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The map label for this gene is moaE2 [H]

Identifier: 38233105

GI number: 38233105

Start: 458800

End: 459795

Strand: Reverse

Name: moaE2 [H]

Synonym: DIP0493

Alternate gene names: 38233105

Gene position: 459795-458800 (Counterclockwise)

Preceding gene: 38233106

Following gene: 38233104

Centisome position: 18.48

GC content: 55.42

Gene sequence:

>996_bases
ATGTCATCACATTCTCCTGTGCAGCCACGTCGCGCACGTGTTGTTGTGGCGTCGACACGCGCCGCAGCAGGTCAGTACGC
CGATACCTCCGGCCCCATCTTGGTGGAGTGGCTGCGAGCGCGTGGTTTTGATACCCCAGAACCACTCGTTGTTGCTGATG
CTGACATGCATACTGCCATCGCCACTATGTTTGCTGAGGCGGAGTCACTGCCTGATGTTGTCCTCACAACCGGTGGCACG
GGGATTACTGCCGACGATCATACTGTCGATGTAGTAGCCCCACTGATTGATACGCCGCTTCCGGGTATTTCACAGGCGTT
CTGGCATCGCGGACTGCTCAATAGTGTGGACACAGCTATTCTTAGTCGCTGCGTAGCGGGTATTCATCGCGGTTCTACGT
TTATTATGACCCTGCCTGGTTCTCAGAGCGGATGCAATGATGGCATCGCTGTCCTCGATACCATCATTGATCATGTGTGC
GACCTCTTGGCTCGCACACCTTCTTCTCCCCCACAAGCGCATCAGTGCTGTTCCCATTCCGCCCCCGACCCAGATTATGT
GAAGGCGCAGGTAGGCAAAGTCATTGATGCGTTTATCACCGAAGATCCATTGGAGCCGCTAGCGGCCCAAGCCTATGATG
ACGTGCGCACTGATGCTATGGGCGCGGTCGTGGTTTTTGATGGTCTGGTACGAGATCATGATGGAGGTAAGCGTGTCAGC
AACCTCACCTACTCCGCACACCCCACCTCTCATGCAGTGTTAAAAAAGGTAGTAGCCCGTGTCAGTGTCAAGCACCCCGA
TGCACGAATCTGGGCAGCACACCGCGTTGGTCGCCTTGCTGTGGGGGAGGCTGCCTTCATTGTGATTGCTGCCGCAGCGC
ACCGCCGATCAGCATTTGATGCAGCAAGCGCAGTAGCTGATGAAGTCAAAGCTTCGGTTCCGATCTGGAAAGAGCAGAAA
ATGGCAGATGGTTCCATCCAGTGGGTTGGACTCTGA

Upstream 100 bases:

>100_bases
CAGCAGCAAAATAATGCACATCCATCACACCAGTGTGCCCTAGACTGTTCTTTTTACGCTACTTGGGCACTCTATTCATT
TATATTATAAGGAAAGTTTT

Downstream 100 bases:

>100_bases
TGACTATTGACCACGCACGCTATGCCCGTCAGATCGCGCTCAGTGGTTTTGGTGTAGCTGGGCAAACAGCGCTTTCTGGT
GCGCATGTGGTCTGCATTGG

Product: putative bifunctional molybdopterim biosynthesis protein

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 2; Molybdopterin-converting factor large subunit 2; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSSHSPVQPRRARVVVASTRAAAGQYADTSGPILVEWLRARGFDTPEPLVVADADMHTAIATMFAEAESLPDVVLTTGGT
GITADDHTVDVVAPLIDTPLPGISQAFWHRGLLNSVDTAILSRCVAGIHRGSTFIMTLPGSQSGCNDGIAVLDTIIDHVC
DLLARTPSSPPQAHQCCSHSAPDPDYVKAQVGKVIDAFITEDPLEPLAAQAYDDVRTDAMGAVVVFDGLVRDHDGGKRVS
NLTYSAHPTSHAVLKKVVARVSVKHPDARIWAAHRVGRLAVGEAAFIVIAAAAHRRSAFDAASAVADEVKASVPIWKEQK
MADGSIQWVGL

Sequences:

>Translated_331_residues
MSSHSPVQPRRARVVVASTRAAAGQYADTSGPILVEWLRARGFDTPEPLVVADADMHTAIATMFAEAESLPDVVLTTGGT
GITADDHTVDVVAPLIDTPLPGISQAFWHRGLLNSVDTAILSRCVAGIHRGSTFIMTLPGSQSGCNDGIAVLDTIIDHVC
DLLARTPSSPPQAHQCCSHSAPDPDYVKAQVGKVIDAFITEDPLEPLAAQAYDDVRTDAMGAVVVFDGLVRDHDGGKRVS
NLTYSAHPTSHAVLKKVVARVSVKHPDARIWAAHRVGRLAVGEAAFIVIAAAAHRRSAFDAASAVADEVKASVPIWKEQK
MADGSIQWVGL
>Mature_330_residues
SSHSPVQPRRARVVVASTRAAAGQYADTSGPILVEWLRARGFDTPEPLVVADADMHTAIATMFAEAESLPDVVLTTGGTG
ITADDHTVDVVAPLIDTPLPGISQAFWHRGLLNSVDTAILSRCVAGIHRGSTFIMTLPGSQSGCNDGIAVLDTIIDHVCD
LLARTPSSPPQAHQCCSHSAPDPDYVKAQVGKVIDAFITEDPLEPLAAQAYDDVRTDAMGAVVVFDGLVRDHDGGKRVSN
LTYSAHPTSHAVLKKVVARVSVKHPDARIWAAHRVGRLAVGEAAFIVIAAAAHRRSAFDAASAVADEVKASVPIWKEQKM
ADGSIQWVGL

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=171, Percent_Identity=30.9941520467836, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787003, Length=113, Percent_Identity=35.3982300884956, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509279, Length=113, Percent_Identity=31.858407079646, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17564954, Length=161, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 35005; Mature: 34874

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHSPVQPRRARVVVASTRAAAGQYADTSGPILVEWLRARGFDTPEPLVVADADMHTAI
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCHHHHHH
ATMFAEAESLPDVVLTTGGTGITADDHTVDVVAPLIDTPLPGISQAFWHRGLLNSVDTAI
HHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LSRCVAGIHRGSTFIMTLPGSQSGCNDGIAVLDTIIDHVCDLLARTPSSPPQAHQCCSHS
HHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
APDPDYVKAQVGKVIDAFITEDPLEPLAAQAYDDVRTDAMGAVVVFDGLVRDHDGGKRVS
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHEEEHHHHHCCCCCCHHH
NLTYSAHPTSHAVLKKVVARVSVKHPDARIWAAHRVGRLAVGEAAFIVIAAAAHRRSAFD
CCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHH
AASAVADEVKASVPIWKEQKMADGSIQWVGL
HHHHHHHHHHHCCCCCHHHHCCCCCEEEEEC
>Mature Secondary Structure 
SSHSPVQPRRARVVVASTRAAAGQYADTSGPILVEWLRARGFDTPEPLVVADADMHTAI
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCHHHHHH
ATMFAEAESLPDVVLTTGGTGITADDHTVDVVAPLIDTPLPGISQAFWHRGLLNSVDTAI
HHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LSRCVAGIHRGSTFIMTLPGSQSGCNDGIAVLDTIIDHVCDLLARTPSSPPQAHQCCSHS
HHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
APDPDYVKAQVGKVIDAFITEDPLEPLAAQAYDDVRTDAMGAVVVFDGLVRDHDGGKRVS
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHEEEHHHHHCCCCCCHHH
NLTYSAHPTSHAVLKKVVARVSVKHPDARIWAAHRVGRLAVGEAAFIVIAAAAHRRSAFD
CCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHH
AASAVADEVKASVPIWKEQKMADGSIQWVGL
HHHHHHHHHHHCCCCCHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]