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The map label for this gene is tkt [H]

Identifier: 21674682

GI number: 21674682

Start: 1767153

End: 1769219

Strand: Direct

Name: tkt [H]

Synonym: CT1870

Alternate gene names: 21674682

Gene position: 1767153-1769219 (Clockwise)

Preceding gene: 21674681

Following gene: 21674683

Centisome position: 82.0

GC content: 63.52

Gene sequence:

>2067_bases
TTGACTGTCAGAGTCCGTCCGATTTCTCTCAATCTCAGAAACAATCCGATTATGACACGCACCCGTTCCATCGATGAAGA
GGCCGTCGCCACCATCAGGCTTCTGGCGGTCGATATGGTAGAAAAGGCCAAATCGGGCCACCCTGGACTGCCGCTTGGTG
CGGCTCCGATGGCGTACACGCTCTTTACCAAAATCATGCGGTTTAACCCCGCCAATCCGGAGTGGCCGAATCGCGACCGC
TTCGTGCTCTCGGCGGGCCACGGCTCCGCGCTGCTCTACTCCATGTTGCACCTCTGCGGCTACGGCCTCGGCATGGATGA
GCTGAAGCAGTTCCGGCAGCTCGGCAGCCGCACGCCTGGCCACCCCGAATACGGTCACACGCCGGGCGTCGAAACGACCA
CTGGCCCGCTCGGCCAGGGCATTGCCACTGCCGTCGGAATGGCTGCCGCCGAACGCTTCCTCGCCACGAAACTCAACACG
GCAGAGCGGGCACTCATCGACCACTTCACCTACGTCATCTGCGGCGACGGTGACCTCATGGAGGGCATCAGTTCGGAAGC
CTCGTCGCTTGCCGGACACCTCAGGCTCGGGCGCCTCATCTGCCTCTACGACAGCAACCACATCAGCATCGAAGGCTCGA
CCGGTCTGGCCTTCACGGAGGATGTTGCCCGCCGCTACGAGGCGTACGGCTGGCACGTCCTGTCGCACATCGACGGCAAC
GACCTTGCGGCCATCGAGCAAGCAGTGCGCAATGCACAGGAGATCGACGACCGCCCGTCGCTCATCATCGTCAACACCAC
CATCGGCTACGGTAGCCCGCACAAGCAGGGCACCGCGTCAGCACACGGCGAGCCGCTTGGCCCGGAAGAAACGAAGCTGG
TCAAGCAGGCTTTCGGGTTTGATGAAAATGAATCGTTCGTCGTGTCGGATCGTGTGTACGACCATTTTCACGCGATAGCC
GAACGCGGCGCGGCGCTCGAAGCCGAATGGCAAACGCAGTGGCAGTCGTTCAGGCAGGAAGAACCCGGCCTCGCCTCGGC
GCTGACCGACCTGCTCGCGGGCCGCTTCCCTGAATCGTGGCTGCCCGAAATGCCGAAATTCACGACTGGCGAAAAGCTCG
CCACGCGGCAGGCATCGAAAAGCGTGCTTGCCAAAATCGCAGAAAAGGCGCCGCTGCTGGCGGGCGGCTCGGCTGACCTC
GCCCCGTCGAACGGCACGCTCATCGGAGCCGCTTTCGAGGCTGGAAGCTACGGCGGCTCGACCTTCCACTTCGGCGTTCG
GGAACACGCAATGGGCGCACTTGTCAACGGCATGGCACTCTCAAAAATGATGATCCCCTATGGCGCGACCTTCCTCGTCT
TTGCCGATTACATGAAACCCGCGCTGCGCATCGCCGCAATGATGCAATCCCCCTCGATCTTCATCTTCACGCACGACAGC
ATCGGCCTTGGCGAGGACGGCCCAACCCACCAGCCCATCGAGCAGCTCGCCATGCTCCGCGCCATGCCGGGCTTCGACGT
CTATCGCCCGGCGGACGCGAATGAAACGGCAGCGGCGTGGCTGCTCGCGCTGAAACGCCGCAAACCGGCAGCGCTCGTGC
TCACACGCCAGGGTTTGCCAGTGCTCGACGACGCCGATGGACGCCTCCGCAACGGCGTGACAAAAGGCGGCTATGTGCTC
GCGGAATGGGCAGATACGGACGACGACGACGACCGCCGGATCATTATCGTGGCGACGGGATCGGAGGTGCATCCCGCGCT
CGAAGCAAAAACGCTGATCGAACAGGAGGGATTCGCGGCACGGGTGGTCTCGATGCCGTCGCGGGAGCTGTTCGCCGAGC
AACCGGCGGAGTATCGCGCCGCCGTGCTGCCTCCGACGGTGCGGGCACGAGCCGTGGTCGAAGCCGCCGCGACCTTCGGC
TGGCACGACATTGCGGGCGACGGCGGAATCGTGATCGGCATCGACCGCTTCGGCATGTCAGCCCCCAGCTCGCAGGTGAT
GGAGCACTTCGGCTTCACGGCGGAAAACATCGCCGCCCGCGCCCTCGAACTCCTGAACCGGAAATGA

Upstream 100 bases:

>100_bases
GACGCACTGTTATCAAATTAGGCTTCCTGCCTTTACCGCCCAAACCGGAGCGCATGTCAAATGTTTCCGATTTTTGTGAT
AACCATCGGCAGTTGATACT

Downstream 100 bases:

>100_bases
CCGCCATGACGCACTGGATCAGCGAACCGCTCGACGCGCTTCTCGAAAAAGCGGTCGCCTTCATCACCGACACGGCCTAC
CGCGCGGTCGCCGAGCGTGG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MTVRVRPISLNLRNNPIMTRTRSIDEEAVATIRLLAVDMVEKAKSGHPGLPLGAAPMAYTLFTKIMRFNPANPEWPNRDR
FVLSAGHGSALLYSMLHLCGYGLGMDELKQFRQLGSRTPGHPEYGHTPGVETTTGPLGQGIATAVGMAAAERFLATKLNT
AERALIDHFTYVICGDGDLMEGISSEASSLAGHLRLGRLICLYDSNHISIEGSTGLAFTEDVARRYEAYGWHVLSHIDGN
DLAAIEQAVRNAQEIDDRPSLIIVNTTIGYGSPHKQGTASAHGEPLGPEETKLVKQAFGFDENESFVVSDRVYDHFHAIA
ERGAALEAEWQTQWQSFRQEEPGLASALTDLLAGRFPESWLPEMPKFTTGEKLATRQASKSVLAKIAEKAPLLAGGSADL
APSNGTLIGAAFEAGSYGGSTFHFGVREHAMGALVNGMALSKMMIPYGATFLVFADYMKPALRIAAMMQSPSIFIFTHDS
IGLGEDGPTHQPIEQLAMLRAMPGFDVYRPADANETAAAWLLALKRRKPAALVLTRQGLPVLDDADGRLRNGVTKGGYVL
AEWADTDDDDDRRIIIVATGSEVHPALEAKTLIEQEGFAARVVSMPSRELFAEQPAEYRAAVLPPTVRARAVVEAAATFG
WHDIAGDGGIVIGIDRFGMSAPSSQVMEHFGFTAENIAARALELLNRK

Sequences:

>Translated_688_residues
MTVRVRPISLNLRNNPIMTRTRSIDEEAVATIRLLAVDMVEKAKSGHPGLPLGAAPMAYTLFTKIMRFNPANPEWPNRDR
FVLSAGHGSALLYSMLHLCGYGLGMDELKQFRQLGSRTPGHPEYGHTPGVETTTGPLGQGIATAVGMAAAERFLATKLNT
AERALIDHFTYVICGDGDLMEGISSEASSLAGHLRLGRLICLYDSNHISIEGSTGLAFTEDVARRYEAYGWHVLSHIDGN
DLAAIEQAVRNAQEIDDRPSLIIVNTTIGYGSPHKQGTASAHGEPLGPEETKLVKQAFGFDENESFVVSDRVYDHFHAIA
ERGAALEAEWQTQWQSFRQEEPGLASALTDLLAGRFPESWLPEMPKFTTGEKLATRQASKSVLAKIAEKAPLLAGGSADL
APSNGTLIGAAFEAGSYGGSTFHFGVREHAMGALVNGMALSKMMIPYGATFLVFADYMKPALRIAAMMQSPSIFIFTHDS
IGLGEDGPTHQPIEQLAMLRAMPGFDVYRPADANETAAAWLLALKRRKPAALVLTRQGLPVLDDADGRLRNGVTKGGYVL
AEWADTDDDDDRRIIIVATGSEVHPALEAKTLIEQEGFAARVVSMPSRELFAEQPAEYRAAVLPPTVRARAVVEAAATFG
WHDIAGDGGIVIGIDRFGMSAPSSQVMEHFGFTAENIAARALELLNRK
>Mature_687_residues
TVRVRPISLNLRNNPIMTRTRSIDEEAVATIRLLAVDMVEKAKSGHPGLPLGAAPMAYTLFTKIMRFNPANPEWPNRDRF
VLSAGHGSALLYSMLHLCGYGLGMDELKQFRQLGSRTPGHPEYGHTPGVETTTGPLGQGIATAVGMAAAERFLATKLNTA
ERALIDHFTYVICGDGDLMEGISSEASSLAGHLRLGRLICLYDSNHISIEGSTGLAFTEDVARRYEAYGWHVLSHIDGND
LAAIEQAVRNAQEIDDRPSLIIVNTTIGYGSPHKQGTASAHGEPLGPEETKLVKQAFGFDENESFVVSDRVYDHFHAIAE
RGAALEAEWQTQWQSFRQEEPGLASALTDLLAGRFPESWLPEMPKFTTGEKLATRQASKSVLAKIAEKAPLLAGGSADLA
PSNGTLIGAAFEAGSYGGSTFHFGVREHAMGALVNGMALSKMMIPYGATFLVFADYMKPALRIAAMMQSPSIFIFTHDSI
GLGEDGPTHQPIEQLAMLRAMPGFDVYRPADANETAAAWLLALKRRKPAALVLTRQGLPVLDDADGRLRNGVTKGGYVLA
EWADTDDDDDRRIIIVATGSEVHPALEAKTLIEQEGFAARVVSMPSRELFAEQPAEYRAAVLPPTVRARAVVEAAATFGW
HDIAGDGGIVIGIDRFGMSAPSSQVMEHFGFTAENIAARALELLNRK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=576, Percent_Identity=25.8680555555556, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI4507521, Length=576, Percent_Identity=25.8680555555556, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI133778974, Length=601, Percent_Identity=25.1247920133111, Blast_Score=156, Evalue=8e-38,
Organism=Homo sapiens, GI225637459, Length=596, Percent_Identity=22.6510067114094, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI225637463, Length=557, Percent_Identity=23.1597845601436, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI225637461, Length=557, Percent_Identity=23.1597845601436, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1788808, Length=664, Percent_Identity=47.1385542168675, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI48994911, Length=667, Percent_Identity=46.4767616191904, Blast_Score=593, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17539652, Length=603, Percent_Identity=26.3681592039801, Blast_Score=175, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6325331, Length=676, Percent_Identity=49.7041420118343, Blast_Score=616, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6319593, Length=682, Percent_Identity=47.3607038123167, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI45551847, Length=668, Percent_Identity=24.8502994011976, Blast_Score=187, Evalue=3e-47,
Organism=Drosophila melanogaster, GI45550715, Length=668, Percent_Identity=24.8502994011976, Blast_Score=187, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24645119, Length=640, Percent_Identity=24.84375, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24666278, Length=583, Percent_Identity=25.7289879931389, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74373; Mature: 74242

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRVRPISLNLRNNPIMTRTRSIDEEAVATIRLLAVDMVEKAKSGHPGLPLGAAPMAYT
CEEEEEEEEEEECCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LFTKIMRFNPANPEWPNRDRFVLSAGHGSALLYSMLHLCGYGLGMDELKQFRQLGSRTPG
HHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
HPEYGHTPGVETTTGPLGQGIATAVGMAAAERFLATKLNTAERALIDHFTYVICGDGDLM
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEECCCHHH
EGISSEASSLAGHLRLGRLICLYDSNHISIEGSTGLAFTEDVARRYEAYGWHVLSHIDGN
HHHHHHHHHHHHHHEECEEEEEEECCEEEEECCCCCEEHHHHHHHHHHHCEEEEEECCCC
DLAAIEQAVRNAQEIDDRPSLIIVNTTIGYGSPHKQGTASAHGEPLGPEETKLVKQAFGF
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
DENESFVVSDRVYDHFHAIAERGAALEAEWQTQWQSFRQEEPGLASALTDLLAGRFPESW
CCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
LPEMPKFTTGEKLATRQASKSVLAKIAEKAPLLAGGSADLAPSNGTLIGAAFEAGSYGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEEECCCCCCCC
TFHFGVREHAMGALVNGMALSKMMIPYGATFLVFADYMKPALRIAAMMQSPSIFIFTHDS
EEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
IGLGEDGPTHQPIEQLAMLRAMPGFDVYRPADANETAAAWLLALKRRKPAALVLTRQGLP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCC
VLDDADGRLRNGVTKGGYVLAEWADTDDDDDRRIIIVATGSEVHPALEAKTLIEQEGFAA
CEECCCCHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCE
RVVSMPSRELFAEQPAEYRAAVLPPTVRARAVVEAAATFGWHDIAGDGGIVIGIDRFGMS
EECCCCCHHHHHCCCHHHEEEECCCCHHHHHHHHHHHHCCCCEECCCCCEEEEECCCCCC
APSSQVMEHFGFTAENIAARALELLNRK
CCHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVRVRPISLNLRNNPIMTRTRSIDEEAVATIRLLAVDMVEKAKSGHPGLPLGAAPMAYT
EEEEEEEEEEECCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LFTKIMRFNPANPEWPNRDRFVLSAGHGSALLYSMLHLCGYGLGMDELKQFRQLGSRTPG
HHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
HPEYGHTPGVETTTGPLGQGIATAVGMAAAERFLATKLNTAERALIDHFTYVICGDGDLM
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEECCCHHH
EGISSEASSLAGHLRLGRLICLYDSNHISIEGSTGLAFTEDVARRYEAYGWHVLSHIDGN
HHHHHHHHHHHHHHEECEEEEEEECCEEEEECCCCCEEHHHHHHHHHHHCEEEEEECCCC
DLAAIEQAVRNAQEIDDRPSLIIVNTTIGYGSPHKQGTASAHGEPLGPEETKLVKQAFGF
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
DENESFVVSDRVYDHFHAIAERGAALEAEWQTQWQSFRQEEPGLASALTDLLAGRFPESW
CCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
LPEMPKFTTGEKLATRQASKSVLAKIAEKAPLLAGGSADLAPSNGTLIGAAFEAGSYGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEEECCCCCCCC
TFHFGVREHAMGALVNGMALSKMMIPYGATFLVFADYMKPALRIAAMMQSPSIFIFTHDS
EEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
IGLGEDGPTHQPIEQLAMLRAMPGFDVYRPADANETAAAWLLALKRRKPAALVLTRQGLP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCC
VLDDADGRLRNGVTKGGYVLAEWADTDDDDDRRIIIVATGSEVHPALEAKTLIEQEGFAA
CEECCCCHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCE
RVVSMPSRELFAEQPAEYRAAVLPPTVRARAVVEAAATFGWHDIAGDGGIVIGIDRFGMS
EECCCCCHHHHHCCCHHHEEEECCCCHHHHHHHHHHHHCCCCEECCCCCEEEEECCCCCC
APSSQVMEHFGFTAENIAARALELLNRK
CCHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]