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The map label for this gene is manB [C]

Identifier: 38232895

GI number: 38232895

Start: 237124

End: 238776

Strand: Direct

Name: manB [C]

Synonym: DIP0274

Alternate gene names: 38232895

Gene position: 237124-238776 (Clockwise)

Preceding gene: 38232894

Following gene: 38232896

Centisome position: 9.53

GC content: 62.79

Gene sequence:

>1653_bases
ATGAGCTACGCAGAGCTAGAGCGCACAGCCCGCGAGTGGGCGGATCACGATCCCGACCCTCGCACCAAAGAAACCATCGA
GGGCTGGCTTAAAACTCACGACGAAGAATCCCTCCAGCAGGCATTCAACGGACCGCTGACTTTTGGCACCGCCGGCCTGC
GAGCACGAGTGGGCGCAGGTGAATCCCAGCTCAGCCTGGCAGTCATCCTGCGCACCACCTACGGCCTAGTCGACTGGGTA
AAAACCCAGCTCGGCGCAGATGCCACCCCTACGATCGTGATCGGCTGCGACGCCCGCCACGGATCCCTAGAGTTCCACCA
AGCCGCAGCGGAGGTAGTCTCCGCAGCCGGCGGACGCGCCCTGCTGCTACCAGCTAAAAACCCCACCCCACTGACCGCCT
TTAGTGTGAAGAAGTTTGGTGCCGATGCCGGCATCATGGTCACCGCCTCGCACAACCCACCAGCCGACAACGGCTACAAG
GTCTACCTCGGTGGACGCATCGCCCAAGGCCCAGCCGAAGGCGTGCAACTGATCAGCCCAGCTGACAAAGAAATCTCCGA
GGCAATCGCAGCAGCACCGTACGCAGACGAAATCCCACGCACCACCGACAACATCGAACATGTTGACCCACGCGAGGACT
ACCTCACCCGCGCACTGACCCTCGCAGACAAGAAGAGCGACATCCTCATCGCCCTGACTGCCATGCATGGTGTCGGCGCA
GCCTTGGGCGAAAAGGTGCTCACCGCTGCCGGATTCAACGTCTCCCTCGTCCCAGAACAAGCCGAGCCAGACCCAGATTT
CCCTACGGTGTCCTTCCCGAACCCAGAGGAAAAAGGTGCCCTCGACCTGGCGAAAGCACACGCCAACACCATCGGTGCAG
ATGTCATCATCGCCTACGATCCTGACGCGGACCGCTGTGCCGTCGCCACCCCAGACGCTAACGCCGAAGGCGGATGGCGC
CAGCTCAGCGGCGACGAGACAGGTGCGGTGCTAGGTGCATACCGTGCGAGCGTCGCAAAGCCAGGCTCCATGGCCAACTC
CATCGTCTCCGGCCGCCTGCTCTCCAAGATCGCCGAAGCCGCAGGGCGTACCCACGCCACCACGCTCACCGGATTCAAAT
GGATCGCACGCACCCCTGAACTCGTATTCGGCTATGAGGAAGCCATCGGATTCTGCTGCGACCCAGAAGCAGTCGCCGAC
AAAGATGGTGTCTCCGCCTCCGTGGTCGTAGCAAGCCTCGTCAGTGCCCTCAAAGCCGAAGGCCGCACCCTCGATGACGC
CCTCGACGACCTAGCCCGCGAACACGGCCTCTACCAGACCGCGCCGCTGACCTTCCGCGTCGACGACCTCTCCATCATCG
CCCGCGCCATGAGCACCCTACGCGCACAACCGCCAACGGAACTCGCAGGTGCAACCGTCACCGAGGTCACCGACCTCAAC
GACCCAACCCTGCCATGGGGCGCAACCGACGGCATGATGTTTATCACCGACCACAACGACCGCATCATCTGCCGCCCATC
CGGCACCGAGCCAAAACTCAAGTGCTACCTCGAAGTGGTTATGCCTGTCACCGGCGACACCATCCCACGCGCCGAAGCCG
CCCAACGCCTCGACGCTATCGCCACCGCACTGCGCACCCACCTCGGAATGTAG

Upstream 100 bases:

>100_bases
ACCGCCAAGGATGCCCTCGCCATGATCGAAGCAGGCGCTACCCGCTTGGGTCTGTCTGCCTCCGCAGCCATTCTTGAAGA
ACTAGGAGAGTAGAACAATC

Downstream 100 bases:

>100_bases
GCGAGAAACAACCTCCGCGTTCAGCCTTGCTACATTAGTGACAAGTATGAACAAGGTACTCACAGCACTAGCCCTCGTAG
CCGCAACCACCGCGTTGCGG

Product: putative mutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MSYAELERTAREWADHDPDPRTKETIEGWLKTHDEESLQQAFNGPLTFGTAGLRARVGAGESQLSLAVILRTTYGLVDWV
KTQLGADATPTIVIGCDARHGSLEFHQAAAEVVSAAGGRALLLPAKNPTPLTAFSVKKFGADAGIMVTASHNPPADNGYK
VYLGGRIAQGPAEGVQLISPADKEISEAIAAAPYADEIPRTTDNIEHVDPREDYLTRALTLADKKSDILIALTAMHGVGA
ALGEKVLTAAGFNVSLVPEQAEPDPDFPTVSFPNPEEKGALDLAKAHANTIGADVIIAYDPDADRCAVATPDANAEGGWR
QLSGDETGAVLGAYRASVAKPGSMANSIVSGRLLSKIAEAAGRTHATTLTGFKWIARTPELVFGYEEAIGFCCDPEAVAD
KDGVSASVVVASLVSALKAEGRTLDDALDDLAREHGLYQTAPLTFRVDDLSIIARAMSTLRAQPPTELAGATVTEVTDLN
DPTLPWGATDGMMFITDHNDRIICRPSGTEPKLKCYLEVVMPVTGDTIPRAEAAQRLDAIATALRTHLGM

Sequences:

>Translated_550_residues
MSYAELERTAREWADHDPDPRTKETIEGWLKTHDEESLQQAFNGPLTFGTAGLRARVGAGESQLSLAVILRTTYGLVDWV
KTQLGADATPTIVIGCDARHGSLEFHQAAAEVVSAAGGRALLLPAKNPTPLTAFSVKKFGADAGIMVTASHNPPADNGYK
VYLGGRIAQGPAEGVQLISPADKEISEAIAAAPYADEIPRTTDNIEHVDPREDYLTRALTLADKKSDILIALTAMHGVGA
ALGEKVLTAAGFNVSLVPEQAEPDPDFPTVSFPNPEEKGALDLAKAHANTIGADVIIAYDPDADRCAVATPDANAEGGWR
QLSGDETGAVLGAYRASVAKPGSMANSIVSGRLLSKIAEAAGRTHATTLTGFKWIARTPELVFGYEEAIGFCCDPEAVAD
KDGVSASVVVASLVSALKAEGRTLDDALDDLAREHGLYQTAPLTFRVDDLSIIARAMSTLRAQPPTELAGATVTEVTDLN
DPTLPWGATDGMMFITDHNDRIICRPSGTEPKLKCYLEVVMPVTGDTIPRAEAAQRLDAIATALRTHLGM
>Mature_549_residues
SYAELERTAREWADHDPDPRTKETIEGWLKTHDEESLQQAFNGPLTFGTAGLRARVGAGESQLSLAVILRTTYGLVDWVK
TQLGADATPTIVIGCDARHGSLEFHQAAAEVVSAAGGRALLLPAKNPTPLTAFSVKKFGADAGIMVTASHNPPADNGYKV
YLGGRIAQGPAEGVQLISPADKEISEAIAAAPYADEIPRTTDNIEHVDPREDYLTRALTLADKKSDILIALTAMHGVGAA
LGEKVLTAAGFNVSLVPEQAEPDPDFPTVSFPNPEEKGALDLAKAHANTIGADVIIAYDPDADRCAVATPDANAEGGWRQ
LSGDETGAVLGAYRASVAKPGSMANSIVSGRLLSKIAEAAGRTHATTLTGFKWIARTPELVFGYEEAIGFCCDPEAVADK
DGVSASVVVASLVSALKAEGRTLDDALDDLAREHGLYQTAPLTFRVDDLSIIARAMSTLRAQPPTELAGATVTEVTDLND
PTLPWGATDGMMFITDHNDRIICRPSGTEPKLKCYLEVVMPVTGDTIPRAEAAQRLDAIATALRTHLGM

Specific function: Involved In The Biosynthesis Of The Capsular Polysaccharide Colanic Acid. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=605, Percent_Identity=32.7272727272727, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI31377548, Length=592, Percent_Identity=31.9256756756757, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71993870, Length=566, Percent_Identity=31.8021201413428, Blast_Score=251, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI71993878, Length=325, Percent_Identity=31.3846153846154, Blast_Score=153, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323934, Length=583, Percent_Identity=33.1046312178388, Blast_Score=264, Evalue=2e-71,
Organism=Drosophila melanogaster, GI20129809, Length=574, Percent_Identity=31.8815331010453, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24651977, Length=475, Percent_Identity=33.2631578947368, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24653722, Length=500, Percent_Identity=30, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 58136; Mature: 58005

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYAELERTAREWADHDPDPRTKETIEGWLKTHDEESLQQAFNGPLTFGTAGLRARVGAG
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCEEECCCC
ESQLSLAVILRTTYGLVDWVKTQLGADATPTIVIGCDARHGSLEFHQAAAEVVSAAGGRA
CCHHEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
LLLPAKNPTPLTAFSVKKFGADAGIMVTASHNPPADNGYKVYLGGRIAQGPAEGVQLISP
EEEECCCCCCCEEEHHHHHCCCCCEEEEECCCCCCCCCEEEEECCEECCCCHHCEEEECC
ADKEISEAIAAAPYADEIPRTTDNIEHVDPREDYLTRALTLADKKSDILIALTAMHGVGA
CHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHH
ALGEKVLTAAGFNVSLVPEQAEPDPDFPTVSFPNPEEKGALDLAKAHANTIGADVIIAYD
HHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEC
PDADRCAVATPDANAEGGWRQLSGDETGAVLGAYRASVAKPGSMANSIVSGRLLSKIAEA
CCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AGRTHATTLTGFKWIARTPELVFGYEEAIGFCCDPEAVADKDGVSASVVVASLVSALKAE
HCCCCEEEHHHHHHHHCCCHHEEEHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHC
GRTLDDALDDLAREHGLYQTAPLTFRVDDLSIIARAMSTLRAQPPTELAGATVTEVTDLN
CCCHHHHHHHHHHHCCCEECCCCEEEECHHHHHHHHHHHHCCCCCHHHCCCEEEEEECCC
DPTLPWGATDGMMFITDHNDRIICRPSGTEPKLKCYLEVVMPVTGDTIPRAEAAQRLDAI
CCCCCCCCCCCEEEEEECCCEEEECCCCCCCHHEEEEEEEEECCCCCCCHHHHHHHHHHH
ATALRTHLGM
HHHHHHHHCC
>Mature Secondary Structure 
SYAELERTAREWADHDPDPRTKETIEGWLKTHDEESLQQAFNGPLTFGTAGLRARVGAG
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCEEECCCC
ESQLSLAVILRTTYGLVDWVKTQLGADATPTIVIGCDARHGSLEFHQAAAEVVSAAGGRA
CCHHEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
LLLPAKNPTPLTAFSVKKFGADAGIMVTASHNPPADNGYKVYLGGRIAQGPAEGVQLISP
EEEECCCCCCCEEEHHHHHCCCCCEEEEECCCCCCCCCEEEEECCEECCCCHHCEEEECC
ADKEISEAIAAAPYADEIPRTTDNIEHVDPREDYLTRALTLADKKSDILIALTAMHGVGA
CHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHH
ALGEKVLTAAGFNVSLVPEQAEPDPDFPTVSFPNPEEKGALDLAKAHANTIGADVIIAYD
HHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEC
PDADRCAVATPDANAEGGWRQLSGDETGAVLGAYRASVAKPGSMANSIVSGRLLSKIAEA
CCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AGRTHATTLTGFKWIARTPELVFGYEEAIGFCCDPEAVADKDGVSASVVVASLVSALKAE
HCCCCEEEHHHHHHHHCCCHHEEEHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHC
GRTLDDALDDLAREHGLYQTAPLTFRVDDLSIIARAMSTLRAQPPTELAGATVTEVTDLN
CCCHHHHHHHHHHHCCCEECCCCEEEECHHHHHHHHHHHHCCCCCHHHCCCEEEEEECCC
DPTLPWGATDGMMFITDHNDRIICRPSGTEPKLKCYLEVVMPVTGDTIPRAEAAQRLDAI
CCCCCCCCCCCEEEEEECCCEEEECCCCCCCHHEEEEEEEEECCCCCCCHHHHHHHHHHH
ATALRTHLGM
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]