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The map label for this gene is f1pep1 [H]

Identifier: 21674124

GI number: 21674124

Start: 1222692

End: 1224779

Strand: Direct

Name: f1pep1 [H]

Synonym: CT1301

Alternate gene names: 21674124

Gene position: 1222692-1224779 (Clockwise)

Preceding gene: 21674123

Following gene: 21674127

Centisome position: 56.74

GC content: 58.57

Gene sequence:

>2088_bases
ATGGATGCGCCTTCCGCCAATGTCGTCGAAACCGTCTGCGGCGAACGCATCGCAGACCCATACCGTCCGCTCGAAAATCT
CAAAGACCCGAAAGTCGCCGCCTGGTACCGGCGCGAGTCGGATCACGCCCGCCAGGTGCTCGACGCCATTCCGGGCCGCA
ACGAACTCATCGAAAAGATGAAGGAGTTCGACCAGCGCAGAAAAGAGAAGGTTTTCGATCTTTCCATTACGGATAACGAC
CACTACTTCTACCTCAAGCAGACGCCCGTGGACGAAACCGGCAAACTCTACACCCGCAAGGGATACAAAGGTCAGGAGCG
ATTGCTTTTCGATCCGACAACATACAAGGACGGAAGCGGCAGCACCTTCGTCATCAGCGAAGTCGCACCGAATATCGACG
CCTCAAAGGTGATCGTCACCGTCTCGCCGAACGGTTCGGAAAATTCCGTCATGCTGATCATTGACGTCAGGGACGGCCAC
ATCTGGCCCGAGAGGATTGACCGCTGCTGGTTCGCTTCGCCGTCGTGGCTTCCAGACGGCAAGTCGTTTTTCTACAACCG
GATGAACACCGCCGATCTGCACGACAAAGCACGTGAGCTCGACAGCAAGGTGTTGCTGCACGTGGTTGGCACCGATCCAT
CGACCGACCGCGAAATCTTTTCACGCACCCACAATCCCGCCCTGCCCATCAAGCCTGAGGACATTCCGTCGGTCATATAC
GACCGGAAAAGCGAGAAAATTTTCGCCTTCGTCGGCAGCGTCGATCCCAGAGTCACCGCATGGTATGCTCCTGCCAGGTT
CTGGAACGAAAAAACCATCCCCTGGAAAACGCTCTTCCGCCCTGAAGACGATGTTTACGATTTTGCCGCGACCAAACACA
ATCTCTACGTCTTCACACCGAAGAACGCGCCGCGCTTCAAAGTACTGAAAACCTCGCTCGACCACCCCGATCTGGCGACC
GCCGAAACGGTCATTCCGGAACCGGCGGAGGGCACCCTTACCGCCCTGGCGCTGACCAACGAAGGACTCTTCTACACCAT
CTCCACCAACGGCGTCCGGGAGGAGTTGTATCATCTGAACTACGGCAGCACAAAGCCGGAAAAGATCGAGACTCCGTTCG
AGGCGGGCACGATGTCGATCGGTTCAAAGGGATTCGACAGGCCTGAACTGTGGACGGTCATAGGCGGCTGGAACCACGAC
TATCGCCGCTACCGCTACGATGCGAAGCACAATCGTTTCATCGACGAAACGCTCTCGTCGAAGGCGAGCTACCCCGAATA
CGACAACCTTGAAGTCAAGGAGGTAATGGCGACCTCCTATGACGGCGTCAAGGTGCCGCTGTCGCTGATCTACAATCGCG
GCATCAGGATGGATGGCAAAAATCCCGTGCTGATCTACGGTTACGGCGCGTATGGCAACTCGATGACCCCGTTCTTCAAC
CCCTCGTTCCTGCTCTGGACCTACAAGGGCGGCATCCTCGCCGTGGCCCACGTACGCGGCGGCGGAGAGCTGGGCGACGC
CTGGCACAAGGCGGGCATGAAATCGACCAAGCCCAACACCTGGAAAGACCTCATCGCCTGCGCCGAATATCTGATTCATG
AGGGCTACACCTCGCCCGAACACATCGCCATCAACTCGGCCAGCGCAGGCGGCATTCTCATCGGGCGCGCCATAACCGAG
CGCCCCGACCTCTTCGCCGCCGCCATGCCGCAGGTCGGCGTGCTCAACGCGGTGAGAGGCGAATTCAGCCCCAATGGCCC
GGTCAACGTGCCCGAATTCGGCACCGTCAAAAACCCCGAGGAGTGCAAGGCGCTCCTCGAAATGGATGCCTACCTGCACA
TCCGCGACGGCGTAAAATACCCCGCAGTGCTCATCACAGCAGGCATGAACGACCCGAGAGTCCCCGCCTGGCAACCGGCC
AAATTCGCCGCAAGGTTACAGGAAGCCACCACCTCCGGCAAACCGGTGCTTTTTTTCACGGATTACAAAGCCGGCCACGG
CATCGGCGACACGAAGACGAAGCAGTTCGAATCGCTCGCCGACATGCTGAGCTTCGGATTGTGGCAGACCGGCGGAGCCG
CCCAATGA

Upstream 100 bases:

>100_bases
TTACAGAACCATGCTCGCCGGGCACACCCCGGCCATCCTGTGCCTCTCAGCCCTCCTGTTTTCCACGCCAATTCCTGCCC
GTGCAGATAACAAGGCAAAC

Downstream 100 bases:

>100_bases
TGAATTTTGAATGAAGAATTGCAGGGGCCACCAAGTCCACGACGTCTCTCCAGTCCACAATTTCCGAAGCCTCTTGGCTG
CCCACTCAAAACGTGAAGCA

Product: prolyl oligopeptidase family protein

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MDAPSANVVETVCGERIADPYRPLENLKDPKVAAWYRRESDHARQVLDAIPGRNELIEKMKEFDQRRKEKVFDLSITDND
HYFYLKQTPVDETGKLYTRKGYKGQERLLFDPTTYKDGSGSTFVISEVAPNIDASKVIVTVSPNGSENSVMLIIDVRDGH
IWPERIDRCWFASPSWLPDGKSFFYNRMNTADLHDKARELDSKVLLHVVGTDPSTDREIFSRTHNPALPIKPEDIPSVIY
DRKSEKIFAFVGSVDPRVTAWYAPARFWNEKTIPWKTLFRPEDDVYDFAATKHNLYVFTPKNAPRFKVLKTSLDHPDLAT
AETVIPEPAEGTLTALALTNEGLFYTISTNGVREELYHLNYGSTKPEKIETPFEAGTMSIGSKGFDRPELWTVIGGWNHD
YRRYRYDAKHNRFIDETLSSKASYPEYDNLEVKEVMATSYDGVKVPLSLIYNRGIRMDGKNPVLIYGYGAYGNSMTPFFN
PSFLLWTYKGGILAVAHVRGGGELGDAWHKAGMKSTKPNTWKDLIACAEYLIHEGYTSPEHIAINSASAGGILIGRAITE
RPDLFAAAMPQVGVLNAVRGEFSPNGPVNVPEFGTVKNPEECKALLEMDAYLHIRDGVKYPAVLITAGMNDPRVPAWQPA
KFAARLQEATTSGKPVLFFTDYKAGHGIGDTKTKQFESLADMLSFGLWQTGGAAQ

Sequences:

>Translated_695_residues
MDAPSANVVETVCGERIADPYRPLENLKDPKVAAWYRRESDHARQVLDAIPGRNELIEKMKEFDQRRKEKVFDLSITDND
HYFYLKQTPVDETGKLYTRKGYKGQERLLFDPTTYKDGSGSTFVISEVAPNIDASKVIVTVSPNGSENSVMLIIDVRDGH
IWPERIDRCWFASPSWLPDGKSFFYNRMNTADLHDKARELDSKVLLHVVGTDPSTDREIFSRTHNPALPIKPEDIPSVIY
DRKSEKIFAFVGSVDPRVTAWYAPARFWNEKTIPWKTLFRPEDDVYDFAATKHNLYVFTPKNAPRFKVLKTSLDHPDLAT
AETVIPEPAEGTLTALALTNEGLFYTISTNGVREELYHLNYGSTKPEKIETPFEAGTMSIGSKGFDRPELWTVIGGWNHD
YRRYRYDAKHNRFIDETLSSKASYPEYDNLEVKEVMATSYDGVKVPLSLIYNRGIRMDGKNPVLIYGYGAYGNSMTPFFN
PSFLLWTYKGGILAVAHVRGGGELGDAWHKAGMKSTKPNTWKDLIACAEYLIHEGYTSPEHIAINSASAGGILIGRAITE
RPDLFAAAMPQVGVLNAVRGEFSPNGPVNVPEFGTVKNPEECKALLEMDAYLHIRDGVKYPAVLITAGMNDPRVPAWQPA
KFAARLQEATTSGKPVLFFTDYKAGHGIGDTKTKQFESLADMLSFGLWQTGGAAQ
>Mature_695_residues
MDAPSANVVETVCGERIADPYRPLENLKDPKVAAWYRRESDHARQVLDAIPGRNELIEKMKEFDQRRKEKVFDLSITDND
HYFYLKQTPVDETGKLYTRKGYKGQERLLFDPTTYKDGSGSTFVISEVAPNIDASKVIVTVSPNGSENSVMLIIDVRDGH
IWPERIDRCWFASPSWLPDGKSFFYNRMNTADLHDKARELDSKVLLHVVGTDPSTDREIFSRTHNPALPIKPEDIPSVIY
DRKSEKIFAFVGSVDPRVTAWYAPARFWNEKTIPWKTLFRPEDDVYDFAATKHNLYVFTPKNAPRFKVLKTSLDHPDLAT
AETVIPEPAEGTLTALALTNEGLFYTISTNGVREELYHLNYGSTKPEKIETPFEAGTMSIGSKGFDRPELWTVIGGWNHD
YRRYRYDAKHNRFIDETLSSKASYPEYDNLEVKEVMATSYDGVKVPLSLIYNRGIRMDGKNPVLIYGYGAYGNSMTPFFN
PSFLLWTYKGGILAVAHVRGGGELGDAWHKAGMKSTKPNTWKDLIACAEYLIHEGYTSPEHIAINSASAGGILIGRAITE
RPDLFAAAMPQVGVLNAVRGEFSPNGPVNVPEFGTVKNPEECKALLEMDAYLHIRDGVKYPAVLITAGMNDPRVPAWQPA
KFAARLQEATTSGKPVLFFTDYKAGHGIGDTKTKQFESLADMLSFGLWQTGGAAQ

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=703, Percent_Identity=26.0312944523471, Blast_Score=252, Evalue=9e-67,
Organism=Homo sapiens, GI284172420, Length=222, Percent_Identity=33.7837837837838, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI284172413, Length=222, Percent_Identity=33.7837837837838, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI70778815, Length=222, Percent_Identity=33.7837837837838, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI108860686, Length=222, Percent_Identity=33.7837837837838, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI284172438, Length=222, Percent_Identity=33.7837837837838, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI284172431, Length=222, Percent_Identity=33.7837837837838, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI108860692, Length=213, Percent_Identity=33.8028169014084, Blast_Score=106, Evalue=7e-23,
Organism=Escherichia coli, GI1788150, Length=701, Percent_Identity=25.8202567760342, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24583414, Length=704, Percent_Identity=27.1306818181818, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI221510989, Length=702, Percent_Identity=24.9287749287749, Blast_Score=188, Evalue=9e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 77944; Mature: 77944

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAPSANVVETVCGERIADPYRPLENLKDPKVAAWYRRESDHARQVLDAIPGRNELIEKM
CCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHH
KEFDQRRKEKVFDLSITDNDHYFYLKQTPVDETGKLYTRKGYKGQERLLFDPTTYKDGSG
HHHHHHHHHEEEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCC
STFVISEVAPNIDASKVIVTVSPNGSENSVMLIIDVRDGHIWPERIDRCWFASPSWLPDG
CEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHEECCCCCCCCCC
KSFFYNRMNTADLHDKARELDSKVLLHVVGTDPSTDREIFSRTHNPALPIKPEDIPSVIY
HHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCHHHH
DRKSEKIFAFVGSVDPRVTAWYAPARFWNEKTIPWKTLFRPEDDVYDFAATKHNLYVFTP
CCCCCEEEEEECCCCCCEEEEECHHHHCCCCCCCHHEECCCCCCHHHHHCCCCCEEEEEC
KNAPRFKVLKTSLDHPDLATAETVIPEPAEGTLTALALTNEGLFYTISTNGVREELYHLN
CCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEEEECCCEEEEEECCCHHHHHHCCC
YGSTKPEKIETPFEAGTMSIGSKGFDRPELWTVIGGWNHDYRRYRYDAKHNRFIDETLSS
CCCCCCHHCCCCCCCCCEECCCCCCCCCCEEEEECCCCCCHHHEECCCHHCHHHHHHHHC
KASYPEYDNLEVKEVMATSYDGVKVPLSLIYNRGIRMDGKNPVLIYGYGAYGNSMTPFFN
CCCCCCCCCCCHHHHHHCCCCCCEEEHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCC
PSFLLWTYKGGILAVAHVRGGGELGDAWHKAGMKSTKPNTWKDLIACAEYLIHEGYTSPE
CCEEEEEECCCEEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
HIAINSASAGGILIGRAITERPDLFAAAMPQVGVLNAVRGEFSPNGPVNVPEFGTVKNPE
EEEEECCCCCCEEEECHHCCCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHH
ECKALLEMDAYLHIRDGVKYPAVLITAGMNDPRVPAWQPAKFAARLQEATTSGKPVLFFT
HHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
DYKAGHGIGDTKTKQFESLADMLSFGLWQTGGAAQ
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDAPSANVVETVCGERIADPYRPLENLKDPKVAAWYRRESDHARQVLDAIPGRNELIEKM
CCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHH
KEFDQRRKEKVFDLSITDNDHYFYLKQTPVDETGKLYTRKGYKGQERLLFDPTTYKDGSG
HHHHHHHHHEEEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCC
STFVISEVAPNIDASKVIVTVSPNGSENSVMLIIDVRDGHIWPERIDRCWFASPSWLPDG
CEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHEECCCCCCCCCC
KSFFYNRMNTADLHDKARELDSKVLLHVVGTDPSTDREIFSRTHNPALPIKPEDIPSVIY
HHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCHHHH
DRKSEKIFAFVGSVDPRVTAWYAPARFWNEKTIPWKTLFRPEDDVYDFAATKHNLYVFTP
CCCCCEEEEEECCCCCCEEEEECHHHHCCCCCCCHHEECCCCCCHHHHHCCCCCEEEEEC
KNAPRFKVLKTSLDHPDLATAETVIPEPAEGTLTALALTNEGLFYTISTNGVREELYHLN
CCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEEEECCCEEEEEECCCHHHHHHCCC
YGSTKPEKIETPFEAGTMSIGSKGFDRPELWTVIGGWNHDYRRYRYDAKHNRFIDETLSS
CCCCCCHHCCCCCCCCCEECCCCCCCCCCEEEEECCCCCCHHHEECCCHHCHHHHHHHHC
KASYPEYDNLEVKEVMATSYDGVKVPLSLIYNRGIRMDGKNPVLIYGYGAYGNSMTPFFN
CCCCCCCCCCCHHHHHHCCCCCCEEEHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCC
PSFLLWTYKGGILAVAHVRGGGELGDAWHKAGMKSTKPNTWKDLIACAEYLIHEGYTSPE
CCEEEEEECCCEEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
HIAINSASAGGILIGRAITERPDLFAAAMPQVGVLNAVRGEFSPNGPVNVPEFGTVKNPE
EEEEECCCCCCEEEECHHCCCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHH
ECKALLEMDAYLHIRDGVKYPAVLITAGMNDPRVPAWQPAKFAARLQEATTSGKPVLFFT
HHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
DYKAGHGIGDTKTKQFESLADMLSFGLWQTGGAAQ
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]