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The map label for this gene is dnaA

Identifier: 38232643

GI number: 38232643

Start: 19

End: 1677

Strand: Direct

Name: dnaA

Synonym: DIP0001

Alternate gene names: 38232643

Gene position: 19-1677 (Clockwise)

Preceding gene: NA

Following gene: 161598680

Centisome position: 0.0

GC content: 53.59

Gene sequence:

>1659_bases
GTGTGGAACGAGACGTGGAATGAGATCACCAATGAACTCATTCAGCTATCTCGCGAACCCGAAAGCGAGATTCCACGAAT
CACTGCTGAACAACGCGCTTATCTCAAACTCGTCCGACCTGCGGCTTTTGTCGAAGGCATCGCCGTTTTACGGGTACCGC
ACTCCCGCGCCAAGGAGACGATTGAAACCCATTTGGGGCAAGCGATAACCTCCGTGCTCTCCCGTCGTATGGGACGCCCC
TTTACTGTGGCAGTCACCGTCGACCCCACGTTGGACGTCATCCAAGATTTGCCGCATGACGTGCCAGAACAGCACATTGT
TCAGCACCACGTGCCCGAGCACCCCCACTACTCGCCGGTATCCCAAGGGTATCCACCGCACTATGCTCCGGAACAGTCGG
AATACAACACCGAGTATTCCGACGAGTACCCCTCTGGTTGGGCTACTTACCACGTGCAGACCCCACAGCCATCGCAATCT
TCGCAGTCGGCACAGCAGCAACCAGCTCAACGCATGCCGGATCGTCGTCGTTATGCTGAGCAGCAGCAAGTTCCACAGCG
TTCCGAAGAACCAGTTATGGGGCAACGCCGCGCGAGAGAAAAGCCAGCTCACGACCCAGATCGCAATGGTTCATTGAATC
CGCGCTACACCTTTGACACCTACGTTGTCTCAGATTCCAACAAACTTCCGTGGTCGGCGGCGTGGGCTGTCGCAGAAAAA
CCTGCGCGCGCATACAACCCACTGTTTATCTGGGGCGATTCCGGTTTGGGCAAAACCCACCTCATGCACGCAATCGGTAA
CTACGCCCAAGAGCTCGATCCAAAGCTCAAGGTCAAGTACGTTTCTTCCGAAGAGTTCACCAACGATTACATCAATTCAG
TGCGTGATGACCGCCAGGAAGCATTTAAGCGCCGCTACCGTGACCTCGATATTTTGATGGTCGACGATATCCAGTTCTTG
CAGGGTAAAGAGGGCACCCAGGAAGAGTTCTTCCACACATTCAATGCTTTGCAGCAGGCTGATAAACAAATCGTTTTGTC
TTCAGACCGCCCGCCAAAACAGCTCACTACCTTGGAAGATCGCCTGCGCACGCGCTTCCAATCTGGCTTGATCGCGGATA
TTTACCCACCAGATTTGGAAACTCGTATCGCTATTTTGCTGAATAAGGCATCGGCGGAAGGCATTACTGCAGATCGTGAT
GTATTGGAGCTTATTGCGAGCCGTTTCAACGCGTCGATTCGTGAGCTCGAAGGCGCGTTCATTCGAGTATCTGCCTATGC
GTCGCTCAACGAGGCCCCCATCAACATGGCCACGGCACAGGAAGCACTGCGCGATATGATGCCTGAGCAGGCAGATATCG
AAATTACGGCAGGCATGATTATGTCGGTGACTGCTGAGTACTTCCACATTGACGTCGATACGCTCAAAGGCAGCGGTAAG
TCGCGTTCGGTGGCTCATCCGCGACAGCTTGCGATGTATCTGTGCCGTGAGTTGACGGATTTGTCGTTGCCTAAGATTGG
TGAGCATTTTGGTGGCAAGGACCATACGACGGTGATGTATGCGTACCGCAAGATCGGTAAAGAGATCACGGAAAAGCGTG
ATACTTACGACGAGATTCAGCAGTTGACGCAGCAGATTAAGAGCTCTGATCGCGCCTAG

Upstream 100 bases:

>100_bases
CTGCGAATGCAATCTCTTCGTAGCTGCCACAACTGGCGCACATCGTCGTCAATCATTCGCTTGACCTTATAAAGGAAGTA
CAGTGTCGGAAACGCCATCC

Downstream 100 bases:

>100_bases
TTAGGCTATTTTCGCAGTTCAGAACGTTAAGAGGCTGTAGGTGGCCCCTGTGGGGATACAACACCTACAGCCTCTTTTTA
TGAGCAACACGCGAGGATAA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MWNETWNEITNELIQLSREPESEIPRITAEQRAYLKLVRPAAFVEGIAVLRVPHSRAKETIETHLGQAITSVLSRRMGRP
FTVAVTVDPTLDVIQDLPHDVPEQHIVQHHVPEHPHYSPVSQGYPPHYAPEQSEYNTEYSDEYPSGWATYHVQTPQPSQS
SQSAQQQPAQRMPDRRRYAEQQQVPQRSEEPVMGQRRAREKPAHDPDRNGSLNPRYTFDTYVVSDSNKLPWSAAWAVAEK
PARAYNPLFIWGDSGLGKTHLMHAIGNYAQELDPKLKVKYVSSEEFTNDYINSVRDDRQEAFKRRYRDLDILMVDDIQFL
QGKEGTQEEFFHTFNALQQADKQIVLSSDRPPKQLTTLEDRLRTRFQSGLIADIYPPDLETRIAILLNKASAEGITADRD
VLELIASRFNASIRELEGAFIRVSAYASLNEAPINMATAQEALRDMMPEQADIEITAGMIMSVTAEYFHIDVDTLKGSGK
SRSVAHPRQLAMYLCRELTDLSLPKIGEHFGGKDHTTVMYAYRKIGKEITEKRDTYDEIQQLTQQIKSSDRA

Sequences:

>Translated_552_residues
MWNETWNEITNELIQLSREPESEIPRITAEQRAYLKLVRPAAFVEGIAVLRVPHSRAKETIETHLGQAITSVLSRRMGRP
FTVAVTVDPTLDVIQDLPHDVPEQHIVQHHVPEHPHYSPVSQGYPPHYAPEQSEYNTEYSDEYPSGWATYHVQTPQPSQS
SQSAQQQPAQRMPDRRRYAEQQQVPQRSEEPVMGQRRAREKPAHDPDRNGSLNPRYTFDTYVVSDSNKLPWSAAWAVAEK
PARAYNPLFIWGDSGLGKTHLMHAIGNYAQELDPKLKVKYVSSEEFTNDYINSVRDDRQEAFKRRYRDLDILMVDDIQFL
QGKEGTQEEFFHTFNALQQADKQIVLSSDRPPKQLTTLEDRLRTRFQSGLIADIYPPDLETRIAILLNKASAEGITADRD
VLELIASRFNASIRELEGAFIRVSAYASLNEAPINMATAQEALRDMMPEQADIEITAGMIMSVTAEYFHIDVDTLKGSGK
SRSVAHPRQLAMYLCRELTDLSLPKIGEHFGGKDHTTVMYAYRKIGKEITEKRDTYDEIQQLTQQIKSSDRA
>Mature_552_residues
MWNETWNEITNELIQLSREPESEIPRITAEQRAYLKLVRPAAFVEGIAVLRVPHSRAKETIETHLGQAITSVLSRRMGRP
FTVAVTVDPTLDVIQDLPHDVPEQHIVQHHVPEHPHYSPVSQGYPPHYAPEQSEYNTEYSDEYPSGWATYHVQTPQPSQS
SQSAQQQPAQRMPDRRRYAEQQQVPQRSEEPVMGQRRAREKPAHDPDRNGSLNPRYTFDTYVVSDSNKLPWSAAWAVAEK
PARAYNPLFIWGDSGLGKTHLMHAIGNYAQELDPKLKVKYVSSEEFTNDYINSVRDDRQEAFKRRYRDLDILMVDDIQFL
QGKEGTQEEFFHTFNALQQADKQIVLSSDRPPKQLTTLEDRLRTRFQSGLIADIYPPDLETRIAILLNKASAEGITADRD
VLELIASRFNASIRELEGAFIRVSAYASLNEAPINMATAQEALRDMMPEQADIEITAGMIMSVTAEYFHIDVDTLKGSGK
SRSVAHPRQLAMYLCRELTDLSLPKIGEHFGGKDHTTVMYAYRKIGKEITEKRDTYDEIQQLTQQIKSSDRA

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=402, Percent_Identity=43.2835820895522, Blast_Score=316, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_CORDI (Q6NKL7)

Other databases:

- EMBL:   BX248354
- RefSeq:   NP_938410.1
- ProteinModelPortal:   Q6NKL7
- GeneID:   2650569
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0001
- NMPDR:   fig|257309.1.peg.1
- HOGENOM:   HBG695666
- OMA:   DRQESFK
- PhylomeDB:   Q6NKL7
- ProtClustDB:   PRK00149
- BioCyc:   CDIP257309:DIP0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 63030; Mature: 63030

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNETWNEITNELIQLSREPESEIPRITAEQRAYLKLVRPAAFVEGIAVLRVPHSRAKET
CCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHEECCCHHHHHH
IETHLGQAITSVLSRRMGRPFTVAVTVDPTLDVIQDLPHDVPEQHIVQHHVPEHPHYSPV
HHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
SQGYPPHYAPEQSEYNTEYSDEYPSGWATYHVQTPQPSQSSQSAQQQPAQRMPDRRRYAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCHHHHCCHHHHHHH
QQQVPQRSEEPVMGQRRAREKPAHDPDRNGSLNPRYTFDTYVVSDSNKLPWSAAWAVAEK
HHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHC
PARAYNPLFIWGDSGLGKTHLMHAIGNYAQELDPKLKVKYVSSEEFTNDYINSVRDDRQE
CHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
AFKRRYRDLDILMVDDIQFLQGKEGTQEEFFHTFNALQQADKQIVLSSDRPPKQLTTLED
HHHHHHCCCCEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
RLRTRFQSGLIADIYPPDLETRIAILLNKASAEGITADRDVLELIASRFNASIRELEGAF
HHHHHHHCCCEEECCCCCHHHEEHHEEECCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCE
IRVSAYASLNEAPINMATAQEALRDMMPEQADIEITAGMIMSVTAEYFHIDVDTLKGSGK
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHEEEHHHHCCCCC
SRSVAHPRQLAMYLCRELTDLSLPKIGEHFGGKDHTTVMYAYRKIGKEITEKRDTYDEIQ
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
QLTQQIKSSDRA
HHHHHHHHCCCC
>Mature Secondary Structure
MWNETWNEITNELIQLSREPESEIPRITAEQRAYLKLVRPAAFVEGIAVLRVPHSRAKET
CCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHEECCCHHHHHH
IETHLGQAITSVLSRRMGRPFTVAVTVDPTLDVIQDLPHDVPEQHIVQHHVPEHPHYSPV
HHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
SQGYPPHYAPEQSEYNTEYSDEYPSGWATYHVQTPQPSQSSQSAQQQPAQRMPDRRRYAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCHHHHCCHHHHHHH
QQQVPQRSEEPVMGQRRAREKPAHDPDRNGSLNPRYTFDTYVVSDSNKLPWSAAWAVAEK
HHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHC
PARAYNPLFIWGDSGLGKTHLMHAIGNYAQELDPKLKVKYVSSEEFTNDYINSVRDDRQE
CHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
AFKRRYRDLDILMVDDIQFLQGKEGTQEEFFHTFNALQQADKQIVLSSDRPPKQLTTLED
HHHHHHCCCCEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
RLRTRFQSGLIADIYPPDLETRIAILLNKASAEGITADRDVLELIASRFNASIRELEGAF
HHHHHHHCCCEEECCCCCHHHEEHHEEECCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCE
IRVSAYASLNEAPINMATAQEALRDMMPEQADIEITAGMIMSVTAEYFHIDVDTLKGSGK
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHEEEHHHHCCCCC
SRSVAHPRQLAMYLCRELTDLSLPKIGEHFGGKDHTTVMYAYRKIGKEITEKRDTYDEIQ
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
QLTQQIKSSDRA
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910