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The map label for this gene is pat

Identifier: 38232803

GI number: 38232803

Start: 150627

End: 151661

Strand: Reverse

Name: pat

Synonym: DIP0178

Alternate gene names: 38232803

Gene position: 151661-150627 (Counterclockwise)

Preceding gene: 38232807

Following gene: 38232802

Centisome position: 6.09

GC content: 60.1

Gene sequence:

>1035_bases
ATGATCCGCAAAGACCTTTCCCAGATCCCGACGTACGTTCCTGGCAAGCGCAACGACCACGCCCTCAAGTTATCCAGTAA
CGAGGTCACTCATCGTCCGCTGCCGTCCGCAGCCCAGGCAATGGCGGAGGCCGCAGCTGGCGCGAATCGCTACCCAGACA
TGGGTGTTACTGAATTACGCGGTGCACTTTCGGAGCATCTCGGCGTCCCAGCGGAGCAGATTGCCGTGGGCTGTGGCTCC
TCCGCGTTGTGCCAGCAGCTTGTGCAGATCACCTGCACCCCGGGGGATGAGGTGGTGTTCCCGTGGCGCAGCTTCGAGGC
ATACCCCATATTCGTGCAGGTAGTGGGCGCAACACCGGTGGCAGTGCCGCTAACCAGCGACGGATTTAATGATCTCGATG
CGATGGCGGCAGCAATTACCCCAAAAACGAAGCTGGTGTTCGTGTGCAATCCGAATAACCCTTCGGGCACAGTGGTGCGT
CGAGAAGCGTTTTTGGAGTTCATGGCGAAGGTGCCAGCGGATGTCGTCGTAGCGCTTGACGAGGCCTACACCGAATACGT
CCGCGACGAAGACACCATCTTCGCCACCGAAATCCTCAGCGAATTCCCCAACCTCGTGGGCCTGCGCACCTTCTCCAAAG
CATTCGGACTCGCCGGCGTCCGCGTGGGCTACGCCTTCGGACCACACGAGCTTATCGACGCCCTCAACAAAGTCGCCCTC
CCCTTCGGAGTCAATGCCGTCGGCCAAGCCGGCGCACTCGCATCACTGAACAACCTCGACGAACTCATGGAACACACCGA
AGAAGTAGTAGCCGTACGCGACCGCGTCGCCGACCACATCGGCGCCGCACACTCGCAAGCAAACTTCGTGTGGATCCCCG
CCGAATCACGCAGCGAAACCCCCTTCGAAATCGCCGAAAAACTCGCAGCTCACGACGTCCTCGTGCGCGCCTTCCCCGAA
GGAGTTCGCATCACCGTAACTAACGAAGAAGAAAGCGATCGTCTGCTAGCCGCATGGGACGCGAGCTTCGCCTAA

Upstream 100 bases:

>100_bases
CTAAAAAAGAATCGTCGTTCATTTTATCCAACATCATCGGCTGGTACAAAACACGAGGCAGTGCCCCCTATCTACGGCAC
GCGGGGCTACAATTGCCGGC

Downstream 100 bases:

>100_bases
GCAGTTGTAGTGCTTGCGCTAGCACGAATCCGAGAACTCGAATTCAAGACCACGAAAACCCAAGGACAGCATTTCGGCGA
GAAAATCGCGTCCTGCGGTT

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MIRKDLSQIPTYVPGKRNDHALKLSSNEVTHRPLPSAAQAMAEAAAGANRYPDMGVTELRGALSEHLGVPAEQIAVGCGS
SALCQQLVQITCTPGDEVVFPWRSFEAYPIFVQVVGATPVAVPLTSDGFNDLDAMAAAITPKTKLVFVCNPNNPSGTVVR
REAFLEFMAKVPADVVVALDEAYTEYVRDEDTIFATEILSEFPNLVGLRTFSKAFGLAGVRVGYAFGPHELIDALNKVAL
PFGVNAVGQAGALASLNNLDELMEHTEEVVAVRDRVADHIGAAHSQANFVWIPAESRSETPFEIAEKLAAHDVLVRAFPE
GVRITVTNEEESDRLLAAWDASFA

Sequences:

>Translated_344_residues
MIRKDLSQIPTYVPGKRNDHALKLSSNEVTHRPLPSAAQAMAEAAAGANRYPDMGVTELRGALSEHLGVPAEQIAVGCGS
SALCQQLVQITCTPGDEVVFPWRSFEAYPIFVQVVGATPVAVPLTSDGFNDLDAMAAAITPKTKLVFVCNPNNPSGTVVR
REAFLEFMAKVPADVVVALDEAYTEYVRDEDTIFATEILSEFPNLVGLRTFSKAFGLAGVRVGYAFGPHELIDALNKVAL
PFGVNAVGQAGALASLNNLDELMEHTEEVVAVRDRVADHIGAAHSQANFVWIPAESRSETPFEIAEKLAAHDVLVRAFPE
GVRITVTNEEESDRLLAAWDASFA
>Mature_344_residues
MIRKDLSQIPTYVPGKRNDHALKLSSNEVTHRPLPSAAQAMAEAAAGANRYPDMGVTELRGALSEHLGVPAEQIAVGCGS
SALCQQLVQITCTPGDEVVFPWRSFEAYPIFVQVVGATPVAVPLTSDGFNDLDAMAAAITPKTKLVFVCNPNNPSGTVVR
REAFLEFMAKVPADVVVALDEAYTEYVRDEDTIFATEILSEFPNLVGLRTFSKAFGLAGVRVGYAFGPHELIDALNKVAL
PFGVNAVGQAGALASLNNLDELMEHTEEVVAVRDRVADHIGAAHSQANFVWIPAESRSETPFEIAEKLAAHDVLVRAFPE
GVRITVTNEEESDRLLAAWDASFA

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=313, Percent_Identity=28.1150159744409, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788627, Length=184, Percent_Identity=29.3478260869565, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788722, Length=262, Percent_Identity=27.0992366412214, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=269, Percent_Identity=27.5092936802974, Blast_Score=99, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PATR_CORDI (P61004)

Other databases:

- EMBL:   BX248354
- RefSeq:   NP_938570.1
- ProteinModelPortal:   P61004
- SMR:   P61004
- GeneID:   2648854
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0178
- NMPDR:   fig|257309.1.peg.161
- HOGENOM:   HBG646350
- OMA:   ENTLIVI
- ProtClustDB:   PRK03321
- BioCyc:   CDIP257309:DIP0178-MONOMER
- HAMAP:   MF_01513
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.9

Molecular weight: Translated: 37000; Mature: 37000

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKDLSQIPTYVPGKRNDHALKLSSNEVTHRPLPSAAQAMAEAAAGANRYPDMGVTELR
CCCCCHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
GALSEHLGVPAEQIAVGCGSSALCQQLVQITCTPGDEVVFPWRSFEAYPIFVQVVGATPV
HHHHHHHCCCHHHHHCCCCCHHHHHHHHHEECCCCCCEEECCCCCCCCEEEEEEECCCCE
AVPLTSDGFNDLDAMAAAITPKTKLVFVCNPNNPSGTVVRREAFLEFMAKVPADVVVALD
EEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHCCHHHEEHHH
EAYTEYVRDEDTIFATEILSEFPNLVGLRTFSKAFGLAGVRVGYAFGPHELIDALNKVAL
HHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCC
PFGVNAVGQAGALASLNNLDELMEHTEEVVAVRDRVADHIGAAHSQANFVWIPAESRSET
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
PFEIAEKLAAHDVLVRAFPEGVRITVTNEEESDRLLAAWDASFA
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCCC
>Mature Secondary Structure
MIRKDLSQIPTYVPGKRNDHALKLSSNEVTHRPLPSAAQAMAEAAAGANRYPDMGVTELR
CCCCCHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
GALSEHLGVPAEQIAVGCGSSALCQQLVQITCTPGDEVVFPWRSFEAYPIFVQVVGATPV
HHHHHHHCCCHHHHHCCCCCHHHHHHHHHEECCCCCCEEECCCCCCCCEEEEEEECCCCE
AVPLTSDGFNDLDAMAAAITPKTKLVFVCNPNNPSGTVVRREAFLEFMAKVPADVVVALD
EEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHCCHHHEEHHH
EAYTEYVRDEDTIFATEILSEFPNLVGLRTFSKAFGLAGVRVGYAFGPHELIDALNKVAL
HHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCC
PFGVNAVGQAGALASLNNLDELMEHTEEVVAVRDRVADHIGAAHSQANFVWIPAESRSET
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
PFEIAEKLAAHDVLVRAFPEGVRITVTNEEESDRLLAAWDASFA
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910