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The map label for this gene is cysG [H]

Identifier: 21675048

GI number: 21675048

Start: 2102616

End: 2103089

Strand: Reverse

Name: cysG [H]

Synonym: CT2239

Alternate gene names: 21675048

Gene position: 2103089-2102616 (Counterclockwise)

Preceding gene: 21675049

Following gene: 21675047

Centisome position: 97.59

GC content: 53.16

Gene sequence:

>474_bases
ATGGACACATCAATGAAAGTGTTTTTGCCGCTCAATATCCGGGTGGACAACAAGAAGATTCTGTTCGTGGGCGGTGGCAA
AATTGCTCATCACAAGATTCAGACCATCGAAAAATATACCCGGGATATCACCATCGTCTCGCCTGAAATCATTGACGAAC
TTAAGGGTAAGGGGTTTACGGAAATCTACAAGGAGTACGACTCCTCTGATCTCGATGGCGCATTTCTGGTCTATGCCAGC
ACCAACGTCGAGGAGGTCAACCGGCGCGTGCGCGATGACGCAGAGGCGCGGGGCATCTTGGTGAACGTCGTCGATAACCG
CGAGCTTTCGGGCTTCATCTCCCCGGCCATCATCAAGCAGGGCGAAATGACCGTCGCGGTCTCCTCCAACGGCCAGAATG
TCAAAAAGTCTGTTGAGTGGCGCAACCGGCTCCGGGAGTTTGTCAGCGAAACCTGGCCGGAAGACAACCAGTAA

Upstream 100 bases:

>100_bases
ATCCGGCGTGAAGTCGTTATAAAACGGACGCCAACGCATCTCTTCACTGGCCCCGGTGCGGGAACTGAACCTGCCCCGGG
GTCGTTGCATATTTGTCAAA

Downstream 100 bases:

>100_bases
TTTTGTCAGGAAGTATCCGCAATGACCGGTTCAATCCATACAGAGCCGCAGGCCGCGGCAAAGAGAGGCTACGTCTATAT
CGCGGGCGCGGGGCCGGGTG

Product: porphyrin biosynthesis protein, putative

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MDTSMKVFLPLNIRVDNKKILFVGGGKIAHHKIQTIEKYTRDITIVSPEIIDELKGKGFTEIYKEYDSSDLDGAFLVYAS
TNVEEVNRRVRDDAEARGILVNVVDNRELSGFISPAIIKQGEMTVAVSSNGQNVKKSVEWRNRLREFVSETWPEDNQ

Sequences:

>Translated_157_residues
MDTSMKVFLPLNIRVDNKKILFVGGGKIAHHKIQTIEKYTRDITIVSPEIIDELKGKGFTEIYKEYDSSDLDGAFLVYAS
TNVEEVNRRVRDDAEARGILVNVVDNRELSGFISPAIIKQGEMTVAVSSNGQNVKKSVEWRNRLREFVSETWPEDNQ
>Mature_157_residues
MDTSMKVFLPLNIRVDNKKILFVGGGKIAHHKIQTIEKYTRDITIVSPEIIDELKGKGFTEIYKEYDSSDLDGAFLVYAS
TNVEEVNRRVRDDAEARGILVNVVDNRELSGFISPAIIKQGEMTVAVSSNGQNVKKSVEWRNRLREFVSETWPEDNQ

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=144, Percent_Identity=30.5555555555556, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 17833; Mature: 17833

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSMKVFLPLNIRVDNKKILFVGGGKIAHHKIQTIEKYTRDITIVSPEIIDELKGKGFT
CCCCEEEEEEEEEEECCEEEEEEECCEEHHHHHHHHHHHHCCEEEECHHHHHHHCCCCHH
EIYKEYDSSDLDGAFLVYASTNVEEVNRRVRDDAEARGILVNVVDNRELSGFISPAIIKQ
HHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHCCC
GEMTVAVSSNGQNVKKSVEWRNRLREFVSETWPEDNQ
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDTSMKVFLPLNIRVDNKKILFVGGGKIAHHKIQTIEKYTRDITIVSPEIIDELKGKGFT
CCCCEEEEEEEEEEECCEEEEEEECCEEHHHHHHHHHHHHCCEEEECHHHHHHHCCCCHH
EIYKEYDSSDLDGAFLVYASTNVEEVNRRVRDDAEARGILVNVVDNRELSGFISPAIIKQ
HHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHCCC
GEMTVAVSSNGQNVKKSVEWRNRLREFVSETWPEDNQ
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA