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The map label for this gene is lpxH [H]

Identifier: 21674800

GI number: 21674800

Start: 1887251

End: 1887982

Strand: Reverse

Name: lpxH [H]

Synonym: CT1989

Alternate gene names: 21674800

Gene position: 1887982-1887251 (Counterclockwise)

Preceding gene: 21674801

Following gene: 21674799

Centisome position: 87.61

GC content: 55.19

Gene sequence:

>732_bases
ATGCCTGGACTCTATTTTCTCAGCGATCTTCATCTCGGCCTGCAAGAGCCTCAGGCGGAGCAGGAAAAACTCGAACGCCT
CGAAAAACTTTTTTCGCTTATCCGCGAACAGGGCGGGGCTCTTTACCTTCTCGGCGACATTCTCGACTACTGGATGGAGT
TCCGCCACGTTGTTCCCAAGGGCTTCACCCGGTTTTTCTGCATGCTTTCGGGGCTTGTCCGGAGTGGCGTCGAAGTGACC
TGGTTGGCGGGCAACCACGACTTTTACCTCGGCAGTTTTTTCGACGACGAGCTTGGCGTCAAAACCTGCTACGGATTGCA
GGAGGTGCGTTACGACGGCAAGCTGTTTCTCGTTGCGCATGGCGACGGGCTGGGCGAGGGCGATCTCGGTTACAAGCTGT
TCGCCCGTTTTATCCGCAACCGTTTCAATCTCGGCCTTCTGACTGCTTTTCACTCCGACCTCTCGACGGCGCTCATGAAG
CACTTTTCCCTGCTCAGTCGAAAGCACAAAAAGGTCGATATGCGCGCTGAATCGACGCGCCTCCTTGATTTTGCCGCCGC
TTTGGCGCGTGAACGTGATTTTGATTACTTTGTCTGCGGTCATAACCACTCGGAGCGCGTGCAGGCGCTGCATGATTCGG
GCAGTACCTACGTCAATCTCGGCTCGTGGATCGAAGGACGCTATCACTATGGCGTTTACGAACAGGGGCAGTTCCGGCTC
GAAAAGCTTTAA

Upstream 100 bases:

>100_bases
CGTCATTGAAGCGCTCAGCCCGAAAGAGGTAGACAACATTCTCATTCCGGCGGAGGTCATCGCGCTCGCCGCGGTGCTCT
GAACCTGCTCACTCTACGCG

Downstream 100 bases:

>100_bases
GTCAACTATCAGATTCTATTTTATCACATGAGCAACAACAAGGTTCTCAAGCTGGGTCTGCCGAAGGGCAGCCTTCAGGA
TTCGACTCTCGAACTTTTCG

Product: hypothetical protein

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MPGLYFLSDLHLGLQEPQAEQEKLERLEKLFSLIREQGGALYLLGDILDYWMEFRHVVPKGFTRFFCMLSGLVRSGVEVT
WLAGNHDFYLGSFFDDELGVKTCYGLQEVRYDGKLFLVAHGDGLGEGDLGYKLFARFIRNRFNLGLLTAFHSDLSTALMK
HFSLLSRKHKKVDMRAESTRLLDFAAALARERDFDYFVCGHNHSERVQALHDSGSTYVNLGSWIEGRYHYGVYEQGQFRL
EKL

Sequences:

>Translated_243_residues
MPGLYFLSDLHLGLQEPQAEQEKLERLEKLFSLIREQGGALYLLGDILDYWMEFRHVVPKGFTRFFCMLSGLVRSGVEVT
WLAGNHDFYLGSFFDDELGVKTCYGLQEVRYDGKLFLVAHGDGLGEGDLGYKLFARFIRNRFNLGLLTAFHSDLSTALMK
HFSLLSRKHKKVDMRAESTRLLDFAAALARERDFDYFVCGHNHSERVQALHDSGSTYVNLGSWIEGRYHYGVYEQGQFRL
EKL
>Mature_242_residues
PGLYFLSDLHLGLQEPQAEQEKLERLEKLFSLIREQGGALYLLGDILDYWMEFRHVVPKGFTRFFCMLSGLVRSGVEVTW
LAGNHDFYLGSFFDDELGVKTCYGLQEVRYDGKLFLVAHGDGLGEGDLGYKLFARFIRNRFNLGLLTAFHSDLSTALMKH
FSLLSRKHKKVDMRAESTRLLDFAAALARERDFDYFVCGHNHSERVQALHDSGSTYVNLGSWIEGRYHYGVYEQGQFRLE
KL

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=224, Percent_Identity=25.8928571428571, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 27997; Mature: 27866

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLYFLSDLHLGLQEPQAEQEKLERLEKLFSLIREQGGALYLLGDILDYWMEFRHVVPK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCH
GFTRFFCMLSGLVRSGVEVTWLAGNHDFYLGSFFDDELGVKTCYGLQEVRYDGKLFLVAH
HHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEC
GDGLGEGDLGYKLFARFIRNRFNLGLLTAFHSDLSTALMKHFSLLSRKHKKVDMRAESTR
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLDFAAALARERDFDYFVCGHNHSERVQALHDSGSTYVNLGSWIEGRYHYGVYEQGQFRL
HHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCEEEECCEECCCEEECCCCCCCEEE
EKL
CCC
>Mature Secondary Structure 
PGLYFLSDLHLGLQEPQAEQEKLERLEKLFSLIREQGGALYLLGDILDYWMEFRHVVPK
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCH
GFTRFFCMLSGLVRSGVEVTWLAGNHDFYLGSFFDDELGVKTCYGLQEVRYDGKLFLVAH
HHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEC
GDGLGEGDLGYKLFARFIRNRFNLGLLTAFHSDLSTALMKHFSLLSRKHKKVDMRAESTR
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLDFAAALARERDFDYFVCGHNHSERVQALHDSGSTYVNLGSWIEGRYHYGVYEQGQFRL
HHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCEEEECCEECCCEEECCCCCCCEEE
EKL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA