496062992126, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=186, Percent_Identity=40.8602150537634, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17552384, Length=207, Percent_Identity=34.7826086956522, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=36.8983957219251, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=162, Percent_Identity=34.5679012345679, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=163, Percent_Identity=33.7423312883436, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=187, Percent_Identity=38.5026737967914, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=179, Percent_Identity=31.8435754189944, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=32.0197044334975, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=39.1304347826087, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24663208, Length=183, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=159, Percent_Identity=33.9622641509434, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356893, Length=159, Percent_Identity=33.9622641509434, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17647141, Length=183, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=32.2751322751323, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=32.2751322751323, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CORDI (Q6NJ71)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_938917.1
- ProteinModelPortal:   Q6NJ71
- SMR:   Q6NJ71
- GeneID:   2650860
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0541
- NMPDR:   fig|257309.1.peg.508
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   CDIP257309:DIP0541-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 19742; Mature: 19742

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGAGKGTQAAILSEKLRIPHISTGDLFRANIGEGTPLGKEAKSYIDAGKLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCC
TDVTARMVKARLQKDDAEVGFLLDGFPRTVEQAEILKEMLKGFGVELNGVINYEVAEDVV
CHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEECCEEEHHHHHHHH
VERMLARGRADDNEDTIRTRLQVYRDETAPLIRHYGDDIITIKAEGSIEDINARTLGALG
HHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCC
K
C
>Mature Secondary Structure
MRLVLLGPPGAGKGTQAAILSEKLRIPHISTGDLFRANIGEGTPLGKEAKSYIDAGKLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCC
TDVTARMVKARLQKDDAEVGFLLDGFPRTVEQAEILKEMLKGFGVELNGVINYEVAEDVV
CHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEECCEEEHHHHHHHH
VERMLARGRADDNEDTIRTRLQVYRDETAPLIRHYGDDIITIKAEGSIEDINARTLGALG
HHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910