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The map label for this gene is gpt [H]

Identifier: 21674347

GI number: 21674347

Start: 1431037

End: 1431567

Strand: Direct

Name: gpt [H]

Synonym: CT1527

Alternate gene names: 21674347

Gene position: 1431037-1431567 (Clockwise)

Preceding gene: 21674346

Following gene: 21674348

Centisome position: 66.41

GC content: 60.45

Gene sequence:

>531_bases
ATGATCGAGAACGTGCCGTTCACCGAGCTGATCTCCGCCGAGCGCATCGCGGCTCGTGTCGCCGAGCTGGGCGCAGAAAT
TTCACGCGACCTGGCCGGTATCGACGAGCTGACTGTGGTGTGCGTGCTGAAAGGCGGATTCATTTTCACAGCCGATCTGG
TGCGGCACATCACCATTCCCTGCCGCATCGAGTTCATCCGCGCTTCGAGTTACGGCACGCACCGCGCCTCCACAGGCAAG
GTGATGCTCGATCATCACCACGATCCGCATGTCGAGGGCAAGAACGTGCTGCTCGTCGAAGATATCCTCGATACCGGGCT
GACCATCACCCGCGTCCTCGAAGAGCTGCGCGGCCACAATCCTGCATCCCTGCATGTCTGCACCCTGCTCGACAAGCCTT
CAGCGCGCACCACACCCGTCAAGGCGGACTTCACCGGCTTCACCATTCCGGATGTTTACGTCGTGGGTTATGGACTCGAT
GCCGCCGGAAAGCATCGCGAGTTGCCTTACGTCGCATCACTGAACGCCTGA

Upstream 100 bases:

>100_bases
GCGCGGAAAAAGTGCAAAAACTCGCTCGATACTACAACAACGTCGCGCCATTCTTCGACCTGCCATCGGTGCCGCCCGTG
CTGCTGGGCAAAGAGAAAAC

Downstream 100 bases:

>100_bases
AGCCCTCTCCACCGCTCTCTCCAGGAGAACCCTCCATGCCCTTCGATCCTTGCGCCGCACCTTCTCTTCACCGGCACATA
CCGTCACCATACTACCATAA

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MIENVPFTELISAERIAARVAELGAEISRDLAGIDELTVVCVLKGGFIFTADLVRHITIPCRIEFIRASSYGTHRASTGK
VMLDHHHDPHVEGKNVLLVEDILDTGLTITRVLEELRGHNPASLHVCTLLDKPSARTTPVKADFTGFTIPDVYVVGYGLD
AAGKHRELPYVASLNA

Sequences:

>Translated_176_residues
MIENVPFTELISAERIAARVAELGAEISRDLAGIDELTVVCVLKGGFIFTADLVRHITIPCRIEFIRASSYGTHRASTGK
VMLDHHHDPHVEGKNVLLVEDILDTGLTITRVLEELRGHNPASLHVCTLLDKPSARTTPVKADFTGFTIPDVYVVGYGLD
AAGKHRELPYVASLNA
>Mature_176_residues
MIENVPFTELISAERIAARVAELGAEISRDLAGIDELTVVCVLKGGFIFTADLVRHITIPCRIEFIRASSYGTHRASTGK
VMLDHHHDPHVEGKNVLLVEDILDTGLTITRVLEELRGHNPASLHVCTLLDKPSARTTPVKADFTGFTIPDVYVVGYGLD
AAGKHRELPYVASLNA

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=170, Percent_Identity=38.2352941176471, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI9910262, Length=170, Percent_Identity=34.7058823529412, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=43.3734939759036, Blast_Score=143, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17510817, Length=165, Percent_Identity=33.9393939393939, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19193; Mature: 19193

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENVPFTELISAERIAARVAELGAEISRDLAGIDELTVVCVLKGGFIFTADLVRHITIP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCEEEEEHHHHHCCCC
CRIEFIRASSYGTHRASTGKVMLDHHHDPHVEGKNVLLVEDILDTGLTITRVLEELRGHN
EEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHCCC
PASLHVCTLLDKPSARTTPVKADFTGFTIPDVYVVGYGLDAAGKHRELPYVASLNA
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MIENVPFTELISAERIAARVAELGAEISRDLAGIDELTVVCVLKGGFIFTADLVRHITIP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCEEEEEHHHHHCCCC
CRIEFIRASSYGTHRASTGKVMLDHHHDPHVEGKNVLLVEDILDTGLTITRVLEELRGHN
EEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHCCC
PASLHVCTLLDKPSARTTPVKADFTGFTIPDVYVVGYGLDAAGKHRELPYVASLNA
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756169 [H]