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The map label for this gene is gcvP2

Identifier: 21674932

GI number: 21674932

Start: 2008132

End: 2009592

Strand: Direct

Name: gcvP2

Synonym: CT2123

Alternate gene names: 21674932

Gene position: 2008132-2009592 (Clockwise)

Preceding gene: 21674930

Following gene: 21674933

Centisome position: 93.19

GC content: 62.22

Gene sequence:

>1461_bases
ATGAAAGAACAACTGATCTTTGACCTTTCCCGCAGCGGTCGCAAGGGCTACAGCCTCTCGCCGCTCGACATTCCCGAACG
CCCGGCGGATGAACTGCTGCCGTCGAAATTCCTGCGCAAAGAGCCGGCTGAACTGCCGGAAATGGCGGAGAGCGAGGTGG
TGCGCCACTTCATTCGGCTGTCAAACCTGAACTACCACGTTGACAAGAACATGTACCCGCTTGGGAGCTGTACCATGAAG
TACAATCCCAAGATCAACGACTACACCTGCGACCTGCCGGGCTTCGCGTCGATGCACCCGTTGCAGCCAGAATCGACGTC
GCAGGGCGCGTTGCAGCTCATGTACGAGCTGGCGGAGATGCTCAAGGAGATCGCGGGCATGAAGGCGGTGACGCTGCAAC
CGGCGGCGGGCGCGCATGGCGAGCTGACCGGCATTCTGCTCATCAAGAAGTATCACGAAAAGCTTGGCAACAAGCGCCAC
AAGTTGCTCGTGGTCGATTCGGCCCACGGCACCAACCCGGCATCTGCGGCGCTCGGCGGATACGAGTGCGTGTCGGTCAA
GTGCGATGAATCGGGCTGCACCGACATGGGTGACCTCCGCGCCAAGCTCGATGGCGAGGTGGCGGCGCTGATGCTCACCA
ATCCGAACACGGTCGGCATTTTCGAGAAGCAGATTCCCGAAATCGAGAAGCTGGTGCACGGCAACGGCAGCCTGCTTTAC
ATGGACGGCGCGAACATGAACGCGCTGCTCGGCATCACCCGTCCCGGCGATATGGGCTTCGACGTGATGCACTACAATCT
GCACAAAACCTTCTCCGCGCCCCACGGCGGCGGCGGCCCCGGCAGCGGCCCGGTCGGCGTCAGCGAGCGCCTTGTGGAGT
TCCTGCCGGTGCCGGTGATCGAGAAATTCGAGAAAGACGGCCAGACGCGCTACCGCCTGAACTCCAGCAAGCCCAACACG
ATTGGCCGCATGATGAACTTCTACGGCAACTTCTCGGTGCTGGTGCGCGCCTACACCTACATCCGGATGCTCGGCGCGGA
TGGATTACGCCGCGTGTCGGAGAACGCCATCATCAACGCCAACTACCTGCTCCAGCGGCTCGTCGAGCACTACGCGCTGC
CCTACCCGCGCCCGGTGATGCACGAGTTCTGCCTGTCGGGCGACCGCCAGAAAAAGGAGCACGGCGTCCGCACGCTCGAC
ATCGCCAAGCGGCTGCTCGACTACGGCTACCACGCGCCGACGGTCTACTTCCCGCTCATCGTCAGCGAAGCGCTCATGAT
CGAGCCGACCGAGACCGAGGCAAAAGAGACGCTCAACGCCTTCGCCGACGCCATGATCGCCATTGCCGAAGAGGCCAAGT
CGAATCCCGACCTCATCAAATCCGCGCCGACAACCACGCCGGTCAAGCGCCTCGACGAAGCGCAGGCCTCGCGCCAGCTC
AACATCTGCTGCCAGCACTGA

Upstream 100 bases:

>100_bases
CTTCCGGCCAGACTGTCCGGCCGGGAACATCGTTAATCCATGCAGGTTGCGGCGCTTTGCGCTGGCGATGCACTGAATGC
CTATCAATCAAGGCCTGTCC

Downstream 100 bases:

>100_bases
AGCGGCAGATTGCGGCAAGGCATTCCCCAAAAAAAGCTGTTCCGGAAAAACTCCGGAGCAGCTTTTTTTTTGACCAGTCC
GATCAGACCGATCAGCCCGA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MKEQLIFDLSRSGRKGYSLSPLDIPERPADELLPSKFLRKEPAELPEMAESEVVRHFIRLSNLNYHVDKNMYPLGSCTMK
YNPKINDYTCDLPGFASMHPLQPESTSQGALQLMYELAEMLKEIAGMKAVTLQPAAGAHGELTGILLIKKYHEKLGNKRH
KLLVVDSAHGTNPASAALGGYECVSVKCDESGCTDMGDLRAKLDGEVAALMLTNPNTVGIFEKQIPEIEKLVHGNGSLLY
MDGANMNALLGITRPGDMGFDVMHYNLHKTFSAPHGGGGPGSGPVGVSERLVEFLPVPVIEKFEKDGQTRYRLNSSKPNT
IGRMMNFYGNFSVLVRAYTYIRMLGADGLRRVSENAIINANYLLQRLVEHYALPYPRPVMHEFCLSGDRQKKEHGVRTLD
IAKRLLDYGYHAPTVYFPLIVSEALMIEPTETEAKETLNAFADAMIAIAEEAKSNPDLIKSAPTTTPVKRLDEAQASRQL
NICCQH

Sequences:

>Translated_486_residues
MKEQLIFDLSRSGRKGYSLSPLDIPERPADELLPSKFLRKEPAELPEMAESEVVRHFIRLSNLNYHVDKNMYPLGSCTMK
YNPKINDYTCDLPGFASMHPLQPESTSQGALQLMYELAEMLKEIAGMKAVTLQPAAGAHGELTGILLIKKYHEKLGNKRH
KLLVVDSAHGTNPASAALGGYECVSVKCDESGCTDMGDLRAKLDGEVAALMLTNPNTVGIFEKQIPEIEKLVHGNGSLLY
MDGANMNALLGITRPGDMGFDVMHYNLHKTFSAPHGGGGPGSGPVGVSERLVEFLPVPVIEKFEKDGQTRYRLNSSKPNT
IGRMMNFYGNFSVLVRAYTYIRMLGADGLRRVSENAIINANYLLQRLVEHYALPYPRPVMHEFCLSGDRQKKEHGVRTLD
IAKRLLDYGYHAPTVYFPLIVSEALMIEPTETEAKETLNAFADAMIAIAEEAKSNPDLIKSAPTTTPVKRLDEAQASRQL
NICCQH
>Mature_486_residues
MKEQLIFDLSRSGRKGYSLSPLDIPERPADELLPSKFLRKEPAELPEMAESEVVRHFIRLSNLNYHVDKNMYPLGSCTMK
YNPKINDYTCDLPGFASMHPLQPESTSQGALQLMYELAEMLKEIAGMKAVTLQPAAGAHGELTGILLIKKYHEKLGNKRH
KLLVVDSAHGTNPASAALGGYECVSVKCDESGCTDMGDLRAKLDGEVAALMLTNPNTVGIFEKQIPEIEKLVHGNGSLLY
MDGANMNALLGITRPGDMGFDVMHYNLHKTFSAPHGGGGPGSGPVGVSERLVEFLPVPVIEKFEKDGQTRYRLNSSKPNT
IGRMMNFYGNFSVLVRAYTYIRMLGADGLRRVSENAIINANYLLQRLVEHYALPYPRPVMHEFCLSGDRQKKEHGVRTLD
IAKRLLDYGYHAPTVYFPLIVSEALMIEPTETEAKETLNAFADAMIAIAEEAKSNPDLIKSAPTTTPVKRLDEAQASRQL
NICCQH

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=411, Percent_Identity=42.5790754257908, Blast_Score=279, Evalue=4e-75,
Organism=Escherichia coli, GI1789269, Length=411, Percent_Identity=43.7956204379562, Blast_Score=292, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17535605, Length=430, Percent_Identity=40.9302325581395, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI32564013, Length=373, Percent_Identity=42.3592493297587, Blast_Score=244, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=415, Percent_Identity=43.1325301204819, Blast_Score=295, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24645648, Length=431, Percent_Identity=42.4593967517401, Blast_Score=297, Evalue=9e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_CHLTE (Q8KAN3)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662997.1
- ProteinModelPortal:   Q8KAN3
- SMR:   Q8KAN3
- GeneID:   1007438
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2123
- NMPDR:   fig|194439.1.peg.2091
- TIGR:   CT2123
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   CTEP194439:CT_2123-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 53811; Mature: 53811

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEQLIFDLSRSGRKGYSLSPLDIPERPADELLPSKFLRKEPAELPEMAESEVVRHFIRL
CCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SNLNYHVDKNMYPLGSCTMKYNPKINDYTCDLPGFASMHPLQPESTSQGALQLMYELAEM
CCCCEEECCCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LKEIAGMKAVTLQPAAGAHGELTGILLIKKYHEKLGNKRHKLLVVDSAHGTNPASAALGG
HHHHHCCEEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCC
YECVSVKCDESGCTDMGDLRAKLDGEVAALMLTNPNTVGIFEKQIPEIEKLVHGNGSLLY
EEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHCCCCCEEE
MDGANMNALLGITRPGDMGFDVMHYNLHKTFSAPHGGGGPGSGPVGVSERLVEFLPVPVI
ECCCCCCEEEEECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHH
EKFEKDGQTRYRLNSSKPNTIGRMMNFYGNFSVLVRAYTYIRMLGADGLRRVSENAIINA
HHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCEECH
NYLLQRLVEHYALPYPRPVMHEFCLSGDRQKKEHGVRTLDIAKRLLDYGYHAPTVYFPLI
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
VSEALMIEPTETEAKETLNAFADAMIAIAEEAKSNPDLIKSAPTTTPVKRLDEAQASRQL
HCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCC
NICCQH
CEEECC
>Mature Secondary Structure
MKEQLIFDLSRSGRKGYSLSPLDIPERPADELLPSKFLRKEPAELPEMAESEVVRHFIRL
CCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SNLNYHVDKNMYPLGSCTMKYNPKINDYTCDLPGFASMHPLQPESTSQGALQLMYELAEM
CCCCEEECCCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LKEIAGMKAVTLQPAAGAHGELTGILLIKKYHEKLGNKRHKLLVVDSAHGTNPASAALGG
HHHHHCCEEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCC
YECVSVKCDESGCTDMGDLRAKLDGEVAALMLTNPNTVGIFEKQIPEIEKLVHGNGSLLY
EEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHCCCCCEEE
MDGANMNALLGITRPGDMGFDVMHYNLHKTFSAPHGGGGPGSGPVGVSERLVEFLPVPVI
ECCCCCCEEEEECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHH
EKFEKDGQTRYRLNSSKPNTIGRMMNFYGNFSVLVRAYTYIRMLGADGLRRVSENAIINA
HHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCEECH
NYLLQRLVEHYALPYPRPVMHEFCLSGDRQKKEHGVRTLDIAKRLLDYGYHAPTVYFPLI
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
VSEALMIEPTETEAKETLNAFADAMIAIAEEAKSNPDLIKSAPTTTPVKRLDEAQASRQL
HCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCC
NICCQH
CEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901