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The map label for this gene is thrS

Identifier: 21674935

GI number: 21674935

Start: 2013356

End: 2015329

Strand: Direct

Name: thrS

Synonym: CT2126

Alternate gene names: 21674935

Gene position: 2013356-2015329 (Clockwise)

Preceding gene: 21674934

Following gene: 21674936

Centisome position: 93.43

GC content: 60.64

Gene sequence:

>1974_bases
ATGTCTGAAATAACGGATGACCGTCAACAGGTGATTATCACCTTGCCCGACGGTTCTGAAAGAACCTACTCTTCCGGCGT
TACCGGCCTCGAAATCGCTGAATCCATTGGCAAAAAACTTGCCGAAGCAGCACTCGCCTTCACCATCGACGGCAAACCGC
GTGACCTCGATACGCCCGTCACTGAGAATGCGAGGGTCTCGATCATCACCTTCGATTCTCCGGAAGGCAAAGAGATTTTC
TGGCACAGTTCGAGCCACCTGATGGCCCACGCCATTGAGGAGCTGTTCCCCGGTGCGAAGTTCGGCGCTGGCCCGGCCAT
CGAGCAGGGCTTTTATTACGACATCGCCTGCGAGCACCGCTTCAACGAAGAGGATCTCCGTGCCATCGAAGCGAAAATGC
TGGAGATCAGCAAGCGCAACCTTAGCATCAACCGCGAGGAGATGCCGCGCGAACAGGCCATCGAATACTTCTCGAACGAG
CGCAAAGACCCGTACAAGGTCGAAATTCTCGAAGACACGCTGAAGGATGTCCCGACGGTTTCGGTCTATCACCAGGACGG
TTTCGCTGACCTGTGCAGCGGCCCGCACCTGCCCTCGACCGGCAAGGTCAAGGCGGTTCTGCTGACTAATATTTCGTCAT
CGTACTGGCGTGGCGACTCGTCGCGTGAAACGATGCAGCGCATCTACGGCATCACCTTTCCGAGTGACAAGCTGCTCAAG
GAGCACATCGCCCGGCTGGAAGAGGCCCGCAAGCGCGACCACCGCAAGCTCGGCGCGGAGCTGGGGCTATTCATGCTGAC
CCCGGAAGTCGGCAGCGGCCTGCCGATCTGGCTGCCAAACGGCGCGATCATTCGCAACGAACTCGAAACCTTTCTGAAAG
CCGAGCAGCGCAAGCGCGGCTACGTGCCGGTGTACACGCCGCACATCGGCAACATCGAGCTATACAAGCGTTCGGGCCAC
TACCCGTATTACAGCGACTCGCAGTTCCCGCCGCTCACCTACAAGGACGAGACGGGTCGCGAGGAGCAGTACCTGCTCAA
GCCGATGAACTGCCCGCATCATCACCTGATCTACAGCCAGACGCTGCGCAGCTATCGCGACCTGCCGATCCGGCTGACCG
AGTTCGGTACCGTCTATCGCCACGAGCAGTCCGGCGAGCTGAACGGCCTGGTTCGCGCCCGCGGCTTCACGCAGGACGAC
TCGCACATCTACTGCCGTCCCGACCAGCTCGTTGACGAAATCTGCAACGCCATCGACCTGACCCGCTTCGTCTTCAATAC
GCTCGGCTTCGACGAGGTCGAAACGCGCCTGTCGCTGCACGATCCGGAGAACCAGTCCAAGTACGGCGGCACCGCCGAGG
TGTGGGGGCAGGCCGAAAAGGATGTGAAGGAAGCCGCCGACCGCATGGGCATCAAATACTTCATCGGCATCGGCGAAGCG
AGCTTTTACGGTCCGAAGATCGACTTCATCGTGCGCGACGCGATTGGCCGCAAGTGGCAGCTCGGCACCGTGCAGGTCGA
CTACGTCATGCCAGAGCGCTTCGACCTCAGCTACATCGGCAGTGACGGCCAGAAGCACCGCCCGGTGGTGATCCACCGCG
CACCGTTTGGTTCGATGGAGCGCTTCATCGGCGTCCTGATCGAGCACACGGCAGGCAACTTCCCGCTCTGGCTCGCGCCC
GTGCAGGCGGTCGTGCTGCCCATCGCCGAGGAGGTGCACGACTACGCCCGCGAGGTGTACGCCAAGCTGCACGAAGCGGG
CATCCGCACCGAACTCGACTTGCGCAGCGAGAAGATTGGCAAGAAAATCCGCGAGGCGGAACTCTCCAAAATCCCCGCCA
TGCTCGTCATCGGCAGGAACGAGCAGGAGAAGGGCGAGGTCTCGCTACGCCGTCACCGCAAGGGCGACGAAGGCAGCTTC
GGCGTTGACGAGCTGATCGCCAGGCTCTGTGAGGAAAGAGATCGACGATTCTGA

Upstream 100 bases:

>100_bases
ATACTGACAAAAAGCGGCTGTCAAGGATTTTTCCCTGCTGAGGGGAGGGGCTGGTCTCAAGACCTTCACCCCGAAAACAT
GATTATGGACAACAAATTCA

Downstream 100 bases:

>100_bases
TCTGACTATCAACCAAAAAAGATCGAATGAAAAAACAGAAAACATCCGGCAACCAGAAGCCCAAAGTTTCTTACAGGATC
AACGAACAGATCCGTGTACC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSEITDDRQQVIITLPDGSERTYSSGVTGLEIAESIGKKLAEAALAFTIDGKPRDLDTPVTENARVSIITFDSPEGKEIF
WHSSSHLMAHAIEELFPGAKFGAGPAIEQGFYYDIACEHRFNEEDLRAIEAKMLEISKRNLSINREEMPREQAIEYFSNE
RKDPYKVEILEDTLKDVPTVSVYHQDGFADLCSGPHLPSTGKVKAVLLTNISSSYWRGDSSRETMQRIYGITFPSDKLLK
EHIARLEEARKRDHRKLGAELGLFMLTPEVGSGLPIWLPNGAIIRNELETFLKAEQRKRGYVPVYTPHIGNIELYKRSGH
YPYYSDSQFPPLTYKDETGREEQYLLKPMNCPHHHLIYSQTLRSYRDLPIRLTEFGTVYRHEQSGELNGLVRARGFTQDD
SHIYCRPDQLVDEICNAIDLTRFVFNTLGFDEVETRLSLHDPENQSKYGGTAEVWGQAEKDVKEAADRMGIKYFIGIGEA
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQKHRPVVIHRAPFGSMERFIGVLIEHTAGNFPLWLAP
VQAVVLPIAEEVHDYAREVYAKLHEAGIRTELDLRSEKIGKKIREAELSKIPAMLVIGRNEQEKGEVSLRRHRKGDEGSF
GVDELIARLCEERDRRF

Sequences:

>Translated_657_residues
MSEITDDRQQVIITLPDGSERTYSSGVTGLEIAESIGKKLAEAALAFTIDGKPRDLDTPVTENARVSIITFDSPEGKEIF
WHSSSHLMAHAIEELFPGAKFGAGPAIEQGFYYDIACEHRFNEEDLRAIEAKMLEISKRNLSINREEMPREQAIEYFSNE
RKDPYKVEILEDTLKDVPTVSVYHQDGFADLCSGPHLPSTGKVKAVLLTNISSSYWRGDSSRETMQRIYGITFPSDKLLK
EHIARLEEARKRDHRKLGAELGLFMLTPEVGSGLPIWLPNGAIIRNELETFLKAEQRKRGYVPVYTPHIGNIELYKRSGH
YPYYSDSQFPPLTYKDETGREEQYLLKPMNCPHHHLIYSQTLRSYRDLPIRLTEFGTVYRHEQSGELNGLVRARGFTQDD
SHIYCRPDQLVDEICNAIDLTRFVFNTLGFDEVETRLSLHDPENQSKYGGTAEVWGQAEKDVKEAADRMGIKYFIGIGEA
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQKHRPVVIHRAPFGSMERFIGVLIEHTAGNFPLWLAP
VQAVVLPIAEEVHDYAREVYAKLHEAGIRTELDLRSEKIGKKIREAELSKIPAMLVIGRNEQEKGEVSLRRHRKGDEGSF
GVDELIARLCEERDRRF
>Mature_656_residues
SEITDDRQQVIITLPDGSERTYSSGVTGLEIAESIGKKLAEAALAFTIDGKPRDLDTPVTENARVSIITFDSPEGKEIFW
HSSSHLMAHAIEELFPGAKFGAGPAIEQGFYYDIACEHRFNEEDLRAIEAKMLEISKRNLSINREEMPREQAIEYFSNER
KDPYKVEILEDTLKDVPTVSVYHQDGFADLCSGPHLPSTGKVKAVLLTNISSSYWRGDSSRETMQRIYGITFPSDKLLKE
HIARLEEARKRDHRKLGAELGLFMLTPEVGSGLPIWLPNGAIIRNELETFLKAEQRKRGYVPVYTPHIGNIELYKRSGHY
PYYSDSQFPPLTYKDETGREEQYLLKPMNCPHHHLIYSQTLRSYRDLPIRLTEFGTVYRHEQSGELNGLVRARGFTQDDS
HIYCRPDQLVDEICNAIDLTRFVFNTLGFDEVETRLSLHDPENQSKYGGTAEVWGQAEKDVKEAADRMGIKYFIGIGEAS
FYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQKHRPVVIHRAPFGSMERFIGVLIEHTAGNFPLWLAPV
QAVVLPIAEEVHDYAREVYAKLHEAGIRTELDLRSEKIGKKIREAELSKIPAMLVIGRNEQEKGEVSLRRHRKGDEGSFG
VDELIARLCEERDRRF

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=654, Percent_Identity=38.3792048929664, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI38570111, Length=633, Percent_Identity=37.5987361769352, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI20070344, Length=661, Percent_Identity=38.4266263237519, Blast_Score=443, Evalue=1e-124,
Organism=Escherichia coli, GI1788013, Length=641, Percent_Identity=41.6536661466459, Blast_Score=534, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71984192, Length=652, Percent_Identity=39.4171779141104, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71984184, Length=652, Percent_Identity=39.4171779141104, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322112, Length=670, Percent_Identity=35.9701492537313, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=391, Percent_Identity=36.0613810741688, Blast_Score=260, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24583842, Length=650, Percent_Identity=40.1538461538462, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI28574141, Length=650, Percent_Identity=40.1538461538462, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24583839, Length=650, Percent_Identity=40.1538461538462, Blast_Score=481, Evalue=1e-136,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CHLTE (Q8KAN0)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_663000.1
- ProteinModelPortal:   Q8KAN0
- SMR:   Q8KAN0
- GeneID:   1007436
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2126
- NMPDR:   fig|194439.1.peg.2094
- TIGR:   CT2126
- HOGENOM:   HBG352811
- OMA:   GRKWQLG
- ProtClustDB:   PRK00413
- BioCyc:   CTEP194439:CT_2126-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74886; Mature: 74754

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEITDDRQQVIITLPDGSERTYSSGVTGLEIAESIGKKLAEAALAFTIDGKPRDLDTPV
CCCCCCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
TENARVSIITFDSPEGKEIFWHSSSHLMAHAIEELFPGAKFGAGPAIEQGFYYDIACEHR
CCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
FNEEDLRAIEAKMLEISKRNLSINREEMPREQAIEYFSNERKDPYKVEILEDTLKDVPTV
CCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHHCCEE
SVYHQDGFADLCSGPHLPSTGKVKAVLLTNISSSYWRGDSSRETMQRIYGITFPSDKLLK
EEEECCCCHHHHCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHHHHHHCCCCCCHHHHH
EHIARLEEARKRDHRKLGAELGLFMLTPEVGSGLPIWLPNGAIIRNELETFLKAEQRKRG
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCC
YVPVYTPHIGNIELYKRSGHYPYYSDSQFPPLTYKDETGREEQYLLKPMNCPHHHLIYSQ
CCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHH
TLRSYRDLPIRLTEFGTVYRHEQSGELNGLVRARGFTQDDSHIYCRPDQLVDEICNAIDL
HHHHHCCCCEEEECCCHHEEECCCCCCCCEEEECCCCCCCCEEEECHHHHHHHHHHHHHH
TRFVFNTLGFDEVETRLSLHDPENQSKYGGTAEVWGQAEKDVKEAADRMGIKYFIGIGEA
HHHHHHHCCHHHHHHHEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCEEEEEEECCC
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQKHRPVVIHRAPFGSME
CCCCCCEEEEEHHHCCCEEEECEEEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCHHH
RFIGVLIEHTAGNFPLWLAPVQAVVLPIAEEVHDYAREVYAKLHEAGIRTELDLRSEKIG
HHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KKIREAELSKIPAMLVIGRNEQEKGEVSLRRHRKGDEGSFGVDELIARLCEERDRRF
HHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEITDDRQQVIITLPDGSERTYSSGVTGLEIAESIGKKLAEAALAFTIDGKPRDLDTPV
CCCCCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
TENARVSIITFDSPEGKEIFWHSSSHLMAHAIEELFPGAKFGAGPAIEQGFYYDIACEHR
CCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
FNEEDLRAIEAKMLEISKRNLSINREEMPREQAIEYFSNERKDPYKVEILEDTLKDVPTV
CCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHHCCEE
SVYHQDGFADLCSGPHLPSTGKVKAVLLTNISSSYWRGDSSRETMQRIYGITFPSDKLLK
EEEECCCCHHHHCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHHHHHHCCCCCCHHHHH
EHIARLEEARKRDHRKLGAELGLFMLTPEVGSGLPIWLPNGAIIRNELETFLKAEQRKRG
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCC
YVPVYTPHIGNIELYKRSGHYPYYSDSQFPPLTYKDETGREEQYLLKPMNCPHHHLIYSQ
CCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHH
TLRSYRDLPIRLTEFGTVYRHEQSGELNGLVRARGFTQDDSHIYCRPDQLVDEICNAIDL
HHHHHCCCCEEEECCCHHEEECCCCCCCCEEEECCCCCCCCEEEECHHHHHHHHHHHHHH
TRFVFNTLGFDEVETRLSLHDPENQSKYGGTAEVWGQAEKDVKEAADRMGIKYFIGIGEA
HHHHHHHCCHHHHHHHEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCEEEEEEECCC
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQKHRPVVIHRAPFGSME
CCCCCCEEEEEHHHCCCEEEECEEEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCHHH
RFIGVLIEHTAGNFPLWLAPVQAVVLPIAEEVHDYAREVYAKLHEAGIRTELDLRSEKIG
HHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KKIREAELSKIPAMLVIGRNEQEKGEVSLRRHRKGDEGSFGVDELIARLCEERDRRF
HHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901