Click here to switch to the map view.

The map label for this gene is hemD

Identifier: 21674249

GI number: 21674249

Start: 1340786

End: 1341526

Strand: Direct

Name: hemD

Synonym: CT1428

Alternate gene names: 21674249

Gene position: 1340786-1341526 (Clockwise)

Preceding gene: 21674248

Following gene: 21674252

Centisome position: 62.22

GC content: 56.28

Gene sequence:

>741_bases
ATGAAAACCGTTCTCGTTACACGCCCGAAGCATCAGGCCGAGCCTTTTGTGAGGGAACTTGCGCAGTACGGCCTGGACTC
GGTTGTCTTTCCAACGATCGAGATCAGGCCGGTTACCGGCTGGAGCGTTCCTGATCTCACCAGATTCGCCGGTATCTTCT
TTACCAGCCCCAACAGCGTCCAGTTCTTTCTCGAACGCTTGCTTGAAGAGTCTCCCGACGAACTGCCAAATCTTCAGCAG
GCCCGCGTCTGGGCGGTCGGCAAAACCACTGGTGGCGATCTGGAGAAACATGGCGTCTCAATCGAGCCTCTTCCGAAGAG
CGCTGACGCCGTCAGCCTCATGTCTGGCATCGACGCCAGCGAAATCGAAGGCAAAACCTTCCTCTTTGTTCGGGGTAGCC
TCTCGCTCGGCACCATTCCCGAAGTCATCGCCAAACGCGGCGGCATCTGCGTCGAGCTGACCGTTTACGACAATATTCAG
CCTTCACTCGAAGAGACCCAGAAAATCAAATCACTGCTCACAGAAGGCAAAATCGACTGCCTCTCGTTCACCAGTCCGTC
AACTGCCATCAACTTCTTTGAAGCCATAGACTCAAAGGAAGTGCCGAGCGACGTACTCATCGCCGCCATCGGCACCACCA
CCTCCAGCGCACTCGAAAAGCTGGGTGTCAAGGTGGACATCATCCCCGAATACTTCGACGGCCCCAACTTCGCCAAAGCC
ATCGCCGCTGCCCTCAGCTGA

Upstream 100 bases:

>100_bases
ACACCCCGGAAGAGGCCGAGGCTGTCGGTATTGAGCTGGCTGAAGTTCTGCTTTCGATGGGCGCGGAGAAAATTCTCGCC
GACATCCGCAAAACCCGCTG

Downstream 100 bases:

>100_bases
TTGCTTCTCTAAAAGAAACAGCACCTACTCCACATCCGGAATGTCATCGACATAACCCATGTGGATAGTCTCGCCTTCAG
GTTCCCGCTCTTTGGTTTTA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKTVLVTRPKHQAEPFVRELAQYGLDSVVFPTIEIRPVTGWSVPDLTRFAGIFFTSPNSVQFFLERLLEESPDELPNLQQ
ARVWAVGKTTGGDLEKHGVSIEPLPKSADAVSLMSGIDASEIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQ
PSLEETQKIKSLLTEGKIDCLSFTSPSTAINFFEAIDSKEVPSDVLIAAIGTTTSSALEKLGVKVDIIPEYFDGPNFAKA
IAAALS

Sequences:

>Translated_246_residues
MKTVLVTRPKHQAEPFVRELAQYGLDSVVFPTIEIRPVTGWSVPDLTRFAGIFFTSPNSVQFFLERLLEESPDELPNLQQ
ARVWAVGKTTGGDLEKHGVSIEPLPKSADAVSLMSGIDASEIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQ
PSLEETQKIKSLLTEGKIDCLSFTSPSTAINFFEAIDSKEVPSDVLIAAIGTTTSSALEKLGVKVDIIPEYFDGPNFAKA
IAAALS
>Mature_246_residues
MKTVLVTRPKHQAEPFVRELAQYGLDSVVFPTIEIRPVTGWSVPDLTRFAGIFFTSPNSVQFFLERLLEESPDELPNLQQ
ARVWAVGKTTGGDLEKHGVSIEPLPKSADAVSLMSGIDASEIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQ
PSLEETQKIKSLLTEGKIDCLSFTSPSTAINFFEAIDSKEVPSDVLIAAIGTTTSSALEKLGVKVDIIPEYFDGPNFAKA
IAAALS

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM4_CHLTE (Q8KCJ3)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662314.1
- ProteinModelPortal:   Q8KCJ3
- SMR:   Q8KCJ3
- GeneID:   1005977
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1428
- NMPDR:   fig|194439.1.peg.1408
- TIGR:   CT1428
- HOGENOM:   HBG405786
- OMA:   VVFPTIE
- ProtClustDB:   CLSK637759
- BioCyc:   CTEP194439:CT_1428-MONOMER
- BRENDA:   4.2.1.75
- InterPro:   IPR003754

Pfam domain/function: PF02602 HEM4; SSF69618 HEM4_synth

EC number: =4.2.1.75

Molecular weight: Translated: 26617; Mature: 26617

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLVTRPKHQAEPFVRELAQYGLDSVVFPTIEIRPVTGWSVPDLTRFAGIFFTSPNSV
CCCEEEECCCHHCCHHHHHHHHCCCCCEEECEEEEEECCCCCCCHHHHHHEEEEECCCHH
QFFLERLLEESPDELPNLQQARVWAVGKTTGGDLEKHGVSIEPLPKSADAVSLMSGIDAS
HHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCHH
EIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQPSLEETQKIKSLLTEGKIDC
HCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEE
LSFTSPSTAINFFEAIDSKEVPSDVLIAAIGTTTSSALEKLGVKVDIIPEYFDGPNFAKA
EEECCCHHHHHHHHHHCCCCCCCHHEEEEECCCHHHHHHHHCCEEEEECCCCCCCCHHHH
IAAALS
HHHHCC
>Mature Secondary Structure
MKTVLVTRPKHQAEPFVRELAQYGLDSVVFPTIEIRPVTGWSVPDLTRFAGIFFTSPNSV
CCCEEEECCCHHCCHHHHHHHHCCCCCEEECEEEEEECCCCCCCHHHHHHEEEEECCCHH
QFFLERLLEESPDELPNLQQARVWAVGKTTGGDLEKHGVSIEPLPKSADAVSLMSGIDAS
HHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCHH
EIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQPSLEETQKIKSLLTEGKIDC
HCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEE
LSFTSPSTAINFFEAIDSKEVPSDVLIAAIGTTTSSALEKLGVKVDIIPEYFDGPNFAKA
EEECCCHHHHHHHHHHCCCCCCCHHEEEEECCCHHHHHHHHCCEEEEECCCCCCCCHHHH
IAAALS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901