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The map label for this gene is thrC [H]

Identifier: 21674845

GI number: 21674845

Start: 1933548

End: 1934873

Strand: Direct

Name: thrC [H]

Synonym: CT2035

Alternate gene names: 21674845

Gene position: 1933548-1934873 (Clockwise)

Preceding gene: 21674844

Following gene: 21674846

Centisome position: 89.73

GC content: 60.48

Gene sequence:

>1326_bases
ATGATCTTCTACAGCACGACGAAAGCGTCTGCTCCCGTCACGATGAAAAAAGCCACCCTCGAAGGGCTCGCACCCGATGG
AGGGTTGTATGTTCCATCGACGATGCCGCACTTCTCCGCCGAAGAGATTGCCCTTCTGGAGAACGGCTCGTTCAACAATA
TTGCCTTTGCCGTCGCCAAGAAGTTCGCCGGTGACGAAATCCCGCTCGACCGCCTCTCGGAACTGATCGACGAGTGCTTT
ACCTTCGACACGCCGCTGCACGAACTTGACCCGGACACCTTCGTCGAGGAGCTGTTCCACGGTCCGACGCTCGCATTCAA
GGACTACGGCGCCCGATTTCTCGCGCGGATGACCGGCTATTTCGCCGCCGAAGAGAGCCGCCTCATCACGGTGCTGGTCG
CCACGTCGGGCGACACCGGCAGCGCTGTGGCCTACGGCTTCCACGGCATTCCGAACACCCGCGTGGTGCTGCTCTATCCG
TCGGGCAAGGTGAGCCGCCTTCAGGAGCAGCAGCTCACCACGGCAGGCGACAACGTCTTCGCGCTCGAAGTGAAAGGCGA
TTTCGACGACTGCCAGCGCCTCGTCAAGCAGGCCTTCGTCGACCAATCGCTGCGTCAGAAGCTGACGCTCACTTCGGCAA
ACTCCATCAACATCTCGCGCCTGATTCCGCAGTCGTTCTACTATGCCTGGGCGGCGCTCCAGCTCCGCCAGCGCAAGCCA
GACGCTCTGCCGATCTTCTCAGTACCAAGCGGCAACTACGGCAACCTGACGGCGGGCGTCATGGCAAAGATGATGGGCTT
TCCGATCGGCCACTTCATCGCCGCCTCGAACGCCAACGACAGCGTCACCCGCTATCTCGACGAGGGGCGCTACGAGCCGA
AACCGACCGTCCGGACGCTGACCACGGCGATGGATGTGGGCAACCCGAGCAACTTCGCGAGGCTGCGCTATTTCTTCGAA
AACGATTTCCGGAAAATGGGCCAAGAGATCACCGGCATCGCGGTCTCGGATGCAGAAACCCTCGAAACGATCCGCTCGGT
TTACGAGAAATACGGCTATGTCATGGATCCGCACACCGCCGTCGGCTACCGGGCGCTCGACCGGTTCCGTCAGGATCATG
CCGGAGCGGGCACCCCGGGCGTCGTGCTTTCGACCGCTCACCCGGTCAAATTCGACGAGGCGATCAAAGAGGCAACCGGC
AATGAGGTGCCACTTCCGGAAACGATGGAAGAAATCATGAGCAAGCCGAAAAAAGCCACGCTGATCGGCAACCGCTACGA
AGAGCTGGCTCGCTTTCTCTCGGAGCTCAACACCCAGACAAACTGA

Upstream 100 bases:

>100_bases
CTGCACTCAAGGGCTGCACTCCAGTCGGACATGTGGGTCTCGCCGATTTGCAGCCAGGGCGCACGCATCATCAGCACAAC
TTCTTGAAACGCATCACGAT

Downstream 100 bases:

>100_bases
ACGGCTGATCCATGAACTTCCAGACGCTTCTTTTCTTTCTGGTCATCATACCGGTCATGTTTTTCGGGATGCTCTTTGCG
CTCGTTTTGAACCTGTTCGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSTMPHFSAEEIALLENGSFNNIAFAVAKKFAGDEIPLDRLSELIDECF
TFDTPLHELDPDTFVEELFHGPTLAFKDYGARFLARMTGYFAAEESRLITVLVATSGDTGSAVAYGFHGIPNTRVVLLYP
SGKVSRLQEQQLTTAGDNVFALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQRKP
DALPIFSVPSGNYGNLTAGVMAKMMGFPIGHFIAASNANDSVTRYLDEGRYEPKPTVRTLTTAMDVGNPSNFARLRYFFE
NDFRKMGQEITGIAVSDAETLETIRSVYEKYGYVMDPHTAVGYRALDRFRQDHAGAGTPGVVLSTAHPVKFDEAIKEATG
NEVPLPETMEEIMSKPKKATLIGNRYEELARFLSELNTQTN

Sequences:

>Translated_441_residues
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSTMPHFSAEEIALLENGSFNNIAFAVAKKFAGDEIPLDRLSELIDECF
TFDTPLHELDPDTFVEELFHGPTLAFKDYGARFLARMTGYFAAEESRLITVLVATSGDTGSAVAYGFHGIPNTRVVLLYP
SGKVSRLQEQQLTTAGDNVFALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQRKP
DALPIFSVPSGNYGNLTAGVMAKMMGFPIGHFIAASNANDSVTRYLDEGRYEPKPTVRTLTTAMDVGNPSNFARLRYFFE
NDFRKMGQEITGIAVSDAETLETIRSVYEKYGYVMDPHTAVGYRALDRFRQDHAGAGTPGVVLSTAHPVKFDEAIKEATG
NEVPLPETMEEIMSKPKKATLIGNRYEELARFLSELNTQTN
>Mature_441_residues
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSTMPHFSAEEIALLENGSFNNIAFAVAKKFAGDEIPLDRLSELIDECF
TFDTPLHELDPDTFVEELFHGPTLAFKDYGARFLARMTGYFAAEESRLITVLVATSGDTGSAVAYGFHGIPNTRVVLLYP
SGKVSRLQEQQLTTAGDNVFALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQRKP
DALPIFSVPSGNYGNLTAGVMAKMMGFPIGHFIAASNANDSVTRYLDEGRYEPKPTVRTLTTAMDVGNPSNFARLRYFFE
NDFRKMGQEITGIAVSDAETLETIRSVYEKYGYVMDPHTAVGYRALDRFRQDHAGAGTPGVVLSTAHPVKFDEAIKEATG
NEVPLPETMEEIMSKPKKATLIGNRYEELARFLSELNTQTN

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=431, Percent_Identity=33.6426914153132, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI149193323, Length=459, Percent_Identity=30.5010893246187, Blast_Score=196, Evalue=5e-50,
Organism=Escherichia coli, GI1786185, Length=416, Percent_Identity=43.75, Blast_Score=333, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=36.1050328227571, Blast_Score=254, Evalue=1e-68,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 48724; Mature: 48724

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSTMPHFSAEEIALLENGSFNNIAFAVAK
CEEEECCCCCCCEEEHHHHHHCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHH
KFAGDEIPLDRLSELIDECFTFDTPLHELDPDTFVEELFHGPTLAFKDYGARFLARMTGY
HHCCCCCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
FAAEESRLITVLVATSGDTGSAVAYGFHGIPNTRVVLLYPSGKVSRLQEQQLTTAGDNVF
HCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEE
ALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQRKP
EEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DALPIFSVPSGNYGNLTAGVMAKMMGFPIGHFIAASNANDSVTRYLDEGRYEPKPTVRTL
CCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHEEECCCCHHHHHHHHCCCCCCCCHHHHH
TTAMDVGNPSNFARLRYFFENDFRKMGQEITGIAVSDAETLETIRSVYEKYGYVMDPHTA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHCCCEECCCHH
VGYRALDRFRQDHAGAGTPGVVLSTAHPVKFDEAIKEATGNEVPLPETMEEIMSKPKKAT
HHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEE
LIGNRYEELARFLSELNTQTN
ECCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSTMPHFSAEEIALLENGSFNNIAFAVAK
CEEEECCCCCCCEEEHHHHHHCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHH
KFAGDEIPLDRLSELIDECFTFDTPLHELDPDTFVEELFHGPTLAFKDYGARFLARMTGY
HHCCCCCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
FAAEESRLITVLVATSGDTGSAVAYGFHGIPNTRVVLLYPSGKVSRLQEQQLTTAGDNVF
HCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEE
ALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQRKP
EEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DALPIFSVPSGNYGNLTAGVMAKMMGFPIGHFIAASNANDSVTRYLDEGRYEPKPTVRTL
CCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHEEECCCCHHHHHHHHCCCCCCCCHHHHH
TTAMDVGNPSNFARLRYFFENDFRKMGQEITGIAVSDAETLETIRSVYEKYGYVMDPHTA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHCCCEECCCHH
VGYRALDRFRQDHAGAGTPGVVLSTAHPVKFDEAIKEATGNEVPLPETMEEIMSKPKKAT
HHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEE
LIGNRYEELARFLSELNTQTN
ECCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]