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The map label for this gene is deoD [H]

Identifier: 21674629

GI number: 21674629

Start: 1719070

End: 1719891

Strand: Direct

Name: deoD [H]

Synonym: CT1815

Alternate gene names: 21674629

Gene position: 1719070-1719891 (Clockwise)

Preceding gene: 21674628

Following gene: 21674630

Centisome position: 79.77

GC content: 58.27

Gene sequence:

>822_bases
ATGACTGAACAAAGGCAGAAAATCCGGGAAGCCGTTGAATTCATCAGAAAAAAAACCACGGCTGAATATCCGGTAGGTAT
CGTGCTCGGAACCGGCCTTGGCGGACTGGTCAAGGAGATTGAAATCGATTTTTCGCTCGATTATGCCGATATTCCCTATT
TTCCGATTTCGACGGTTGAAACCCATCACGGCAAGCTGATTTTCGGCACCCTCGCCGGCAAGAAAGTCGTTGCCATGCAG
GGCCGTTTCCACTACTACGAAGGCTACTCGATGACGCAGATCGTCTTCCCGATCAGGGTCATGAAAGAGCTCGGCATGAA
GACCCTCGGCATCACCAACGCCTGCGGCGGCATGAACCCCGGCTACAGCAAGGGCGACATCATGCTCATCGACGACCATA
TCAACCTGCTTGGCGCCAACCCGCTCATCGGCCCGAACGATCCTGAAATGGGCCCCCGCTTCCCCGATATGTGCGCCCCC
TACTCGCCGAGGATTCTCGAGATCGCCGAAAAGGTCGCGCTCGAACACGGCATCAAGGTGCAGCGCGGCGTCTATGTCGC
CGTCACCGGTCCGTGCCTCGAAACCCGCGCCGAGTACCGGATGCTGCGCGCCATCGGCGCTGACGTGGTCGGCATGTCCA
CCGTCCCGGAGGTGATCGCCGCCGTGCACCAGGGCACCGAAGTGTTCGGCATGTCCATCGTCACCGACGAGTGCTTCCCG
GACTGCCTCGTGCCGGTCAGCATCGAAGAGATCATCGAAGTCTCCAGCCGCGCCGAGCCGAACATGACCACCATTTTCAG
GAACGTCGTAGCCAATCTTTAA

Upstream 100 bases:

>100_bases
ATCAACGCCTCCCCGCCTTTCATCTCTCCCCGTCGCTACTTATATTTAATGTCTTTTTTTTGCATGCCGTTTTAAATCCA
TCAAAACCACAGGGAATATC

Downstream 100 bases:

>100_bases
TCCTTAACAAGGCAATACCTGTTCTCTCATGATAGACGCTATCTCATTTAAAAACGGAACGTTCCGTTACCTCGACCAGC
GCTTTCTGCCCCTGCAGGAG

Product: purine nucleoside phosphorylase

Products: NA

Alternate protein names: Inosine phosphorylase; Purine nucleoside phosphorylase I; PNP I; PU-NPase I [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTEQRQKIREAVEFIRKKTTAEYPVGIVLGTGLGGLVKEIEIDFSLDYADIPYFPISTVETHHGKLIFGTLAGKKVVAMQ
GRFHYYEGYSMTQIVFPIRVMKELGMKTLGITNACGGMNPGYSKGDIMLIDDHINLLGANPLIGPNDPEMGPRFPDMCAP
YSPRILEIAEKVALEHGIKVQRGVYVAVTGPCLETRAEYRMLRAIGADVVGMSTVPEVIAAVHQGTEVFGMSIVTDECFP
DCLVPVSIEEIIEVSSRAEPNMTTIFRNVVANL

Sequences:

>Translated_273_residues
MTEQRQKIREAVEFIRKKTTAEYPVGIVLGTGLGGLVKEIEIDFSLDYADIPYFPISTVETHHGKLIFGTLAGKKVVAMQ
GRFHYYEGYSMTQIVFPIRVMKELGMKTLGITNACGGMNPGYSKGDIMLIDDHINLLGANPLIGPNDPEMGPRFPDMCAP
YSPRILEIAEKVALEHGIKVQRGVYVAVTGPCLETRAEYRMLRAIGADVVGMSTVPEVIAAVHQGTEVFGMSIVTDECFP
DCLVPVSIEEIIEVSSRAEPNMTTIFRNVVANL
>Mature_272_residues
TEQRQKIREAVEFIRKKTTAEYPVGIVLGTGLGGLVKEIEIDFSLDYADIPYFPISTVETHHGKLIFGTLAGKKVVAMQG
RFHYYEGYSMTQIVFPIRVMKELGMKTLGITNACGGMNPGYSKGDIMLIDDHINLLGANPLIGPNDPEMGPRFPDMCAPY
SPRILEIAEKVALEHGIKVQRGVYVAVTGPCLETRAEYRMLRAIGADVVGMSTVPEVIAAVHQGTEVFGMSIVTDECFPD
CLVPVSIEEIIEVSSRAEPNMTTIFRNVVANL

Specific function: Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=275, Percent_Identity=43.2727272727273, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI47132622, Length=243, Percent_Identity=29.6296296296296, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1788746, Length=212, Percent_Identity=42.9245283018868, Blast_Score=175, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17541190, Length=273, Percent_Identity=36.996336996337, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323238, Length=262, Percent_Identity=41.6030534351145, Blast_Score=183, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24656093, Length=238, Percent_Identity=47.4789915966387, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI45552887, Length=238, Percent_Identity=47.4789915966387, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24656090, Length=238, Percent_Identity=47.4789915966387, Blast_Score=215, Evalue=2e-56,
Organism=Drosophila melanogaster, GI45552885, Length=238, Percent_Identity=47.4789915966387, Blast_Score=215, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24762376, Length=215, Percent_Identity=36.7441860465116, Blast_Score=138, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR011270
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.1 [H]

Molecular weight: Translated: 29969; Mature: 29838

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQRQKIREAVEFIRKKTTAEYPVGIVLGTGLGGLVKEIEIDFSLDYADIPYFPISTVE
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHEEEEEEECCCCCCCCCCCCCC
THHGKLIFGTLAGKKVVAMQGRFHYYEGYSMTQIVFPIRVMKELGMKTLGITNACGGMNP
CCCCEEEEEECCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCC
GYSKGDIMLIDDHINLLGANPLIGPNDPEMGPRFPDMCAPYSPRILEIAEKVALEHGIKV
CCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
QRGVYVAVTGPCLETRAEYRMLRAIGADVVGMSTVPEVIAAVHQGTEVFGMSIVTDECFP
ECCEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHEEEEEECHHCCC
DCLVPVSIEEIIEVSSRAEPNMTTIFRNVVANL
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TEQRQKIREAVEFIRKKTTAEYPVGIVLGTGLGGLVKEIEIDFSLDYADIPYFPISTVE
CHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHEEEEEEECCCCCCCCCCCCCC
THHGKLIFGTLAGKKVVAMQGRFHYYEGYSMTQIVFPIRVMKELGMKTLGITNACGGMNP
CCCCEEEEEECCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCC
GYSKGDIMLIDDHINLLGANPLIGPNDPEMGPRFPDMCAPYSPRILEIAEKVALEHGIKV
CCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
QRGVYVAVTGPCLETRAEYRMLRAIGADVVGMSTVPEVIAAVHQGTEVFGMSIVTDECFP
ECCEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHEEEEEECHHCCC
DCLVPVSIEEIIEVSSRAEPNMTTIFRNVVANL
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9058965 [H]