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The map label for this gene is mapA [H]

Identifier: 38233151

GI number: 38233151

Start: 511740

End: 512534

Strand: Direct

Name: mapA [H]

Synonym: DIP0542

Alternate gene names: 38233151

Gene position: 511740-512534 (Clockwise)

Preceding gene: 38233150

Following gene: 38233152

Centisome position: 20.56

GC content: 57.11

Gene sequence:

>795_bases
ATGGGCTTTAGGTCTAAGCGAAAAGTAATCCCAGCAAAAACACCAGGTGAGCTCGACGCCATGCAGGCGGCAGGTGAAAT
CGTCGGCGAGGCACTCCAAGCGGTGCGCGCCGCGGCAGCCGTTGGAGTAAGCACCCTTGAGCTCGACGCTATCGCCGAGC
AGGCCATCCGTGATCGTGGAGCAATCCCGACCTTCAAAGGCTACGGCGGATTCCCAGGCTCTATCTGCGCCTCGGTCAAC
GACGTTATCGTGCACGGAATCCCCAACAAAGAAACCATCCTCAAAGAGGGCGACCTGGTTTCCATCGACTGCGGTGCCAC
CTTGGATGGTTGGGTTGGCGACTCCGCATGGACCTTCGGCATCGGCACCATTGCCGACGATGTACGTGCGCTGAATGAGG
CCACCGAGTGGGTTCTCTATGAAGGCATGAAGGCAATGATCCCTGGTAACAGGCTTACCGACGTCTCCCACGCCTTAGAG
ATGGCTACCCGCGCAGCGGAAAAGAAATTCAATGTACAACTCGGCATTGTTGACGGCTACGGTGGCCACGGAATCGGTCA
CGAAATGCACGAAGAGCCCTACCTTGCTAACGAAGGTAAAGGCGGCCGCGGCCCAATGATCCAAGAAGGATCGGTACTGG
CCATCGAGCCCATGCTGACCCTTGGATCCGTGGATTCCATCGTGCTCGCCGACGAATGGACCGTAGTTACCGACGATAAC
TCTTGGTCCTCACACTGGGAGCATACGGTTGCGGCAACCAACGATGGTCCTAGGATTTTGACTCCGCGAAAGTAA

Upstream 100 bases:

>100_bases
TAGCTCCGCATATCGTTGAAATCCGAGGCGTTTTCCGTGACACCACACAGGGGAACGATCCTCGGATTTTTTATGAACAC
AACAGAAAGAAAACACAGCC

Downstream 100 bases:

>100_bases
TAGAACTTTCGGATAACTAATCGGTGGTTGGTTGTGGTAATACACAATCGACCACCGATTTCTTTTCGGTATGGGGGTAA
AGAGTGGGGGTTATTTACTT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MGFRSKRKVIPAKTPGELDAMQAAGEIVGEALQAVRAAAAVGVSTLELDAIAEQAIRDRGAIPTFKGYGGFPGSICASVN
DVIVHGIPNKETILKEGDLVSIDCGATLDGWVGDSAWTFGIGTIADDVRALNEATEWVLYEGMKAMIPGNRLTDVSHALE
MATRAAEKKFNVQLGIVDGYGGHGIGHEMHEEPYLANEGKGGRGPMIQEGSVLAIEPMLTLGSVDSIVLADEWTVVTDDN
SWSSHWEHTVAATNDGPRILTPRK

Sequences:

>Translated_264_residues
MGFRSKRKVIPAKTPGELDAMQAAGEIVGEALQAVRAAAAVGVSTLELDAIAEQAIRDRGAIPTFKGYGGFPGSICASVN
DVIVHGIPNKETILKEGDLVSIDCGATLDGWVGDSAWTFGIGTIADDVRALNEATEWVLYEGMKAMIPGNRLTDVSHALE
MATRAAEKKFNVQLGIVDGYGGHGIGHEMHEEPYLANEGKGGRGPMIQEGSVLAIEPMLTLGSVDSIVLADEWTVVTDDN
SWSSHWEHTVAATNDGPRILTPRK
>Mature_263_residues
GFRSKRKVIPAKTPGELDAMQAAGEIVGEALQAVRAAAAVGVSTLELDAIAEQAIRDRGAIPTFKGYGGFPGSICASVND
VIVHGIPNKETILKEGDLVSIDCGATLDGWVGDSAWTFGIGTIADDVRALNEATEWVLYEGMKAMIPGNRLTDVSHALEM
ATRAAEKKFNVQLGIVDGYGGHGIGHEMHEEPYLANEGKGGRGPMIQEGSVLAIEPMLTLGSVDSIVLADEWTVVTDDNS
WSSHWEHTVAATNDGPRILTPRK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=252, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=31.9838056680162, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786364, Length=256, Percent_Identity=34.765625, Blast_Score=160, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71996291, Length=257, Percent_Identity=31.5175097276265, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323273, Length=255, Percent_Identity=32.9411764705882, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=32.9317269076305, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=32.258064516129, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28005; Mature: 27874

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFRSKRKVIPAKTPGELDAMQAAGEIVGEALQAVRAAAAVGVSTLELDAIAEQAIRDRG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
AIPTFKGYGGFPGSICASVNDVIVHGIPNKETILKEGDLVSIDCGATLDGWVGDSAWTFG
CCCCCCCCCCCCHHHHHCCCCEEEECCCCCHHEEECCCEEEEECCCCCCCCCCCCEEEEE
IGTIADDVRALNEATEWVLYEGMKAMIPGNRLTDVSHALEMATRAAEKKFNVQLGIVDGY
CHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECC
GGHGIGHEMHEEPYLANEGKGGRGPMIQEGSVLAIEPMLTLGSVDSIVLADEWTVVTDDN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEECCCCCEEEEECCEEEEECCC
SWSSHWEHTVAATNDGPRILTPRK
CCCCCCCEEEEECCCCCEECCCCC
>Mature Secondary Structure 
GFRSKRKVIPAKTPGELDAMQAAGEIVGEALQAVRAAAAVGVSTLELDAIAEQAIRDRG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
AIPTFKGYGGFPGSICASVNDVIVHGIPNKETILKEGDLVSIDCGATLDGWVGDSAWTFG
CCCCCCCCCCCCHHHHHCCCCEEEECCCCCHHEEECCCEEEEECCCCCCCCCCCCEEEEE
IGTIADDVRALNEATEWVLYEGMKAMIPGNRLTDVSHALEMATRAAEKKFNVQLGIVDGY
CHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECC
GGHGIGHEMHEEPYLANEGKGGRGPMIQEGSVLAIEPMLTLGSVDSIVLADEWTVVTDDN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEECCCCCEEEEECCEEEEECCC
SWSSHWEHTVAATNDGPRILTPRK
CCCCCCCEEEEECCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]