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The map label for this gene is menA [H]

Identifier: 21674331

GI number: 21674331

Start: 1417832

End: 1418755

Strand: Reverse

Name: menA [H]

Synonym: CT1511

Alternate gene names: 21674331

Gene position: 1418755-1417832 (Counterclockwise)

Preceding gene: 21674332

Following gene: 21674330

Centisome position: 65.84

GC content: 59.42

Gene sequence:

>924_bases
ATGTCCGTTTCAAGTTCATCACAGCTGTCGGCGTTTCAGGCATGGATGCTGGCTATCCGCCCGAAAACGCTTCCAGCGGG
AGCAATGCCTGTCGTGATCGGTGCGGCTCTCGCTGCAGCCAGTGGTGTATTCAAGCCGCTTCCGGCGCTGGTTGCGCTGA
TCTGCGCGCTCGGTATCCAGATCGCCACCAACTTCATCAACGAAATTTACGACTTTCGCAAGGGCGCAGACACCGCCGAG
CGGCTTGGCCCGACGCGCACAGTTGCTGCCGGAATCATCACCGAACAGACGATGATTCGCGTCTCGATCGTACTCGGTGT
TTCGGTGTTCGTGCTTGGCTTGTATCTCGTCGCCATCGGCGGCTGGCCGATTTTGCTGATTGGCGTGCTCTCGCTGCTCT
TCGCCTGGGCTTACACCGGCGGACCGTTTCCGATCGCCTATTCCGGGCTTGGCGATGTGTTCGTCTTCATCTTTTTCGGC
CTCGTGGCGGTCGGCGGCACCTATTATGTTCAGGCGCTTTCGCTGCCGATGGAGGTACTCGTTGCCGCAGCCGCGCCCGG
CGCGTTCTCGGTCTGCATCCTGCTCGTCAACAATATCCGCGACATCGACACCGACCGGAAGGTTGGCAAGATGACGCTTC
CGGCCCGCATTGGCGCTCCGGCGGCCCGCGCTTTGTACGTCGCGCTTGTGGTGCTGGCCTATCTCGTTCCGTTTTATATG
ATTAGCACCGGTTATTCGCTCTGGTGCCTTCTGAGTCTGCTGAGCATTCCGCTCGCCATCGGCATGGTGCGCACGCTCTA
CGCTTCCGAGGGCCAGGCGCTGAATGCGGTGCTGGCTGGCACCGGCAAGGTGCTTACCGTGCACGGCTTACTCTTTTCGC
TCGGGCTTGTCATTCCCAATATCATTTCGATTTTTCGTCCATGA

Upstream 100 bases:

>100_bases
GGCGAGAAAATTCGTAATGTCTTCAGCAGCGTCAAGATGGCCAAGGAGAAGAAGGCCGCCGAGGCGGGCAACGCGACGGA
GAACAAGGCAGAGTAAGTGT

Downstream 100 bases:

>100_bases
ATACCGATCAGGTTCGCATAGCGCTCGTCCAGATGAGCTGCGTTGAGAATCCGCAGGAAAACCTCAGGAAAGCGCAGGAG
CGCATCCGCCAGGCTGCCGC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSVSSSSQLSAFQAWMLAIRPKTLPAGAMPVVIGAALAAASGVFKPLPALVALICALGIQIATNFINEIYDFRKGADTAE
RLGPTRTVAAGIITEQTMIRVSIVLGVSVFVLGLYLVAIGGWPILLIGVLSLLFAWAYTGGPFPIAYSGLGDVFVFIFFG
LVAVGGTYYVQALSLPMEVLVAAAAPGAFSVCILLVNNIRDIDTDRKVGKMTLPARIGAPAARALYVALVVLAYLVPFYM
ISTGYSLWCLLSLLSIPLAIGMVRTLYASEGQALNAVLAGTGKVLTVHGLLFSLGLVIPNIISIFRP

Sequences:

>Translated_307_residues
MSVSSSSQLSAFQAWMLAIRPKTLPAGAMPVVIGAALAAASGVFKPLPALVALICALGIQIATNFINEIYDFRKGADTAE
RLGPTRTVAAGIITEQTMIRVSIVLGVSVFVLGLYLVAIGGWPILLIGVLSLLFAWAYTGGPFPIAYSGLGDVFVFIFFG
LVAVGGTYYVQALSLPMEVLVAAAAPGAFSVCILLVNNIRDIDTDRKVGKMTLPARIGAPAARALYVALVVLAYLVPFYM
ISTGYSLWCLLSLLSIPLAIGMVRTLYASEGQALNAVLAGTGKVLTVHGLLFSLGLVIPNIISIFRP
>Mature_306_residues
SVSSSSQLSAFQAWMLAIRPKTLPAGAMPVVIGAALAAASGVFKPLPALVALICALGIQIATNFINEIYDFRKGADTAER
LGPTRTVAAGIITEQTMIRVSIVLGVSVFVLGLYLVAIGGWPILLIGVLSLLFAWAYTGGPFPIAYSGLGDVFVFIFFGL
VAVGGTYYVQALSLPMEVLVAAAAPGAFSVCILLVNNIRDIDTDRKVGKMTLPARIGAPAARALYVALVVLAYLVPFYMI
STGYSLWCLLSLLSIPLAIGMVRTLYASEGQALNAVLAGTGKVLTVHGLLFSLGLVIPNIISIFRP

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=293, Percent_Identity=32.7645051194539, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1790365, Length=305, Percent_Identity=38.0327868852459, Blast_Score=178, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17737429, Length=295, Percent_Identity=29.4915254237288, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32223; Mature: 32092

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCC
>Mature Secondary Structure 
SVSSSSQLSAFQAWMLAIRPKTLPAGAMPVVIGAALAAASGVFKPLPALVALICALGIQ
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH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HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]