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The map label for this gene is clpP

Identifier: 21674371

GI number: 21674371

Start: 1463111

End: 1463788

Strand: Reverse

Name: clpP

Synonym: CT1553

Alternate gene names: 21674371

Gene position: 1463788-1463111 (Counterclockwise)

Preceding gene: 21674373

Following gene: 21674370

Centisome position: 67.93

GC content: 57.96

Gene sequence:

>678_bases
ATGGCAAATATCAATTTCGGTTTCGACCATCACGCAAAAAAACTCTACTCCGGAGCGATTGAAAACAGCATCAACAGCCA
GCTCGTGCCGATGGTCATCGAGACCTCGGGACGCGGCGAGCGTGCGTTCGATATCTTTTCCCGTCTGCTCAGGGAGCGCA
TCATTTTTCTCGGCTCTCCCATCGACGAGCATGTGGCCGGTCTGATCATTGCGCAGCTCATCTTCCTCGAATCGGAAGAC
CCGGAGCGCGACATCTACATCTACATCAACTCACCCGGCGGCAGCGTTTCGGCAGGGCTCGGCATCTACGATACGATGCA
GTACATCCGCCCGGATATTTCGACGGTGTGCGTCGGCATGGCAGCCAGCATGGGCGCGTTCCTGCTCGCCAGCGGCACCT
CGGGCAAGCGGGCTTCGCTTCCGCACTCGCGCATCATGATCCACCAGCCTTCGGGCGGCGCACAGGGCCAGGAGACCGAC
ATCCTCATTCAGGCCCGCGAGATAGAAAAGATCCGCCACCTGCTCGAAGATCTGCTTGCAAAGCATACCGGTCAGGAGGT
ATCGAGAATCCGCGAAGATTCCGAGCGTGACCGCTGGATGAGCGCCGTAGAGGCGAAGGAGTACGGCTTGATCGACCAGA
TTTTCGAGAAACGTCCGGCTCCTAAAAGTGAGGAGTGA

Upstream 100 bases:

>100_bases
TTGAAATCTTGTTCCGTCTCTGTATTTTAGGTGTTTATTGCACCACTCTGCGGAATTTGAGCGTATATTTCGCCGGGCAA
CAACAAAAAAGTTCAGGCAC

Downstream 100 bases:

>100_bases
CGCAGGCCGGGCAGATCGGGAAATAACGATTTTCAGACGCCTCCTCACAGGGGGGCGTCTGTAATTTTCAACCTTGCTTT
GAATCAGACTCATGAGTGAC

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MANINFGFDHHAKKLYSGAIENSINSQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSPIDEHVAGLIIAQLIFLESED
PERDIYIYINSPGGSVSAGLGIYDTMQYIRPDISTVCVGMAASMGAFLLASGTSGKRASLPHSRIMIHQPSGGAQGQETD
ILIQAREIEKIRHLLEDLLAKHTGQEVSRIREDSERDRWMSAVEAKEYGLIDQIFEKRPAPKSEE

Sequences:

>Translated_225_residues
MANINFGFDHHAKKLYSGAIENSINSQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSPIDEHVAGLIIAQLIFLESED
PERDIYIYINSPGGSVSAGLGIYDTMQYIRPDISTVCVGMAASMGAFLLASGTSGKRASLPHSRIMIHQPSGGAQGQETD
ILIQAREIEKIRHLLEDLLAKHTGQEVSRIREDSERDRWMSAVEAKEYGLIDQIFEKRPAPKSEE
>Mature_224_residues
ANINFGFDHHAKKLYSGAIENSINSQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSPIDEHVAGLIIAQLIFLESEDP
ERDIYIYINSPGGSVSAGLGIYDTMQYIRPDISTVCVGMAASMGAFLLASGTSGKRASLPHSRIMIHQPSGGAQGQETDI
LIQAREIEKIRHLLEDLLAKHTGQEVSRIREDSERDRWMSAVEAKEYGLIDQIFEKRPAPKSEE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=60.4166666666667, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI1786641, Length=204, Percent_Identity=60.2941176470588, Blast_Score=268, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=51.8134715025907, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI20129427, Length=209, Percent_Identity=54.5454545454545, Blast_Score=232, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_CHLTE (Q8KC73)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662436.1
- ProteinModelPortal:   Q8KC73
- SMR:   Q8KC73
- MEROPS:   S14.001
- GeneID:   1006078
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1553
- NMPDR:   fig|194439.1.peg.1530
- TIGR:   CT1553
- HOGENOM:   HBG558421
- OMA:   QHSRIMI
- ProtClustDB:   CLSK637818
- BioCyc:   CTEP194439:CT_1553-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 24999; Mature: 24868

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 123-123 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINFGFDHHAKKLYSGAIENSINSQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSP
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIIAQLIFLESEDPERDIYIYINSPGGSVSAGLGIYDTMQYIRPDISTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
AASMGAFLLASGTSGKRASLPHSRIMIHQPSGGAQGQETDILIQAREIEKIRHLLEDLLA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
KHTGQEVSRIREDSERDRWMSAVEAKEYGLIDQIFEKRPAPKSEE
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ANINFGFDHHAKKLYSGAIENSINSQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSP
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIIAQLIFLESEDPERDIYIYINSPGGSVSAGLGIYDTMQYIRPDISTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
AASMGAFLLASGTSGKRASLPHSRIMIHQPSGGAQGQETDILIQAREIEKIRHLLEDLLA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
KHTGQEVSRIREDSERDRWMSAVEAKEYGLIDQIFEKRPAPKSEE
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901