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The map label for this gene is uvrC

Identifier: 21674621

GI number: 21674621

Start: 1711266

End: 1713146

Strand: Direct

Name: uvrC

Synonym: CT1807

Alternate gene names: 21674621

Gene position: 1711266-1713146 (Clockwise)

Preceding gene: 21674620

Following gene: 21674622

Centisome position: 79.41

GC content: 59.17

Gene sequence:

>1881_bases
ATGAGCGACACCGCAGCAGCACCAGACAAAACTGCAAAATCGGCTCTGGCCGAAAAACTCGCCACGCTGCCGACTTCGCC
CGGCGTTTACCGCTTCAGCAACGCAGCGGGAACGGTGATCTACGTCGGCAAGGCGCGGAACCTGCGCAACCGGGTGCGTT
CGTATTTCAACAGCCAGGGGCGCCAGCCGGGCAAGACCGCCGTGATGGTAAGCCACATCGCTGACCTGAACGTCATCATC
ACCAGCTCGGAAGTCGAAGCGCTGATCCTCGAAAACAACCTTATCAAGGAGCTGAAGCCACGCTACAACGTCAACCTCAA
GGACGACAAGAGCTACCCGTGGCTGGTCATCACCAACGAGCGTTTTCCGCGAATTTTTCTCACCCGCCAGGTCAGGCGCG
ATGGTTCGCTCTATTTCGGCCCCTACACCGAAGCCTCGCAGCTCCGGCTCATTCTCGACCTGATCGGCTCGATTTTTCCG
GTCAGGAGCTGCAAATACAAGCTCACCGAGGAGGCTGTCGCATCCGGCAGGTATCGGGTCTGCCTCGATTATCATATCCA
CAAGTGCAAAGGACCATGCGAAGGGTTGCAATCTGAGGAAGAGTACCAGGCGATGATCCGCGAAATCGTCACGTTGCTCA
AGGGCAAAACTTCAGCTCTCTTGCGCGACCTCAGCGCCGAGATGCAGAAGAAGGCAAAGGAGCTGAAGTTCGAGGAGGCC
GCAGCCCTGAAAGCGCAGATCGAGGGGCTGAAACGCTACGCGGAGCGCCAGAAGATCGTGAGCACCGAAGCGATCGACCG
CGATGTCTTCGCCGTTGCTGCGGGCGAAGATGATGCGTGTGGTGTGGTCTTCCGCATCCGCGAAGGAAAGCTGATCGGCT
CGCGCCACACCTACCTCTCCAACACGGGCAACACGCCGCTGCCGAACCTGCTGGCCTCTTTCGTGGAGCACTACTACCTC
GAAACCCCCGACCTGATTCCACAGGAACTCATGCTCCAGGCGGAGCTGCCTGAAGAGGAACTCGAAGCCCTCCGGCAACT
GCTCTCGTCGCGGCAGACCGAGCGGCGGCAGGTGCGTTTCACGGTGCCCCGCATCGGCGAAAAGGCTCATCTCATCGCCA
TGTGCCTCGACAACGCCAAGCACCACCTGCACGAGTTCATGGTGCAGAAAAAACTGCGCGGCGAAATCGCGCGCAAATCC
CCGGCCCTCGAATCGCTCAAGCAGGTGCTCCATCTTGGCAAACTGCCCGAGCGGATCGAGTGCTTCGACAACTCGCATTT
CCAGGGCACCGATTACGTCAGCTCGATGGTCACTTTCGTATCGGGAAAACCGAAAAAATCGGACTACCGCAAGTTCAGGC
TCAAAAGTTTCGAAGGCTCGGACGACTACGCGGCCATGCGCGAAGCGGTCACCAGGCGCTACGGAGGCTCACTGGCGGGA
GAGCTGCCCCTGCCCGACCTGGTGCTGATCGACGGCGGCAAGGGGCAAGTGAACGTCGCCTGGCAAGTCTTGCAGGAGCT
TGGCCTTGACCTGCCTGTGGCGGGGCTGGCGAAACGGCTCGAAGAGATTTACGTGCCCAACGAGCCAGACCCGTACAACC
TTCCGAAAACCTCACCAGCCCTCAAGCTTTTGCAACAATTGCGTGACGAAGCACACCGCTTCGCCATCACCTACCACCGC
AAGCTCCGGAGCGACCGGACGATCCGAACGGAACTGACCGGCATCAAGGGAGTCGGCGAAAAAAGCGCCGAAAAGCTGCT
GAAGCACTTCGGCTCGGTAGAAAGCGTCTCGAAAGCTTCTATTGACGAGCTTTCCGCCGTAGCCGGAAGAAAAACCGCAG
AAAGCATTTACCGCTACTTCAACGCCGGAGACGCCCCCTGA

Upstream 100 bases:

>100_bases
AGTTCGGTTAAAGCAAAAAACCTCTGACTTGCACTGTTTGTGTTTTTTGTCGCCGGAAACTATCATAGAAAAACCGCAAC
GCAGATTCTCCGATTTCTTC

Downstream 100 bases:

>100_bases
AGCCTGAAAGAATGGCCCGGCCGGGCACTTTTTTTGAAAAAATCTGCTATATTGGTTTTGTTATTATGATCGTGAAATTT
GCACGAAAGAGAGTGTATGA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MSDTAAAPDKTAKSALAEKLATLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQGRQPGKTAVMVSHIADLNVII
TSSEVEALILENNLIKELKPRYNVNLKDDKSYPWLVITNERFPRIFLTRQVRRDGSLYFGPYTEASQLRLILDLIGSIFP
VRSCKYKLTEEAVASGRYRVCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALLRDLSAEMQKKAKELKFEEA
AALKAQIEGLKRYAERQKIVSTEAIDRDVFAVAAGEDDACGVVFRIREGKLIGSRHTYLSNTGNTPLPNLLASFVEHYYL
ETPDLIPQELMLQAELPEEELEALRQLLSSRQTERRQVRFTVPRIGEKAHLIAMCLDNAKHHLHEFMVQKKLRGEIARKS
PALESLKQVLHLGKLPERIECFDNSHFQGTDYVSSMVTFVSGKPKKSDYRKFRLKSFEGSDDYAAMREAVTRRYGGSLAG
ELPLPDLVLIDGGKGQVNVAWQVLQELGLDLPVAGLAKRLEEIYVPNEPDPYNLPKTSPALKLLQQLRDEAHRFAITYHR
KLRSDRTIRTELTGIKGVGEKSAEKLLKHFGSVESVSKASIDELSAVAGRKTAESIYRYFNAGDAP

Sequences:

>Translated_626_residues
MSDTAAAPDKTAKSALAEKLATLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQGRQPGKTAVMVSHIADLNVII
TSSEVEALILENNLIKELKPRYNVNLKDDKSYPWLVITNERFPRIFLTRQVRRDGSLYFGPYTEASQLRLILDLIGSIFP
VRSCKYKLTEEAVASGRYRVCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALLRDLSAEMQKKAKELKFEEA
AALKAQIEGLKRYAERQKIVSTEAIDRDVFAVAAGEDDACGVVFRIREGKLIGSRHTYLSNTGNTPLPNLLASFVEHYYL
ETPDLIPQELMLQAELPEEELEALRQLLSSRQTERRQVRFTVPRIGEKAHLIAMCLDNAKHHLHEFMVQKKLRGEIARKS
PALESLKQVLHLGKLPERIECFDNSHFQGTDYVSSMVTFVSGKPKKSDYRKFRLKSFEGSDDYAAMREAVTRRYGGSLAG
ELPLPDLVLIDGGKGQVNVAWQVLQELGLDLPVAGLAKRLEEIYVPNEPDPYNLPKTSPALKLLQQLRDEAHRFAITYHR
KLRSDRTIRTELTGIKGVGEKSAEKLLKHFGSVESVSKASIDELSAVAGRKTAESIYRYFNAGDAP
>Mature_625_residues
SDTAAAPDKTAKSALAEKLATLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQGRQPGKTAVMVSHIADLNVIIT
SSEVEALILENNLIKELKPRYNVNLKDDKSYPWLVITNERFPRIFLTRQVRRDGSLYFGPYTEASQLRLILDLIGSIFPV
RSCKYKLTEEAVASGRYRVCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALLRDLSAEMQKKAKELKFEEAA
ALKAQIEGLKRYAERQKIVSTEAIDRDVFAVAAGEDDACGVVFRIREGKLIGSRHTYLSNTGNTPLPNLLASFVEHYYLE
TPDLIPQELMLQAELPEEELEALRQLLSSRQTERRQVRFTVPRIGEKAHLIAMCLDNAKHHLHEFMVQKKLRGEIARKSP
ALESLKQVLHLGKLPERIECFDNSHFQGTDYVSSMVTFVSGKPKKSDYRKFRLKSFEGSDDYAAMREAVTRRYGGSLAGE
LPLPDLVLIDGGKGQVNVAWQVLQELGLDLPVAGLAKRLEEIYVPNEPDPYNLPKTSPALKLLQQLRDEAHRFAITYHRK
LRSDRTIRTELTGIKGVGEKSAEKLLKHFGSVESVSKASIDELSAVAGRKTAESIYRYFNAGDAP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=616, Percent_Identity=37.5, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788037, Length=197, Percent_Identity=29.4416243654822, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CHLTE (Q8KBI0)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662686.1
- ProteinModelPortal:   Q8KBI0
- GeneID:   1008197
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1807
- NMPDR:   fig|194439.1.peg.1780
- TIGR:   CT1807
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK14671
- BioCyc:   CTEP194439:CT_1807-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70342; Mature: 70210

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTAAAPDKTAKSALAEKLATLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQG
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHCC
RQPGKTAVMVSHIADLNVIITSSEVEALILENNLIKELKPRYNVNLKDDKSYPWLVITNE
CCCCCHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEECC
RFPRIFLTRQVRRDGSLYFGPYTEASQLRLILDLIGSIFPVRSCKYKLTEEAVASGRYRV
CCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
CLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALLRDLSAEMQKKAKELKFEEA
EEEEHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AALKAQIEGLKRYAERQKIVSTEAIDRDVFAVAAGEDDACGVVFRIREGKLIGSRHTYLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCEECCCCCEEC
NTGNTPLPNLLASFVEHYYLETPDLIPQELMLQAELPEEELEALRQLLSSRQTERRQVRF
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHEEE
TVPRIGEKAHLIAMCLDNAKHHLHEFMVQKKLRGEIARKSPALESLKQVLHLGKLPERIE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHH
CFDNSHFQGTDYVSSMVTFVSGKPKKSDYRKFRLKSFEGSDDYAAMREAVTRRYGGSLAG
HCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
ELPLPDLVLIDGGKGQVNVAWQVLQELGLDLPVAGLAKRLEEIYVPNEPDPYNLPKTSPA
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
LKLLQQLRDEAHRFAITYHRKLRSDRTIRTELTGIKGVGEKSAEKLLKHFGSVESVSKAS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHH
IDELSAVAGRKTAESIYRYFNAGDAP
HHHHHHHHCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDTAAAPDKTAKSALAEKLATLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHCC
RQPGKTAVMVSHIADLNVIITSSEVEALILENNLIKELKPRYNVNLKDDKSYPWLVITNE
CCCCCHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEECC
RFPRIFLTRQVRRDGSLYFGPYTEASQLRLILDLIGSIFPVRSCKYKLTEEAVASGRYRV
CCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
CLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALLRDLSAEMQKKAKELKFEEA
EEEEHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AALKAQIEGLKRYAERQKIVSTEAIDRDVFAVAAGEDDACGVVFRIREGKLIGSRHTYLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCEECCCCCEEC
NTGNTPLPNLLASFVEHYYLETPDLIPQELMLQAELPEEELEALRQLLSSRQTERRQVRF
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHEEE
TVPRIGEKAHLIAMCLDNAKHHLHEFMVQKKLRGEIARKSPALESLKQVLHLGKLPERIE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHH
CFDNSHFQGTDYVSSMVTFVSGKPKKSDYRKFRLKSFEGSDDYAAMREAVTRRYGGSLAG
HCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
ELPLPDLVLIDGGKGQVNVAWQVLQELGLDLPVAGLAKRLEEIYVPNEPDPYNLPKTSPA
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
LKLLQQLRDEAHRFAITYHRKLRSDRTIRTELTGIKGVGEKSAEKLLKHFGSVESVSKAS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHH
IDELSAVAGRKTAESIYRYFNAGDAP
HHHHHHHHCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901