Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 21674685

GI number: 21674685

Start: 1770697

End: 1772136

Strand: Reverse

Name: zwf [H]

Synonym: CT1873

Alternate gene names: 21674685

Gene position: 1772136-1770697 (Counterclockwise)

Preceding gene: 161485726

Following gene: 21674684

Centisome position: 82.24

GC content: 60.49

Gene sequence:

>1440_bases
ATGAGCGGCACTCTCGACAACTTCACCATCGTCATCTTCGGCGCGAGCAGCGACCTGGCTTCGCGCAAGCTTTTTCCGTC
GATTTTCCAGCTCGCGCGGTGGGGGCACATGCCTGAGAGCTTCCGGCTGATTGGCGTCGGGCGGCAGGAGCAAAGCCACG
AGGAGTTCCGCGCGTTCGTCCGCAGTCGCCTGCTGGAGCACTCGCCCGAAGCCGCCGGTGACGCCGCGCGGCTCGACGCC
TTCTGCCTCCGCCTCTTTTATGCCCGCGTCGATCTGGACGATCCGGCGAGCTACGAAGTGCTGCGCGACGAGATCATGCG
CGAGGAAAAAGTGGGAGGGAGCACTTGCCGCAACCTGATGTTCTATCTGTCGATACCGCCGAGCCTTGCGCCTGCCGTGG
TGCGCAATCTCGGCAAGGCCGGGCTGGGTGGACGTGAACAGTCGTGCACCGGGTGGCGCAAGCTCATCGCCGAAAAGCCC
TACGGCCACGATCTCGAAAGCGCCCGCGAGCTGAACCGCGTTATCAACGAGGTGTTCGAGGAGAACCAGGTCTATCGCAT
CGACCACTACCTCGGCAAGGAGCCGGTGCAGAACATCATGGTGTTCCGCTTCTCGAACGGTATTTTCGAGCCGCTCTGGA
ACCGGCAGTATATCGCGCAGGTGCAGATCACCATCGCCGAGGATTTCGGCATCCGGGATCGCGGCGCGTACTACGAGGAG
TCGGGACTTTTGCGTGACATCATCCAGAACCACGGCTTGCAGTTGCTCACGGCCATCGCGATGGAGCCGCCGGTCGATCT
CAGCGCCGATTCGATCCGCGACGAGAAAGCGAAAGTTCTGCGTTCGGTGCGGCACTTCACTCCTGATTCGGTTCGGGAGT
CGGTGGTGATCGGCCAATACGAGGGGTACCGCAACGAGAAAAATGTCGCGCCGGACTCGAAAGTCGAGACCTTCGCTGCC
GTGAAGTTTCACGTGGATAACTGGCGTTGGTCGGGTGTGCCGTTCTACATGAAAGCGGGCAAGAATCTCGCCAAGCGCGT
GACCGAAATCGTCATCACCTTCCGCTGCCCGCCGCAGAATTATTACGGCCCATCCGGCGGGGCGGCGTGCTGTACGCCGA
ACCAGGTGGTACTCGGCATCCAGCCCGACGAAACGGTTGCCATCCGCTTTGGCGCCAAGCGCCCCGGCGAGCAGATGATT
ACCGATCCGGTGTTCATGAAGTTCGACTACCGCGATACTTTTCAGGGCGAAGGTCTTACGCCGTACCACCGCCTCCTGCT
CGATGCCATCGAGGGCAACCAGATGAACTTCATCCGCAAAGACAGCGTGGAGTACTCGTGGGAAATTATCGACAGCCTGA
AAAATTCAATCGACGGCCAGGTTCCGGAGCAATATCCAGTTCATAGCTGGGGGCCGGAATCGTCGAGGATTTACGGGTGA

Upstream 100 bases:

>100_bases
CGCAGAACGAAGAACACTTTTCTGACAAGGTGGTTGCTGCGCTTCGCCACGAGTTCGGCGGGCACGCCTACGAGAAACCT
GGCGAAGGGGAGGGCAAAGC

Downstream 100 bases:

>100_bases
GATTGGTGGAGGGGGTGAAAATTCTGTAGAGGCTGGTCTGCGTGTCCGCACTTTCTGTGTCGGGGATAGATGACAAGAGG
CTCAGAGTAAAACATTACAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSGTLDNFTIVIFGASSDLASRKLFPSIFQLARWGHMPESFRLIGVGRQEQSHEEFRAFVRSRLLEHSPEAAGDAARLDA
FCLRLFYARVDLDDPASYEVLRDEIMREEKVGGSTCRNLMFYLSIPPSLAPAVVRNLGKAGLGGREQSCTGWRKLIAEKP
YGHDLESARELNRVINEVFEENQVYRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRQYIAQVQITIAEDFGIRDRGAYYEE
SGLLRDIIQNHGLQLLTAIAMEPPVDLSADSIRDEKAKVLRSVRHFTPDSVRESVVIGQYEGYRNEKNVAPDSKVETFAA
VKFHVDNWRWSGVPFYMKAGKNLAKRVTEIVITFRCPPQNYYGPSGGAACCTPNQVVLGIQPDETVAIRFGAKRPGEQMI
TDPVFMKFDYRDTFQGEGLTPYHRLLLDAIEGNQMNFIRKDSVEYSWEIIDSLKNSIDGQVPEQYPVHSWGPESSRIYG

Sequences:

>Translated_479_residues
MSGTLDNFTIVIFGASSDLASRKLFPSIFQLARWGHMPESFRLIGVGRQEQSHEEFRAFVRSRLLEHSPEAAGDAARLDA
FCLRLFYARVDLDDPASYEVLRDEIMREEKVGGSTCRNLMFYLSIPPSLAPAVVRNLGKAGLGGREQSCTGWRKLIAEKP
YGHDLESARELNRVINEVFEENQVYRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRQYIAQVQITIAEDFGIRDRGAYYEE
SGLLRDIIQNHGLQLLTAIAMEPPVDLSADSIRDEKAKVLRSVRHFTPDSVRESVVIGQYEGYRNEKNVAPDSKVETFAA
VKFHVDNWRWSGVPFYMKAGKNLAKRVTEIVITFRCPPQNYYGPSGGAACCTPNQVVLGIQPDETVAIRFGAKRPGEQMI
TDPVFMKFDYRDTFQGEGLTPYHRLLLDAIEGNQMNFIRKDSVEYSWEIIDSLKNSIDGQVPEQYPVHSWGPESSRIYG
>Mature_478_residues
SGTLDNFTIVIFGASSDLASRKLFPSIFQLARWGHMPESFRLIGVGRQEQSHEEFRAFVRSRLLEHSPEAAGDAARLDAF
CLRLFYARVDLDDPASYEVLRDEIMREEKVGGSTCRNLMFYLSIPPSLAPAVVRNLGKAGLGGREQSCTGWRKLIAEKPY
GHDLESARELNRVINEVFEENQVYRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRQYIAQVQITIAEDFGIRDRGAYYEES
GLLRDIIQNHGLQLLTAIAMEPPVDLSADSIRDEKAKVLRSVRHFTPDSVRESVVIGQYEGYRNEKNVAPDSKVETFAAV
KFHVDNWRWSGVPFYMKAGKNLAKRVTEIVITFRCPPQNYYGPSGGAACCTPNQVVLGIQPDETVAIRFGAKRPGEQMIT
DPVFMKFDYRDTFQGEGLTPYHRLLLDAIEGNQMNFIRKDSVEYSWEIIDSLKNSIDGQVPEQYPVHSWGPESSRIYG

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=473, Percent_Identity=36.1522198731501, Blast_Score=301, Evalue=8e-82,
Organism=Homo sapiens, GI109389365, Length=473, Percent_Identity=36.1522198731501, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI52145310, Length=504, Percent_Identity=29.7619047619048, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1788158, Length=481, Percent_Identity=38.6694386694387, Blast_Score=337, Evalue=8e-94,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=35.1351351351351, Blast_Score=303, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6324088, Length=486, Percent_Identity=37.037037037037, Blast_Score=310, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=33.195020746888, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=33.195020746888, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI221513548, Length=482, Percent_Identity=29.253112033195, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54441; Mature: 54310

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTLDNFTIVIFGASSDLASRKLFPSIFQLARWGHMPESFRLIGVGRQEQSHEEFRAFV
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
RSRLLEHSPEAAGDAARLDAFCLRLFYARVDLDDPASYEVLRDEIMREEKVGGSTCRNLM
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHCEE
FYLSIPPSLAPAVVRNLGKAGLGGREQSCTGWRKLIAEKPYGHDLESARELNRVINEVFE
EEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ENQVYRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRQYIAQVQITIAEDFGIRDRGAYYEE
CCCEEEEHHHHCCCHHHHEEEEEECCCCCCHHCCCEEEEEEEEEEECCCCCCCCCCCCHH
SGLLRDIIQNHGLQLLTAIAMEPPVDLSADSIRDEKAKVLRSVRHFTPDSVRESVVIGQY
CCHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCEEEECC
EGYRNEKNVAPDSKVETFAAVKFHVDNWRWSGVPFYMKAGKNLAKRVTEIVITFRCPPQN
CCCCCCCCCCCCCHHCEEEEEEEEECCEEECCCCHHHHCCHHHHHHHHHEEEEEECCCCC
YYGPSGGAACCTPNQVVLGIQPDETVAIRFGAKRPGEQMITDPVFMKFDYRDTFQGEGLT
CCCCCCCCEEECCCEEEEEECCCCEEEEEECCCCCCHHHCCCCEEEEECCCCCCCCCCCC
PYHRLLLDAIEGNQMNFIRKDSVEYSWEIIDSLKNSIDGQVPEQYPVHSWGPESSRIYG
HHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGTLDNFTIVIFGASSDLASRKLFPSIFQLARWGHMPESFRLIGVGRQEQSHEEFRAFV
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
RSRLLEHSPEAAGDAARLDAFCLRLFYARVDLDDPASYEVLRDEIMREEKVGGSTCRNLM
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHCEE
FYLSIPPSLAPAVVRNLGKAGLGGREQSCTGWRKLIAEKPYGHDLESARELNRVINEVFE
EEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ENQVYRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRQYIAQVQITIAEDFGIRDRGAYYEE
CCCEEEEHHHHCCCHHHHEEEEEECCCCCCHHCCCEEEEEEEEEEECCCCCCCCCCCCHH
SGLLRDIIQNHGLQLLTAIAMEPPVDLSADSIRDEKAKVLRSVRHFTPDSVRESVVIGQY
CCHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCEEEECC
EGYRNEKNVAPDSKVETFAAVKFHVDNWRWSGVPFYMKAGKNLAKRVTEIVITFRCPPQN
CCCCCCCCCCCCCHHCEEEEEEEEECCEEECCCCHHHHCCHHHHHHHHHEEEEEECCCCC
YYGPSGGAACCTPNQVVLGIQPDETVAIRFGAKRPGEQMITDPVFMKFDYRDTFQGEGLT
CCCCCCCCEEECCCEEEEEECCCCEEEEEECCCCCCHHHCCCCEEEEECCCCCCCCCCCC
PYHRLLLDAIEGNQMNFIRKDSVEYSWEIIDSLKNSIDGQVPEQYPVHSWGPESSRIYG
HHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]