Click here to switch to the map view.

The map label for this gene is atpA

Identifier: 21674843

GI number: 21674843

Start: 1930769

End: 1932349

Strand: Reverse

Name: atpA

Synonym: CT2033

Alternate gene names: 21674843

Gene position: 1932349-1930769 (Counterclockwise)

Preceding gene: 21674847

Following gene: 21674842

Centisome position: 89.67

GC content: 58.06

Gene sequence:

>1581_bases
ATGTCAACAGCAGTCAGACCCGATGAGGTGTCTTCCATACTCCGCAAGCAGCTCGCCGGCTTCGAGTCGGAAGCGGATGT
ATATGATGTAGGAACCGTGCTGCAGGTCGGAGACGGTATCGCCCGTATTTACGGGTTGTCCAAAGTGGCCGCAGGCGAGC
TCCTCGAATTTCCCCACAATGTGATGGGAATGGCTTTGAACCTCGAAGAAGACAACGTCGGTGCTGTGCTGTTCGGCGAG
TCCAACGCGGTCAAGGAGGGCGATACGGTCAAAAGAACCAATATCCTCGCTTCGATTCCGGTCGGCGAGGCGATGCTCGG
CAGGGTTATCAACCCGCTCGGCGAACCGATCGACGGCAAGGGGCCGATCAACACCGACATCCGTCTGCCGCTCGAGCGTC
GCGCTCCCGGTGTTATTTTCCGTAAGTCGGTGCACGAGCCGCTTCAGACCGGTCTGAAAGCTATCGACGCCATGATTCCG
ATTGGCCGCGGCCAGCGTGAGCTGATCATCGGCGACCGCCAGACAGGCAAGACCGCTGTCGCGCTCGATACCATCATCAA
CCAGAAGGGCAAGGGTGTTCAGTGCATCTATGTGGCAATCGGCCTGAAAGGCTCGACGGTCGCCCAGGTGGTTAACACCC
TTGAAAAGTATGGCGCAATGGAGTACACCACGGTCGTATCGGCTACCGCCTCCGACCCGGCTCCGCTTCAGTTCATCGCT
CCGTTCGCCGGCGCAACCATCGGCGAGTTCTTCCGCGACACCGGCCGTCACGCGCTGGTCGTCTACGATGATCTTTCCAA
ACAGGCCGTGGCTTACCGCCAGCTCTCCCTGCTCCTCCGCCGTCCGCCGGGACGTGAAGCGTACCCCGGTGACGTGTTCT
ATCTGCACTCCCGTCTTCTCGAGCGTGCAGCAAAGATCACCGACGACATCGAGGTGGCAAAGAAGATGAATGACCTTCCC
GAACCGCTGAAGCCTCTCGTCAAGGGTGGCGGCAGCCTCACGGCGCTTCCCGTCATCGAGACGCAGGCCGGTGACGTTTC
GGCTTACATCCCGACCAACGTGATCTCGATCACCGACGGCCAGATTTTCCTTGAGTCGAACCTGTTCAACGCCGGTCAGC
GTCCGGCTATCAACGTCGGTATCTCGGTTTCCCGCGTTGGCGGTGCTGCGCAGATCAAGGCGATGAAAAAGGTTGCCGGT
ACGCTCAGGCTTGATCTGGCGCAGTTCCGCGAACTTGAGGCCTTCTCGAAATTCGGTTCCGATCTCGACAAGAGCACCAA
GGCGCAGCTCGACCGCGGCGCCCGTCTGGTTGAAATCCTCAAGCAGGGCCAGTATATCCCGATGCCGGTTGAGAAGCAGG
TTGCCATTATCTTTATTGGTACGCAGGGTCTGCTCGACTCGGTTGACCTCAAGCAGGTTCGCCGTTTTGAAGAGGAGTTC
CTCGCCATGCTTGAGCAAAAGCATCCCGAGATTCTCTCCTCCATCGCCGAGAAGGGAACACTTGAGTCTGATATCGCTTC
GAAGCTGAAAGAACTGGGTGAAAAATATGTCGCCTCTTTCAAAGAGAAGAGCAAAGCTTGA

Upstream 100 bases:

>100_bases
TTCTGAATCGTTTTTCTGGAGAGTTGTGGGCCGTAGCCGAAATCATGAGAAGGTACGGAGAATCTTTTTCTTTTCTTAAT
AATAACCTATCGATTTCCAT

Downstream 100 bases:

>100_bases
AGGCAGATGCAAGAGTGAGCTGAACGCCCCTGTAAGATCAGGGGCGTTAGCAAGATTATTGGCAATACCAACAATGTTTC
GGAATACATGCCTACTTTAA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSTAVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARIYGLSKVAAGELLEFPHNVMGMALNLEEDNVGAVLFGE
SNAVKEGDTVKRTNILASIPVGEAMLGRVINPLGEPIDGKGPINTDIRLPLERRAPGVIFRKSVHEPLQTGLKAIDAMIP
IGRGQRELIIGDRQTGKTAVALDTIINQKGKGVQCIYVAIGLKGSTVAQVVNTLEKYGAMEYTTVVSATASDPAPLQFIA
PFAGATIGEFFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKITDDIEVAKKMNDLP
EPLKPLVKGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESNLFNAGQRPAINVGISVSRVGGAAQIKAMKKVAG
TLRLDLAQFRELEAFSKFGSDLDKSTKAQLDRGARLVEILKQGQYIPMPVEKQVAIIFIGTQGLLDSVDLKQVRRFEEEF
LAMLEQKHPEILSSIAEKGTLESDIASKLKELGEKYVASFKEKSKA

Sequences:

>Translated_526_residues
MSTAVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARIYGLSKVAAGELLEFPHNVMGMALNLEEDNVGAVLFGE
SNAVKEGDTVKRTNILASIPVGEAMLGRVINPLGEPIDGKGPINTDIRLPLERRAPGVIFRKSVHEPLQTGLKAIDAMIP
IGRGQRELIIGDRQTGKTAVALDTIINQKGKGVQCIYVAIGLKGSTVAQVVNTLEKYGAMEYTTVVSATASDPAPLQFIA
PFAGATIGEFFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKITDDIEVAKKMNDLP
EPLKPLVKGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESNLFNAGQRPAINVGISVSRVGGAAQIKAMKKVAG
TLRLDLAQFRELEAFSKFGSDLDKSTKAQLDRGARLVEILKQGQYIPMPVEKQVAIIFIGTQGLLDSVDLKQVRRFEEEF
LAMLEQKHPEILSSIAEKGTLESDIASKLKELGEKYVASFKEKSKA
>Mature_525_residues
STAVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARIYGLSKVAAGELLEFPHNVMGMALNLEEDNVGAVLFGES
NAVKEGDTVKRTNILASIPVGEAMLGRVINPLGEPIDGKGPINTDIRLPLERRAPGVIFRKSVHEPLQTGLKAIDAMIPI
GRGQRELIIGDRQTGKTAVALDTIINQKGKGVQCIYVAIGLKGSTVAQVVNTLEKYGAMEYTTVVSATASDPAPLQFIAP
FAGATIGEFFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKITDDIEVAKKMNDLPE
PLKPLVKGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESNLFNAGQRPAINVGISVSRVGGAAQIKAMKKVAGT
LRLDLAQFRELEAFSKFGSDLDKSTKAQLDRGARLVEILKQGQYIPMPVEKQVAIIFIGTQGLLDSVDLKQVRRFEEEFL
AMLEQKHPEILSSIAEKGTLESDIASKLKELGEKYVASFKEKSKA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=521, Percent_Identity=58.9251439539347, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI4757810, Length=521, Percent_Identity=58.9251439539347, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI19913426, Length=423, Percent_Identity=26.7139479905437, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19913428, Length=414, Percent_Identity=25.6038647342995, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI32189394, Length=467, Percent_Identity=24.6252676659529, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI19913424, Length=255, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790172, Length=512, Percent_Identity=55.859375, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI1788251, Length=341, Percent_Identity=27.8592375366569, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1790170, Length=355, Percent_Identity=25.0704225352113, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=521, Percent_Identity=59.3090211132438, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71988080, Length=521, Percent_Identity=59.3090211132438, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71988074, Length=521, Percent_Identity=56.2380038387716, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17570191, Length=424, Percent_Identity=25.9433962264151, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=396, Percent_Identity=25.7575757575758, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144756, Length=470, Percent_Identity=22.7659574468085, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=66, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71988068, Length=71, Percent_Identity=49.2957746478873, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565854, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319370, Length=527, Percent_Identity=60.3415559772296, Blast_Score=639, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=398, Percent_Identity=27.3869346733668, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322581, Length=442, Percent_Identity=26.2443438914027, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24658560, Length=529, Percent_Identity=58.2230623818526, Blast_Score=632, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=388, Percent_Identity=26.8041237113402, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646341, Length=388, Percent_Identity=26.8041237113402, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136796, Length=388, Percent_Identity=26.8041237113402, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24638766, Length=445, Percent_Identity=25.6179775280899, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574560, Length=422, Percent_Identity=24.4075829383886, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583992, Length=364, Percent_Identity=25.5494505494505, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583988, Length=283, Percent_Identity=25.0883392226148, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583986, Length=283, Percent_Identity=25.0883392226148, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583984, Length=283, Percent_Identity=25.0883392226148, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129479, Length=267, Percent_Identity=26.9662921348315, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_CHLTE (Q8KAW8)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662908.1
- ProteinModelPortal:   Q8KAW8
- SMR:   Q8KAW8
- GeneID:   1007527
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2033
- NMPDR:   fig|194439.1.peg.2002
- TIGR:   CT2033
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   CTEP194439:CT_2033-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 56848; Mature: 56717

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARIYGLSKVAAGELLEFPHN
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHH
VMGMALNLEEDNVGAVLFGESNAVKEGDTVKRTNILASIPVGEAMLGRVINPLGEPIDGK
HHEEEEEECCCCCCEEEECCCCCCCCCCCEEHHCEEEECCCCHHHHHHHHHHHCCCCCCC
GPINTDIRLPLERRAPGVIFRKSVHEPLQTGLKAIDAMIPIGRGQRELIIGDRQTGKTAV
CCCCCCEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHH
ALDTIINQKGKGVQCIYVAIGLKGSTVAQVVNTLEKYGAMEYTTVVSATASDPAPLQFIA
HHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEHHEEEECCCCCCCCEEEC
PFAGATIGEFFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLL
HHHCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ERAAKITDDIEVAKKMNDLPEPLKPLVKGGGSLTALPVIETQAGDVSAYIPTNVISITDG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCEEEEECC
QIFLESNLFNAGQRPAINVGISVSRVGGAAQIKAMKKVAGTLRLDLAQFRELEAFSKFGS
EEEEECCCCCCCCCCEEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLDKSTKAQLDRGARLVEILKQGQYIPMPVEKQVAIIFIGTQGLLDSVDLKQVRRFEEEF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHH
LAMLEQKHPEILSSIAEKGTLESDIASKLKELGEKYVASFKEKSKA
HHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STAVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARIYGLSKVAAGELLEFPHN
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHH
VMGMALNLEEDNVGAVLFGESNAVKEGDTVKRTNILASIPVGEAMLGRVINPLGEPIDGK
HHEEEEEECCCCCCEEEECCCCCCCCCCCEEHHCEEEECCCCHHHHHHHHHHHCCCCCCC
GPINTDIRLPLERRAPGVIFRKSVHEPLQTGLKAIDAMIPIGRGQRELIIGDRQTGKTAV
CCCCCCEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHH
ALDTIINQKGKGVQCIYVAIGLKGSTVAQVVNTLEKYGAMEYTTVVSATASDPAPLQFIA
HHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEHHEEEECCCCCCCCEEEC
PFAGATIGEFFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLL
HHHCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ERAAKITDDIEVAKKMNDLPEPLKPLVKGGGSLTALPVIETQAGDVSAYIPTNVISITDG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCEEEEECC
QIFLESNLFNAGQRPAINVGISVSRVGGAAQIKAMKKVAGTLRLDLAQFRELEAFSKFGS
EEEEECCCCCCCCCCEEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLDKSTKAQLDRGARLVEILKQGQYIPMPVEKQVAIIFIGTQGLLDSVDLKQVRRFEEEF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHH
LAMLEQKHPEILSSIAEKGTLESDIASKLKELGEKYVASFKEKSKA
HHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12093901