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The map label for this gene is lldP [H]

Identifier: 38232654

GI number: 38232654

Start: 12992

End: 14662

Strand: Reverse

Name: lldP [H]

Synonym: DIP0012

Alternate gene names: 38232654

Gene position: 14662-12992 (Counterclockwise)

Preceding gene: 38232661

Following gene: 38232653

Centisome position: 0.59

GC content: 58.41

Gene sequence:

>1671_bases
ATGGACACTTTTACCGCAAACGTGAGCGCAGTCGGAGGCAGCACCACTGCCTCGGCTATCGTCGCACTTCTGCCCCTCAT
CACGTTCTTTGTCATGCTTTTGGTCGTTAAAGCAAAAGCATATGTTTCCGGCCTCACAGCCCTCGCCGTTGCCATCATCG
TGGCCATCGCAGCGTTCCACATGCCCTGGAATTTCGCCCTACTATCTGCCACCCAAGGTGCAGCATTCGGCCTGTTCCCC
ATCGTATGGATCGTGGTACTAGCCCTGTGGTTCTACCAAGTCACAGTCGCTAGCGGACGCTTTCAAGACATGCGCGCCAT
CTTCGACACCGTCGGCGGTGGCGACCTGCGCATCCAAACAATCTTGATCGCGTTCTGTTTCGGAGGACTCCTCGAAGCAC
TCGCCGGTTTCGGTGCCCCAGTAGCGATCACCGCAACCATGATCATGGCGCTTGGTCTTAAACCGCTCAAGACCGCCACC
GTGGTACTAATCGCCAACACCGCACCCGTCGCATTCGGTGCGGTCGCCATCCCAATTACCACCGCCGGTACCCTGACCGG
ACTCGACTCGGCCCACATCGGTGCCGTCGTCGGCCACCAAGCGCCCTTCTTTGCAGCACTCGTGCCGTTTATCATCGTGC
TCATCATCGATGGCGTACGTGGCCTGCGCGAAACCTGGCCAGCAGCGCTCACCATCGGCCTAAGCTTCGCCATCTCCCAG
TGGTGGAGTGCCACCTACTTCTCCTACGAGCTTACCGACGTCGTCGCATCCCTCGTTGGCCTCATCGCCGCCGTACTGTT
GCTGCAGGTGTGGAAGCCCAAAGGACTCGACGCAGTCCGCGAGCGTCTGGGCGTCGAAAAGCACGAAGCCGCCGGCCGTC
TCACCCTGTCACGCACATGGATGGCCGTCTTCCCCTACGTTTTGGTCGTCGCGATCTTCGGTGTTGCCAAACTATGGACG
CTCGGCATCGACATCCCCAAAGCACTCGCCGCAACCGACGTGAAAATCCCATGGCCAGGCCTGCACGGACATATCCTGAA
CAGCTCCGGTGAAGCCATCAAATCCACCACTTACAACTTCCAGTGGCTATCTTCACCCGGCACCCTCCTGCTGATCACCG
GCATCATCGTCGCCATCGTCTACTCGATTTTCGACGACAAAGGCCGCTACCAACTCCCACTCGGACGCGCAGCCATGGAG
CTGGGATTATGCTTCTACAGGATGCGCTTCTCCGCACTGACCATCGTCAGCGTCCTCTCCTTGGCCTACGTTATGAACTT
CTCCGGCCAAACACTCGCCATCGGCACCGCAGTCGCAAGCCTCGGCGCAGCATTCGCATTCTTCTCCCCAGTACTCGGCT
GGGTCGGCACCGCCGTCACAGGCTCCGACACCTCAGCCAACGCACTCTTCTCCAACCTGCAAAAAACCGCAGCTGAAAAC
ATCGGACTAGATCCCCACCTCATGACCGCAGCCAACACCTCCGGTGGCGTCGTCGGCAAGATGATCTCCCCACAATCACT
CGCCATCGCCGCAAGCTCCGTAGGAATGGAAGGCAAAGAATCCCAGATCTTCCGCTCCGTCATCTGGTGGTCCATAGGAC
TCCTCGTAGTCCTATGCACCATGGTGTTCCTACAATCCAATGTATTGGCATGGATGCTACCAACACCATAA

Upstream 100 bases:

>100_bases
GACCAACTCGGATTGTTTTCGAGTCGATAGTGGTAGAGCCCCTGCCTGTTCTTAGCTCCCATTGGGCAGCTAACTTAAAG
ACTCCAGGAGTTTCCTCAAG

Downstream 100 bases:

>100_bases
CGGCACGACTTCCAAGGCACGTGGATTAGGATTACACCTAACACATCCACCCATATCCGCCCACATCCGCCTTGAACAAG
GGAGCCTTTGCACATGTCTC

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MDTFTANVSAVGGSTTASAIVALLPLITFFVMLLVVKAKAYVSGLTALAVAIIVAIAAFHMPWNFALLSATQGAAFGLFP
IVWIVVLALWFYQVTVASGRFQDMRAIFDTVGGGDLRIQTILIAFCFGGLLEALAGFGAPVAITATMIMALGLKPLKTAT
VVLIANTAPVAFGAVAIPITTAGTLTGLDSAHIGAVVGHQAPFFAALVPFIIVLIIDGVRGLRETWPAALTIGLSFAISQ
WWSATYFSYELTDVVASLVGLIAAVLLLQVWKPKGLDAVRERLGVEKHEAAGRLTLSRTWMAVFPYVLVVAIFGVAKLWT
LGIDIPKALAATDVKIPWPGLHGHILNSSGEAIKSTTYNFQWLSSPGTLLLITGIIVAIVYSIFDDKGRYQLPLGRAAME
LGLCFYRMRFSALTIVSVLSLAYVMNFSGQTLAIGTAVASLGAAFAFFSPVLGWVGTAVTGSDTSANALFSNLQKTAAEN
IGLDPHLMTAANTSGGVVGKMISPQSLAIAASSVGMEGKESQIFRSVIWWSIGLLVVLCTMVFLQSNVLAWMLPTP

Sequences:

>Translated_556_residues
MDTFTANVSAVGGSTTASAIVALLPLITFFVMLLVVKAKAYVSGLTALAVAIIVAIAAFHMPWNFALLSATQGAAFGLFP
IVWIVVLALWFYQVTVASGRFQDMRAIFDTVGGGDLRIQTILIAFCFGGLLEALAGFGAPVAITATMIMALGLKPLKTAT
VVLIANTAPVAFGAVAIPITTAGTLTGLDSAHIGAVVGHQAPFFAALVPFIIVLIIDGVRGLRETWPAALTIGLSFAISQ
WWSATYFSYELTDVVASLVGLIAAVLLLQVWKPKGLDAVRERLGVEKHEAAGRLTLSRTWMAVFPYVLVVAIFGVAKLWT
LGIDIPKALAATDVKIPWPGLHGHILNSSGEAIKSTTYNFQWLSSPGTLLLITGIIVAIVYSIFDDKGRYQLPLGRAAME
LGLCFYRMRFSALTIVSVLSLAYVMNFSGQTLAIGTAVASLGAAFAFFSPVLGWVGTAVTGSDTSANALFSNLQKTAAEN
IGLDPHLMTAANTSGGVVGKMISPQSLAIAASSVGMEGKESQIFRSVIWWSIGLLVVLCTMVFLQSNVLAWMLPTP
>Mature_556_residues
MDTFTANVSAVGGSTTASAIVALLPLITFFVMLLVVKAKAYVSGLTALAVAIIVAIAAFHMPWNFALLSATQGAAFGLFP
IVWIVVLALWFYQVTVASGRFQDMRAIFDTVGGGDLRIQTILIAFCFGGLLEALAGFGAPVAITATMIMALGLKPLKTAT
VVLIANTAPVAFGAVAIPITTAGTLTGLDSAHIGAVVGHQAPFFAALVPFIIVLIIDGVRGLRETWPAALTIGLSFAISQ
WWSATYFSYELTDVVASLVGLIAAVLLLQVWKPKGLDAVRERLGVEKHEAAGRLTLSRTWMAVFPYVLVVAIFGVAKLWT
LGIDIPKALAATDVKIPWPGLHGHILNSSGEAIKSTTYNFQWLSSPGTLLLITGIIVAIVYSIFDDKGRYQLPLGRAAME
LGLCFYRMRFSALTIVSVLSLAYVMNFSGQTLAIGTAVASLGAAFAFFSPVLGWVGTAVTGSDTSANALFSNLQKTAAEN
IGLDPHLMTAANTSGGVVGKMISPQSLAIAASSVGMEGKESQIFRSVIWWSIGLLVVLCTMVFLQSNVLAWMLPTP

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=557, Percent_Identity=40.754039497307, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1790031, Length=563, Percent_Identity=40.1420959147425, Blast_Score=332, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58651; Mature: 58651

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTFTANVSAVGGSTTASAIVALLPLITFFVMLLVVKAKAYVSGLTALAVAIIVAIAAFH
CCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPWNFALLSATQGAAFGLFPIVWIVVLALWFYQVTVASGRFQDMRAIFDTVGGGDLRIQT
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHH
ILIAFCFGGLLEALAGFGAPVAITATMIMALGLKPLKTATVVLIANTAPVAFGAVAIPIT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCEEEEEEE
TAGTLTGLDSAHIGAVVGHQAPFFAALVPFIIVLIIDGVRGLRETWPAALTIGLSFAISQ
CCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WWSATYFSYELTDVVASLVGLIAAVLLLQVWKPKGLDAVRERLGVEKHEAAGRLTLSRTW
HHHHHEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCEEHHHHH
MAVFPYVLVVAIFGVAKLWTLGIDIPKALAATDVKIPWPGLHGHILNSSGEAIKSTTYNF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEECCCCCHHHCCCEEE
QWLSSPGTLLLITGIIVAIVYSIFDDKGRYQLPLGRAAMELGLCFYRMRFSALTIVSVLS
EEECCCCHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYVMNFSGQTLAIGTAVASLGAAFAFFSPVLGWVGTAVTGSDTSANALFSNLQKTAAEN
HHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IGLDPHLMTAANTSGGVVGKMISPQSLAIAASSVGMEGKESQIFRSVIWWSIGLLVVLCT
CCCCCCEEEECCCCCCEEECCCCCCHHHEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
MVFLQSNVLAWMLPTP
HHHHHCCCEEEEECCC
>Mature Secondary Structure
MDTFTANVSAVGGSTTASAIVALLPLITFFVMLLVVKAKAYVSGLTALAVAIIVAIAAFH
CCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPWNFALLSATQGAAFGLFPIVWIVVLALWFYQVTVASGRFQDMRAIFDTVGGGDLRIQT
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHH
ILIAFCFGGLLEALAGFGAPVAITATMIMALGLKPLKTATVVLIANTAPVAFGAVAIPIT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCEEEEEEE
TAGTLTGLDSAHIGAVVGHQAPFFAALVPFIIVLIIDGVRGLRETWPAALTIGLSFAISQ
CCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WWSATYFSYELTDVVASLVGLIAAVLLLQVWKPKGLDAVRERLGVEKHEAAGRLTLSRTW
HHHHHEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCEEHHHHH
MAVFPYVLVVAIFGVAKLWTLGIDIPKALAATDVKIPWPGLHGHILNSSGEAIKSTTYNF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEECCCCCHHHCCCEEE
QWLSSPGTLLLITGIIVAIVYSIFDDKGRYQLPLGRAAMELGLCFYRMRFSALTIVSVLS
EEECCCCHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYVMNFSGQTLAIGTAVASLGAAFAFFSPVLGWVGTAVTGSDTSANALFSNLQKTAAEN
HHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IGLDPHLMTAANTSGGVVGKMISPQSLAIAASSVGMEGKESQIFRSVIWWSIGLLVVLCT
CCCCCCEEEECCCCCCEEECCCCCCHHHEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
MVFLQSNVLAWMLPTP
HHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]