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The map label for this gene is pgl [H]

Identifier: 21674683

GI number: 21674683

Start: 1769216

End: 1770019

Strand: Direct

Name: pgl [H]

Synonym: CT1871

Alternate gene names: 21674683

Gene position: 1769216-1770019 (Clockwise)

Preceding gene: 21674682

Following gene: 21674687

Centisome position: 82.1

GC content: 62.56

Gene sequence:

>804_bases
ATGACCGCCATGACGCACTGGATCAGCGAACCGCTCGACGCGCTTCTCGAAAAAGCGGTCGCCTTCATCACCGACACGGC
CTACCGCGCGGTCGCCGAGCGTGGCCGCTTCACCTTGGTGCTGTCGGGCGGCAACACCCCGCGAGCGCTACACCAGAAAC
TTGCGAGAGGCATCCGCGAAGAGCGCTACCTCGAACTCGGCTACAAACTGCCTGAAGAGGCGCGCCGCTGCACCCGCAAT
CCGGATGTGATCGTGCCGCCCTGGACGCACACGCTGCTCTTCCAGGGCGACGAGCGCTACCTGCCGCCGAGCCACCCCGA
CAGCAACTACGGCATGGCCCGCCAGACGCTCATCCGCAACGTCTGCCTCAAACCGTCGAACATCCACCGGATGCCGACCG
AATCGGGCGACCCGGAAGCAGACGCCCAGCGCTACGAAATGCTGTTGAAAGGATTGTTCCACAAACGCAACAGTAACAAC
GCCCCACCATCGTTCGACCTCATCCTCCTCGGCCTCGGCGACGACGGCCACACCGCCTCGCTGATGCCTGATGATAAAGG
AGCGCTCGAAGAAAAAGAGCGCTGGGTCATCGCCGTCAACGCCCCCAACGGCAAACCACCGGGGATAAGACTGACGCTGA
CGCTACCGGTCATCAACGAAGCAAGAGCGGTGCTCTTCCTCGTCCCGCCATCGCGCCACGAGCTTGCCCGCTCAATCAGC
AACGGAGAAAGGCCGGAGCTGCCTGCGGGAATGGTGAAGCCGAGAAGTGGAGATGTGTGGTGGTTTGTGGAAGGGGTTGT
TTGA

Upstream 100 bases:

>100_bases
ACCGCTTCGGCATGTCAGCCCCCAGCTCGCAGGTGATGGAGCACTTCGGCTTCACGGCGGAAAACATCGCCGCCCGCGCC
CTCGAACTCCTGAACCGGAA

Downstream 100 bases:

>100_bases
TTGATGACGAATGCATTGAATCAGAAAAAAACCCTTTACTGATGAGCAGGAAATCGGCTATTACTGACTCAAATGAAACA
TTTTAGCCCTTATGAAAGCC

Product: Sol/DevB family oxidoreductase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTAMTHWISEPLDALLEKAVAFITDTAYRAVAERGRFTLVLSGGNTPRALHQKLARGIREERYLELGYKLPEEARRCTRN
PDVIVPPWTHTLLFQGDERYLPPSHPDSNYGMARQTLIRNVCLKPSNIHRMPTESGDPEADAQRYEMLLKGLFHKRNSNN
APPSFDLILLGLGDDGHTASLMPDDKGALEEKERWVIAVNAPNGKPPGIRLTLTLPVINEARAVLFLVPPSRHELARSIS
NGERPELPAGMVKPRSGDVWWFVEGVV

Sequences:

>Translated_267_residues
MTAMTHWISEPLDALLEKAVAFITDTAYRAVAERGRFTLVLSGGNTPRALHQKLARGIREERYLELGYKLPEEARRCTRN
PDVIVPPWTHTLLFQGDERYLPPSHPDSNYGMARQTLIRNVCLKPSNIHRMPTESGDPEADAQRYEMLLKGLFHKRNSNN
APPSFDLILLGLGDDGHTASLMPDDKGALEEKERWVIAVNAPNGKPPGIRLTLTLPVINEARAVLFLVPPSRHELARSIS
NGERPELPAGMVKPRSGDVWWFVEGVV
>Mature_266_residues
TAMTHWISEPLDALLEKAVAFITDTAYRAVAERGRFTLVLSGGNTPRALHQKLARGIREERYLELGYKLPEEARRCTRNP
DVIVPPWTHTLLFQGDERYLPPSHPDSNYGMARQTLIRNVCLKPSNIHRMPTESGDPEADAQRYEMLLKGLFHKRNSNNA
PPSFDLILLGLGDDGHTASLMPDDKGALEEKERWVIAVNAPNGKPPGIRLTLTLPVINEARAVLFLVPPSRHELARSISN
GERPELPAGMVKPRSGDVWWFVEGVV

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=260, Percent_Identity=33.8461538461538, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912586, Length=258, Percent_Identity=32.5581395348837, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115533058, Length=253, Percent_Identity=25.6916996047431, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533060, Length=253, Percent_Identity=25.6916996047431, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319918, Length=238, Percent_Identity=33.1932773109244, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324362, Length=237, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321687, Length=233, Percent_Identity=30.0429184549356, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321957, Length=253, Percent_Identity=25.6916996047431, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641119, Length=243, Percent_Identity=30.0411522633745, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 29880; Mature: 29748

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMTHWISEPLDALLEKAVAFITDTAYRAVAERGRFTLVLSGGNTPRALHQKLARGIRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHH
ERYLELGYKLPEEARRCTRNPDVIVPPWTHTLLFQGDERYLPPSHPDSNYGMARQTLIRN
HHHHHHCCCCCHHHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
VCLKPSNIHRMPTESGDPEADAQRYEMLLKGLFHKRNSNNAPPSFDLILLGLGDDGHTAS
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEC
LMPDDKGALEEKERWVIAVNAPNGKPPGIRLTLTLPVINEARAVLFLVPPSRHELARSIS
CCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCHHHHHHHHC
NGERPELPAGMVKPRSGDVWWFVEGVV
CCCCCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
TAMTHWISEPLDALLEKAVAFITDTAYRAVAERGRFTLVLSGGNTPRALHQKLARGIRE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHH
ERYLELGYKLPEEARRCTRNPDVIVPPWTHTLLFQGDERYLPPSHPDSNYGMARQTLIRN
HHHHHHCCCCCHHHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
VCLKPSNIHRMPTESGDPEADAQRYEMLLKGLFHKRNSNNAPPSFDLILLGLGDDGHTAS
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEC
LMPDDKGALEEKERWVIAVNAPNGKPPGIRLTLTLPVINEARAVLFLVPPSRHELARSIS
CCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCHHHHHHHHC
NGERPELPAGMVKPRSGDVWWFVEGVV
CCCCCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]