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The map label for this gene is pyrH

Identifier: 21674593

GI number: 21674593

Start: 1685502

End: 1686221

Strand: Reverse

Name: pyrH

Synonym: CT1779

Alternate gene names: 21674593

Gene position: 1686221-1685502 (Counterclockwise)

Preceding gene: 21674594

Following gene: 21674590

Centisome position: 78.25

GC content: 56.11

Gene sequence:

>720_bases
ATGCGAAAATACCGGAGAATCCTGCTCAAGATCAGTGGCGAATCACTTGCTGGAGAGAGCGGATATGGCATCGATGCCGG
TGTTCTGGAAAGCTTTGCTGACGACATTAAGGAGGCCACTGATCTCGGTGCCGAAATTGCGCTGGTGATTGGCGGTGGCA
ATATTTTCCGGGGGCTTTCCGCGGCGGCTGCGTCGATGGATCGCGTGCAGGCCGATTACATGGGAATGCTCGCCACGGTT
ATCAACTCGCTGGCGCTCCAGGATGCGCTTGAGCGGAAAGGCATTTTCACCCGCCTTGTGACCGCGATCAAGATGGAGCA
GATCGCCGAGCCGTTCATCCGCCGCCGCGCCGTGCGTCACCTCGAAAAAGGGCGTGTCGTGATTTTTGGTGCCGGTACCG
GCAACCCCTATTTCACCACCGATACAGCCGCCTCGCTTCGCGCCATCGAGATCGAGGCCGACGTCATCGTCAAGGGCACC
AGAGTCGAAGGGGTTTACGATTCCGATCCCGAAAAGAATCCCAATGCGGAGTTCTTCCCCAAGATCTCCTACGTTGATGT
GATCCGCAAAAACCTCAGGGTGATGGATATGACCGCTATTACGCTCTGCCGAGAAAACACTCTGCCGATCGTGGTGATGA
ACATGAACATTAAGGGCAACTTCACTCGTCTGCTCAAGGGTGAACCGATTGGTACGCTGGTGCACGTGGGGGAAGAGTAG

Upstream 100 bases:

>100_bases
AACTGAAAAAAGCCTCGTTGACGCGAGGCTTTTTTTTGCTTATTTGAAAGTCCCGATCAGTTATGTCGCAAGAGTCAAAT
AGAAACAAGGAGAACCAGCC

Downstream 100 bases:

>100_bases
CTGATAAAATGGATCGTTGATCATTGAAGGGGGCGAGCTGGTTGGTTCGCCCTTTTGTTTTGGGGGCGTTTGCCAGATCA
GTCCAATTGGTCGGATCTGG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MRKYRRILLKISGESLAGESGYGIDAGVLESFADDIKEATDLGAEIALVIGGGNIFRGLSAAAASMDRVQADYMGMLATV
INSLALQDALERKGIFTRLVTAIKMEQIAEPFIRRRAVRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADVIVKGT
RVEGVYDSDPEKNPNAEFFPKISYVDVIRKNLRVMDMTAITLCRENTLPIVVMNMNIKGNFTRLLKGEPIGTLVHVGEE

Sequences:

>Translated_239_residues
MRKYRRILLKISGESLAGESGYGIDAGVLESFADDIKEATDLGAEIALVIGGGNIFRGLSAAAASMDRVQADYMGMLATV
INSLALQDALERKGIFTRLVTAIKMEQIAEPFIRRRAVRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADVIVKGT
RVEGVYDSDPEKNPNAEFFPKISYVDVIRKNLRVMDMTAITLCRENTLPIVVMNMNIKGNFTRLLKGEPIGTLVHVGEE
>Mature_239_residues
MRKYRRILLKISGESLAGESGYGIDAGVLESFADDIKEATDLGAEIALVIGGGNIFRGLSAAAASMDRVQADYMGMLATV
INSLALQDALERKGIFTRLVTAIKMEQIAEPFIRRRAVRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADVIVKGT
RVEGVYDSDPEKNPNAEFFPKISYVDVIRKNLRVMDMTAITLCRENTLPIVVMNMNIKGNFTRLLKGEPIGTLVHVGEE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=51.0822510822511, Blast_Score=247, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CHLTE (P59003)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662658.1
- ProteinModelPortal:   P59003
- SMR:   P59003
- GeneID:   1008150
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1779
- NMPDR:   fig|194439.1.peg.1752
- TIGR:   CT1779
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   CTEP194439:CT_1779-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26139; Mature: 26139

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKYRRILLKISGESLAGESGYGIDAGVLESFADDIKEATDLGAEIALVIGGGNIFRGLS
CCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
AAAASMDRVQADYMGMLATVINSLALQDALERKGIFTRLVTAIKMEQIAEPFIRRRAVRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADVIVKGTRVEGVYDSDPEKNPNAEFFP
HHCCCEEEEECCCCCCEEEECCCCCEEEEEEEEEEEEECCEECCCCCCCCCCCCCCCCCC
KISYVDVIRKNLRVMDMTAITLCRENTLPIVVMNMNIKGNFTRLLKGEPIGTLVHVGEE
CHHHHHHHHHCCEEHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEECCC
>Mature Secondary Structure
MRKYRRILLKISGESLAGESGYGIDAGVLESFADDIKEATDLGAEIALVIGGGNIFRGLS
CCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
AAAASMDRVQADYMGMLATVINSLALQDALERKGIFTRLVTAIKMEQIAEPFIRRRAVRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADVIVKGTRVEGVYDSDPEKNPNAEFFP
HHCCCEEEEECCCCCCEEEECCCCCEEEEEEEEEEEEECCEECCCCCCCCCCCCCCCCCC
KISYVDVIRKNLRVMDMTAITLCRENTLPIVVMNMNIKGNFTRLLKGEPIGTLVHVGEE
CHHHHHHHHHCCEEHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901