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The map label for this gene is cysG [H]

Identifier: 21675047

GI number: 21675047

Start: 2101209

End: 2102594

Strand: Reverse

Name: cysG [H]

Synonym: CT2238

Alternate gene names: 21675047

Gene position: 2102594-2101209 (Counterclockwise)

Preceding gene: 21675048

Following gene: 21675042

Centisome position: 97.57

GC content: 61.47

Gene sequence:

>1386_bases
ATGACCGGTTCAATCCATACAGAGCCGCAGGCCGCGGCAAAGAGAGGCTACGTCTATATCGCGGGCGCGGGGCCGGGTGA
TCCGGAGCTGCTCACGCTCAAGGCTGATCGGGTGCTGCGCGGGGCGGACGTGATTCTCTTCGACGATCTCGTGCTGCCCC
AGATGCTTGAACCCTACAAGGCCGAGAAGATCTATACCGGCAAGCGCAAGGATGCGCATCACTTCGCGCAGGACGAAATC
AACCAGGAGATCGTGCGCCATGCGCTCATGGGCAAGACCGTCGTGAGGCTCAAGGGCGGCGATCCCTTCATCTTTGGACG
CGGCGGCGAGGAGATCGAGACGCTGCGCCAGCACGGCATCGGTTACGAGATCATTCCCGGCATCACCGCAGCGCACGGAG
CTAGCGCCTACAGTGAAATTCCGCTCACCATGCGCAAGGTCTCCTCGTCGGTCGCCTTCTGCACCGGCCATCCGGTCAAC
AGCATCCAGGTGCCCGATACCGACACGATCGTCTATTACATGGTGGCCTCGAACGTGCACGACGTGCTCGACAAGGTGGC
GGCGTCGGGGCGGAGCGGCGAGACGATGGTCGCCGTGGTTCAGAACGCCACGCGCTATAACCAGCGCGTCATTACCAGCA
CGCTCGACGAGTTCCGCAAGCGCGAAAAGGCGGTTTACTCACCGGCGTTGCTTATCATCGGCCAGAACATCAGCCAGTAC
ATCGAAGAGAACTGGTTCTCCCGCAAGAAGAAGGTGCTCATGACCGGCGAAGCGCCGAAAAAATACCCGCCTGCCGACTA
CATCACCGTGCCCTTCCCGTGCCAACAGGTGGCGGGCGCGGATCTCGGCGCGGTGAAAGCCTGCATCGAGGGGATCGACC
GGTTCTCGATGCTCTTTTTCCAGAACCGCTTCGCCGTCCGGTATTTCTTTAAATATCTCTTCGAACATGGCCGCGACGTG
AGGCATCTGGCGCATCTCGTCATCTGCACCGCGAACCGTTCGGTCGCCTCGGCGTTGCAGGAGTACGGCATCATTCCCGA
CTGCTGCCTTGACCGGGAGGGCGTGGATGCGATCGCCGCGATGCTGCGCAAGGAGGAACTCACCGGCCAGCGCATTCTTC
TGTCGGGCGCGGAGCATGTCGATGAGCTGGTGGCCGGGCAACTCCGTGAGGGGGGCAACGAGGTCACGCCGCTCGTCGTT
TACGTGCATGGCGCGCAGGATCAGGTCGAGAAGATCGACCTCGACTTCATCGACGAAATCTACTTCGCCTCGGCAGATTG
CGTGAAAAAATTCAGAGGGATGTACGACGCGATTCCCGCCCGAATCGCCGTCACCCCGGCGGACGAGCGCACCGCAGAGG
AGATGCGGCGTCAGTTTGGCGGATAG

Upstream 100 bases:

>100_bases
GAATGTCAAAAAGTCTGTTGAGTGGCGCAACCGGCTCCGGGAGTTTGTCAGCGAAACCTGGCCGGAAGACAACCAGTAAT
TTTGTCAGGAAGTATCCGCA

Downstream 100 bases:

>100_bases
CGTCCGTCAAGGTGCCGTCATCAAACCGTTAACGCCCCGAATTACTCGGGGCGTTTTCTGCGTTCCAGCATGGCGATGAA
GAGCAGCGACATTGCGAGGT

Product: siroheme synthetase, putative

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTGSIHTEPQAAAKRGYVYIAGAGPGDPELLTLKADRVLRGADVILFDDLVLPQMLEPYKAEKIYTGKRKDAHHFAQDEI
NQEIVRHALMGKTVVRLKGGDPFIFGRGGEEIETLRQHGIGYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVN
SIQVPDTDTIVYYMVASNVHDVLDKVAASGRSGETMVAVVQNATRYNQRVITSTLDEFRKREKAVYSPALLIIGQNISQY
IEENWFSRKKKVLMTGEAPKKYPPADYITVPFPCQQVAGADLGAVKACIEGIDRFSMLFFQNRFAVRYFFKYLFEHGRDV
RHLAHLVICTANRSVASALQEYGIIPDCCLDREGVDAIAAMLRKEELTGQRILLSGAEHVDELVAGQLREGGNEVTPLVV
YVHGAQDQVEKIDLDFIDEIYFASADCVKKFRGMYDAIPARIAVTPADERTAEEMRRQFGG

Sequences:

>Translated_461_residues
MTGSIHTEPQAAAKRGYVYIAGAGPGDPELLTLKADRVLRGADVILFDDLVLPQMLEPYKAEKIYTGKRKDAHHFAQDEI
NQEIVRHALMGKTVVRLKGGDPFIFGRGGEEIETLRQHGIGYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVN
SIQVPDTDTIVYYMVASNVHDVLDKVAASGRSGETMVAVVQNATRYNQRVITSTLDEFRKREKAVYSPALLIIGQNISQY
IEENWFSRKKKVLMTGEAPKKYPPADYITVPFPCQQVAGADLGAVKACIEGIDRFSMLFFQNRFAVRYFFKYLFEHGRDV
RHLAHLVICTANRSVASALQEYGIIPDCCLDREGVDAIAAMLRKEELTGQRILLSGAEHVDELVAGQLREGGNEVTPLVV
YVHGAQDQVEKIDLDFIDEIYFASADCVKKFRGMYDAIPARIAVTPADERTAEEMRRQFGG
>Mature_460_residues
TGSIHTEPQAAAKRGYVYIAGAGPGDPELLTLKADRVLRGADVILFDDLVLPQMLEPYKAEKIYTGKRKDAHHFAQDEIN
QEIVRHALMGKTVVRLKGGDPFIFGRGGEEIETLRQHGIGYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNS
IQVPDTDTIVYYMVASNVHDVLDKVAASGRSGETMVAVVQNATRYNQRVITSTLDEFRKREKAVYSPALLIIGQNISQYI
EENWFSRKKKVLMTGEAPKKYPPADYITVPFPCQQVAGADLGAVKACIEGIDRFSMLFFQNRFAVRYFFKYLFEHGRDVR
HLAHLVICTANRSVASALQEYGIIPDCCLDREGVDAIAAMLRKEELTGQRILLSGAEHVDELVAGQLREGGNEVTPLVVY
VHGAQDQVEKIDLDFIDEIYFASADCVKKFRGMYDAIPARIAVTPADERTAEEMRRQFGG

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=241, Percent_Identity=44.3983402489627, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322922, Length=245, Percent_Identity=28.9795918367347, Blast_Score=109, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 51107; Mature: 50976

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSIHTEPQAAAKRGYVYIAGAGPGDPELLTLKADRVLRGADVILFDDLVLPQMLEPYK
CCCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEECCCHHCCCCEEEECCHHHHHHHCCHH
AEKIYTGKRKDAHHFAQDEINQEIVRHALMGKTVVRLKGGDPFIFGRGGEEIETLRQHGI
HCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCHHHHHHHHCCC
GYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNSIQVPDTDTIVYYMVASNVH
CEEECCCCHHHCCCCHHHHCCHHHHHHHCCEEEEECCCCCCEECCCCCCEEEEEECCCHH
DVLDKVAASGRSGETMVAVVQNATRYNQRVITSTLDEFRKREKAVYSPALLIIGQNISQY
HHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHH
IEENWFSRKKKVLMTGEAPKKYPPADYITVPFPCQQVAGADLGAVKACIEGIDRFSMLFF
HHHHHHHHCCEEEEECCCCCCCCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
QNRFAVRYFFKYLFEHGRDVRHLAHLVICTANRSVASALQEYGIIPDCCLDREGVDAIAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCHHHHHHHHHCCCCCHHHCCCCCHHHHHH
MLRKEELTGQRILLSGAEHVDELVAGQLREGGNEVTPLVVYVHGAQDQVEKIDLDFIDEI
HHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHCCHHHHHHH
YFASADCVKKFRGMYDAIPARIAVTPADERTAEEMRRQFGG
HHCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TGSIHTEPQAAAKRGYVYIAGAGPGDPELLTLKADRVLRGADVILFDDLVLPQMLEPYK
CCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEECCCHHCCCCEEEECCHHHHHHHCCHH
AEKIYTGKRKDAHHFAQDEINQEIVRHALMGKTVVRLKGGDPFIFGRGGEEIETLRQHGI
HCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCHHHHHHHHCCC
GYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNSIQVPDTDTIVYYMVASNVH
CEEECCCCHHHCCCCHHHHCCHHHHHHHCCEEEEECCCCCCEECCCCCCEEEEEECCCHH
DVLDKVAASGRSGETMVAVVQNATRYNQRVITSTLDEFRKREKAVYSPALLIIGQNISQY
HHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHH
IEENWFSRKKKVLMTGEAPKKYPPADYITVPFPCQQVAGADLGAVKACIEGIDRFSMLFF
HHHHHHHHCCEEEEECCCCCCCCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
QNRFAVRYFFKYLFEHGRDVRHLAHLVICTANRSVASALQEYGIIPDCCLDREGVDAIAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCHHHHHHHHHCCCCCHHHCCCCCHHHHHH
MLRKEELTGQRILLSGAEHVDELVAGQLREGGNEVTPLVVYVHGAQDQVEKIDLDFIDEI
HHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHCCHHHHHHH
YFASADCVKKFRGMYDAIPARIAVTPADERTAEEMRRQFGG
HHCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA