Click here to switch to the map view.

The map label for this gene is frr

Identifier: 21674395

GI number: 21674395

Start: 1487415

End: 1487975

Strand: Direct

Name: frr

Synonym: CT1577

Alternate gene names: 21674395

Gene position: 1487415-1487975 (Clockwise)

Preceding gene: 21674394

Following gene: 21674396

Centisome position: 69.02

GC content: 58.47

Gene sequence:

>561_bases
ATGACTGTCAGGGACGTTATCCAGAAAATCGAGCCTCGCATGAAGAAAACCATCGAGGCCTTCCAGCACGAACTCGCCTC
GATCAGAACCGGCAAGGCCACCACGGCACTGCTCGACCGGGTGAAGGTGGAGGCTTATGGATCGCAGATGCCGCTCAAGC
AGGTCGGCAACGTCGGCGTGCTCGATGCTCACACCCTCACCGTGCAGGTCTGGGACAAGTCGATGGTTGGCGCAACCGAA
CGCGCGATCCGTGACGCCGGTCTCGGTCTGAACCCTTCAGCCGACGGCCAGAACATCCGCATCAGCATTCCGCCGCTCAC
CGAGGAGCGCCGCAAGGAGTTCGTGAAGCTGACCAAGAAGTTCGGTGAGGATTCCAAAGTCTCGCTGCGCAACCACCGCC
GCGACCTGATCCATGAGGTCGAGAAGCTCGAAAAGGAGAAGCTGATCAGCGAGGATGAGTTGAAACGCGGCAAGAAGGAC
GCGGACGACCTGCTGCACAAATACGAGAAGCAGATCACCGAACTGATCGCCCAGAAAGAAAAGGAGATCATGGAGGTCTG
A

Upstream 100 bases:

>100_bases
CGCTGGCCGCGTCGATCGCTTCAACAAGCGCTTCGCCAAAGCTGCTCCCAAAGCCAGCGCCCAGTAAGCGATTGCCTGAA
ACAATCAATCCGATACTGCC

Downstream 100 bases:

>100_bases
CAGCAGAACTCAGCACAGATTCAGCAAAAGCCGGAAATTCCCGGCTTTTCGCGTTTGTGCGCGGATAGATTGAAAAGGCA
ATCTGACACCCAAATCGGCG

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTVRDVIQKIEPRMKKTIEAFQHELASIRTGKATTALLDRVKVEAYGSQMPLKQVGNVGVLDAHTLTVQVWDKSMVGATE
RAIRDAGLGLNPSADGQNIRISIPPLTEERRKEFVKLTKKFGEDSKVSLRNHRRDLIHEVEKLEKEKLISEDELKRGKKD
ADDLLHKYEKQITELIAQKEKEIMEV

Sequences:

>Translated_186_residues
MTVRDVIQKIEPRMKKTIEAFQHELASIRTGKATTALLDRVKVEAYGSQMPLKQVGNVGVLDAHTLTVQVWDKSMVGATE
RAIRDAGLGLNPSADGQNIRISIPPLTEERRKEFVKLTKKFGEDSKVSLRNHRRDLIHEVEKLEKEKLISEDELKRGKKD
ADDLLHKYEKQITELIAQKEKEIMEV
>Mature_185_residues
TVRDVIQKIEPRMKKTIEAFQHELASIRTGKATTALLDRVKVEAYGSQMPLKQVGNVGVLDAHTLTVQVWDKSMVGATER
AIRDAGLGLNPSADGQNIRISIPPLTEERRKEFVKLTKKFGEDSKVSLRNHRRDLIHEVEKLEKEKLISEDELKRGKKDA
DDLLHKYEKQITELIAQKEKEIMEV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786368, Length=183, Percent_Identity=43.1693989071038, Blast_Score=157, Evalue=6e-40,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_CHLTE (Q8KC49)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662460.1
- ProteinModelPortal:   Q8KC49
- SMR:   Q8KC49
- GeneID:   1006089
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1577
- NMPDR:   fig|194439.1.peg.1554
- TIGR:   CT1577
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- BioCyc:   CTEP194439:CT_1577-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 21223; Mature: 21092

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRDVIQKIEPRMKKTIEAFQHELASIRTGKATTALLDRVKVEAYGSQMPLKQVGNVGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
LDAHTLTVQVWDKSMVGATERAIRDAGLGLNPSADGQNIRISIPPLTEERRKEFVKLTKK
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
FGEDSKVSLRNHRRDLIHEVEKLEKEKLISEDELKRGKKDADDLLHKYEKQITELIAQKE
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KEIMEV
HHHHCC
>Mature Secondary Structure 
TVRDVIQKIEPRMKKTIEAFQHELASIRTGKATTALLDRVKVEAYGSQMPLKQVGNVGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
LDAHTLTVQVWDKSMVGATERAIRDAGLGLNPSADGQNIRISIPPLTEERRKEFVKLTKK
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
FGEDSKVSLRNHRRDLIHEVEKLEKEKLISEDELKRGKKDADDLLHKYEKQITELIAQKE
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KEIMEV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901