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The map label for this gene is plsC [H]

Identifier: 21674846

GI number: 21674846

Start: 1934885

End: 1935583

Strand: Direct

Name: plsC [H]

Synonym: CT2036

Alternate gene names: 21674846

Gene position: 1934885-1935583 (Clockwise)

Preceding gene: 21674845

Following gene: 21674862

Centisome position: 89.79

GC content: 54.51

Gene sequence:

>699_bases
ATGAACTTCCAGACGCTTCTTTTCTTTCTGGTCATCATACCGGTCATGTTTTTCGGGATGCTCTTTGCGCTCGTTTTGAA
CCTGTTCGATCCGAGCGGTGATCAGTTTCACAAAATGGCCGCATGGTGGGGACGCTTTTCGGCAAGGGTGCTCGGAATTG
AGGTCAAGGTGGAAGGCGAGGAAAACTACAACCCCAACAAGAACTACCTGGTGGTGAGCAACCATGCCGGCATGGCAGAT
ATTCCGCTGATTCTGGGTTCGATGAAGCTCAATCTGAGGTTTGTGGCCAAAGAGGAGCTGGGCAAGATTCCGGTGTTCGG
CCCTGCGCTGAAATCTGCCGGATACGTCTTCATCAAGCGCGGGCAGAACCGCGAGGCGCTGCAAAGTATGCTGAAAGCGG
CCGACACCCTCAAGGCGGGACGCTCGATCCACATTTTCCCCGAAGGCACCCGGTCCAAAACCGGCAAGATACTTCCCTTC
AAGCGAGGCGCCTTTATCATCGCGGAAAAAGCTAAGGTGCCCGTGCTGCCGGTCACGATTGTTGGCAGCAACCTCATCAC
CCCGAAAAAGAGCCTGAAGATCAACCACGGCACCGTGCGTCTGATCATCGGCAAACCCATCGAACCTGCCAAAGCTGAAG
CGCTGATGAAGGAGAGCTACAGCGTCATCAGCGAAAATCTTGAAAAGAGCGCCGCGTAG

Upstream 100 bases:

>100_bases
TGAGCAAGCCGAAAAAAGCCACGCTGATCGGCAACCGCTACGAAGAGCTGGCTCGCTTTCTCTCGGAGCTCAACACCCAG
ACAAACTGAACGGCTGATCC

Downstream 100 bases:

>100_bases
AGGTTTTTCGTGGGACGAATGGGGATCGAGAGAATAAAACGATAGAGATCGTTTTCCCTGTTGTTCCCGCTGCCCTTAAT
TCCGAAACAACAGCAGAATC

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNFQTLLFFLVIIPVMFFGMLFALVLNLFDPSGDQFHKMAAWWGRFSARVLGIEVKVEGEENYNPNKNYLVVSNHAGMAD
IPLILGSMKLNLRFVAKEELGKIPVFGPALKSAGYVFIKRGQNREALQSMLKAADTLKAGRSIHIFPEGTRSKTGKILPF
KRGAFIIAEKAKVPVLPVTIVGSNLITPKKSLKINHGTVRLIIGKPIEPAKAEALMKESYSVISENLEKSAA

Sequences:

>Translated_232_residues
MNFQTLLFFLVIIPVMFFGMLFALVLNLFDPSGDQFHKMAAWWGRFSARVLGIEVKVEGEENYNPNKNYLVVSNHAGMAD
IPLILGSMKLNLRFVAKEELGKIPVFGPALKSAGYVFIKRGQNREALQSMLKAADTLKAGRSIHIFPEGTRSKTGKILPF
KRGAFIIAEKAKVPVLPVTIVGSNLITPKKSLKINHGTVRLIIGKPIEPAKAEALMKESYSVISENLEKSAA
>Mature_232_residues
MNFQTLLFFLVIIPVMFFGMLFALVLNLFDPSGDQFHKMAAWWGRFSARVLGIEVKVEGEENYNPNKNYLVVSNHAGMAD
IPLILGSMKLNLRFVAKEELGKIPVFGPALKSAGYVFIKRGQNREALQSMLKAADTLKAGRSIHIFPEGTRSKTGKILPF
KRGAFIIAEKAKVPVLPVTIVGSNLITPKKSLKINHGTVRLIIGKPIEPAKAEALMKESYSVISENLEKSAA

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=180, Percent_Identity=31.1111111111111, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI15100175, Length=180, Percent_Identity=31.1111111111111, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI6041665, Length=138, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1789395, Length=181, Percent_Identity=29.8342541436464, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568319, Length=166, Percent_Identity=23.4939759036145, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17564032, Length=144, Percent_Identity=29.8611111111111, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320151, Length=238, Percent_Identity=30.672268907563, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281364648, Length=238, Percent_Identity=26.890756302521, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24582856, Length=238, Percent_Identity=26.890756302521, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24582854, Length=238, Percent_Identity=26.890756302521, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641614, Length=232, Percent_Identity=27.1551724137931, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641612, Length=232, Percent_Identity=27.1551724137931, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 25598; Mature: 25598

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQTLLFFLVIIPVMFFGMLFALVLNLFDPSGDQFHKMAAWWGRFSARVLGIEVKVEGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEEEECCC
ENYNPNKNYLVVSNHAGMADIPLILGSMKLNLRFVAKEELGKIPVFGPALKSAGYVFIKR
CCCCCCCCEEEEECCCCCCHHHHEECCEEEEEEEEEHHHHCCCCCCCHHHHCCCEEEEEE
GQNREALQSMLKAADTLKAGRSIHIFPEGTRSKTGKILPFKRGAFIIAEKAKVPVLPVTI
CCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCCEEEEEE
VGSNLITPKKSLKINHGTVRLIIGKPIEPAKAEALMKESYSVISENLEKSAA
ECCCCCCCCHHEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFQTLLFFLVIIPVMFFGMLFALVLNLFDPSGDQFHKMAAWWGRFSARVLGIEVKVEGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEEEECCC
ENYNPNKNYLVVSNHAGMADIPLILGSMKLNLRFVAKEELGKIPVFGPALKSAGYVFIKR
CCCCCCCCEEEEECCCCCCHHHHEECCEEEEEEEEEHHHHCCCCCCCHHHHCCCEEEEEE
GQNREALQSMLKAADTLKAGRSIHIFPEGTRSKTGKILPFKRGAFIIAEKAKVPVLPVTI
CCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCCEEEEEE
VGSNLITPKKSLKINHGTVRLIIGKPIEPAKAEALMKESYSVISENLEKSAA
ECCCCCCCCHHEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]