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The map label for this gene is lspA

Identifier: 21674624

GI number: 21674624

Start: 1715628

End: 1716116

Strand: Direct

Name: lspA

Synonym: CT1810

Alternate gene names: 21674624

Gene position: 1715628-1716116 (Clockwise)

Preceding gene: 21674623

Following gene: 21674625

Centisome position: 79.61

GC content: 56.65

Gene sequence:

>489_bases
ATGGCCCTTTTTTATCTGCTCGCGATAGCTGCTGCCCTGCTCGACCGGGTGACCAAACTTCTCGCCATCCACTACCTGCG
CGACGGCGCGCAAAGCATCGTCATCATCCCTGACTGGCTCAAGCTGACCTACGCCGAAAACCTCGGCATCGCATTCAGCG
TCCGGTTCCTCCCGCCGACGGGCCTGCTTTTTCTGACCCTCGCTATTTCTGCGGGCGTTGTCTGGTATGTCCACAAATCG
AACAACCGGAGTCCGCTCTTCCTCACGGCTTTTGGACTCATTCTGGGCGGCGGGATCGGCAACCTGATCGACCGCGTCAT
GCTCGGCCATGTGGTGGATTTCATCTATTTCGATCTCTATCACGGCGCACTCTTTGGCATCCCGCTCGATCTGTGGCCGA
TTTTCAACGTCGCCGACTCCTGCATCACCATCGGCGCGTGCATGATCGTGCTGTTTCACGAAAAAATTTTCACCAGGAAA
CACGCATGA

Upstream 100 bases:

>100_bases
AATCGAAAAGAGCGAAGGCTGAGGCGGCGGTTTGAAAGAGGCCTGAATGGTATTACATTCTCTTCGACCTCTTTTGACCT
CCTGACAACAACACTACTCT

Downstream 100 bases:

>100_bases
ACACCCCGGGTTTCTGCGACATCCACTGCCATCTCTCCTTTCCCGATTTCGACGATGACCGTGACCGGGTGATCGGCGAT
CTCCGCGCGGCTGGCTTGCA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MALFYLLAIAAALLDRVTKLLAIHYLRDGAQSIVIIPDWLKLTYAENLGIAFSVRFLPPTGLLFLTLAISAGVVWYVHKS
NNRSPLFLTAFGLILGGGIGNLIDRVMLGHVVDFIYFDLYHGALFGIPLDLWPIFNVADSCITIGACMIVLFHEKIFTRK
HA

Sequences:

>Translated_162_residues
MALFYLLAIAAALLDRVTKLLAIHYLRDGAQSIVIIPDWLKLTYAENLGIAFSVRFLPPTGLLFLTLAISAGVVWYVHKS
NNRSPLFLTAFGLILGGGIGNLIDRVMLGHVVDFIYFDLYHGALFGIPLDLWPIFNVADSCITIGACMIVLFHEKIFTRK
HA
>Mature_161_residues
ALFYLLAIAAALLDRVTKLLAIHYLRDGAQSIVIIPDWLKLTYAENLGIAFSVRFLPPTGLLFLTLAISAGVVWYVHKSN
NRSPLFLTAFGLILGGGIGNLIDRVMLGHVVDFIYFDLYHGALFGIPLDLWPIFNVADSCITIGACMIVLFHEKIFTRKH
A

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_CHLTE (Q8KBH7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662689.1
- MEROPS:   A08.001
- GeneID:   1008194
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1810
- NMPDR:   fig|194439.1.peg.1783
- TIGR:   CT1810
- HOGENOM:   HBG724422
- OMA:   FYGYVID
- ProtClustDB:   PRK14787
- BioCyc:   CTEP194439:CT_1810-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17962; Mature: 17830

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 104-104 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

HASH(0xf5b059c)-; HASH(0xf5eddb0)-; HASH(0xe8c645c)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFYLLAIAAALLDRVTKLLAIHYLRDGAQSIVIIPDWLKLTYAENLGIAFSVRFLPPT
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCEEEEEEECCCC
GLLFLTLAISAGVVWYVHKSNNRSPLFLTAFGLILGGGIGNLIDRVMLGHVVDFIYFDLY
HHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
HGALFGIPLDLWPIFNVADSCITIGACMIVLFHEKIFTRKHA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
ALFYLLAIAAALLDRVTKLLAIHYLRDGAQSIVIIPDWLKLTYAENLGIAFSVRFLPPT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCEEEEEEECCCC
GLLFLTLAISAGVVWYVHKSNNRSPLFLTAFGLILGGGIGNLIDRVMLGHVVDFIYFDLY
HHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
HGALFGIPLDLWPIFNVADSCITIGACMIVLFHEKIFTRKHA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12093901