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The map label for this gene is uvrB

Identifier: 21674365

GI number: 21674365

Start: 1451866

End: 1453920

Strand: Reverse

Name: uvrB

Synonym: CT1546

Alternate gene names: 21674365

Gene position: 1453920-1451866 (Counterclockwise)

Preceding gene: 21674366

Following gene: 21674364

Centisome position: 67.47

GC content: 61.7

Gene sequence:

>2055_bases
ATGCGGAATGTTGTGCATCGGGGAGGAGAGTTCAAACTTGAAAGTCCGTACGGGCCGACGGGGGATCAGCCCTCGGCCAT
CAAGGCGCTGACCGATGGGGTGCTGCGAGGCGACCGATGGCAGACGCTGCTCGGCGTGACCGGATCGGGCAAGACCTTCA
CGGTCTCGAACGTCATCGCCCAGGTCAACCGTCCGACGCTCGTGCTGAGCCACAACAAGACCCTTGCTGCGCAGCTTTAT
GGCGAGCTGAAGCAGTTCTTTCCGCACAACGCGGTGGAATACTTCATCAGCTACTACGATTTTTACCAGCCAGAGGCGTA
TATCCCGTCGTTGGACAAGTACATTGCCAAGGACCTCAAGATCAACGACGAAATCGAGCGGCTCCGGCTGCGGGCGACCA
GCGCGTTGCTCAGTGGGCGGAACGACGTGATCGTGGTCAGCTCGGTGAGCTGCATCTACGGTCTCGGTTCACCGGAGGAC
TGGATGGCGCAGATCGTCGAGCTGCGGCAGGGCATGGAGCTGGATCGCGACGAGTTTCTGCAAAGGCTGGTGGCGCTGCA
CTATTTCCGTGACGACGTCGATCTCTCGCCGGGGCGCTTCCGCGTGCGCGGCGACGTGATCGACCTGGTGCCGGGTCACG
AAGAGCTGGCGCTGCGCATCGAATTTTTCGGCAGCGAGATCGACTCCATCCACACCTTCGACCCCAAGAGCGGCGAGATC
ATCGGGCGCGATGAGTACGCCTTCATCTATCCGGCGCGTCAGTTCGTGGCCGACAGCGAAAAGCTGGAGGTGGCGATGCT
CGCCATCGAGAACGAGCTGGCGGAGCGGCTGAACGCCCTTCGCGCCGAAGAGAAGCTGGTCGAGGCGCAGCGGCTTGAAG
AGCGCACGCGCTACGATCTCGAAATGATGAAGGAGCTTGGTTACTGCTCCGGCATCGAGAACTACGCCCGCCACATTGCC
GGACGCAAGCCGGGCGAGCGACCGTGGTGCCTGCTTGACTACTTCCCGGAAGACTTTCTCGTTGTGGTCGATGAGTCCCA
CGTTACTCTGCCGCAGATTCGCGGCATGTATGGCGGCGACCGGTCGCGCAAGACGGTGCTCGTTGAGCACGGTTTCCGGC
TGCCCTCGGCGCTCGACAACCGTCCTCTGCGCTTTGAGGAGTTCGAGGAGATGGTGCCGCAGGTGATCTGCGTTTCGGCA
ACCCCCTCCGCCCACGAGCTGATGCGCTCCGGCGGCGTGGTGGTCGAGCAGCTCATCCGCCCCACAGGCCTGCTCGATCC
GCAAATCGAGGTGCACCCCGTTGCCGGCCAGATCGATCACCTGCTGGCGCGAATCCGGGAGCGCATCGCCAAGGGGCAGA
AGTCGCTGGTGCTGACGCTGACCAAGCGCATGTCCGAAGACCTGCACGCCTACTTTCGCAAGCTGGGTCTGCGCTCGCAG
TATCTGCACTCCGAAATCAAGAGCCTCGAACGGATGCAGATTCTGCGCGAACTACGCGCAGGCGACATCGAAGTGCTGGT
CGGCGTCAACCTGCTGCGTGAGGGGCTCGACCTGCCGGAGGTGGCGCTGGTGGCGATTCTCGACGCCGACAAGGAGGGGT
TTTTGCGTGACGCAACATCGCTCATGCAGATCGCCGGACGTGCGGCGCGAAACGTCGAGGGGCTGGTGCTTTTTTACGCC
GACAAGATCACCGATTCGATGCGCGAGGTGCTCGATGAAACCGAGCGCCGCCGCCGCATCCAGCGGGAGTACAACGAAAA
GCACGGCATCGAGCCGCGTTCCATCATCAAGTCGGTCGATCAGGTGCTCAACACCACCAGCGTGGCGGACGCCGAAGAGC
GTTATCGCCGCAAGCGTCTCGGATTGCAGAAGCGCCCTGAACTCGAGCTGCGCGGTGTGCTCGACAGCATGAGCCGCAGC
GATGTGATGCTGATGGTGGCGGAGATGAACGCTGAGATGCAGAAGGCTGCCGAACAGACCGATTACGAAAAAGCGGCCTA
CCTGCGTGACGAAATTCTGATGCTTCAAGAGCGAATCGAGCAGATGACAGAGTAA

Upstream 100 bases:

>100_bases
AACCGGTCTTGACACATCGTGTCTGAGGCTTGAAGAACTATAAGCAGGCGTTATTAGTTCTTTGTGAGGTATTTGTCATC
GTTATCATCGAGAGTTGTCT

Downstream 100 bases:

>100_bases
AAAGTATTGACCTGAAGCCTCGATTTCATATCATAATAATAGTATAGAAAATCAGGCGATAACAACTCTTTATTACGGAG
AGGCTTACCTCCATGCTGGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MRNVVHRGGEFKLESPYGPTGDQPSAIKALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQVNRPTLVLSHNKTLAAQLY
GELKQFFPHNAVEYFISYYDFYQPEAYIPSLDKYIAKDLKINDEIERLRLRATSALLSGRNDVIVVSSVSCIYGLGSPED
WMAQIVELRQGMELDRDEFLQRLVALHYFRDDVDLSPGRFRVRGDVIDLVPGHEELALRIEFFGSEIDSIHTFDPKSGEI
IGRDEYAFIYPARQFVADSEKLEVAMLAIENELAERLNALRAEEKLVEAQRLEERTRYDLEMMKELGYCSGIENYARHIA
GRKPGERPWCLLDYFPEDFLVVVDESHVTLPQIRGMYGGDRSRKTVLVEHGFRLPSALDNRPLRFEEFEEMVPQVICVSA
TPSAHELMRSGGVVVEQLIRPTGLLDPQIEVHPVAGQIDHLLARIRERIAKGQKSLVLTLTKRMSEDLHAYFRKLGLRSQ
YLHSEIKSLERMQILRELRAGDIEVLVGVNLLREGLDLPEVALVAILDADKEGFLRDATSLMQIAGRAARNVEGLVLFYA
DKITDSMREVLDETERRRRIQREYNEKHGIEPRSIIKSVDQVLNTTSVADAEERYRRKRLGLQKRPELELRGVLDSMSRS
DVMLMVAEMNAEMQKAAEQTDYEKAAYLRDEILMLQERIEQMTE

Sequences:

>Translated_684_residues
MRNVVHRGGEFKLESPYGPTGDQPSAIKALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQVNRPTLVLSHNKTLAAQLY
GELKQFFPHNAVEYFISYYDFYQPEAYIPSLDKYIAKDLKINDEIERLRLRATSALLSGRNDVIVVSSVSCIYGLGSPED
WMAQIVELRQGMELDRDEFLQRLVALHYFRDDVDLSPGRFRVRGDVIDLVPGHEELALRIEFFGSEIDSIHTFDPKSGEI
IGRDEYAFIYPARQFVADSEKLEVAMLAIENELAERLNALRAEEKLVEAQRLEERTRYDLEMMKELGYCSGIENYARHIA
GRKPGERPWCLLDYFPEDFLVVVDESHVTLPQIRGMYGGDRSRKTVLVEHGFRLPSALDNRPLRFEEFEEMVPQVICVSA
TPSAHELMRSGGVVVEQLIRPTGLLDPQIEVHPVAGQIDHLLARIRERIAKGQKSLVLTLTKRMSEDLHAYFRKLGLRSQ
YLHSEIKSLERMQILRELRAGDIEVLVGVNLLREGLDLPEVALVAILDADKEGFLRDATSLMQIAGRAARNVEGLVLFYA
DKITDSMREVLDETERRRRIQREYNEKHGIEPRSIIKSVDQVLNTTSVADAEERYRRKRLGLQKRPELELRGVLDSMSRS
DVMLMVAEMNAEMQKAAEQTDYEKAAYLRDEILMLQERIEQMTE
>Mature_684_residues
MRNVVHRGGEFKLESPYGPTGDQPSAIKALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQVNRPTLVLSHNKTLAAQLY
GELKQFFPHNAVEYFISYYDFYQPEAYIPSLDKYIAKDLKINDEIERLRLRATSALLSGRNDVIVVSSVSCIYGLGSPED
WMAQIVELRQGMELDRDEFLQRLVALHYFRDDVDLSPGRFRVRGDVIDLVPGHEELALRIEFFGSEIDSIHTFDPKSGEI
IGRDEYAFIYPARQFVADSEKLEVAMLAIENELAERLNALRAEEKLVEAQRLEERTRYDLEMMKELGYCSGIENYARHIA
GRKPGERPWCLLDYFPEDFLVVVDESHVTLPQIRGMYGGDRSRKTVLVEHGFRLPSALDNRPLRFEEFEEMVPQVICVSA
TPSAHELMRSGGVVVEQLIRPTGLLDPQIEVHPVAGQIDHLLARIRERIAKGQKSLVLTLTKRMSEDLHAYFRKLGLRSQ
YLHSEIKSLERMQILRELRAGDIEVLVGVNLLREGLDLPEVALVAILDADKEGFLRDATSLMQIAGRAARNVEGLVLFYA
DKITDSMREVLDETERRRRIQREYNEKHGIEPRSIIKSVDQVLNTTSVADAEERYRRKRLGLQKRPELELRGVLDSMSRS
DVMLMVAEMNAEMQKAAEQTDYEKAAYLRDEILMLQERIEQMTE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=669, Percent_Identity=54.8579970104634, Blast_Score=704, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=229, Percent_Identity=24.4541484716157, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CHLTE (Q8KC79)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662430.1
- ProteinModelPortal:   Q8KC79
- SMR:   Q8KC79
- GeneID:   1006906
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1546
- NMPDR:   fig|194439.1.peg.1524
- TIGR:   CT1546
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   CTEP194439:CT_1546-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 78186; Mature: 78186

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNVVHRGGEFKLESPYGPTGDQPSAIKALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIA
CCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHEEEEECCCCCEEEHHHHHH
QVNRPTLVLSHNKTLAAQLYGELKQFFPHNAVEYFISYYDFYQPEAYIPSLDKYIAKDLK
HCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
INDEIERLRLRATSALLSGRNDVIVVSSVSCIYGLGSPEDWMAQIVELRQGMELDRDEFL
CCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHH
QRLVALHYFRDDVDLSPGRFRVRGDVIDLVPGHEELALRIEFFGSEIDSIHTFDPKSGEI
HHHHHHHHHHCCCCCCCCCEEEECCEEEECCCCHHHEEEEEECCCCCCCCCCCCCCCCCE
IGRDEYAFIYPARQFVADSEKLEVAMLAIENELAERLNALRAEEKLVEAQRLEERTRYDL
ECCCCEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMMKELGYCSGIENYARHIAGRKPGERPWCLLDYFPEDFLVVVDESHVTLPQIRGMYGGD
HHHHHCHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCC
RSRKTVLVEHGFRLPSALDNRPLRFEEFEEMVPQVICVSATPSAHELMRSGGVVVEQLIR
CCCCEEEEECCCCCCHHCCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHCCCHHHHHHHC
PTGLLDPQIEVHPVAGQIDHLLARIRERIAKGQKSLVLTLTKRMSEDLHAYFRKLGLRSQ
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
YLHSEIKSLERMQILRELRAGDIEVLVGVNLLREGLDLPEVALVAILDADKEGFLRDATS
HHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCHHHHHHEECCCCCHHHHHHHH
LMQIAGRAARNVEGLVLFYADKITDSMREVLDETERRRRIQREYNEKHGIEPRSIIKSVD
HHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QVLNTTSVADAEERYRRKRLGLQKRPELELRGVLDSMSRSDVMLMVAEMNAEMQKAAEQT
HHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHCHHHHHHHHHC
DYEKAAYLRDEILMLQERIEQMTE
CHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRNVVHRGGEFKLESPYGPTGDQPSAIKALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIA
CCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHEEEEECCCCCEEEHHHHHH
QVNRPTLVLSHNKTLAAQLYGELKQFFPHNAVEYFISYYDFYQPEAYIPSLDKYIAKDLK
HCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
INDEIERLRLRATSALLSGRNDVIVVSSVSCIYGLGSPEDWMAQIVELRQGMELDRDEFL
CCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHH
QRLVALHYFRDDVDLSPGRFRVRGDVIDLVPGHEELALRIEFFGSEIDSIHTFDPKSGEI
HHHHHHHHHHCCCCCCCCCEEEECCEEEECCCCHHHEEEEEECCCCCCCCCCCCCCCCCE
IGRDEYAFIYPARQFVADSEKLEVAMLAIENELAERLNALRAEEKLVEAQRLEERTRYDL
ECCCCEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMMKELGYCSGIENYARHIAGRKPGERPWCLLDYFPEDFLVVVDESHVTLPQIRGMYGGD
HHHHHCHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCC
RSRKTVLVEHGFRLPSALDNRPLRFEEFEEMVPQVICVSATPSAHELMRSGGVVVEQLIR
CCCCEEEEECCCCCCHHCCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHCCCHHHHHHHC
PTGLLDPQIEVHPVAGQIDHLLARIRERIAKGQKSLVLTLTKRMSEDLHAYFRKLGLRSQ
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
YLHSEIKSLERMQILRELRAGDIEVLVGVNLLREGLDLPEVALVAILDADKEGFLRDATS
HHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCHHHHHHEECCCCCHHHHHHHH
LMQIAGRAARNVEGLVLFYADKITDSMREVLDETERRRRIQREYNEKHGIEPRSIIKSVD
HHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QVLNTTSVADAEERYRRKRLGLQKRPELELRGVLDSMSRSDVMLMVAEMNAEMQKAAEQT
HHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHCHHHHHHHHHC
DYEKAAYLRDEILMLQERIEQMTE
CHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901