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The map label for this gene is yqeC [H]

Identifier: 161485726

GI number: 161485726

Start: 1772133

End: 1773050

Strand: Reverse

Name: yqeC [H]

Synonym: CT1874

Alternate gene names: 161485726

Gene position: 1773050-1772133 (Counterclockwise)

Preceding gene: 21674690

Following gene: 21674685

Centisome position: 82.28

GC content: 63.4

Gene sequence:

>918_bases
ATGAAGATAGGCTTTGTAGGCCTCGGCAAGATGGGCTCCAATATGGTCGAGCATCTGCTTGAACTTGGTCACGAAGTAGT
TGCATTCGATCTCTCGGCGGAAGCGGTCAAAGCGATTGCGGCCAAAGGGGCGACGGCGGCCAGTTCGTTGCAGCATCTGG
TCGGTGAACTTGCCGCGCCGCGCGTCGTGTGGATGATGGTGCCTGCCGGTCGTCCGGTCGATGCGGTGATCGACGGTCTC
ACGCCGTTTCTCAGAGCGGGTGACATCGTTATCGACGGCGGCAACTCGCGCTACACCGACTCGGTCGCCCGAGCGGAAAA
GCTTCGCAAGCAGGGCATCCGGATGCTCGACATCGGTACCAGCGGCGGGCTGGACGGCGCCCGGCACGGGGCGTGCATGA
TGGCCGGGGGCGACCGCGAGGCCTATGAGCACGTCGAGCCGGTGCTGCGCGACCTCTGCGTCGAGAACGGCTACGGCTAT
ATGGGCGCGTCTGGCTCCGGGCACTTCGTGAAGATGGTGCACAACGGCATCGAATACGGCATGATGCAGGCGATCGGCGA
AGGGTTCGAGCTGCTCCGGGCCAGCGGCTACGACCTCGATAACCAGAATGTGGCGCGGGTCTGGTCGAACGGTTCGGTCA
TCCGTGGCTGGCTCATGGATCTGGCGGGCAAGGCGTTCGCTCAGGGTAACGATCTCGGCTGGCTTGGCGGCAAGGTGGCC
GATTCTGGCGAGGGGCGCTGGACGGTCGAGGCGGCCATCGAACTCGGCGTGGCGGTACCGATCATCTCTGGTTCGCTGTT
CCGGCGCTTCCAGTCGCAGAACGAAGAACACTTTTCTGACAAGGTGGTTGCTGCGCTTCGCCACGAGTTCGGCGGGCACG
CCTACGAGAAACCTGGCGAAGGGGAGGGCAAAGCATGA

Upstream 100 bases:

>100_bases
GATTCGATGTTTCTGTCGCGCTGGTTTTCGGGTTGTTAACAGGAGGGCGGAACCAATAATCAACGAAGGGGGTAACAACT
CCTAAAAACGGAGATTTCAT

Downstream 100 bases:

>100_bases
GCGGCACTCTCGACAACTTCACCATCGTCATCTTCGGCGCGAGCAGCGACCTGGCTTCGCGCAAGCTTTTTCCGTCGATT
TTCCAGCTCGCGCGGTGGGG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKIGFVGLGKMGSNMVEHLLELGHEVVAFDLSAEAVKAIAAKGATAASSLQHLVGELAAPRVVWMMVPAGRPVDAVIDGL
TPFLRAGDIVIDGGNSRYTDSVARAEKLRKQGIRMLDIGTSGGLDGARHGACMMAGGDREAYEHVEPVLRDLCVENGYGY
MGASGSGHFVKMVHNGIEYGMMQAIGEGFELLRASGYDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQGNDLGWLGGKVA
DSGEGRWTVEAAIELGVAVPIISGSLFRRFQSQNEEHFSDKVVAALRHEFGGHAYEKPGEGEGKA

Sequences:

>Translated_305_residues
MKIGFVGLGKMGSNMVEHLLELGHEVVAFDLSAEAVKAIAAKGATAASSLQHLVGELAAPRVVWMMVPAGRPVDAVIDGL
TPFLRAGDIVIDGGNSRYTDSVARAEKLRKQGIRMLDIGTSGGLDGARHGACMMAGGDREAYEHVEPVLRDLCVENGYGY
MGASGSGHFVKMVHNGIEYGMMQAIGEGFELLRASGYDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQGNDLGWLGGKVA
DSGEGRWTVEAAIELGVAVPIISGSLFRRFQSQNEEHFSDKVVAALRHEFGGHAYEKPGEGEGKA
>Mature_305_residues
MKIGFVGLGKMGSNMVEHLLELGHEVVAFDLSAEAVKAIAAKGATAASSLQHLVGELAAPRVVWMMVPAGRPVDAVIDGL
TPFLRAGDIVIDGGNSRYTDSVARAEKLRKQGIRMLDIGTSGGLDGARHGACMMAGGDREAYEHVEPVLRDLCVENGYGY
MGASGSGHFVKMVHNGIEYGMMQAIGEGFELLRASGYDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQGNDLGWLGGKVA
DSGEGRWTVEAAIELGVAVPIISGSLFRRFQSQNEEHFSDKVVAALRHEFGGHAYEKPGEGEGKA

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=309, Percent_Identity=36.2459546925566, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI23308751, Length=217, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788341, Length=310, Percent_Identity=36.1290322580645, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI145693186, Length=204, Percent_Identity=28.4313725490196, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790315, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786719, Length=202, Percent_Identity=27.2277227722772, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=287, Percent_Identity=37.2822299651568, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321695, Length=300, Percent_Identity=36.3333333333333, Blast_Score=175, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321977, Length=299, Percent_Identity=35.7859531772575, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24639279, Length=283, Percent_Identity=36.0424028268551, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24655230, Length=216, Percent_Identity=30.5555555555556, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922568, Length=216, Percent_Identity=30.5555555555556, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32400; Mature: 32400

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00895 3_HYDROXYISOBUT_DH ; PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFVGLGKMGSNMVEHLLELGHEVVAFDLSAEAVKAIAAKGATAASSLQHLVGELAAP
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCC
RVVWMMVPAGRPVDAVIDGLTPFLRAGDIVIDGGNSRYTDSVARAEKLRKQGIRMLDIGT
EEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECC
SGGLDGARHGACMMAGGDREAYEHVEPVLRDLCVENGYGYMGASGSGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHH
MMQAIGEGFELLRASGYDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQGNDLGWLGGKVA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DSGEGRWTVEAAIELGVAVPIISGSLFRRFQSQNEEHFSDKVVAALRHEFGGHAYEKPGE
CCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GEGKA
CCCCC
>Mature Secondary Structure
MKIGFVGLGKMGSNMVEHLLELGHEVVAFDLSAEAVKAIAAKGATAASSLQHLVGELAAP
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCC
RVVWMMVPAGRPVDAVIDGLTPFLRAGDIVIDGGNSRYTDSVARAEKLRKQGIRMLDIGT
EEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECC
SGGLDGARHGACMMAGGDREAYEHVEPVLRDLCVENGYGYMGASGSGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHH
MMQAIGEGFELLRASGYDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQGNDLGWLGGKVA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DSGEGRWTVEAAIELGVAVPIISGSLFRRFQSQNEEHFSDKVVAALRHEFGGHAYEKPGE
CCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GEGKA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]