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The map label for this gene is panB [H]

Identifier: 21674163

GI number: 21674163

Start: 1260856

End: 1261689

Strand: Reverse

Name: panB [H]

Synonym: CT1341

Alternate gene names: 21674163

Gene position: 1261689-1260856 (Counterclockwise)

Preceding gene: 21674164

Following gene: 21674162

Centisome position: 58.55

GC content: 60.91

Gene sequence:

>834_bases
ATGAACCAGCCCTCTGGCAATAAATTGCCCCACGTCACAACCCGCCGGATGCTCGATATGAAAGAGCGCGGCGAGAAGAT
CGCCATGCTGACCGCCTATGACTACACGATGGCGCGGATTCTGGACCGCTCGGGCGTTGACGCGATTCTTGTCGGCGATT
CGGCGAGCAACGTCTTCGCCGGGCACAGCACCACGCTGCCGATGACCGTTGACGAGATGATCTACCACGCCAAGGCGGTG
GTGCGTGGCGTGCAGGCAGAGACGCGACGGGCGATGGTGATTGTCGATATGCCCTTCATGAGCTACCAGCTCTCGCCGGA
AGATGCGGTGCGCAACGCCGGGAAAATCATGAAAGAGCACGAGTGCGACGCGGTGAAAATGGAGGGGGGCAAGGTGATCG
CCGAAGCGGTCAAGCGGATCACCGATATCGGCATTCCGGTGATGGGCCACCTCGGCCTCATGCCGCAGTCGATCTACAAA
TATGGCAGCTACAAGGTGCGCGCGATGGAGGAGGAGGAGGCCCGGCAGCTCATCGAGGATGCGAAGATCATCGAGGAGGC
TGGAGCGTTCGCCATCGTGCTCGAAAAGATTCCATCGAAGCTCGCCGGTGAGGTGAGCCGCTTGCTGACCATTCCGACTA
TCGGCATCGGCGCGGGGCCGGAGTGCGACGGCCAGGTTCTGGTCATCAACGACATGCTTGGCCTCAGCACCGACTTCCGC
CCTCGCTTCGTCCGCCGCTACGCTGACCTCTCCTCGGTGATCGAGCAAGCGGTCAAAAGCTACGTCGAGGATGTGCGGAG
CAACAGCTTCCCGTCGGAGGATGAGAGTTACTGA

Upstream 100 bases:

>100_bases
TGAAGCAGGAAAATCTTTCGGATCGGAAGCTAAAATGCTGACTTTGGGGGAGATCGGACGCCTCGAAGGTTTTCAACAAT
CACTCTAACTGACGACCATC

Downstream 100 bases:

>100_bases
CGGGAACAGGCATTGTTTCCGGATTGCAAAATTTCATGAATCAATTATCTTTCATGACGATCTCCGCAATCGGGCTCCGG
TATTTTTAACGTGCAGTGAC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNQPSGNKLPHVTTRRMLDMKERGEKIAMLTAYDYTMARILDRSGVDAILVGDSASNVFAGHSTTLPMTVDEMIYHAKAV
VRGVQAETRRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEHECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYK
YGSYKVRAMEEEEARQLIEDAKIIEEAGAFAIVLEKIPSKLAGEVSRLLTIPTIGIGAGPECDGQVLVINDMLGLSTDFR
PRFVRRYADLSSVIEQAVKSYVEDVRSNSFPSEDESY

Sequences:

>Translated_277_residues
MNQPSGNKLPHVTTRRMLDMKERGEKIAMLTAYDYTMARILDRSGVDAILVGDSASNVFAGHSTTLPMTVDEMIYHAKAV
VRGVQAETRRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEHECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYK
YGSYKVRAMEEEEARQLIEDAKIIEEAGAFAIVLEKIPSKLAGEVSRLLTIPTIGIGAGPECDGQVLVINDMLGLSTDFR
PRFVRRYADLSSVIEQAVKSYVEDVRSNSFPSEDESY
>Mature_277_residues
MNQPSGNKLPHVTTRRMLDMKERGEKIAMLTAYDYTMARILDRSGVDAILVGDSASNVFAGHSTTLPMTVDEMIYHAKAV
VRGVQAETRRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEHECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYK
YGSYKVRAMEEEEARQLIEDAKIIEEAGAFAIVLEKIPSKLAGEVSRLLTIPTIGIGAGPECDGQVLVINDMLGLSTDFR
PRFVRRYADLSSVIEQAVKSYVEDVRSNSFPSEDESY

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=39.6887159533074, Blast_Score=204, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6319653, Length=255, Percent_Identity=36.4705882352941, Blast_Score=176, Evalue=5e-45,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 30609; Mature: 30609

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPSGNKLPHVTTRRMLDMKERGEKIAMLTAYDYTMARILDRSGVDAILVGDSASNVFA
CCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHCCCCCEEEECCCCCCEEC
GHSTTLPMTVDEMIYHAKAVVRGVQAETRRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEH
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHC
ECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYKYGSYKVRAMEEEEARQLIED
CCCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCEEEEECCHHHHHHHHHH
AKIIEEAGAFAIVLEKIPSKLAGEVSRLLTIPTIGIGAGPECDGQVLVINDMLGLSTDFR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCCCCCC
PRFVRRYADLSSVIEQAVKSYVEDVRSNSFPSEDESY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNQPSGNKLPHVTTRRMLDMKERGEKIAMLTAYDYTMARILDRSGVDAILVGDSASNVFA
CCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHCCCCCEEEECCCCCCEEC
GHSTTLPMTVDEMIYHAKAVVRGVQAETRRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEH
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHC
ECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYKYGSYKVRAMEEEEARQLIED
CCCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCEEEEECCHHHHHHHHHH
AKIIEEAGAFAIVLEKIPSKLAGEVSRLLTIPTIGIGAGPECDGQVLVINDMLGLSTDFR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCCCCCC
PRFVRRYADLSSVIEQAVKSYVEDVRSNSFPSEDESY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA