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The map label for this gene is macA [H]

Identifier: 21674170

GI number: 21674170

Start: 1266553

End: 1267821

Strand: Direct

Name: macA [H]

Synonym: CT1348

Alternate gene names: 21674170

Gene position: 1266553-1267821 (Clockwise)

Preceding gene: 21674169

Following gene: 21674171

Centisome position: 58.77

GC content: 57.37

Gene sequence:

>1269_bases
ATGGCTAACACCAAACGCTCCGGAAAACTCCGCAACATCTTCATCATCGGCGGCGCGCTCTTCGCCATCGGAGTCGCAGC
GCTCATCTGGCTGAACACGCGCGAAAAAGCGGTCGAGGTGACCACCGAAAAGGTGTTCCGCAAGGAGGTGGTGCACACCG
TTACTGCAACCGGCAAGATTCAGCCTGAAACCGAAGTAGCCATGTCTCCCGACGTCTCCGGCGAGATCATCGAGCTGCCG
GTCGTGGAGGGGCAGGAGGTGAAAGCCGGGCAACTGCTCTTCCGGATCCAGCCCGACATCTACGTCAACCAGGTCAAGCA
GAGCCGGGCGCAGCTCAATCTGTCGAAGGCGCAAAGCATGGAGGCCAAAGCACGGATGCTTAAGGCGGAGGACGATTTTC
GCAAAGCAGACATTTTGTATAAAGACAAGCTCATTTCCCAAACCGACTGGCTCTCGGCGAAAACCAACGCCGAAACGAGC
CGTGCAGCCTGGAAAGCAGCCCGATATTCCATCGACCAGAACCAGAGCCTGCTCGACCAGAACGAAGAGCGCCTTACCAA
AACCGTGGTGCGTTCGCCCATCAACGGCACGATCATTTCGCTAAGTAGCAAACCAGGCGAGCGCGTTGTCGGCACCGGCC
AGTTCCCCGGCACCGAGGTGCTCAAGATCGCCAATCTGGACAACATGCTGCTCAAGGTCGAGGTGAACGAGAACGACATC
GTGAACGTGCAGGTCGGCAACCCAGTCACCGTAACGGTCGATGCGTTCGGCGACCGCACCTTCAAAGGTGAGGTGAGCGA
AATCGCCAATTCTGCCAAAACTCAGGCCGCGAACACGCAGGAGGAGGCAACCAACTTCGAGGTCAAGATCAAAATCCTCA
ACCACCAGCGCCTGCTCAAACCCGGCATGAGCGGCACGGCAAATATCGAAACCCAGCGAGTGCCGAACGCGCTGGTAGTG
CCGATCCAGAGCGTCACCATGCGAACGGCGGGCGGCAAAAAAGCGGCAACGCCAACCGATTCCACAAGCAACAACAAGGT
CGTGCAGCTCAACCAGAATCATCGCCTTACCGATGAAACCGAAGGCGTGTTCGTCGTCGAAGGCGACCATGTGCGCTTCA
GAAAGGTCAAAACCGGCACGACCGACAACACCCATATTATTATCCTCGAAGGAGTGAAAGAGGGCGAAGAGGTCGTGTCG
GGCAGTTACGGCGCCATCAGCCGCGAATTGCAGGACGGTAGCACCGTGAAGCTTCAGAAGAAACGATGA

Upstream 100 bases:

>100_bases
GACGCAGGCGATTTACAACCTCGCGCTGCAAAAGGCGCTGCTCGATTACACCAGTGGCGTCGGCATCGAAGAGGTCAGCA
ACGCATCATCTCACTGATTT

Downstream 100 bases:

>100_bases
GCAAGCAGCCGTACATCATCCGGATCAGCAACCTCTGCCGGTATTACACCATGGGCGACCAGACGGTCAAGGCGCTCGAC
GACATTAACCTCGATTTTCG

Product: membrane fusion efflux protein, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MANTKRSGKLRNIFIIGGALFAIGVAALIWLNTREKAVEVTTEKVFRKEVVHTVTATGKIQPETEVAMSPDVSGEIIELP
VVEGQEVKAGQLLFRIQPDIYVNQVKQSRAQLNLSKAQSMEAKARMLKAEDDFRKADILYKDKLISQTDWLSAKTNAETS
RAAWKAARYSIDQNQSLLDQNEERLTKTVVRSPINGTIISLSSKPGERVVGTGQFPGTEVLKIANLDNMLLKVEVNENDI
VNVQVGNPVTVTVDAFGDRTFKGEVSEIANSAKTQAANTQEEATNFEVKIKILNHQRLLKPGMSGTANIETQRVPNALVV
PIQSVTMRTAGGKKAATPTDSTSNNKVVQLNQNHRLTDETEGVFVVEGDHVRFRKVKTGTTDNTHIIILEGVKEGEEVVS
GSYGAISRELQDGSTVKLQKKR

Sequences:

>Translated_422_residues
MANTKRSGKLRNIFIIGGALFAIGVAALIWLNTREKAVEVTTEKVFRKEVVHTVTATGKIQPETEVAMSPDVSGEIIELP
VVEGQEVKAGQLLFRIQPDIYVNQVKQSRAQLNLSKAQSMEAKARMLKAEDDFRKADILYKDKLISQTDWLSAKTNAETS
RAAWKAARYSIDQNQSLLDQNEERLTKTVVRSPINGTIISLSSKPGERVVGTGQFPGTEVLKIANLDNMLLKVEVNENDI
VNVQVGNPVTVTVDAFGDRTFKGEVSEIANSAKTQAANTQEEATNFEVKIKILNHQRLLKPGMSGTANIETQRVPNALVV
PIQSVTMRTAGGKKAATPTDSTSNNKVVQLNQNHRLTDETEGVFVVEGDHVRFRKVKTGTTDNTHIIILEGVKEGEEVVS
GSYGAISRELQDGSTVKLQKKR
>Mature_421_residues
ANTKRSGKLRNIFIIGGALFAIGVAALIWLNTREKAVEVTTEKVFRKEVVHTVTATGKIQPETEVAMSPDVSGEIIELPV
VEGQEVKAGQLLFRIQPDIYVNQVKQSRAQLNLSKAQSMEAKARMLKAEDDFRKADILYKDKLISQTDWLSAKTNAETSR
AAWKAARYSIDQNQSLLDQNEERLTKTVVRSPINGTIISLSSKPGERVVGTGQFPGTEVLKIANLDNMLLKVEVNENDIV
NVQVGNPVTVTVDAFGDRTFKGEVSEIANSAKTQAANTQEEATNFEVKIKILNHQRLLKPGMSGTANIETQRVPNALVVP
IQSVTMRTAGGKKAATPTDSTSNNKVVQLNQNHRLTDETEGVFVVEGDHVRFRKVKTGTTDNTHIIILEGVKEGEEVVSG
SYGAISRELQDGSTVKLQKKR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=352, Percent_Identity=25.2840909090909, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790519, Length=301, Percent_Identity=24.5847176079734, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081951, Length=222, Percent_Identity=27.9279279279279, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 46301; Mature: 46170

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTKRSGKLRNIFIIGGALFAIGVAALIWLNTREKAVEVTTEKVFRKEVVHTVTATGKI
CCCCCCCCCEEEEEEECHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHEECCCC
QPETEVAMSPDVSGEIIELPVVEGQEVKAGQLLFRIQPDIYVNQVKQSRAQLNLSKAQSM
CCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHH
EAKARMLKAEDDFRKADILYKDKLISQTDWLSAKTNAETSRAAWKAARYSIDQNQSLLDQ
HHHHHHHHCCCCCHHHCEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCC
NEERLTKTVVRSPINGTIISLSSKPGERVVGTGQFPGTEVLKIANLDNMLLKVEVNENDI
CHHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCCCCCCEEEEECCCCEEEEEEECCCCE
VNVQVGNPVTVTVDAFGDRTFKGEVSEIANSAKTQAANTQEEATNFEVKIKILNHQRLLK
EEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCEEEEEEEECCHHHHC
PGMSGTANIETQRVPNALVVPIQSVTMRTAGGKKAATPTDSTSNNKVVQLNQNHRLTDET
CCCCCCCCEECCCCCCEEEEEEEHEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
EGVFVVEGDHVRFRKVKTGTTDNTHIIILEGVKEGEEVVSGSYGAISRELQDGSTVKLQK
CCEEEEECCCEEEEEEECCCCCCEEEEEEECCCCCHHHHCCCCHHHHHHCCCCCEEEEEE
KR
CC
>Mature Secondary Structure 
ANTKRSGKLRNIFIIGGALFAIGVAALIWLNTREKAVEVTTEKVFRKEVVHTVTATGKI
CCCCCCCCEEEEEEECHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHEECCCC
QPETEVAMSPDVSGEIIELPVVEGQEVKAGQLLFRIQPDIYVNQVKQSRAQLNLSKAQSM
CCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHH
EAKARMLKAEDDFRKADILYKDKLISQTDWLSAKTNAETSRAAWKAARYSIDQNQSLLDQ
HHHHHHHHCCCCCHHHCEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCC
NEERLTKTVVRSPINGTIISLSSKPGERVVGTGQFPGTEVLKIANLDNMLLKVEVNENDI
CHHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCCCCCCEEEEECCCCEEEEEEECCCCE
VNVQVGNPVTVTVDAFGDRTFKGEVSEIANSAKTQAANTQEEATNFEVKIKILNHQRLLK
EEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCEEEEEEEECCHHHHC
PGMSGTANIETQRVPNALVVPIQSVTMRTAGGKKAATPTDSTSNNKVVQLNQNHRLTDET
CCCCCCCCEECCCCCCEEEEEEEHEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
EGVFVVEGDHVRFRKVKTGTTDNTHIIILEGVKEGEEVVSGSYGAISRELQDGSTVKLQK
CCEEEEECCCEEEEEEECCCCCCEEEEEEECCCCCHHHHCCCCHHHHHHCCCCCEEEEEE
KR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]